Ian Dunham

Ian Dunham

Staff Scientist - Birney research group

Ian Dunham has been involved in genomics since around the time the term was coined. He obtained his D. Phil from Oxford University in 1989, determining the long-range structure of the human MHC. During his postdoctoral studies he worked with the genomic pioneer Maynard Olson in St Louis, before returning to the UK to construct a physical map of human chromosome 22. At the Sanger Centre from 1993 his work focussed first on genome sequencing including the first human chromosome sequence in 1999, and subsequently on developing functional maps of the human genome. This included gene structure maps, variation maps, and the first chromosome-wide linkage disequilibrium map. Recently Ian's research interests include experimental and computational approaches to genome-wide mapping of regulatory elements and chromatin state in the human genome as part of the NHGRI ENCODE project, as well as understanding the influence of variation on regulatory elements in human and other organisms. Ian is now a staff scientist in the Birney Research Group at EMBL-EBI.

ORCID iD: 0000-0003-2525-5598

Tel:+ 44 (0) 1223 492 636 / Fax:+ 44 (0) 1223 494 468



Functional annotation of noncoding sequence variants.
Ritchie GR, Dunham I, Zeggini E, Flicek P.
Nat Methods Volume 11 (2014) p.294-296
DOI: 10.1038/nmeth.2832


Ensembl 2013.
Flicek P, Ahmed I, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fairley S, Fitzgerald S, Gil L, García-Girón C, Gordon L, Hourlier T, Hunt S, Juettemann T, Kähäri AK, Keenan S, Komorowska M, Kulesha E, Longden I, Maurel T, McLaren WM, Muffato M, Nag R, Overduin B, Pignatelli M, Pritchard B, Pritchard E, Riat HS, Ritchie GR, Ruffier M, Schuster M, Sheppard D, Sobral D, Taylor K, Thormann A, Trevanion S, White S, Wilder SP, Aken BL, Birney E, Cunningham F, Dunham I, Harrow J, Herrero J, Hubbard TJ, Johnson N, Kinsella R, Parker A, Spudich G, Yates A, Zadissa A, Searle SM.
Nucleic Acids Res Volume 41 (2013) p.d48-55
DOI: 10.1093/nar/gks1236

Genome-wide meta-analysis identifies new susceptibility loci for migraine.
Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A, North American Brain Expression Consortium, UK Brain Expression Consortium, International Headache Genetics Consortium.
Nat Genet Volume 45 (2013) p.912-917
DOI: 10.1038/ng.2676

Integrative annotation of chromatin elements from ENCODE data.
Hoffman MM, Ernst J, Wilder SP, Kundaje A, Harris RS, Libbrecht M, Giardine B, Ellenbogen PM, Bilmes JA, Birney E, Hardison RC, Dunham I, Kellis M, Noble WS.
Nucleic Acids Res Volume 41 (2013) p.827-841
DOI: 10.1093/nar/gks1284

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
Hughes JR, Lower KM, Dunham I, Taylor S, De Gobbi M, Sloane-Stanley JA, McGowan S, Ragoussis J, Vernimmen D, Gibbons RJ, Higgs DR.
Philos Trans R Soc Lond B Biol Sci Volume 368 (2013) p.20120361
DOI: 10.1098/rstb.2012.0361


Ensembl 2012.
Flicek P, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D, Clapham P, Coates G, Fairley S, Fitzgerald S, Gil L, Gordon L, Hendrix M, Hourlier T, Johnson N, Kähäri AK, Keefe D, Keenan S, Kinsella R, Komorowska M, Koscielny G, Kulesha E, Larsson P, Longden I, McLaren W, Muffato M, Overduin B, Pignatelli M, Pritchard B, Riat HS, Ritchie GR, Ruffier M, Schuster M, Sobral D, Tang YA, Taylor K, Trevanion S, Vandrovcova J, White S, Wilson M, Wilder SP, Aken BL, Birney E, Cunningham F, Dunham I, Durbin R, Fernández-Suarez XM, Harrow J, Herrero J, Hubbard TJ, Parker A, Proctor G, Spudich G, Vogel J, Yates A, Zadissa A, Searle SM.
Nucleic Acids Res Volume 40 (2012) p.d84-90
DOI: 10.1093/nar/gkr991

An integrated encyclopedia of DNA elements in the human genome.
ENCODE Project Consortium.
Nature Volume 489 (2012) p.57-74
DOI: 10.1038/nature11247

MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs.
Lu D, Davis MP, Abreu-Goodger C, Wang W, Campos LS, Siede J, Vigorito E, Skarnes WC, Dunham I, Enright AJ, Liu P.
PLoS One Volume 7 (2012) p.e40938
DOI: 10.1371/journal.pone.0040938

Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines.
Davis MP, Abreu-Goodger C, van Dongen S, Lu D, Tate PH, Bartonicek N, Kutter C, Liu P, Skarnes WC, Enright AJ, Dunham I.
PLoS One Volume 7 (2012) p.e41762
DOI: 10.1371/journal.pone.0041762


Ensembl 2011.
Flicek P, Amode MR, Barrell D, Beal K, Brent S, Chen Y, Clapham P, Coates G, Fairley S, Fitzgerald S, Gordon L, Hendrix M, Hourlier T, Johnson N, Kähäri A, Keefe D, Keenan S, Kinsella R, Kokocinski F, Kulesha E, Larsson P, Longden I, McLaren W, Overduin B, Pritchard B, Riat HS, Rios D, Ritchie GR, Ruffier M, Schuster M, Sobral D, Spudich G, Tang YA, Trevanion S, Vandrovcova J, Vilella AJ, White S, Wilder SP, Zadissa A, Zamora J, Aken BL, Birney E, Cunningham F, Dunham I, Durbin R, Fernández-Suarez XM, Herrero J, Hubbard TJ, Parker A, Proctor G, Vogel J, Searle SM.
Nucleic Acids Res Volume 39 (2011) p.d800-6
DOI: 10.1093/nar/gkq1064

Hes6 is required for actin cytoskeletal organization in differentiating C2C12 myoblasts.
Malone CM, Domaschenz R, Amagase Y, Dunham I, Murai K, Jones PH.
Exp Cell Res Volume 317 (2011) p.1590-1602
DOI: 10.1016/j.yexcr.2011.03.023

A user's guide to the encyclopedia of DNA elements (ENCODE).
ENCODE Project Consortium.
PLoS Biol Volume 9 (2011) p.e1001046
DOI: 10.1371/journal.pbio.1001046


ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, Viprakasit V, Mitson M, De Gobbi M, Marra M, Morris A, Abbott A, Wilder SP, Taylor S, Santos GM, Cross J, Ayyub H, Jones S, Ragoussis J, Rhodes D, Dunham I, Higgs DR, Gibbons RJ.
Cell Volume 143 (2010) p.367-378
DOI: 10.1016/j.cell.2010.09.023

High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
Daelemans C, Ritchie ME, Smits G, Abu-Amero S, Sudbery IM, Forrest MS, Campino S, Clark TG, Stanier P, Kwiatkowski D, Deloukas P, Dermitzakis ET, Tavaré S, Moore GE, Dunham I.
BMC Genet Volume 11 (2010) p.25
DOI: 10.1186/1471-2156-11-25

Ensembl's 10th year.
Flicek P, Aken BL, Ballester B, Beal K, Bragin E, Brent S, Chen Y, Clapham P, Coates G, Fairley S, Fitzgerald S, Fernandez-Banet J, Gordon L, Gräf S, Haider S, Hammond M, Howe K, Jenkinson A, Johnson N, Kähäri A, Keefe D, Keenan S, Kinsella R, Kokocinski F, Koscielny G, Kulesha E, Lawson D, Longden I, Massingham T, McLaren W, Megy K, Overduin B, Pritchard B, Rios D, Ruffier M, Schuster M, Slater G, Smedley D, Spudich G, Tang YA, Trevanion S, Vilella A, Vogel J, White S, Wilder SP, Zadissa A, Birney E, Cunningham F, Dunham I, Durbin R, Fernández-Suarez XM, Herrero J, Hubbard TJ, Parker A, Proctor G, Smith J, Searle SM.
Nucleic Acids Res Volume 38 (2010) p.d557-62
DOI: 10.1093/nar/gkp972

Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis.
Sudbery I, Enright AJ, Fraser AG, Dunham I.
BMC Genomics Volume 11 (2010) p.175
DOI: 10.1186/1471-2164-11-175

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution.
Dhami P, Saffrey P, Bruce AW, Dillon SC, Chiang K, Bonhoure N, Koch CM, Bye J, James K, Foad NS, Ellis P, Watkins NA, Ouwehand WH, Langford C, Andrews RM, Dunham I, Vetrie D.
PLoS One Volume 5 (2010) p.e12339
DOI: 10.1371/journal.pone.0012339

Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene.
Gheldof N, Smith EM, Tabuchi TM, Koch CM, Dunham I, Stamatoyannopoulos JA, Dekker J.
Nucleic Acids Res Volume 38 (2010) p.4325-4336
DOI: 10.1093/nar/gkq175


Applications of high-throughput sequencing to chromatin structure and function in mammals.
Dunham I.
F1000 Biol Rep Volume 1 (2009) p.32
DOI: 10.3410/b1-32

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.
Pink CJ, Swaminathan SK, Dunham I, Rogers J, Ward A, Hurst LD.
Genome Biol Evol Volume 1 (2009) p.13-22
DOI: 10.1093/gbe/evp001

Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection.
Motallebipour M, Enroth S, Punga T, Ameur A, Koch C, Dunham I, Komorowski J, Ericsson J, Wadelius C.
FEBS J Volume 276 (2009) p.1878-1890
DOI: 10.1111/j.1742-4658.2009.06914.x

DNA methylation-histone modification relationships across the desmin locus in human primary cells.
Lindahl Allen M, Koch CM, Clelland GK, Dunham I, Antoniou M.
BMC Mol Biol Volume 10 (2009) p.51
DOI: 10.1186/1471-2199-10-51

Mosaic 22q13 deletions: evidence for concurrent mosaic segmental isodisomy and gene conversion.
Bonaglia MC, Giorda R, Beri S, Bigoni S, Sensi A, Baroncini A, Capucci A, De Agostini C, Gwilliam R, Deloukas P, Dunham I, Zuffardi O.
Eur J Hum Genet Volume 17 (2009) p.426-433
DOI: 10.1038/ejhg.2008.195

Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level.
Bruce AW, López-Contreras AJ, Flicek P, Down TA, Dhami P, Dillon SC, Koch CM, Langford CF, Dunham I, Andrews RM, Vetrie D.
Genome Res Volume 19 (2009) p.994-1005
DOI: 10.1101/gr.089086.108


Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.
Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS.
Genome Res Volume 18 (2008) p.393-403
DOI: 10.1101/gr.7080508

The evolution of the DLK1-DIO3 imprinted domain in mammals.
Edwards CA, Mungall AJ, Matthews L, Ryder E, Gray DJ, Pask AJ, Shaw G, Graves JA, Rogers J, SAVOIR consortium, Dunham I, Renfree MB, Ferguson-Smith AC.
PLoS Biol Volume 6 (2008) p.e135
DOI: 10.1371/journal.pbio.0060135

Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells.
Atkinson SP, Koch CM, Clelland GK, Willcox S, Fowler JC, Stewart R, Lako M, Dunham I, Armstrong L.
Stem Cells Volume 26 (2008) p.1174-1185
DOI: 10.1634/stemcells.2007-0497

Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians.
Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, SAVOIR Consortium, Renfree MB, Reik W, Dunham I.
Nat Genet Volume 40 (2008) p.971-976
DOI: 10.1038/ng.168

Finishing the finished human chromosome 22 sequence.
Cole CG, McCann OT, Collins JE, Oliver K, Willey D, Gribble SM, Yang F, McLaren K, Rogers J, Ning Z, Beare DM, Dunham I.
Genome Biol Volume 9 (2008) p.r78
DOI: 10.1186/gb-2008-9-5-r78

The role of the polycomb complex in silencing alpha-globin gene expression in nonerythroid cells.
Garrick D, De Gobbi M, Samara V, Rugless M, Holland M, Ayyub H, Lower K, Sloane-Stanley J, Gray N, Koch C, Dunham I, Higgs DR.
Blood Volume 112 (2008) p.3889-3899
DOI: 10.1182/blood-2008-06-161901

A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae.
Jones GM, Stalker J, Humphray S, West A, Cox T, Rogers J, Dunham I, Prelich G.
Nat Methods Volume 5 (2008) p.239-241
DOI: 10.1038/nmeth.1181

Epigenomics at the tipping point. Foreword.
Stamatoyannopoulos JA, Dunham I.
Pharmacogenomics Volume 9 (2008) p.1781-1783
DOI: 10.2217/14622416.9.12.1781


hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M.
Genomics Volume 89 (2007) p.307-315
DOI: 10.1016/j.ygeno.2006.11.012

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.
De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, Dunham I, Gibbons RJ, Wood WG, Higgs DR.
Blood Volume 110 (2007) p.4503-4510
DOI: 10.1182/blood-2007-06-097964

Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes.
Rada-Iglesias A, Enroth S, Ameur A, Koch CM, Clelland GK, Respuela-Alonso P, Wilcox S, Dovey OM, Ellis PD, Langford CF, Dunham I, Komorowski J, Wadelius C.
Genome Res Volume 17 (2007) p.708-719
DOI: 10.1101/gr.5540007

RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer.
Bignone PA, Lee KY, Liu Y, Emilion G, Finch J, Soosay AE, Charnock FM, Beck S, Dunham I, Mungall AJ, Ganesan TS.
Oncogene Volume 26 (2007) p.683-700
DOI: 10.1038/sj.onc.1209827

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, NISC Comparative Sequencing Program, Baylor College of Medicine Human Genome Sequencing Center, Washington University Genome Sequencing Center, Broad Institute, Children's Hospital Oakland Research Institute, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ.
Nature Volume 447 (2007) p.799-816
DOI: 10.1038/nature05874

Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.
Nejentsev S, Smink LJ, Smyth D, Bailey R, Lowe CE, Payne F, Masters J, Godfrey L, Lam A, Burren O, Stevens H, Nutland S, Walker NM, Smith A, Twells R, Barratt BJ, Wright C, French L, Chen Y, Deloukas P, Rogers J, Dunham I, Todd JA.
BMC Genet Volume 8 (2007) p.24
DOI: 10.1186/1471-2156-8-24

The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.
Edwards CA, Rens W, Clarke O, Mungall AJ, Hore T, Graves JA, Dunham I, Ferguson-Smith AC, Ferguson-Smith MA.
BMC Evol Biol Volume 7 (2007) p.157
DOI: 10.1186/1471-2148-7-157

The landscape of histone modifications across 1% of the human genome in five human cell lines.
Koch CM, Andrews RM, Flicek P, Dillon SC, Karaöz U, Clelland GK, Wilcox S, Beare DM, Fowler JC, Couttet P, James KD, Lefebvre GC, Bruce AW, Dovey OM, Ellis PD, Dhami P, Langford CF, Weng Z, Birney E, Carter NP, Vetrie D, Dunham I.
Genome Res Volume 17 (2007) p.691-707
DOI: 10.1101/gr.5704207


Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites.
Follows GA, Dhami P, Göttgens B, Bruce AW, Campbell PJ, Dillon SC, Smith AM, Koch C, Donaldson IJ, Scott MA, Dunham I, Janes ME, Vetrie D, Green AR.
Genome Res Volume 16 (2006) p.1310-1319
DOI: 10.1101/gr.5373606

Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH.
Ichimura K, Mungall AJ, Fiegler H, Pearson DM, Dunham I, Carter NP, Collins VP.
Oncogene Volume 25 (2006) p.1261-1271
DOI: 10.1038/sj.onc.1209156

The portability of tagSNPs across populations: a worldwide survey.
González-Neira A, Ke X, Lao O, Calafell F, Navarro A, Comas D, Cann H, Bumpstead S, Ghori J, Hunt S, Deloukas P, Dunham I, Cardon LR, Bertranpetit J.
Genome Res Volume 16 (2006) p.323-330
DOI: 10.1101/gr.4138406

The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E.
Nature Volume 441 (2006) p.315-321
DOI: 10.1038/nature04727


Investigating chromosome organization with genomic microarrays.
Woodfine K, Carter NP, Dunham I, Fiegler H.
Chromosome Res Volume 13 (2005) p.249-257
DOI: 10.1007/s10577-005-1504-5

Evidence for widespread reticulate evolution within human duplicons.
Jackson MS, Oliver K, Loveland J, Humphray S, Dunham I, Rocchi M, Viggiano L, Park JP, Hurles ME, Santibanez-Koref M.
Am J Hum Genet Volume 77 (2005) p.824-840
DOI: 10.1086/497704

Replication timing of human chromosome 6.
Woodfine K, Beare DM, Ichimura K, Debernardi S, Mungall AJ, Fiegler H, Collins VP, Carter NP, Dunham I.
Cell Cycle Volume 4 (2005) p.172-176

Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, Pontén F, Komorowski J, Dunham I, Wadelius C.
Hum Mol Genet Volume 14 (2005) p.3435-3447
DOI: 10.1093/hmg/ddi378


A genome annotation-driven approach to cloning the human ORFeome.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I.
Genome Biol Volume 5 (2004) p.r84
DOI: 10.1186/gb-2004-5-10-r84

The DNA sequence and analysis of human chromosome 13.
Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT.
Nature Volume 428 (2004) p.522-528
DOI: 10.1038/nature02379

Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene.
Langan JE, Cole CG, Huckle EJ, Byrne S, McRonald FE, Rowbottom L, Ellis A, Shaw JM, Leigh IM, Kelsell DP, Dunham I, Field JK, Risk JM.
Hum Genet Volume 114 (2004) p.534-540
DOI: 10.1007/s00439-004-1100-3

Complete MHC haplotype sequencing for common disease gene mapping.
Stewart CA, Horton R, Allcock RJ, Ashurst JL, Atrazhev AM, Coggill P, Dunham I, Forbes S, Halls K, Howson JM, Humphray SJ, Hunt S, Mungall AJ, Osoegawa K, Palmer S, Roberts AN, Rogers J, Sims S, Wang Y, Wilming LG, Elliott JF, de Jong PJ, Sawcer S, Todd JA, Trowsdale J, Beck S.
Genome Res Volume 14 (2004) p.1176-1187
DOI: 10.1101/gr.2188104

DNA sequence and analysis of human chromosome 9.
Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blöcker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I.
Nature Volume 429 (2004) p.369-374
DOI: 10.1038/nature02465

Replication timing of the human genome.
Woodfine K, Fiegler H, Beare DM, Collins JE, McCann OT, Young BD, Debernardi S, Mott R, Dunham I, Carter NP.
Hum Mol Genet Volume 13 (2004) p.191-202
DOI: 10.1093/hmg/ddh016


beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation.
Jeffries AR, Mungall AJ, Dawson E, Halls K, Langford CF, Murray RM, Dunham I, Powell JF.
Mol Psychiatry Volume 8 (2003) p.654-663
DOI: 10.1038/sj.mp.4001382

The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S.
Nature Volume 425 (2003) p.805-811
DOI: 10.1038/nature02055

The characteristics of human genes: analysis of human chromosome 22.
Dunham I, Beare DM, Collins JE.
Comp Funct Genomics Volume 4 (2003) p.635-646
DOI: 10.1002/cfg.335

DNA rescue by the vectorette method.
McAleer MA, Coffey AJ, Dunham I.
Methods Mol Biol Volume 226 (2003) p.393-400

Reevaluating human gene annotation: a second-generation analysis of chromosome 22.
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I.
Genome Res Volume 13 (2003) p.27-36
DOI: 10.1101/gr.695703


A first-generation linkage disequilibrium map of human chromosome 22.
Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, Beare DM, Pabial J, Dibling T, Tinsley E, Kirby S, Carter D, Papaspyridonos M, Livingstone S, Ganske R, Lõhmussaar E, Zernant J, Tõnisson N, Remm M, Mägi R, Puurand T, Vilo J, Kurg A, Rice K, Deloukas P, Mott R, Metspalu A, Bentley DR, Cardon LR, Dunham I.
Nature Volume 418 (2002) p.544-548
DOI: 10.1038/nature00864

Human genome sequences: enigmatic variations.
Dunham I.
Mutagenesis Volume 17 (2002) p.457-461
DOI: 10.1093/mutage/17.6.457

Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer.
Liu Y, Emilion G, Mungall AJ, Dunham I, Beck S, Le Meuth-Metzinger VG, Shelling AN, Charnock FM, Ganesan TS.
Oncogene Volume 21 (2002) p.387-399
DOI: 10.1038/sj.onc.1205067

Lessons from the sequence of human chromosome 22.
Dunham I.
Ernst Schering Res Found Workshop Volume (2002) p.31-50

An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.
Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N.
Genomics Volume 79 (2002) p.285-296
DOI: 10.1006/geno.2002.6718

The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer.
Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS.
BMC Genet Volume 3 (2002) p.20
DOI: 10.1186/1471-2156-3-20

A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications.
Buckley PG, Mantripragada KK, Benetkiewicz M, Tapia-Páez I, Diaz De Ståhl T, Rosenquist M, Ali H, Jarbo C, De Bustos C, Hirvelä C, Sinder Wilén B, Fransson I, Thyr C, Johnsson BI, Bruder CE, Menzel U, Hergersberg M, Mandahl N, Blennow E, Wedell A, Beare DM, Collins JE, Dunham I, Albertson D, Pinkel D, Bastian BC, Faruqi AF, Lasken RS, Ichimura K, Collins VP, Dumanski JP.
Hum Mol Genet Volume 11 (2002) p.3221-3229
DOI: 10.1093/hmg/11.25.3221


A SNP resource for human chromosome 22: extracting dense clusters of SNPs from the genomic sequence.
Dawson E, Chen Y, Hunt S, Smink LJ, Hunt A, Rice K, Livingston S, Bumpstead S, Bruskiewich R, Sham P, Ganske R, Adams M, Kawasaki K, Shimizu N, Minoshima S, Roe B, Bentley D, Dunham I.
Genome Res Volume 11 (2001) p.170-178
DOI: 10.1101/gr.156901

The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
Bentley DR, Deloukas P, Dunham A, French L, Gregory SG, Humphray SJ, Mungall AJ, Ross MT, Carter NP, Dunham I, Scott CE, Ashcroft KJ, Atkinson AL, Aubin K, Beare DM, Bethel G, Brady N, Brook JC, Burford DC, Burrill WD, Burrows C, Butler AP, Carder C, Catanese JJ, Clee CM, Clegg SM, Cobley V, Coffey AJ, Cole CG, Collins JE, Conquer JS, Cooper RA, Culley KM, Dawson E, Dearden FL, Durbin RM, de Jong PJ, Dhami PD, Earthrowl ME, Edwards CA, Evans RS, Gillson CJ, Ghori J, Green L, Gwilliam R, Halls KS, Hammond S, Harper GL, Heathcott RW, Holden JL, Holloway E, Hopkins BL, Howard PJ, Howell GR, Huckle EJ, Hughes J, Hunt PJ, Hunt SE, Izmajlowicz M, Jones CA, Joseph SS, Laird G, Langford CF, Lehvaslaiho MH, Leversha MA, McCann OT, McDonald LM, McDowall J, Maslen GL, Mistry D, Moschonas NK, Neocleous V, Pearson DM, Phillips KJ, Porter KM, Prathalingam SR, Ramsey YH, Ranby SA, Rice CM, Rogers J, Rogers LJ, Sarafidou T, Scott DJ, Sharp GJ, Shaw-Smith CJ, Smink LJ, Soderlund C, Sotheran EC, Steingruber HE, Sulston JE, Taylor A, Taylor RG, Thorpe AA, Tinsley E, Warry GL, Whittaker A, Whittaker P, Williams SH, Wilmer TE, Wooster R, Wright CL.
Nature Volume 409 (2001) p.942-943
DOI: 10.1038/35057165

Initial sequencing and analysis of the human genome.
Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowski J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, International Human Genome Sequencing Consortium.
Nature Volume 409 (2001) p.860-921
DOI: 10.1038/35057062

A sequence-based integrated map of chromosome 22.
Tapper WJ, Morton NE, Dunham I, Ke X, Collins A.
Genome Res Volume 11 (2001) p.1290-1295
DOI: 10.1101/gr.161301


An integrated map of human 6q22.3-q24 including a 3-Mb high-resolution BAC/PAC contig encompassing a QTL for fetal hemoglobin.
Game L, Close J, Stephens P, Mitchell J, Best S, Rochette J, Louis-dit-Sully C, Riley J, See CG, Sanseau P, Kearney L, Bethel G, Humphray S, Dunham I, Mungall A, Thein SL.
Genomics Volume 64 (2000) p.264-276
DOI: 10.1006/geno.2000.6133

Mechanism of spreading of the highly related neurofibromatosis type 1 (NF1) pseudogenes on chromosomes 2, 14 and 22.
Luijten M, Wang Y, Smith BT, Westerveld A, Smink LJ, Dunham I, Roe BA, Hulsebos TJ.
Eur J Hum Genet Volume 8 (2000) p.209-214
DOI: 10.1038/sj.ejhg.5200434

The gene guessing game.
Dunham I.
Yeast Volume 17 (2000) p.218-224
DOI: 10.1002/1097-0061(20000930)17:3<218::aid-yea37>3.0.co;2-x

A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome.
Kirsch IR, Green ED, Yonescu R, Strausberg R, Carter N, Bentley D, Leversha MA, Dunham I, Braden VV, Hilgenfeld E, Schuler G, Lash AE, Shen GL, Martelli M, Kuehl WM, Klausner RD, Ried T.
Nat Genet Volume 24 (2000) p.339-340
DOI: 10.1038/74149

An SNP map of human chromosome 22.
Mullikin JC, Hunt SE, Cole CG, Mortimore BJ, Rice CM, Burton J, Matthews LH, Pavitt R, Plumb RW, Sims SK, Ainscough RM, Attwood J, Bailey JM, Barlow K, Bruskiewich RM, Butcher PN, Carter NP, Chen Y, Clee CM, Coggill PC, Davies J, Davies RM, Dawson E, Francis MD, Joy AA, Lamble RG, Langford CF, Macarthy J, Mall V, Moreland A, Overton-Larty EK, Ross MT, Smith LC, Steward CA, Sulston JE, Tinsley EJ, Turney KJ, Willey DL, Wilson GD, McMurray AA, Dunham I, Rogers J, Bentley DR.
Nature Volume 407 (2000) p.516-520
DOI: 10.1038/35035089

The extent of linkage disequilibrium in four populations with distinct demographic histories.
Dunning AM, Durocher F, Healey CS, Teare MD, McBride SE, Carlomagno F, Xu CF, Dawson E, Rhodes S, Ueda S, Lai E, Luben RN, Van Rensburg EJ, Mannermaa A, Kataja V, Rennart G, Dunham I, Purvis I, Easton D, Ponder BA.
Am J Hum Genet Volume 67 (2000) p.1544-1554
DOI: 10.1086/316906

Genomics - the new rock and roll?
Dunham I.
Trends Genet Volume 16 (2000) p.456-461
DOI: 10.1016/s0168-9525(00)02109-0

Report of the Fourth International Chromosome 6 Workshop 1999. 10-12 June 1999. Cambridge, UK. Abstracts.
Mungall AJ, Beck S, Cann HM, Dunham I, Trowsdale J, Ziegler A.
Cytogenet Cell Genet Volume 88 (2000) p.173-196


Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1.
Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE.
J Invest Dermatol Volume 113 (1999) p.162-169
DOI: 10.1046/j.1523-1747.1999.00682.x

Mapping and complex expression pattern of the human NPAP60L nucleoporin gene.
Trichet V, Shkolny D, Dunham I, Beare D, McDermid HE.
Cytogenet Cell Genet Volume 85 (1999) p.221-226

Localisation of a gene for transient neonatal diabetes mellitus to an 18.72 cR3000 (approximately 5.4 Mb) interval on chromosome 6q.
Gardner RJ, Mungall AJ, Dunham I, Barber JC, Shield JP, Temple IK, Robinson DO.
J Med Genet Volume 36 (1999) p.192-196

Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human.
Southard-Smith EM, Collins JE, Ellison JS, Smith KJ, Baxevanis AD, Touchman JW, Green ED, Dunham I, Pavan WJ.
Mamm Genome Volume 10 (1999) p.744-749
DOI: 10.1007/s003359901083

The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family.
Peyrard M, Seroussi E, Sandberg-Nordqvist AC, Xie YG, Han FY, Fransson I, Collins J, Dunham I, Kost-Alimova M, Imreh S, Dumanski JP.
Proc Natl Acad Sci U S A Volume 96 (1999) p.598-603
DOI: 10.1073/pnas.96.2.598

A molecular cytogenetic clone resource for chromosome 22.
Leversha MA, Dunham I, Carter NP.
Chromosome Res Volume 7 (1999) p.571-573
DOI: 10.1023/a:1009249830811

The DNA sequence of human chromosome 22.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP.
Nature Volume 402 (1999) p.489-495
DOI: 10.1038/990031


Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3.
Moynihan TP, Cole CG, Dunham I, O'Neil L, Markham AF, Robinson PA.
Genomics Volume 51 (1998) p.124-127
DOI: 10.1006/geno.1998.5257

Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy.
Minassian BA, Lee JR, Herbrick JA, Huizenga J, Soder S, Mungall AJ, Dunham I, Gardner R, Fong CY, Carpenter S, Jardim L, Satishchandra P, Andermann E, Snead OC 3rd, Lopes-Cendes I, Tsui LC, Delgado-Escueta AV, Rouleau GA, Scherer SW.
Nat Genet Volume 20 (1998) p.171-174
DOI: 10.1038/2470

Characterization of the human synaptogyrin gene family.
Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP.
Hum Genet Volume 103 (1998) p.131-141
DOI: 10.1007/s004390050795

Data disclosure in the human genome project.
Dunham I.
Mol Med Today Volume 4 (1998) p.335-336
DOI: 10.1016/s1357-4310(98)01307-0


Third single chromosome 6 workshop: meeting report.
Beck S, Cann HM, Campbell RD, Dunham I, Inoko H, Jazwinska EC, Ragoussis J, Trowsdale J, Ziegler A.
DNA Seq Volume 8 (1997) p.113-129

The organization of the gamma-glutamyl transferase genes and other low copy repeats in human chromosome 22q11.
Collins JE, Mungall AJ, Badcock KL, Fay JM, Dunham I.
Genome Res Volume 7 (1997) p.522-531

From long range mapping to sequence-ready contigs on human chromosome 6.
Mungall AJ, Humphray SJ, Ranby SA, Edwards CA, Heathcott RW, Clee CM, Holloway E, Peck AI, Harrison P, Green LD, Butler AP, Langford CF, William RG, Huckle EJ, Baron L, Smith A, Leversha MA, Ramsey YH, Clegg SM, Rice CM, Maslen GL, Hunt SE, Scott CE, Soderlund CA, Dunham I.
DNA Seq Volume 8 (1997) p.151-154

The Chromosome 6 database at the Sanger Centre.
Theaker AJ, Maslen GL, Scott CE, Rice CM, Hunt SE, King A, Mungall AJ, Dunham I, Beck S.
DNA Seq Volume 8 (1997) p.167-171


YAC library screening. II. Hybridization and PCR-based screening protocols.
Cole CG, Collins JE, Dunham I.
Methods Mol Biol Volume 54 (1996) p.33-47

YAC library screening. I. Preparation of hybridization filters and PCRpools.
Cole CG, Collins JE, Dunham I.
Methods Mol Biol Volume 54 (1996) p.23-31

YAC library storage and transport.
Collins JE, Hassock S, Dunham I.
Methods Mol Biol Volume 54 (1996) p.13-21

Physical mapping of chromosome 6: a strategy for the rapid generation of sequence-ready contigs.
Mungall AJ, Edwards CA, Ranby SA, Humphray SJ, Heathcott RW, Clee CM, East CL, Holloway E, Butler AP, Langford CF, Gwilliam R, Rice KM, Maslen GL, Carter NP, Ross MT, Deloukas P, Bentley DR, Dunham I.
DNA Seq Volume 7 (1996) p.47-49

Identification and characterization of NF1-related loci on human chromosomes 22, 14 and 2.
Hulsebos TJ, Bijleveld EH, Riegman PH, Smink LJ, Dunham I.
Hum Genet Volume 98 (1996) p.7-11
DOI: 10.1007/s004390050151

DNA rescue by the vectorette method.
McAleer MA, Coffey A, Dunham I.
Methods Mol Biol Volume 65 (1996) p.201-208

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.
Kedra D, Peyrard M, Fransson I, Collins JE, Dunham I, Roe BA, Dumanski JP.
Hum Mol Genet Volume 5 (1996) p.625-631
DOI: 10.1093/hmg/5.5.625

Use of ACEDB as a database for YAC library data management.
Dunham I, Maslen GL.
Methods Mol Biol Volume 54 (1996) p.253-280

A bacterial artificial chromosome-based framework contig map of human chromosome 22q.
Kim UJ, Shizuya H, Kang HL, Choi SS, Garrett CL, Smink LJ, Birren BW, Korenberg JR, Dunham I, Simon MI.
Proc Natl Acad Sci U S A Volume 93 (1996) p.6297-6301
DOI: 10.1073/pnas.93.13.6297

A gene map of the human genome.
Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tomé P, Aggarwal A, Bajorek E, Bentolila S, Birren BB, Butler A, Castle AB, Chiannilkulchai N, Chu A, Clee C, Cowles S, Day PJ, Dibling T, Drouot N, Dunham I, Duprat S, East C, Edwards C, Fan JB, Fang N, Fizames C, Garrett C, Green L, Hadley D, Harris M, Harrison P, Brady S, Hicks A, Holloway E, Hui L, Hussain S, Louis-Dit-Sully C, Ma J, MacGilvery A, Mader C, Maratukulam A, Matise TC, McKusick KB, Morissette J, Mungall A, Muselet D, Nusbaum HC, Page DC, Peck A, Perkins S, Piercy M, Qin F, Quackenbush J, Ranby S, Reif T, Rozen S, Sanders C, She X, Silva J, Slonim DK, Soderlund C, Sun WL, Tabar P, Thangarajah T, Vega-Czarny N, Vollrath D, Voyticky S, Wilmer T, Wu X, Adams MD, Auffray C, Walter NA, Brandon R, Dehejia A, Goodfellow PN, Houlgatte R, Hudson JR Jr, Ide SE, Iorio KR, Lee WY, Seki N, Nagase T, Ishikawa K, Nomura N, Phillips C, Polymeropoulos MH, Sandusky M, Schmitt K, Berry R, Swanson K, Torres R, Venter JC, Sikela JM, Beckmann JS, Weissenbach J, Myers RM, Cox DR, James MR, Bentley D, Deloukas P, Lander ES, Hudson TJ.
Science Volume 274 (1996) p.540-546
DOI: 10.1126/science.274.5287.540


Mapping human chromosomes.
Bently DR, Dunham I.
Curr Opin Genet Dev Volume 5 (1995) p.328-334
DOI: 10.1016/0959-437x(95)80047-6

SAM: a system for iteratively building marker maps.
Soderlund C, Dunham I.
Comput Appl Biosci Volume 11 (1995) p.645-655

Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome.
Morrow B, Goldberg R, Carlson C, Das Gupta R, Sirotkin H, Collins J, Dunham I, O'Donnell H, Scambler P, Shprintzen R.
Am J Hum Genet Volume 56 (1995) p.1391-1403

Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2.
Frippiat JP, Williams SC, Tomlinson IM, Cook GP, Cherif D, Le Paslier D, Collins JE, Dunham I, Winter G, Lefranc MP.
Hum Mol Genet Volume 4 (1995) p.983-991
DOI: 10.1093/hmg/4.6.983

Assignment of the beta B1 crystallin gene (CRYBB1) to human chromosome 22 and mouse chromosome 5.
Hulsebos TJ, Gilbert DJ, Delattre O, Smink LJ, Dunham I, Westerveld A, Thomas G, Jenkins NA, Copeland NG.
Genomics Volume 29 (1995) p.712-718
DOI: 10.1006/geno.1995.9947


Genetic mapping of 14 short tandem repeat polymorphisms on human chromosome 22.
Vallada HP, Collins JE, Dunham I, Dawson E, Murray RM, Gill M, Collier DA.
Hum Genet Volume 93 (1994) p.688-690
DOI: 10.1007/bf00201571

Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.
Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP.
Hum Mol Genet Volume 3 (1994) p.1393-1399
DOI: 10.1093/hmg/3.8.1393

Generation of alphoid DNA probes for fluorescence in situ hybridization (FISH) using the polymerase chain reaction.
Lengauer C, Dunham I, Featherstone T, Cremer T.
Methods Mol Biol Volume 33 (1994) p.51-61

A YAC contig spanning the ataxia-telangiectasia locus (groups A and C) at 11q22-q23.
Rotman G, Savitsky K, Ziv Y, Cole CG, Higgins MJ, Bar-Am I, Dunham I, Bar-Shira A, Vanagaite L, Qin S, Zhang J, Nowak NJ, Chandrasekharappa SC, Lehrach H, Avivi L, Shows TB, Collins FS, Bentley DR, Shiloh Y.
Genomics Volume 24 (1994) p.234-242
DOI: 10.1006/geno.1994.1611


Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12.
Xie YG, Han FY, Peyrard M, Ruttledge MH, Fransson I, DeJong P, Collins J, Dunham I, Nordenskjöld M, Dumanski JP.
Hum Mol Genet Volume 2 (1993) p.1361-1368
DOI: 10.1093/hmg/2.9.1361

Molecular mapping of the HLA class II region in HLA-DR3 associated idiopathic membranous nephropathy.
Sacks SH, Warner C, Campbell RD, Dunham I.
Kidney Int Suppl Volume 39 (1993) p.s13-9

Isolation of cDNA clones mapping around DXS178: a search for human X-linked agammaglobulinaemia gene using yeast artificial chromosomes, cosmids and direct cDNA selection.
Vorechovský I, Holland J, Sideras P, Dunham I, Hammarström L, Smith CI, Bentley DR, Vetrie D.
Immunodeficiency Volume 4 (1993) p.221-224

Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease.
Halford S, Wadey R, Roberts C, Daw SC, Whiting JA, O'Donnell H, Dunham I, Bentley D, Lindsay E, Baldini A.
Hum Mol Genet Volume 2 (1993) p.2099-2107
DOI: 10.1093/hmg/2.12.2099


Identification of region-specific yeast artificial chromosomes using pools of Alu element-mediated polymerase chain reaction probes labeled via linear amplification.
Cole CG, Patel K, Shipley J, Sheer D, Bobrow M, Bentley DR, Dunham I.
Genomics Volume 14 (1992) p.931-938
DOI: 10.1016/s0888-7543(05)80114-4

The development and application of automated gridding for efficient screening of yeast and bacterial ordered libraries.
Bentley DR, Todd C, Collins J, Holland J, Dunham I, Hassock S, Bankier A, Giannelli F.
Genomics Volume 12 (1992) p.534-541
DOI: 10.1016/0888-7543(92)90445-x

A random STS strategy for construction of YAC contigs spanning defined chromosomal regions.
Cole CG, Dunham I, Coffey AJ, Ross MT, Meier-Ewert S, Bobrow M, Bentley DR.
Genomics Volume 14 (1992) p.256-262
DOI: 10.1016/s0888-7543(05)80214-9

Possible role for COMT in psychosis associated with velo-cardio-facial syndrome.
Dunham I, Collins J, Wadey R, Scambler P.
Lancet Volume 340 (1992) p.1361-1362
DOI: 10.1016/0140-6736(92)92553-r

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction.
Dunham I, Lengauer C, Cremer T, Featherstone T.
Hum Genet Volume 88 (1992) p.457-462
DOI: 10.1007/bf00215682

A panel of human chromosome 22-specific sequence tagged sites.
Collins JE, Everett LA, Bentley DR, Dunham I.
Genomics Volume 14 (1992) p.1098-1103
DOI: 10.1016/s0888-7543(05)80137-5


Characterization of the class III region in different MHC haplotypes by pulsed-field gel electrophoresis.
Dunham I, Sargent CA, Kendall E, Campbell RD.
Immunogenetics Volume 32 (1990) p.175-182
DOI: 10.1007/bf02114970

Molecular analysis of the human MHC class I region in hereditary haemochromatosis. A study by pulsed-field gel electrophoresis.
Lord DK, Dunham I, Campbell RD, Bomford A, Strachan T, Cox TM.
Hum Genet Volume 85 (1990) p.531-536
DOI: 10.1007/bf00194232

Rapid assessment of S. cerevisiae mating type by PCR.
Huxley C, Green ED, Dunham I.
Trends Genet Volume 6 (1990) p.236
DOI: 10.1016/0168-9525(90)90190-h

Polymorphism of the human complement component C4.
Campbell RD, Dunham I, Kendall E, Sargent CA.
Exp Clin Immunogenet Volume 7 (1990) p.69-84


An analysis of variation in the long-range genomic organization of the human major histocompatibility complex class II region by pulsed-field gel electrophoresis.
Dunham I, Sargent CA, Dawkins RL, Campbell RD.
Genomics Volume 5 (1989) p.787-796
DOI: 10.1016/0888-7543(89)90120-1

Direct observation of the gene organization of the complement C4 and 21-hydroxylase loci by pulsed field gel electrophoresis.
Dunham I, Sargent CA, Dawkins RL, Campbell RD.
J Exp Med Volume 169 (1989) p.1803-1818
DOI: 10.1084/jem.169.5.1803

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
Sargent CA, Dunham I, Trowsdale J, Campbell RD.
Proc Natl Acad Sci U S A Volume 86 (1989) p.1968-1972
DOI: 10.1073/pnas.86.6.1968

Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.
Sargent CA, Dunham I, Campbell RD.
EMBO J Volume 8 (1989) p.2305-2312


Molecular mapping of the HLA-linked complement genes and the RCA linkage group.
Campbell RD, Dunham I, Sargent CA.
Exp Clin Immunogenet Volume 5 (1988) p.81-98


Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia.
Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD.
EMBO J Volume 6 (1987) p.1653-1661

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.
Dunham I, Sargent CA, Trowsdale J, Campbell RD.
Proc Natl Acad Sci U S A Volume 84 (1987) p.7237-7241
DOI: 10.1073/pnas.84.20.7237