Nidhi Tyagi

Nidhi Tyagi

Scientific Database Curator - O'Donovan team: Protein Function Content

Nidhi Tyagi joined the Protein Function Content team at EMBL-EBI in 2015 as a biocurator. Her focus is on structural annotation for UniProtKB and she works very closely with the PDBe team as part of the SIFTS project. Prior to joining the team Nidhi was a postdoctoral fellow in the Thornton group at EMBL-EBI, where her research interests included structure, functions and evolutionary analysis of proteins, particularly in reference to parasitic genomes such as Plasmodium, Leishmania, Helicobacter pylori and viruses. Nidhi's postdoctoral work focused on comparing parasite and allergenic proteins, using computational approaches to establish the evolutionary significance of parasite infection with respect to environmental/food allergies. She also explored the effects of point mutations on structure of proteins implicated in cancer and other genetic diseases. Nidhi obtained her PhD in Bioinformatics from Molecular Biophysics Unit (MBU), Indian Institute of Science (IISc), Bangalore, India.

ORCID iD: 0000-0002-2065-9051

Tel:+ 44 (0) 1223 494 632 / Fax:



Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.
Tyagi N, Farnell EJ, Fitzsimmons CM, Ryan S, Tukahebwa E, Maizels RM, Dunne DW, Thornton JM, Furnham N.
PLoS computational biology Volume 11 (2015) p.e1004546

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.
Farnell EJ, Tyagi N, Ryan S, Chalmers IW, Pinot de Moira A, Jones FM, Wawrzyniak J, Fitzsimmons CM, Tukahebwa EM, Furnham N, Maizels RM, Dunne DW.
Frontiers in immunology Volume 6 (2015) p.26


Recognition of nontrivial remote homology relationships involving proteins of Helicobacter pylori: implications for function recognition.
Tyagi N, Srinivasan N.
Methods in molecular biology (Clifton, N.J.) Volume 993 (2013) p.155-175

The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
Hansen AM, Chaerkady R, Sharma J, Díaz-Mejía JJ, Tyagi N, Renuse S, Jacob HK, Pinto SM, Sahasrabuddhe NA, Kim MS, Delanghe B, Srinivasan N, Emili A, Kaper JB, Pandey A.
PLoS pathogens Volume 9 (2013) p.e1003403


Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes.
Rakshambikai R, Yamunadevi S, Anamika K, Tyagi N, Srinivasan N.
Comparative and functional genomics Volume 2012 (2012) p.258284

A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.
Chawla B, Kumar RR, Tyagi N, Subramanian G, Srinivasan N, Park MH, Madhubala R.
PloS one Volume 7 (2012) p.e33138

Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR.
Sudha G, Yamunadevi S, Tyagi N, Das S, Srinivasan N.
BMC structural biology Volume 12 (2012) p.28


Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.
Chawla B, Jhingran A, Singh S, Tyagi N, Park MH, Srinivasan N, Roberts SC, Madhubala R.
The Journal of biological chemistry Volume 285 (2010) p.453-463

A framework for classification of prokaryotic protein kinases.
Tyagi N, Anamika K, Srinivasan N.
PloS one Volume 5 (2010) p.e10608


Prediction of protein-protein interactions between Helicobacter pylori and a human host.
Tyagi N, Krishnadev O, Srinivasan N.
Molecular bioSystems Volume 5 (2009) p.1630-1635

Evolutionary divergence of Plasmodium falciparum: sequences, protein-protein interactions, pathways and processes.
Tyagi N, Swapna LS, Mohanty S, Agarwal G, Gowri VS, Anamika K, Priya ML, Krishnadev O, Srinivasan N.
Infectious disorders drug targets Volume 9 (2009) p.257-271