E-CBIL-6 - Transcription profiling of HNF4 alpha null mice to investigate the phenotype of dis-regulated insulin secretion and abnormal beta cell growth

Status
Released on 5 September 2006, last updated on 2 June 2014
Organism
Mus musculus
Samples (8)
Array (1)
Protocols (7)
Description
The aim of this experiment was to use microarray analysis to examine the phenotype of dis-regulated insulin secretion and abnormal beta cell growth in HNF4 alpha null mice. These mice show impaired glucose tolerance and elevated fasting and fed plasma insulin levels. Rana Gupta from Klaus Kaestner's Lab extracted RNA from isolated islets. Three controls and five mutants were provided for the study.
Experiment types
transcription profiling by array, dye swap, genetic modification
Contact
Citation
Control of Beta-cell Gene Expression by HNF-4alpha. Rana K. Gupta, Regina K. Gorski, Peter White, Olga T. Hardy, John E. Brestelli, Guang Chen, Christian J. Stoeckert, Jr. and Klaus H. Kaestner.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-CBIL-6.idf.txt
Sample and data relationshipE-CBIL-6.sdrf.txt
Raw data (1)E-CBIL-6.raw.1.zip
Experiment designE-CBIL-6.biosamples.png, E-CBIL-6.biosamples.svg
Array designA-CBIL-2.adf.txt
Links