E-GEOD-1017 - Transcription profiling of human acute quadriplegic myopathy patients
Released on 21 July 2007, last updated on 27 March 2012
AQM shows acute muscle wasting and weakness. Key aspects of AQM include muscle atrophy and myofilament loss. Gene expression profiling, using muscle biopsies from AQM, neurogenic atrophy and normal controls, showed that both myogenic and neurogenic atrophy share induction of myofiber-specific ubiquitin/proteosome pathways while only the AQM shows a specific strong induction of transforming growth factor (TGF)-beta/MAPK pathways.
transcription profiling by array, co-expression, disease state, sex
Constitutive activation of MAPK cascade in acute quadriplegic myopathy. Di Giovanni S, Molon A, Broccolini A, Melcon G, Mirabella M, Hoffman EP, Servidei S.