Head of Molecular Archival Resources
Dr Helen Parkinson head of Molecular Archival Resources at EMBL-EBI and leads the Samples, Phenotypes and Ontologies team, delivering databases, data integration tools and ontologies for biomedicine. She is also Interim Team Leader for the Variation Archive team. Trained as a geneticist, Helen's research focused on Drosophila biology, behaviour, molecular biology and medical genetics. In 1999 she shifted focus to bioinformatics and computational biology while performing positional cloning for primary pulmonary hypertension. Helen's passion is semantic data integration and providing users with useful data. Her team participates extensively in external collaborations ranging from data analysis and generation projects to infrastructural integration projects such as the ELIXIR initiatives BioMedBridges, CORBEL and EXELERATE. In collaboration with partners in the KOMP2 project and the International Mouse Phenotyping Consortium, Helen's SPOT team manages, analyses, and distributes complex phenotypic data from knockout mouse lines and promotes mouse data integration internationally.They also develop open-source software tools for managing data, developing and integrating ontologies and data, and integrating semantic web technologies.
Prior to joining EMBL-EBI in 2000, Helen was a post-doctoral researcher at the University of Leicester, where she worked on the genetic basis of Primary Pulmonary Hypertension, Hyphophatasia and synteny at human chromosomes 7 and 12. Her PhD thesis examined the temperature compensation of circadian rhythms in Drosophilawith Professor Bambos Kyriacou.
parkinson [at] ebi.ac.uk
ORCID iD: 0000-0003-3035-4195
Tel:+44 (0)1223 494 672 / Fax:+44 (0)1223 494 468
The Samples, Phenotypes and Ontologies team, led by Helen Parkinson, is organised into three themes: BioSamples and Semantic Data Integration, Mouse Informatics, and the Gene Ontology Editorial Office. The team is part of the Cross Domain Cluster and the Genes, Genomes and Variation Cluster and provides ontologies, ontology tooling, and resources providing access to samples and ontologies both for EBI resources and external users.
Mouse Informatics led by Coordinator Terry Meehan develops international infrastructure for mouse data archiving, integration and dissemination. The team is a partner on several international projects, including: The International Mouse Phenotyping Consortium (IMPC), KOMP2, INFRAFRONTIER-I3, PhenoImageShare and IPAD-MD. All these externally funded projects share a common theme of data integration of rich phenotypic data derived from models species to better understand gene function and how genetic variation contributes to disease.
Gene Ontology Editorial Office
The Gene Ontology Editorial Office, led by GO/GOA Project Lead Melanie Courtot, coordinates the delivery of the Gene Ontology, including adding terms and revising the Ontology's content and structure, alignment with other ontologies, e.g. chemicals, anatomy and cell type, training, software testing and development and outreach.
BioSamples, EFO and OLS
The BioSamples, EFO and OLS resources are led by Coordinator Tony Burdett. We deliver the BioSamples database, a resource which identifies and describes samples across EBI databases, and develops ontologies such as the Experimental Factor Ontology (EFO) , EDAM, SWO and the Cell Line Ontology, delivers ontology tooling such as Webulous and Ontology Lookup Service - tools to build, browse and query ontologies. In collaboration with Paul Flicek's team we deliver the NHGRI GWAS Catalog content and infrastructure.
Members of the team work on ~15 projects with external collaborators where we are funded by the European Commission, the BBSRC, the Wellcome Trust, the National Institutes of Health and the Centre for Therapeutic Target Validation in collaboration with GSK and the Wellcome Trust Sanger Institute. These range from data analysis and generation projects such as IMPC and projects which are mainly infrastructural such as BioMedBridges, CORBEL and EXELERATE.
In collaboration with partners in the KOMP2 project and the International Mouse Phenotyping Consortium, the team manages, analyses, and distributes complex phenotypic data from 20,000 knockout mouse lines and, promotes mouse data integration internationally via the IMPC. The team also develops open-source software tools for managing data, developing and integrating ontologies and data, and works with semantic web technologies.
We collaborate closely with Melissa Haendel and Chris Mungall of the Monarch Inititiave, an integration project for genotype/phenotype data, by supplying human and mouse phenotypic data and using their tools in delivery of the IMPC portal. We consume the Uberon Ontology - a critical integrative resource for vertebrate anatomy used across EBI's sample representation.