E-ERAD-138 - RNA-seq of human cancer patient with BrafV600E mutant melanoma before and after treatment with PLX4032. EGA study.
Released on 7 June 2013, last updated on 1 October 2013
We have collected material from a patient who had BrafV600E mutant melanoma that was treated with PLX4032. We have germline DNA from the patient and DNA and RNA from distinct lesions before and after treatment with PLX4032. We have transcriptome sequenced these samples to obtain a snap shot of the mechanisms of resistance that are operative.
RNA-seq of coding RNA