E-CBIL-16 - Transcription profiling of wild type and C/EBPbeta deficient mice during a partial hepatectomy time series to identify transcriptional targets of C/EBPbeta

Status
Submitted on 27 September 2006, released on 3 October 2006, last updated on 2 June 2014
Organism
Mus musculus
Samples (32)
Array (1)
Protocols (5)
Description
The aim of this experiment was to use microarray analysis to compare the response of wild type (WT) and C/EBPbeta deficient (KO) mice during a partial hepatectomy time course in hopes of identifying transcriptional targets of C/EBPbeta. In addition, the WT time course alone was examined to analyze mammalian cellular proliferation in vivo. In the partial hepatectomy model, quiescent hepatocytes reenter the cell cycle and progress in a synchronous fashion. This allows for the elucidation of regulatory networks operative in mammalian cell cycle. (Identification of transcriptional networks during liver regeneration (2004) Journal of Biological Chemistry)
Experiment types
transcription profiling by array, dye swap, genetic modification, reference, time series
Contacts
Citation
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Friedman JR, Larris B, Le PP, Peiris TH, Arsenlis A, Schug J, Tobias JW, Kaestner KH, Greenbaum LE. Proc Natl Acad Sci U S A 101(35):12986-91 (2004), Europe PMC 15317935
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-CBIL-16.idf.txt
Sample and data relationshipE-CBIL-16.sdrf.txt
Raw data (1)E-CBIL-16.raw.1.zip
Experiment designE-CBIL-16.biosamples.png, E-CBIL-16.biosamples.svg
Array designA-CBIL-2.adf.txt
Links