Brandon Invergo

Brandon Invergo

Postdoctoral Fellow (ESPOD) - Beltrao research group

I received a bachelor's degree in Computer Science at Rose-Hulman Institute of Technology (Terre Haute, IN, USA) in 2004. From 2004 to 2007, I worked as a research associate at Northwestern University (Evanston, IL, USA) in the lab of Lawrence H. Pinto. There, I performed electrophysiological and behavioral assays on mice to screen for mutations in the visual system. I then returned to school, to receive a master's degree in Biology (Evolutionary and Ecological Sciences) at Leiden University (Leiden, NL) in 2009. I went on to receive a PhD from The Institute of Evolutionary Biology (UPF-CSIC, Barcelona, ES) in 2013 under the supervision of Jaume Bertranpetit and Ludovica Montanucci. My thesis was on the molecular evolution of the proteins of the visual phototransduction pathway, with a focus on the influences of the topology and dynamics of molecular interactions on natural selection. In 2013, I began an ESPOD fellowship under the supervision of Pedro Beltrao (EMBL-EBI), Oliver Billker (Malaria Programme, Wellcome Trust Sanger Institute) and Jyoti Choudhary (Proteomics, Wellcome Trust Sanger Institute). In my present research, I am employing mass spectrometry and bioinformatics to study post-translational modification-based signaling in malaria-causing parasites (Plasmodium spp.).

ORCID iD: 0000-0001-8019-798X

Tel:+ 44 (0) 1223 49 2547 / Fax:+44 (0)1223 48 46 96



Palmitoylation and palmitoyl-transferases in Plasmodium parasites.
Hodson N, Invergo B, Rayner JC, Choudhary JS.
Biochem Soc Trans Volume 43 (2015) p.240-245
DOI: 10.1042/bst20140289


Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes.
Colombo M, Laayouni H, Invergo BM, Bertranpetit J, Montanucci L.
Evolution Volume 68 (2014) p.605-613
DOI: 10.1111/evo.12262

A comprehensive model of the phototransduction cascade in mouse rod cells.
Invergo BM, Dell'Orco D, Montanucci L, Koch KW, Bertranpetit J.
Mol Biosyst Volume 10 (2014) p.1481-1489
DOI: 10.1039/c3mb70584f


A system-level, molecular evolutionary analysis of mammalian phototransduction.
Invergo BM, Montanucci L, Laayouni H, Bertranpetit J.
BMC Evol Biol Volume 13 (2013) p.52
DOI: 10.1186/1471-2148-13-52

Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.
Invergo BM, Montanucci L, Koch KW, Bertranpetit J, Dell'orco D.
Cell Commun Signal Volume 11 (2013) p.36
DOI: 10.1186/1478-811x-11-36


Bio.Phylo: a unified toolkit for processing, analyzing and visualizing phylogenetic trees in Biopython.
Talevich E, Invergo BM, Cock PJ, Chapman BA.
BMC Bioinformatics Volume 13 (2012) p.209
DOI: 10.1186/1471-2105-13-209


Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly.
Oostra V, de Jong MA, Invergo BM, Kesbeke F, Wende F, Brakefield PM, Zwaan BJ.
Proc Biol Sci Volume 278 (2011) p.789-797
DOI: 10.1098/rspb.2010.1560

Ten simple rules for getting help from online scientific communities.
Dall'Olio GM, Marino J, Schubert M, Keys KL, Stefan MI, Gillespie CS, Poulain P, Shameer K, Sugar R, Invergo BM, Jensen LJ, Bertranpetit J, Laayouni H.
PLoS Comput Biol Volume 7 (2011) p.e1002202
DOI: 10.1371/journal.pcbi.1002202


Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses.
Maddox DM, Vessey KA, Yarbrough GL, Invergo BM, Cantrell DR, Inayat S, Balannik V, Hicks WL, Hawes NL, Byers S, Smith RS, Hurd R, Howell D, Gregg RG, Chang B, Naggert JK, Troy JB, Pinto LH, Nishina PM, McCall MA.
J Physiol Volume 586 (2008) p.4409-4424
DOI: 10.1113/jphysiol.2008.157289


Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Glawe B, Cantrell DR, Inayat S, Olvera MA, Vessey KA, McCall MA, Maddox D, Morgans CW, Young B, Pletcher MT, Mullins RF, Troy JB, Takahashi JS.
Vis Neurosci Volume 24 (2007) p.111-123
DOI: 10.1017/s0952523807070149

Interpretation of the mouse electroretinogram.
Pinto LH, Invergo B, Shimomura K, Takahashi JS, Troy JB.
Doc Ophthalmol Volume 115 (2007) p.127-136
DOI: 10.1007/s10633-007-9064-y


Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, McDearmon EL, Fenner D, Lumayag SL, Omura C, Andrews AW, Baker M, Invergo BM, Olvera MA, Heffron E, Mullins RF, Sheffield VC, Stone EM, Takahashi JS.
Vis Neurosci Volume 22 (2005) p.619-629
DOI: 10.1017/s0952523805225117