IntAct Update: May 2014
This month we feature a dataset by Butland and colleagues exploring a role for the palmitoyl acyltransferase protein, HIP14, in the pathogenesis of Huntington Disease.
HIP14 and Huntingtin protein (the mutation of which is causative for the condition) share an unusually large number of interactors, suggesting defective palmitoylation of key substrates by HIP14 may be important in disease progression. This was published in Butland, S.L. et al. (2014) The Palmitoyl acyltransferase HIP14 Shares a High Proportion of Interactors with Huntingtin: Implications for a Role in the Pathogenesis of Huntington Disease. Human Molecular Genetics, doi: 10.1093/hmg/ddu137
Updates for this release
There was one release in April: R179. The IntAct database now contains 12,670 publications, 32,922 experiments and 445,813 binary interactions.