Sarah Teichmann

Sarah Teichmann

Group Leader - Teichmann research group

PhD 2000, University of Cambridge and MRC Laboratory of Molecular Biology. Trinity College Junior Research Fellow, 1999-2005. Beit Memorial Fellow for Biomedical Research, University College London, 2000-2001. MRC Career Track Programme Leader, MRC Laboratory of Molecular Biology, 2001-5 and MRC Programme Leader, 2006-12. Fellow and Director of Studies, Trinity College, since 2005. Principle Research Associate at the Dept Physics/Cavendish Laboratory, University of Cambridge, 2013-2016. Group Leader at EMBL-EBI and Sanger Institute since 2013.

Dr Sarah Teichmann is a research group leader at EMBL-EBI and senior group leader at the Wellcome Trust Sanger Institute. She is also a Principle Research Associate in the Dept Physics/Cavendish Laboratory, and a fellow of Trinity College, Cambridge. She is a leader in systems biology, which aims to explain how individual molecules within a cell co-operate to produce the cell’s overall behaviour. Her research also offers new insights into how proteins behave. This work could help scientists to predict how proteins interact with each other and design drugs that can interfere with disease processes. After reading the Natural Science Tripos at Trinity College, University of Cambridge, Sarah received her PhD in computational biology from the UK’s Medical Research Council Laboratory of Molecular Biology (MRC-LMB) in Cyrus Chothia's group. Sarah then moved to University College London as a Beit Memorial Fellow in Janet Thornton's group, where her work shed light on how proteins are formed from combinations of basic modules, and how they form networks of interactions in metabolic pathways. She returned to the LMB to set up her own group in 2001, where she focused on transcription factors, proteins that help to control the activity of genes. This included building a database (http://www.transcriptionfactor.org/) that allows researchers to search for genes predicted to encode transcription factors. Seminal work has shown how proteins club together to form larger “machines”, or complexes, by assembling via ordered pathways, and part of this is a further database, 3DComplex.org. Sarah is a co-founder of the state-of-the-art Single Cell Genomics Centre, a joint EMBL-EBI/Sanger initiative to clarify how gene activity is controlled throughout single cells of different types. Her work has been recognized by a number of awards, including the Biochemical Society's Colworth Medal, the Lister Prize, the Royal Society Crick Lecture and membership of the European Molecular Biology Organisation.

ORCID iD: 0000-0002-6294-6366

Tel:+ 44 (0) 1223 492 520 / Fax:+ 44 (0) 1223 494 468

Research

Find out about research activity in the Teichmann research group

Publications

2014

Parallel dynamics and evolution: Protein conformational fluctuations and assembly reflect evolutionary changes in sequence and structure.
Marsh JA, Teichmann SA.
Bioessays Volume 36 (2014) p.209-218
DOI: 10.1002/bies.201300134

2013

Protein complexes are under evolutionary selection to assemble via ordered pathways.
Marsh JA, Hernández H, Hall Z, Ahnert SE, Perica T, Robinson CV, Teichmann SA.
Cell Volume 153 (2013) p.461-470
DOI: 10.1016/j.cell.2013.02.044

Accounting for technical noise in single-cell RNA-seq experiments.
Brennecke P, Anders S, Kim JK, Kołodziejczyk AA, Zhang X, Proserpio V, Baying B, Benes V, Teichmann SA, Marioni JC, Heisler MG.
Nat Methods Volume 10 (2013) p.1093-1095
DOI: 10.1038/nmeth.2645

Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes.
Nishi H, Fong JH, Chang C, Teichmann SA, Panchenko AR.
Mol Biosyst Volume 9 (2013) p.1620-1626
DOI: 10.1039/c3mb25514j

Structural, evolutionary, and assembly principles of protein oligomerization.
Levy ED, Teichmann S.
Prog Mol Biol Transl Sci Volume 117 (2013) p.25-51
DOI: 10.1016/b978-0-12-386931-9.00002-7

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.
Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O'Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT.
J Exp Med Volume 210 (2013) p.1137-1151
DOI: 10.1084/jem.20122344

The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes.
Hall Z, Hernández H, Marsh JA, Teichmann SA, Robinson CV.
Structure Volume 21 (2013) p.1325-1337
DOI: 10.1016/j.str.2013.06.004

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.
Feig C, Jones JO, Kraman M, Wells RJ, Deonarine A, Chan DS, Connell CM, Roberts EW, Zhao Q, Caballero OL, Teichmann SA, Janowitz T, Jodrell DI, Tuveson DA, Fearon DT.
Proc Natl Acad Sci U S A Volume 110 (2013) p.20212-20217
DOI: 10.1073/pnas.1320318110

Immunology meets genomics.
Teichmann SA.
Brief Funct Genomics Volume 12 (2013) p.469-470
DOI: 10.1093/bfgp/elt037

Evolution of protein structures and interactions from the perspective of residue contact networks.
Zhang X, Perica T, Teichmann SA.
Curr Opin Struct Biol Volume 23 (2013) p.954-963
DOI: 10.1016/j.sbi.2013.07.004

2012

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.
Brookes E, de Santiago I, Hebenstreit D, Morris KJ, Carroll T, Xie SQ, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Ragoussis J, Teichmann SA, Pombo A.
Cell Stem Cell Volume 10 (2012) p.157-170
DOI: 10.1016/j.stem.2011.12.017

Probing the diverse landscape of protein flexibility and binding.
Marsh JA, Teichmann SA, Forman-Kay JD.
Curr Opin Struct Biol Volume 22 (2012) p.643-650
DOI: 10.1016/j.sbi.2012.08.008

DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes.
Charoensawan V, Janga SC, Bulyk ML, Babu MM, Teichmann SA.
Mol Cell Volume 47 (2012) p.183-192
DOI: 10.1016/j.molcel.2012.06.028

The emergence of protein complexes: quaternary structure, dynamics and allostery. Colworth Medal Lecture.
Perica T, Marsh JA, Sousa FL, Natan E, Colwell LJ, Ahnert SE, Teichmann SA.
Biochem Soc Trans Volume 40 (2012) p.475-491
DOI: 10.1042/bst20120056

Duel of the fates: the role of transcriptional circuits and noise in CD4+ cells.
Hebenstreit D, Deonarine A, Babu MM, Teichmann SA.
Curr Opin Cell Biol Volume 24 (2012) p.350-358
DOI: 10.1016/j.ceb.2012.03.007

How do you find transcription factors? Computational approaches to compile and annotate repertoires of regulators for any genome.
Vaquerizas JM, Teichmann SA, Luscombe NM.
Methods Mol Biol Volume 786 (2012) p.3-19
DOI: 10.1007/978-1-61779-292-2_1

Evolution of oligomeric state through geometric coupling of protein interfaces.
Perica T, Chothia C, Teichmann SA.
Proc Natl Acad Sci U S A Volume 109 (2012) p.8127-8132
DOI: 10.1073/pnas.1120028109

Cellular crowding imposes global constraints on the chemistry and evolution of proteomes.
Levy ED, De S, Teichmann SA.
Proc Natl Acad Sci U S A Volume 109 (2012) p.20461-20466
DOI: 10.1073/pnas.1209312109

The interface of protein structure, protein biophysics, and molecular evolution.
Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, Lakner C, Lartillot N, Lovell SC, Naylor G, Perica T, Pollock DD, Pupko T, Regan L, Roger A, Rubinstein N, Shakhnovich E, Sjölander K, Sunyaev S, Teufel AI, Thorne JL, Thornton JW, Weinreich DM, Whelan S.
Protein Sci Volume 21 (2012) p.769-785
DOI: 10.1002/pro.2071

Uncovering the interplay between DNA sequence preferences of transcription factors and nucleosomes.
Teichmann SA, Wigge PA, Charoensawan V.
Cell Cycle Volume 11 (2012) p.4487-4488
DOI: 10.4161/cc.22666

2011

Analysis and simulation of gene expression profiles in pure and mixed cell populations.
Hebenstreit D, Teichmann SA.
Phys Biol Volume 8 (2011) p.035013
DOI: 10.1088/1478-3975/8/3/035013

EpiChIP: gene-by-gene quantification of epigenetic modification levels.
Hebenstreit D, Gu M, Haider S, Turner DJ, Liò P, Teichmann SA.
Nucleic Acids Res Volume 39 (2011) p.e27
DOI: 10.1093/nar/gkq1226

RNA sequencing reveals two major classes of gene expression levels in metazoan cells.
Hebenstreit D, Fang M, Gu M, Charoensawan V, van Oudenaarden A, Teichmann SA.
Mol Syst Biol Volume 7 (2011) p.497
DOI: 10.1038/msb.2011.28

Relative solvent accessible surface area predicts protein conformational changes upon binding.
Marsh JA, Teichmann SA.
Structure Volume 19 (2011) p.859-867
DOI: 10.1016/j.str.2011.03.010

2010

Homomeric protein complexes: evolution and assembly.
Venkatakrishnan AJ, Levy ED, Teichmann SA.
Biochem Soc Trans Volume 38 (2010) p.879-882
DOI: 10.1042/bst0380879

Assessing computational methods of cis-regulatory module prediction.
Su J, Teichmann SA, Down TA.
PLoS Comput Biol Volume 6 (2010) p.e1001020
DOI: 10.1371/journal.pcbi.1001020

Genomic repertoires of DNA-binding transcription factors across the tree of life.
Charoensawan V, Wilson D, Teichmann SA.
Nucleic Acids Res Volume 38 (2010) p.7364-7377
DOI: 10.1093/nar/gkq617

An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y.
Cell Volume 140 (2010) p.744-752
DOI: 10.1016/j.cell.2010.01.044

Sequences and topology: evolution of proteins and evolution of computational approaches.
Teichmann SA, Grishin N.
Curr Opin Struct Biol Volume 20 (2010) p.333-334
DOI: 10.1016/j.sbi.2010.04.004

Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling.
Martin S, Söllner C, Charoensawan V, Adryan B, Thisse B, Thisse C, Teichmann S, Wright GJ.
Mol Cell Proteomics Volume 9 (2010) p.2654-2665
DOI: 10.1074/mcp.m110.004119

Systemizing the structures and structuring the system.
Levy ED, Teichmann SA.
Expert Rev Proteomics Volume 7 (2010) p.319-322
DOI: 10.1586/epr.10.33

The impact of gene expression regulation on evolution of extracellular signaling pathways.
Charoensawan V, Adryan B, Martin S, Söllner C, Thisse B, Thisse C, Wright GJ, Teichmann SA.
Mol Cell Proteomics Volume 9 (2010) p.2666-2677
DOI: 10.1074/mcp.m110.003020

How do proteins gain new domains?
Marsh JA, Teichmann SA.
Genome Biol Volume 11 (2010) p.126
DOI: 10.1186/gb-2010-11-7-126

The developmental expression dynamics of Drosophila melanogaster transcription factors.
Adryan B, Teichmann SA.
Genome Biol Volume 11 (2010) p.r40
DOI: 10.1186/gb-2010-11-4-r40

Lineage-specific expansion of DNA-binding transcription factor families.
Charoensawan V, Wilson D, Teichmann SA.
Trends Genet Volume 26 (2010) p.388-393
DOI: 10.1016/j.tig.2010.06.004

FlyTF: improved annotation and enhanced functionality of the Drosophila transcription factor database.
Pfreundt U, James DP, Tweedie S, Wilson D, Teichmann SA, Adryan B.
Nucleic Acids Res Volume 38 (2010) p.d443-7
DOI: 10.1093/nar/gkp910

2009

The impact of genomic neighborhood on the evolution of human and chimpanzee transcriptome.
De S, Teichmann SA, Babu MM.
Genome Res Volume 19 (2009) p.785-794
DOI: 10.1101/gr.086165.108

A HaemAtlas: characterizing gene expression in differentiated human blood cells.
Watkins NA, Gusnanto A, de Bono B, De S, Miranda-Saavedra D, Hardie DL, Angenent WG, Attwood AP, Ellis PD, Erber W, Foad NS, Garner SF, Isacke CM, Jolley J, Koch K, Macaulay IC, Morley SL, Rendon A, Rice KM, Taylor N, Thijssen-Timmer DC, Tijssen MR, van der Schoot CE, Wernisch L, Winzer T, Dudbridge F, Buckley CD, Langford CF, Teichmann S, Göttgens B, Ouwehand WH, Bloodomics Consortium.
Blood Volume 113 (2009) p.e1-9
DOI: 10.1182/blood-2008-06-162958

BloodExpress: a database of gene expression in mouse haematopoiesis.
Miranda-Saavedra D, De S, Trotter MW, Teichmann SA, Göttgens B.
Nucleic Acids Res Volume 37 (2009) p.d873-9
DOI: 10.1093/nar/gkn854

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM.
Nat Rev Genet Volume 10 (2009) p.252-263
DOI: 10.1038/nrg2538

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.
Wilson NK, Miranda-Saavedra D, Kinston S, Bonadies N, Foster SD, Calero-Nieto F, Dawson MA, Donaldson IJ, Dumon S, Frampton J, Janky R, Sun XH, Teichmann SA, Bannister AJ, Göttgens B.
Blood Volume 113 (2009) p.5456-5465
DOI: 10.1182/blood-2009-01-200048

Protein domain organisation: adding order.
Kummerfeld SK, Teichmann SA.
BMC Bioinformatics Volume 10 (2009) p.39
DOI: 10.1186/1471-2105-10-39

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA, Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y.
Nat Genet Volume 41 (2009) p.553-562
DOI: 10.1038/ng.375

2008

DBD--taxonomically broad transcription factor predictions: new content and functionality.
Wilson D, Charoensawan V, Kummerfeld SK, Teichmann SA.
Nucleic Acids Res Volume 36 (2008) p.d88-92
DOI: 10.1093/nar/gkm964

Tight regulation of unstructured proteins: from transcript synthesis to protein degradation.
Gsponer J, Futschik ME, Teichmann SA, Babu MM.
Science Volume 322 (2008) p.1365-1368
DOI: 10.1126/science.1163581

Assembly reflects evolution of protein complexes.
Levy ED, Boeri Erba E, Robinson CV, Teichmann SA.
Nature Volume 453 (2008) p.1262-1265
DOI: 10.1038/nature06942

Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM, KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L, Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK, Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M, SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN, Wellcome Trust Case Control Consortium, Willer CJ, FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.
Nat Genet Volume 40 (2008) p.768-775
DOI: 10.1038/ng.140

Networks for all.
Ahnert SE, Teichmann SA.
Genome Biol Volume 9 (2008) p.324
DOI: 10.1186/gb-2008-9-10-324

Chance and necessity in chromosomal gene distributions.
Hermsen R, ten Wolde PR, Teichmann S.
Trends Genet Volume 24 (2008) p.216-219
DOI: 10.1016/j.tig.2008.02.004

Patterns of evolutionary constraints on genes in humans.
De S, Lopez-Bigas N, Teichmann SA.
BMC Evol Biol Volume 8 (2008) p.275
DOI: 10.1186/1471-2148-8-275

Functional protein divergence in the evolution of Homo sapiens.
Lopez-Bigas N, De S, Teichmann SA.
Genome Biol Volume 9 (2008) p.r33
DOI: 10.1186/gb-2008-9-2-r33

Genomes and evolution: multidimensional approaches to understanding diversity.
Teichmann S, Patel NH.
Curr Opin Genet Dev Volume 18 (2008) p.469-471
DOI: 10.1016/j.gde.2008.11.003

Sequences and topology: from genome structure to protein structure.
Teichmann SA, Grishin NV.
Curr Opin Struct Biol Volume 18 (2008) p.340-341
DOI: 10.1016/j.sbi.2008.05.006

2007

Evolution of genes and genomes on the Drosophila phylogeny.
Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Bradley RK, Brand AD, Brent MR, Brooks AN, Brown RH, Butlin RK, Caggese C, Calvi BR, Bernardo de Carvalho A, Caspi A, Castrezana S, Celniker SE, Chang JL, Chapple C, Chatterji S, Chinwalla A, Civetta A, Clifton SW, Comeron JM, Costello JC, Coyne JA, Daub J, David RG, Delcher AL, Delehaunty K, Do CB, Ebling H, Edwards K, Eickbush T, Evans JD, Filipski A, Findeiss S, Freyhult E, Fulton L, Fulton R, Garcia AC, Gardiner A, Garfield DA, Garvin BE, Gibson G, Gilbert D, Gnerre S, Godfrey J, Good R, Gotea V, Gravely B, Greenberg AJ, Griffiths-Jones S, Gross S, Guigo R, Gustafson EA, Haerty W, Hahn MW, Halligan DL, Halpern AL, Halter GM, Han MV, Heger A, Hillier L, Hinrichs AS, Holmes I, Hoskins RA, Hubisz MJ, Hultmark D, Huntley MA, Jaffe DB, Jagadeeshan S, Jeck WR, Johnson J, Jones CD, Jordan WC, Karpen GH, Kataoka E, Keightley PD, Kheradpour P, Kirkness EF, Koerich LB, Kristiansen K, Kudrna D, Kulathinal RJ, Kumar S, Kwok R, Lander E, Langley CH, Lapoint R, Lazzaro BP, Lee SJ, Levesque L, Li R, Lin CF, Lin MF, Lindblad-Toh K, Llopart A, Long M, Low L, Lozovsky E, Lu J, Luo M, Machado CA, Makalowski W, Marzo M, Matsuda M, Matzkin L, McAllister B, McBride CS, McKernan B, McKernan K, Mendez-Lago M, Minx P, Mollenhauer MU, Montooth K, Mount SM, Mu X, Myers E, Negre B, Newfeld S, Nielsen R, Noor MA, O'Grady P, Pachter L, Papaceit M, Parisi MJ, Parisi M, Parts L, Pedersen JS, Pesole G, Phillippy AM, Ponting CP, Pop M, Porcelli D, Powell JR, Prohaska S, Pruitt K, Puig M, Quesneville H, Ram KR, Rand D, Rasmussen MD, Reed LK, Reenan R, Reily A, Remington KA, Rieger TT, Ritchie MG, Robin C, Rogers YH, Rohde C, Rozas J, Rubenfield MJ, Ruiz A, Russo S, Salzberg SL, Sanchez-Gracia A, Saranga DJ, Sato H, Schaeffer SW, Schatz MC, Schlenke T, Schwartz R, Segarra C, Singh RS, Sirot L, Sirota M, Sisneros NB, Smith CD, Smith TF, Spieth J, Stage DE, Stark A, Stephan W, Strausberg RL, Strempel S, Sturgill D, Sutton G, Sutton GG, Tao W, Teichmann S, Tobari YN, Tomimura Y, Tsolas JM, Valente VL, Venter E, Venter JC, Vicario S, Vieira FG, Vilella AJ, Villasante A, Walenz B, Wang J, Wasserman M, Watts T, Wilson D, Wilson RK, Wing RA, Wolfner MF, Wong A, Wong GK, Wu CI, Wu G, Yamamoto D, Yang HP, Yang SP, Yorke JA, Yoshida K, Zdobnov E, Zhang P, Zhang Y, Zimin AV, Baldwin J, Abdouelleil A, Abdulkadir J, Abebe A, Abera B, Abreu J, Acer SC, Aftuck L, Alexander A, An P, Anderson E, Anderson S, Arachi H, Azer M, Bachantsang P, Barry A, Bayul T, Berlin A, Bessette D, Bloom T, Blye J, Boguslavskiy L, Bonnet C, Boukhgalter B, Bourzgui I, Brown A, Cahill P, Channer S, Cheshatsang Y, Chuda L, Citroen M, Collymore A, Cooke P, Costello M, D'Aco K, Daza R, De Haan G, DeGray S, DeMaso C, Dhargay N, Dooley K, Dooley E, Doricent M, Dorje P, Dorjee K, Dupes A, Elong R, Falk J, Farina A, Faro S, Ferguson D, Fisher S, Foley CD, Franke A, Friedrich D, Gadbois L, Gearin G, Gearin CR, Giannoukos G, Goode T, Graham J, Grandbois E, Grewal S, Gyaltsen K, Hafez N, Hagos B, Hall J, Henson C, Hollinger A, Honan T, Huard MD, Hughes L, Hurhula B, Husby ME, Kamat A, Kanga B, Kashin S, Khazanovich D, Kisner P, Lance K, Lara M, Lee W, Lennon N, Letendre F, LeVine R, Lipovsky A, Liu X, Liu J, Liu S, Lokyitsang T, Lokyitsang Y, Lubonja R, Lui A, MacDonald P, Magnisalis V, Maru K, Matthews C, McCusker W, McDonough S, Mehta T, Meldrim J, Meneus L, Mihai O, Mihalev A, Mihova T, Mittelman R, Mlenga V, Montmayeur A, Mulrain L, Navidi A, Naylor J, Negash T, Nguyen T, Nguyen N, Nicol R, Norbu C, Norbu N, Novod N, O'Neill B, Osman S, Markiewicz E, Oyono OL, Patti C, Phunkhang P, Pierre F, Priest M, Raghuraman S, Rege F, Reyes R, Rise C, Rogov P, Ross K, Ryan E, Settipalli S, Shea T, Sherpa N, Shi L, Shih D, Sparrow T, Spaulding J, Stalker J, Stange-Thomann N, Stavropoulos S, Stone C, Strader C, Tesfaye S, Thomson T, Thoulutsang Y, Thoulutsang D, Topham K, Topping I, Tsamla T, Vassiliev H, Vo A, Wangchuk T, Wangdi T, Weiand M, Wilkinson J, Wilson A, Yadav S, Young G, Yu Q, Zembek L, Zhong D, Zimmer A, Zwirko Z, Jaffe DB, Alvarez P, Brockman W, Butler J, Chin C, Gnerre S, Grabherr M, Kleber M, Mauceli E, MacCallum I.
Nature Volume 450 (2007) p.203-218
DOI: 10.1038/nature06341

Computational identification of site-specific transcription factors in Drosophila.
Adryan B, Teichmann SA.
Fly (Austin) Volume 1 (2007) p.142-145
DOI: 10.4161/fly.4571

The folding and evolution of multidomain proteins.
Han JH, Batey S, Nickson AA, Teichmann SA, Clarke J.
Nat Rev Mol Cell Biol Volume 8 (2007) p.319-330
DOI: 10.1038/nrm2144

Evolution of protein complexes by duplication of homomeric interactions.
Pereira-Leal JB, Levy ED, Kamp C, Teichmann SA.
Genome Biol Volume 8 (2007) p.r51
DOI: 10.1186/gb-2007-8-4-r51

The (in)dependence of alternative splicing and gene duplication.
Talavera D, Vogel C, Orozco M, Teichmann SA, de la Cruz X.
PLoS Comput Biol Volume 3 (2007) p.e33
DOI: 10.1371/journal.pcbi.0030033

2006

Predicting the strongest domain-domain contact in interacting protein pairs.
Nye TM, Berzuini C, Gilks WR, Babu MM, Teichmann S.
Stat Appl Genet Mol Biol Volume 5 (2006) p.article5
DOI: 10.2202/1544-6115.1195

DBD: a transcription factor prediction database.
Kummerfeld SK, Teichmann SA.
Nucleic Acids Res Volume 34 (2006) p.d74-81
DOI: 10.1093/nar/gkj131

3D complex: a structural classification of protein complexes.
Levy ED, Pereira-Leal JB, Chothia C, Teichmann SA.
PLoS Comput Biol Volume 2 (2006) p.e155
DOI: 10.1371/journal.pcbi.0020155

Evolutionary dynamics of prokaryotic transcriptional regulatory networks.
Madan Babu M, Teichmann SA, Aravind L.
J Mol Biol Volume 358 (2006) p.614-633
DOI: 10.1016/j.jmb.2006.02.019

The origins and evolution of functional modules: lessons from protein complexes.
Pereira-Leal JB, Levy ED, Teichmann SA.
Philos Trans R Soc Lond B Biol Sci Volume 361 (2006) p.507-517
DOI: 10.1098/rstb.2005.1807

Divergence of interdomain geometry in two-domain proteins.
Han JH, Kerrison N, Chothia C, Teichmann SA.
Structure Volume 14 (2006) p.935-945
DOI: 10.1016/j.str.2006.01.016

FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.
Adryan B, Teichmann SA.
Bioinformatics Volume 22 (2006) p.1532-1533
DOI: 10.1093/bioinformatics/btl143

2005

Transcriptional networking.
Teichmann SA, Bornberg-Bauer E, Luscombe NM.
Genome Biol Volume 6 (2005) p.344
DOI: 10.1186/gb-2005-6-9-344

The relationship between domain duplication and recombination.
Vogel C, Teichmann SA, Pereira-Leal J.
J Mol Biol Volume 346 (2005) p.355-365
DOI: 10.1016/j.jmb.2004.11.050

Novel specificities emerge by stepwise duplication of functional modules.
Pereira-Leal JB, Teichmann SA.
Genome Res Volume 15 (2005) p.552-559
DOI: 10.1101/gr.3102105

The properties of protein family space depend on experimental design.
Kunin V, Teichmann SA, Huynen MA, Ouzounis CA.
Bioinformatics Volume 21 (2005) p.2618-2622
DOI: 10.1093/bioinformatics/bti386

The importance of sequence diversity in the aggregation and evolution of proteins.
Wright CF, Teichmann SA, Clarke J, Dobson CM.
Nature Volume 438 (2005) p.878-881
DOI: 10.1038/nature04195

Relative rates of gene fusion and fission in multi-domain proteins.
Kummerfeld SK, Teichmann SA.
Trends Genet Volume 21 (2005) p.25-30
DOI: 10.1016/j.tig.2004.11.007

Statistical analysis of domains in interacting protein pairs.
Nye TM, Berzuini C, Gilks WR, Babu MM, Teichmann SA.
Bioinformatics Volume 21 (2005) p.993-1001
DOI: 10.1093/bioinformatics/bti086

2004

Structure and evolution of transcriptional regulatory networks.
Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA.
Curr Opin Struct Biol Volume 14 (2004) p.283-291
DOI: 10.1016/j.sbi.2004.05.004

Gene regulatory network growth by duplication.
Teichmann SA, Babu MM.
Nat Genet Volume 36 (2004) p.492-496
DOI: 10.1038/ng1340

Supra-domains: evolutionary units larger than single protein domains.
Vogel C, Berzuini C, Bashton M, Gough J, Teichmann SA.
J Mol Biol Volume 336 (2004) p.809-823
DOI: 10.1016/j.jmb.2003.12.026

Structure, function and evolution of multidomain proteins.
Vogel C, Bashton M, Kerrison ND, Chothia C, Teichmann SA.
Curr Opin Struct Biol Volume 14 (2004) p.208-216
DOI: 10.1016/j.sbi.2004.03.011

Genes encoding subunits of stable complexes are clustered on the yeast chromosomes: an interpretation from a dosage balance perspective.
Teichmann SA, Veitia RA.
Genetics Volume 167 (2004) p.2121-2125
DOI: 10.1534/genetics.103.024505

Genomic analysis of regulatory network dynamics reveals large topological changes.
Luscombe NM, Babu MM, Yu H, Snyder M, Teichmann SA, Gerstein M.
Nature Volume 431 (2004) p.308-312
DOI: 10.1038/nature02782

Nuclear receptors: the evolution of diversity.
Schwabe JW, Teichmann SA.
Sci STKE Volume 2004 (2004) p.pe4
DOI: 10.1126/stke.2172004pe4

2003

Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum.
Bankier AT, Spriggs HF, Fartmann B, Konfortov BA, Madera M, Vogel C, Teichmann SA, Ivens A, Dear PH.
Genome Res Volume 13 (2003) p.1787-1799

Functional determinants of transcription factors in Escherichia coli: protein families and binding sites.
Madan Babu M, Teichmann SA.
Trends Genet Volume 19 (2003) p.75-79
DOI: 10.1016/s0168-9525(02)00039-2

The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity.
Vogel C, Teichmann SA, Chothia C.
Development Volume 130 (2003) p.6317-6328
DOI: 10.1242/dev.00848

Evolution of transcription factors and the gene regulatory network in Escherichia coli.
Madan Babu M, Teichmann SA.
Nucleic Acids Res Volume 31 (2003) p.1234-1244
DOI: 10.1093/nar/gkg210

Evolution of the protein repertoire.
Chothia C, Gough J, Vogel C, Teichmann SA.
Science Volume 300 (2003) p.1701-1703
DOI: 10.1126/science.1085371

Multi-domain protein families and domain pairs: comparison with known structures and a random model of domain recombination.
Apic G, Huber W, Teichmann SA.
J Struct Funct Genomics Volume 4 (2003) p.67-78
DOI: 10.1023/a:1026113408773

2002

Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae.
Jardine O, Gough J, Chothia C, Teichmann SA.
Genome Res Volume 12 (2002) p.916-929
DOI: 10.1101/gr.228002

Homology, pathway distance and chromosomal localization of the small molecule metabolism enzymes in Escherichia coli.
Rison SC, Teichmann SA, Thornton JM.
J Mol Biol Volume 318 (2002) p.911-932
DOI: 10.1016/s0022-2836(02)00140-7

Principles of protein-protein interactions.
Teichmann SA.
Bioinformatics Volume 18 Suppl 2 (2002) p.s249

Conservation of gene co-regulation in prokaryotes and eukaryotes.
Teichmann SA, Babu MM.
Trends Biotechnol Volume 20 (2002) p.407-10; discussion 410
DOI: 10.1016/s0167-7799(02)02032-2

The constraints protein-protein interactions place on sequence divergence.
Teichmann SA.
J Mol Biol Volume 324 (2002) p.399-407
DOI: 10.1016/s0022-2836(02)01144-0