IntAct: September 2013 Update

The IntAct molecular interaction database

Database News

MINT   Having successfully collaborated for many years in the establishment of molecular interaction data standards, curation rules and the IMEx Consortium, the MINT and IntAct databases now move closer together to share infrastructure and optimise future software development. All data manually curated by the MINT curators has been moved into the IntAct database at EMBL-EBI, and is merged with the existing IntAct dataset. The IntAct team will be responsible for data maintenance and release, and both groups will actively contribute to continuing curation efforts. The MINT PSICQUIC and IMEx services will be maintained, as will their MENTHA workbench [1]. All manually curated data from MINT will be available from the IntAct ftp site, and will be indexed by and downloadable from the IntAct website.

  1. Calderone A, Castagnoli L, Cesareni G.(2013) Mentha: a resource for browsing integrated protein-interaction networks. Nat Methods 10(8), 690-691.

UCL     IntAct also welcomes the University College London Cardiovascular Gene Ontology Annotation Initiative, who have just started curating interaction data into the IntAct database under a 5-year grant from the British Heart Foundation.

Dataset of the Month

Thomsen C, Grundevik P, Elias P, et al. (2013) A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins. FASEB J.

The data was submitted directly to IntAct as part of the publication process, and can be searched using IMEx ID IM-21252 on the IntAct website and the IMEx Consortium pages.

Release News

There have been three releases in August 2013 (R168-170). The IntAct database now contains 11,879 publications, 30,507 experiments and 430,134 binary interactions.