ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 27-MAR-2024, entry version 135. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; MRCSISLVLG LLALEVALAR NLQEHVFNSV QSMCSDDSFS EDTECINCQT NEECAQNDMC CPSSCGRSCK TPVNIEVQKA GRCPWNPIQM IAAGPCPKDN PCSIDSDCSG TMKCCKNGCI MSCMDPEPKS PTVISFQ //