About us People & groups

I obtained my Bachelor's and Master's in Bioengineering from the Université Libre de Bruxelles (Belgium). My Master's thesis was focused on studying the mechanisms of corticogenesis in mammals using mouse embryonic stem cells. I also did an applied research project in computational fluid dynamics. Following this, I did an Mphil in Computational Biology at the University of Cambridge, in an attempt to combine my biological and mathematical/engineering interests. This Master's included a 3 months research project during which I developed an R/Bioconductor package for gene set and network analysis of large scale RNAi data sets. I applied these and other networks methods to investigate genetic interactions with BRCA2 in order to have a better understanding of its functions and involvement in breast cancer. My PhD at the EMBL-EBI is focused on the development of modelling frameworks for signalling and regulatory networks that can accommodate heterogeneous biological knowledge. My main interest is the use of mass spectrometry (phospho)proteomics data in this context, and in particular the challenges associated with using such data to build logic models of signalling pathway that take advantage of the scope (coverage of the proteome) and level of detail (site-level data) offered by mass spectrometry.