IntAct: August 2013 Update
IntAct update: Rewiring of C. elegans transcription factor network following gene duplication events.
The 2014 course on Networks and Pathways Bioinformatics for Biologists at EMBL-EBI, supported by the PSIMEx project (funded under the Health Theme of the EU's Seventh Framework Programme), by took place at EMBL-EBI with 39 students learning how to analyse their large-scale datasets using a variety of methods.
Dataset of the month
Taken from: Reece-Hoyes, J.S., et al. (2013) Extensive Rewiring and Complex Evolutionary Dynamics in a C. elegans Multiparameter Transcription Factor Network. Mol Cell. 51, 116-127.
The authors characterise network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks following gene duplication events. They found that even highly similar TFs often have different interaction degrees and partners and most TF families have a member that is highly connected in multiple networks. These observations indicate that sequence similarity is generally not predictive of interaction profile similarity and illustrate the continued need for the mapping of molecular interaction networks for different species.