Hubert Denise

Hubert Denise

Bioinformatician - Finn team: Protein families

ORCID iD: 0000-0001-9862-5890

Tel:+ 44 (0) 1223 494 102 / Fax:+ 44 (0) 1223 494 468



TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
Shameer S, Logan-Klumpler FJ, Vinson F, Cottret L, Merlet B, Achcar F, Boshart M, Berriman M, Breitling R, Bringaud F, Bütikofer P, Cattanach AM, Bannerman-Chukualim B, Creek DJ, Crouch K, de Koning HP, Denise H, Ebikeme C, Fairlamb AH, Ferguson MA, Ginger ML, Hertz-Fowler C, Kerkhoven EJ, Mäser P, Michels PA, Nayak A, Nes DW, Nolan DP, Olsen C, Silva-Franco F, Smith TK, Taylor MC, Tielens AG, Urbaniak MD, van Hellemond JJ, Vincent IM, Wilkinson SR, Wyllie S, Opperdoes FR, Barrett MP, Jourdan F.
Nucleic Acids Res Volume 43 (2015) p.d637-44
DOI: 10.1093/nar/gku944


EBI metagenomics--a new resource for the analysis and archiving of metagenomic data.
Hunter S, Corbett M, Denise H, Fraser M, Gonzalez-Beltran A, Hunter C, Jones P, Leinonen R, McAnulla C, Maguire E, Maslen J, Mitchell A, Nuka G, Oisel A, Pesseat S, Radhakrishnan R, Rocca-Serra P, Scheremetjew M, Sterk P, Vaughan D, Cochrane G, Field D, Sansone SA.
Nucleic Acids Res Volume 42 (2014) p.d600-6
DOI: 10.1093/nar/gkt961

Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision.
Denise H, Moschos SA, Sidders B, Burden F, Perkins H, Carter N, Stroud T, Kennedy M, Fancy SA, Lapthorn C, Lavender H, Kinloch R, Suhy D, Corbau R.
Mol Ther Nucleic Acids Volume 3 (2014) p.e145
DOI: 10.1038/mtna.2013.73


In vitro characterization of the activity of PF-05095808, a novel biological agent for hepatitis C virus therapy.
Lavender H, Brady K, Burden F, Delpuech-Adams O, Denise H, Palmer A, Perkins H, Savic B, Scott S, Smith-Burchnell C, Troke P, Wright JF, Suhy D, Corbau R.
Antimicrob Agents Chemother Volume 56 (2012) p.1364-1375
DOI: 10.1128/aac.05357-11

Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model.
Suhy DA, Kao SC, Mao T, Whiteley L, Denise H, Souberbielle B, Burdick AD, Hayes K, Wright JF, Lavender H, Roelvink P, Kolykhalov A, Brady K, Moschos SA, Hauck B, Zelenaia O, Zhou S, Scribner C, High KA, Renison SH, Corbau R.
Mol Ther Volume 20 (2012) p.1737-1749
DOI: 10.1038/mt.2012.119


Pharmaceutical proteins in plants. A strategic genetic engineering approach for the production of tuberculosis antigens.
Frutos R, Denise H, Vivares C, Neuhaus JM, Vitale S, Pedrazzini E, Ma J, Dix P, Gray J, Pezzotti M, Conrad U, Robinson D.
Ann N Y Acad Sci Volume 1149 (2008) p.275-280
DOI: 10.1196/annals.1428.089


Major O-glycans in the spores of two microsporidian parasites are represented by unbranched manno-oligosaccharides containing alpha-1,2 linkages.
Taupin V, Garenaux E, Mazet M, Maes E, Denise H, Prensier G, Vivarès CP, Guérardel Y, Méténier G.
Glycobiology Volume 17 (2007) p.56-67
DOI: 10.1093/glycob/cwl050


Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.
Denise H, Poot J, Jiménez M, Ambit A, Herrmann DC, Vermeulen AN, Coombs GH, Mottram JC.
BMC Mol Biol Volume 7 (2006) p.42
DOI: 10.1186/1471-2199-7-42


Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy.
Denise H, Coombs GH, Mottram JC.
FEMS Microbiol Lett Volume 235 (2004) p.89-94
DOI: 10.1016/j.femsle.2004.04.015


Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity.
Buxbaum LU, Denise H, Coombs GH, Alexander J, Mottram JC, Scott P.
J Immunol Volume 171 (2003) p.3711-3717
DOI: 10.4049/jimmunol.171.7.3711

Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo.
Denise H, McNeil K, Brooks DR, Alexander J, Coombs GH, Mottram JC.
Infect Immun Volume 71 (2003) p.3190-3195
DOI: 10.1128/iai.71.6.3190-3195.2003


Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.
Basselin M, Denise H, Coombs GH, Barrett MP.
Antimicrob Agents Chemother Volume 46 (2002) p.3731-3738
DOI: 10.1128/aac.46.12.3731-3738.2002


Uptake and mode of action of drugs used against sleeping sickness.
Denise H, Barrett MP.
Biochem Pharmacol Volume 61 (2001) p.1-5
DOI: 10.1016/s0006-2952(00)00477-9

The stage-regulated expression of Leishmania mexicana CPB cysteine proteases is mediated by an intercistronic sequence element.
Brooks DR, Denise H, Westrop GD, Coombs GH, Mottram JC.
J Biol Chem Volume 276 (2001) p.47061-47069
DOI: 10.1074/jbc.m108498200


Trypanosomiasis and leishmaniasis: between the idea and the reality of control.
Denise H, Matthews K, Lindergård G, Croft S, Barrett MP.
Parasitol Today Volume 15 (1999) p.43-45
DOI: 10.1016/s0169-4758(98)01374-x

Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.
Denise H, Giroud C, Barrett MP, Baltz T.
Eur J Biochem Volume 259 (1999) p.339-346
DOI: 10.1046/j.1432-1327.1999.00048.x


A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.
Barrett MP, Zhang ZQ, Denise H, Giroud C, Baltz T.
Mol Biochem Parasitol Volume 73 (1995) p.223-229
DOI: 10.1016/0166-6851(95)00120-p