Pedro Beltrao

Pedro Beltrao

Group Leader - Beltrao research group

PhD in Biology, University of Aveiro (research conducted at EMBL-Heidelberg), 09/2007. Postdoctoral research at the University of California San Francisco. Group leader at EMBL-EBI since 2013.

ORCID iD: 0000-0002-2724-7703

Tel:+44 (0) 1223 494 610 / Fax:+44 (0) 1223 494 468

Research

Find out about research activity in the Beltrao research group

Publications

2014

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier.
Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T.
J Am Soc Nephrol Volume 25 (2014) p.1509-1522
DOI: 10.1681/asn.2013070760

2013

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
Nat Methods Volume 10 (2013) p.676-682
DOI: 10.1038/nmeth.2519

Evolution and functional cross-talk of protein post-translational modifications.
Beltrao P, Bork P, Krogan NJ, van Noort V.
Mol Syst Biol Volume 9 (2013) p.714
DOI: 10.1002/msb.201304521

2012

Systematic functional prioritization of protein posttranslational modifications.
Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ.
Cell Volume 150 (2012) p.413-425
DOI: 10.1016/j.cell.2012.05.036

Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ.
Mol Cell Volume 46 (2012) p.691-704
DOI: 10.1016/j.molcel.2012.05.028

2011

Phenotypic landscape of a bacterial cell.
Nichols RJ, Sen S, Choo YJ, Beltrao P, Zietek M, Chaba R, Lee S, Kazmierczak KM, Lee KJ, Wong A, Shales M, Lovett S, Winkler ME, Krogan NJ, Typas A, Gross CA.
Cell Volume 144 (2011) p.143-156
DOI: 10.1016/j.cell.2010.11.052

Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress.
Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ.
Proc Natl Acad Sci U S A Volume 108 (2011) p.10620-10625
DOI: 10.1073/pnas.1019735108

2010

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers.
Lefebvre C, Rajbhandari P, Alvarez MJ, Bandaru P, Lim WK, Sato M, Wang K, Sumazin P, Kustagi M, Bisikirska BC, Basso K, Beltrao P, Krogan N, Gautier J, Dalla-Favera R, Califano A.
Mol Syst Biol Volume 6 (2010) p.377
DOI: 10.1038/msb.2010.31

Quantitative genetic interactions reveal biological modularity.
Beltrao P, Cagney G, Krogan NJ.
Cell Volume 141 (2010) p.739-745
DOI: 10.1016/j.cell.2010.05.019

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.
Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ.
Mol Syst Biol Volume 6 (2010) p.451
DOI: 10.1038/msb.2010.107

2009

ADAN: a database for prediction of protein-protein interaction of modular domains mediated by linear motifs.
Encinar JA, Fernandez-Ballester G, Sánchez IE, Hurtado-Gomez E, Stricher F, Beltrao P, Serrano L.
Bioinformatics Volume 25 (2009) p.2418-2424
DOI: 10.1093/bioinformatics/btp424

Structure-based prediction of the Saccharomyces cerevisiae SH3-ligand interactions.
Fernandez-Ballester G, Beltrao P, Gonzalez JM, Song YH, Wilmanns M, Valencia A, Serrano L.
J Mol Biol Volume 388 (2009) p.902-916
DOI: 10.1016/j.jmb.2009.03.038

Microblogging the ISMB: a new approach to conference reporting.
Saunders N, Beltrão P, Jensen L, Jurczak D, Krause R, Kuhn M, Wu S.
PLoS Comput Biol Volume 5 (2009) p.e1000263
DOI: 10.1371/journal.pcbi.1000263

Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ.
PLoS Biol Volume 7 (2009) p.e1000134
DOI: 10.1371/journal.pbio.1000134

2008

Genome-wide prediction of SH2 domain targets using structural information and the FoldX algorithm.
Sánchez IE, Beltrao P, Stricher F, Schymkowitz J, Ferkinghoff-Borg J, Rousseau F, Serrano L.
PLoS Comput Biol Volume 4 (2008) p.e1000052
DOI: 10.1371/journal.pcbi.1000052

Evolvability and hierarchy in rewired bacterial gene networks.
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L.
Nature Volume 452 (2008) p.840-845
DOI: 10.1038/nature06847

Analyzing protein interaction networks using structural information.
Kiel C, Beltrao P, Serrano L.
Annu Rev Biochem Volume 77 (2008) p.415-441
DOI: 10.1146/annurev.biochem.77.062706.133317

2007

A genome-wide Ras-effector interaction network.
Kiel C, Foglierini M, Kuemmerer N, Beltrao P, Serrano L.
J Mol Biol Volume 370 (2007) p.1020-1032
DOI: 10.1016/j.jmb.2007.05.015

Structures in systems biology.
Beltrao P, Kiel C, Serrano L.
Curr Opin Struct Biol Volume 17 (2007) p.378-384
DOI: 10.1016/j.sbi.2007.05.005

Specificity and evolvability in eukaryotic protein interaction networks.
Beltrao P, Serrano L.
PLoS Comput Biol Volume 3 (2007) p.e25
DOI: 10.1371/journal.pcbi.0030025

2004

SmartCell, a framework to simulate cellular processes that combines stochastic approximation with diffusion and localisation: analysis of simple networks.
Ander M, Beltrao P, Di Ventura B, Ferkinghoff-Borg J, Foglierini M, Kaplan A, Lemerle C, Tomás-Oliveira I, Serrano L.
Syst Biol (Stevenage) Volume 1 (2004) p.129-138
DOI: 10.1049/sb:20045017

2003

Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp.
Massey SE, Moura G, Beltrão P, Almeida R, Garey JR, Tuite MF, Santos MA.
Genome Res Volume 13 (2003) p.544-557
DOI: 10.1101/gr.811003