E-CVDE-1 - Transcription profiling of human heart with heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy
Submitted on 12 December 2006, released on 31 October 2007, last updated on 27 March 2012
End stage heart failure due to ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar characteristics, enlargement of the ventricles, relatively thin-walled ventricle, which leads to a limited contraction force and blood loading. Nevertheless, the response for present therapeutics is very variable and the prognosis is still very bad for ICM and DCM in general. Thus, the ability to differentiate the etiologies of heart failure based structural and physiological changes of the heart would be a step forward to enhance the specificity and the success of given therapy.
transcription profiling by array, disease state, reference
Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies. Kuner, Ruprecht; Barth, Andreas S.; Ruschhaupt, Markus; Buness, Andreas; Zwermann, Ludwig; Kreuzer, Eckart; Steinbeck, Gerhard; Poustka, Annemarie; Sultmann, Holger; Nabauer, Michael. Physiol Genomics 34(1):88 (2008), Europe PMC 18430805