Dbfetch

ID   Z15026; SV 1; linear; genomic DNA; STD; HUM; 16310 BP.
XX
AC   Z15026;
XX
DT   16-FEB-1993 (Rel. 34, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 7)
XX
DE   Homo sapiens TNFa and gene for tumor necrosis factor and TNFb gene for
DE   lymphotoxin
XX
KW   HLA class III; lymphotoxin; TNFa gene; TNFb gene; tumor necrosis factor.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-16310
RX   DOI; 10.1038/ng0293-137.
RX   PUBMED; 8499947.
RA   Iris F., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V.,
RA   Jurka J., Rodriguez-Tome P., Claverie J., Cohen D., Dausset J.;
RT   "Dense Alu clustering and a potential new member of the NF kappa B family
RT   within a 90 kilobase HLA class III segment";
RL   Nat Genet 3(2):137-145(1993).
XX
RN   [2]
RP   1-16310
RA   Bougueleret L.;
RT   ;
RL   Submitted (06-AUG-1992) to the INSDC.
RL   Lydie Bougueleret, CEPH, 27 Rue Juliette Dodu, Paris, 75010, France
XX
DR   MD5; 621a918ee7388ab2dbe94d4bed248b31.
DR   EPD; EP11158; HS_TNF.
DR   EPD; EP11159; HS_LTA.
DR   Ensembl-Gn; ENSG00000204490; homo_sapiens.
DR   Ensembl-Gn; ENSG00000206439; homo_sapiens.
DR   Ensembl-Gn; ENSG00000223952; homo_sapiens.
DR   Ensembl-Gn; ENSG00000226979; homo_sapiens.
DR   Ensembl-Gn; ENSG00000228321; homo_sapiens.
DR   Ensembl-Gn; ENSG00000228849; homo_sapiens.
DR   Ensembl-Gn; ENSG00000230108; homo_sapiens.
DR   Ensembl-Gn; ENSG00000230279; homo_sapiens.
DR   Ensembl-Gn; ENSG00000231408; homo_sapiens.
DR   Ensembl-Gn; ENSG00000232810; homo_sapiens.
DR   Ensembl-Tr; ENST00000376122; homo_sapiens.
DR   Ensembl-Tr; ENST00000383496; homo_sapiens.
DR   Ensembl-Tr; ENST00000412275; homo_sapiens.
DR   Ensembl-Tr; ENST00000412851; homo_sapiens.
DR   Ensembl-Tr; ENST00000418386; homo_sapiens.
DR   Ensembl-Tr; ENST00000420425; homo_sapiens.
DR   Ensembl-Tr; ENST00000426845; homo_sapiens.
DR   Ensembl-Tr; ENST00000436519; homo_sapiens.
DR   Ensembl-Tr; ENST00000443707; homo_sapiens.
DR   Ensembl-Tr; ENST00000448781; homo_sapiens.
DR   Ensembl-Tr; ENST00000449264; homo_sapiens.
DR   Ensembl-Tr; ENST00000454550; homo_sapiens.
DR   Ensembl-Tr; ENST00000454783; homo_sapiens.
DR   EuropePMC; PMC170480; 9008286.
DR   EuropePMC; PMC1798099; 16107511.
DR   EuropePMC; PMC3243656; 22190997.
DR   EuropePMC; PMC98810; 11705896.
XX
CC   This portion of the HLA class III region is centromeric to the
CC   HLA-B region.  Orientation is 5'= centromeric, 3' = telomeric
CC   This fragment contains the integrality of the Tnf a and b genes.
CC   This region is 10 kb telomeric to previous entry Z15025. The human
CC   equivalent of the murine B144 transcript is located in the 10kb
CC   of yet unsequenced  DNA separating the two entries.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..16310
FT                   /organism="Homo sapiens"
FT                   /chromosome="6"
FT                   /map="p21.3"
FT                   /mol_type="genomic DNA"
FT                   /sex="male"
FT                   /haplotype="HLA-Dr4"
FT                   /clone="Cosmid 4.2, 40 kb FRAGMENT CLONED IN PTCF VECTEUR"
FT                   /cell_line="BOLETH"
FT                   /db_xref="taxon:9606"
FT   repeat_region   complement(1365..1654)
FT                   /rpt_family="Alu"
FT                   /note="Alu J subfamily"
FT   repeat_region   complement(1833..1950)
FT                   /rpt_family="Alu"
FT                   /note="Alu J subfamily"
FT   CDS             complement(join(3402..3823,4125..4172,4362..4407,
FT                   5014..5199))
FT                   /gene="TNFa"
FT                   /product="tumor necrosis factor, Tnfa"
FT                   /db_xref="GOA:P01375"
FT                   /db_xref="HGNC:HGNC:11892"
FT                   /db_xref="InterPro:IPR002959"
FT                   /db_xref="InterPro:IPR006052"
FT                   /db_xref="InterPro:IPR006053"
FT                   /db_xref="InterPro:IPR008983"
FT                   /db_xref="InterPro:IPR021184"
FT                   /db_xref="PDB:1A8M"
FT                   /db_xref="PDB:1TNF"
FT                   /db_xref="PDB:2AZ5"
FT                   /db_xref="PDB:2E7A"
FT                   /db_xref="PDB:2TUN"
FT                   /db_xref="PDB:2ZJC"
FT                   /db_xref="PDB:2ZPX"
FT                   /db_xref="PDB:3ALQ"
FT                   /db_xref="PDB:3IT8"
FT                   /db_xref="PDB:3L9J"
FT                   /db_xref="PDB:3WD5"
FT                   /db_xref="PDB:4G3Y"
FT                   /db_xref="PDB:4TSV"
FT                   /db_xref="PDB:4TWT"
FT                   /db_xref="PDB:5TSW"
FT                   /db_xref="UniProtKB/Swiss-Prot:P01375"
FT                   /protein_id="CAA78745.1"
FT                   /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGAT
FT                   TLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQW
FT                   LNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSY
FT                   QTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAE
FT                   SGQVYFGIIAL"
FT   exon            complement(3402..3823)
FT                   /number=4
FT   intron          complement(3824..4124)
FT                   /number=3
FT   exon            complement(4125..4172)
FT                   /number=3
FT   intron          complement(4173..4361)
FT                   /number=2
FT   exon            complement(4362..4407)
FT                   /number=2
FT   intron          complement(4408..5013)
FT                   /number=1
FT   repeat_region   4452..4732
FT                   /rpt_type=DISPERSED
FT                   /note="Medium reiteration frequency sequence MER35"
FT   repeat_region   4762..4823
FT                   /rpt_type=DISPERSED
FT                   /note="Short interspersed repeat SR1"
FT   exon            complement(5014..5379)
FT                   /number=1
FT   CDS             complement(join(7248..7660,7908..8013,8100..8198))
FT                   /gene="TNFb"
FT                   /product="lymphotoxin, Tnfb"
FT                   /db_xref="GOA:P01374"
FT                   /db_xref="HGNC:HGNC:6709"
FT                   /db_xref="InterPro:IPR002960"
FT                   /db_xref="InterPro:IPR006052"
FT                   /db_xref="InterPro:IPR006053"
FT                   /db_xref="InterPro:IPR008983"
FT                   /db_xref="InterPro:IPR021184"
FT                   /db_xref="PDB:1TNR"
FT                   /db_xref="PDB:4MXV"
FT                   /db_xref="PDB:4MXW"
FT                   /db_xref="UniProtKB/Swiss-Prot:P01374"
FT                   /protein_id="CAA78746.1"
FT                   /translation="MTPPERLFLPRVRGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAA
FT                   QTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTS
FT                   GIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPW
FT                   LHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL"
FT   exon            complement(7248..7660)
FT                   /number=4
FT   intron          complement(7661..7907)
FT                   /number=3
FT   exon            complement(7908..8013)
FT                   /number=3
FT   intron          complement(8014..8099)
FT                   /number=2
FT   exon            complement(8100..8207)
FT                   /number=2
FT   intron          complement(8208..8494)
FT                   /number=1
FT   exon            complement(8495..8654)
FT                   /number=1
FT   repeat_region   9582..9870
FT                   /rpt_family="Alu"
FT                   /note="Alu Sx subfamily"
FT   repeat_region   10056..10306
FT                   /rpt_type=DISPERSED
FT                   /note="Medium reiteration frequency sequence MER38"
FT   repeat_region   10713..10923
FT                   /rpt_type=DISPERSED
FT                   /note="Medium reiteration frequency sequence MER39"
FT   repeat_region   10924..11098
FT                   /rpt_type=DISPERSED
FT                   /note="Medium reiteration frequency MER40"
FT   repeat_region   complement(11133..11424)
FT                   /rpt_family="Alu"
FT                   /note="Alu Sq subfamily"
FT   repeat_region   11627..11914
FT                   /rpt_family="Alu"
FT                   /note="Alu Sc subfamily"
FT   repeat_region   complement(13349..13610)
FT                   /rpt_family="Alu"
FT                   /note="Alu J subfamily"
FT   repeat_region   complement(13620..13904)
FT                   /rpt_family="Alu"
FT                   /note="Alu Sp subfamily"
FT   repeat_region   complement(13904..13952)
FT                   /rpt_family="Alu"
FT                   /note="Alu fragment"
FT   repeat_region   complement(13970..14257)
FT                   /rpt_family="Alu"
FT                   /note="Alu Sx subfamily"
FT   repeat_region   complement(14272..14556)
FT                   /rpt_family="Alu"
FT                   /note="Alu Sx subfamily"
FT   repeat_region   complement(14566..14845)
FT                   /rpt_family="Alu"
FT                   /note="Alu J subfamily"
FT   repeat_region   complement(14732..15017)
FT                   /rpt_family="Alu"
FT                   /note="Alu Sx subfamily"
FT   repeat_region   complement(15995..16291)
FT                   /rpt_family="Alu"
FT                   /note="Alu J subfamily"
XX
SQ   Sequence 16310 BP; 3819 A; 4069 C; 4268 G; 4152 T; 2 other;
     tacgggccgg gcactcccga gctgctgctc gagggcgccg agacggtgac tccagtgctg        60
     gacccggcca ggagacaagg gtacgggcct ctctggtaca cgagcgtggg gttcggcggc       120
     ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tcagtcaccc cgatatggtg       180
     gacttcgcga gagggaagac cttctttggg gccgtgatgg tggggtgagg gaatatgagt       240
     gcgtggtgcg agtgcgtgaa tattgggggn ccggacgccc aggaccccat ggcagtggga       300
     aaaatgtagg agactgtttg gaaattgatt ttgaacctga tgaaaataaa gaatggaaag       360
     cttcagtgct gccgataaag atgctgagtt gcgacacacg tcttaattca gggtgggtgc       420
     acgggtgcgg gttaaatatt ctcagtactc ttctggttgc ttgaaacaat tcatcacaac       480
     acagtgtatg gcctttgctc ctagggatga tggtctgcct gtcccacccc ctccctgcct       540
     ctgaatggcc aggccccacc attagcccag ttggagggtg ggaggaaggg ggacttctca       600
     aactccgaag cttctctagg catcctgatt ttcagggcca catggtccca accagactct       660
     gcaccatact cttttctctt gggtaccccc caacagtgag aggggtcatt acagagccca       720
     gcaagcacca ctcagaaagg cccagcagca gagtaagccc ctatcatgac agaggaatga       780
     agcctggagg ggccccgcac ttctccccct agagctgcct gaaggcctct ctgtctccta       840
     cccgacagtc aactcttctc ctccaaggag cttaattcaa ggctcatggg gtctgaaggg       900
     aggaggctga aggagaaaga aggggagaat attagagaga gatggggatg gcaggaagga       960
     gcctgtggtg cctgaaaaca ccaggaagtt ctggggagga ggaaaaaccg atgccccact      1020
     tagggtgtcc catttagggt gagacggaaa atcctcacct ttttttcaca ctttaggtcc      1080
     cccttcccaa aagtgagtaa gtgtgggtgc ttctgggatg agtaacagtg tcccccatta      1140
     cttcatggct gactttcagc cacaggctgg aggaggcaga gggtgaccca aggccctatc      1200
     taggtcaccc caatgggtca ccctaccccc tcagcctacc acatggtttt ctcctgcctg      1260
     gcaccccagg gctggaggta aagcctaatt ttccgaactt cagttggggc tcccagtcta      1320
     ggggggctca atttccgtct ccatattttg ttttggaatt attatttttt tgagacaggg      1380
     tctcgttctg tcacccagac gggggtacag tggcatgatc atagcttact gtaacctcaa      1440
     actcctgggc ttgagtgatc ctcctgcctc agcctcctga ggagctagga ttacaggcat      1500
     gcaccactac acctgactaa tctttaattt tttttctaga aacaaggtct tgctatgttg      1560
     cacaggctgg tcttgaacta gtgggctcaa gtggtcctcc cacctcagcc tcccaaagtg      1620
     ttgggataac aggcatgagc cactgcgccc cacccttatt tgtctttgac tctctccaga      1680
     agagccttca tccagggagg gggtgctttt ctctttccgg attacccacc tctcacctct      1740
     cccctccttc accacaaaga ccagtgggac caagccggca tgtgagtcct tcacccacat      1800
     cttattccta tgtttcattc ttttttaaaa aatagagaca ggatctcact atgttgccca      1860
     ggttgctctg gaactcctgg gttcaagcga tcctctcacc ttggccttgc aaagtggtag      1920
     gattacaggt gcatgccacc acgtccggca gttcggttcc ttgttcttta ttgtcctcag      1980
     tctcttcgat ttcacccact gagagaatgg aaggggatag aacagctgga aactggttga      2040
     aggaagccag aattcactaa gtgcccactg tgccaagggc tgagtgaggt cctctgatgg      2100
     aggtcaggcc ttctctcaca tgccctatgt gtggtggaca ttcctatccc cattggatag      2160
     ataggttaag tggctggttc aggttgcaga gttaggacag ggtgatttga agcctagaca      2220
     cccgaatctc tggaagtccc ttggctgtgt gattcaggta cctgagaatg cggctcctct      2280
     ccagctctct ccggactgct ggccagctgc aacagccgga aatctcacct gagctgcagg      2340
     attttcccag caaggattgg aattcccaga gttggaaatt cccatgccct gagggagagg      2400
     taattaggtt caggctcttg tttcctgggg gatggggaat attctgttgg gctttgttta      2460
     tgtagggtct ccagggccct aggagtctaa ggatgggact gggtccgagg gatcttaaag      2520
     cctgtggaga gaggacttag ggagcttctt cccacccaca agaagaggca gatgcagaat      2580
     taattccaag aaggagacca tgtttctttt ctaagcaaac tttatttctc gccactgaat      2640
     agtagggcga ttacagacac aactccctgg ggagcagagg cctcagcaat gagtgacagt      2700
     tggtcaccaa atcagcattg tttagacaac ttaatcagat aatattttaa aaaacataat      2760
     caaaagaagg cacagaggcc agggggctac atgggaacag cctattgttc agcctccgtt      2820
     ttcacggaaa acatgtctga gccaaggcag ctcctacatt gggtccccca ggataccccg      2880
     gtctcccaaa taaatacatt catctgtaaa taaataaata ataaataaat aataaataat      2940
     cacaagtgca aacataaata gagggagctg gctccatggg gagggctggg ctccgtgtct      3000
     caaggaagtc tggaaacatc tggagagagg aaggcctaag gtccacttgt gtcaatttct      3060
     aggtgaggtc ttctcaagtc ctgcagcatt ctggccagaa ccaaaggctc cctggtctcc      3120
     agattccaga tgtcagggat caaagctgta ggccccagtg agttctggag gccccagttt      3180
     gaattcttag tggttgccag cacttcactg tgcaggccac acattcctga atcccaggtt      3240
     tcgaagtggt ggtcttgttg cttaaagttc taagcttggg ttccgaccct aagcccccaa      3300
     ttctcttttt gagccagaag aggttgaggg tgtctgaagg agggggtaat aaagggattg      3360
     gggcagggga ggcgtttggg aaggttggat gttcgtcctc ctcacagggc aatgatccca      3420
     aagtagacct gcccagactc ggcaaagtcg agatagtcgg gccgattgat ctcagcgctg      3480
     agtcggtcac ccttctccag ctggaagacc cctcccagat agatgggctc ataccagggc      3540
     ttggcctcag ccccctctgg ggtctccctc tggcaggggc tcttgatggc agagaggagg      3600
     ttgaccttgg tctggtagga gacggcgatg cggctgatgg tgtgggtgag gagcacatgg      3660
     gtggaggggc agccttggcc cttgaagagg acctgggagt agatgaggta caggccctct      3720
     gatggcacca ccagctggtt atctctcagc tccacgccat tggccaggag ggcattggcc      3780
     cggcggttca gccactggag ctgcccctca gcttgagggt ttgctggagg gagggagaga      3840
     gggagaggag agtcagtgtg gccatgtcgg ttcactctcc acatcctggc cctcgagctc      3900
     tgcccacccc acatccggtt cctgtcctct ctgtctgtca tcccacatcc cacctggcca      3960
     tgacgttctg agtatcccac taaggcctgt gctgttcctc cacccttccc ttgagctcag      4020
     cgagtccttc tcacattgtc tccaagttct gcctaccatc agccgggctt caatccccaa      4080
     atcctagccc tccaagttcc aagacacatc ctcagagctc ttacctacaa catgggctac      4140
     aggcttgtca ctcggggttc gagaagatga tcctgaagag gagagagaaa agaaaaagct      4200
     gagaccctta aacttcctag aaaatacccc cctactttca cctccatcca tcctccccca      4260
     agaccaaaac tttaaatttc ccccactgct ttccataccg gtactaaccc taccccccaa      4320
     acccaaaccc agaattagga aagaggtttg gagacactta ctgactgcct gggccagagg      4380
     gctgattaga gagaggtccc tggggaactg ttggggagaa ggagaatggt taacatcgag      4440
     ggagtcaccc ttaaaggagg aacagctggc tgcctgtctg gcctgcgctc ttagccctga      4500
     ggtgtctggt tttctctctc cattcatctg tgtattcacc ttccaggcat tcaacagctc      4560
     tttccctgag tgtcttctgt gtgccagaca ccctatcttc ttctctcctt atctccccca      4620
     tctctctcct tagctgtcat atttcccgct ctttctgtct caccatcttt attcatatca      4680
     cttgtttctt cccccatctc tcttctcaca ccccacatct gtctccatat cttatttata      4740
     tatctgcttg ttcattcatt cattcattca ttcactccat acacacttag tgagcacctt      4800
     ccatgtgcca gacatcctgt ctctccatct ttctctctct ctcttcccca tctcttgcca      4860
     catctctttc tgcatccccg tctttctcca cgtttttttc tctccatccc tccctatcag      4920
     cgcacatctt tcacccatcc catctctctc cctctcttgc gtctccattt ccccttgggt      4980
     gggagagtgg atgaaggctg gccaggcact cacctcttcc ctctgggggc cgatcactcc      5040
     aaagtgcagc aggcagaaga gcgtggtggc gcctgccacg atcaggaagg agaagaggct      5100
     gaggaacaag caccgcctgg agccctgggg cccccctgtc ttcttgggga gcgcctcctc      5160
     ggccagctcc acgtcccgga tcatgctttc agtgctcatg gtgtcctttc caggggagag      5220
     agggtggagc cgtgggtcag tatgtgagag gaagagaacc tgcctggcag cttgtcaggg      5280
     gatgtggcgt ctgagggttg ttttcagggg gggtctgtag ttgcttctct ccctcttagc      5340
     tggtcctctg ctgtccttgc tgagggagcg tctgctggct gggtgtgcca acaactgcct      5400
     ttatatgtcc ctggggcgag aggagggcgg ggaaagaatc attcaaccag cggaaaactt      5460
     ccttggtgga gaaacccatg agctcatctg gaggaagcgg tagtgggccc tgcaccttct      5520
     gtctcggttt cttctccatc gcgggggcgg ggatttggaa agttggggac acacaagcat      5580
     caaggatacc cctcacactc cccatcctcc ctgctccgat tccgaggggg gtcttctggg      5640
     ccactgactg atttgtgtgt aggaccctgg aggctgaacc ccgtccccat gcccctcaaa      5700
     acctattgcc tccatttctt ttggggacca ggtctgtggt ctgtttcctt ctaacttcca      5760
     gacaggatgc aggaaaaaga tagaactaga actgggaggg gcttcagaaa gctgagtccg      5820
     ttgagggaga gaaaacgggg ttggagggaa aagctgtgtt gagtcctgag gcctgtgttt      5880
     gggccctgcg gggagaagga gctgggggct tggtggcagg cttgaggcct caggaaaggc      5940
     tgggtgcggg tagcagggac aagcctggga cagccccggg gagtgaaatc acccccggga      6000
     attcacagac cccactgggg caggccctct tctttcattc tgacccggag actcataatg      6060
     cttggttcag tcttggcttc caaggaactc tggggtccct gatttttttc atgaagctct      6120
     cacttctcag ggccccagtg tgtggccata tcttcttaaa cgtcccctgt attccatacc      6180
     tggaggtcct ggaggctctt tcactccctg gggccctcta catggccctg tcttcgttaa      6240
     gtgggggtcc ccatactcga cttccatagc cctggacatt ctcctaccca ttgctgtggt      6300
     cacatctccc cagaggtctc ctgtaaccca ttcctcagag ccgctacatg tggccatatc      6360
     tcccaggagc tccctgaccc ccgcccctcc agaccctgac ttttccttcg tcttctcagc      6420
     ttctcctttg cttcccctgc agcagtctgg cggcctcacc tggtgagtcc atcacatatc      6480
     cctgaagctc tctgagccct tatccttttg ttctccccac agctcttgct ccctttgagc      6540
     cctctgtccc tccctccatt ccttagatag actgggaagt tctcactccc agacacacac      6600
     acacaagcag acagcatttc agagaaaaga ggtttattgg gcttcatcga gggtgcagat      6660
     gcctccgtgt ggggctctgg tcggcagctg gctttcagag cctttccctg ccttctgggg      6720
     ccctgtgatc cctcatgcct acttctttct ctcttggtca gccttgtgcg catgccctct      6780
     cactcttcat ctcttgggcc tgtctctgtt tctccttgga tgttcttcta ttattcccct      6840
     ctctccatcc tccataaata aataatttaa tttttttgcc ttcataaata gtcccctccc      6900
     tgcctctagt catcccccaa gctcctccat gtgcctgctc ttcctctgtg tgtggatcta      6960
     ggccccacct agctggtggg acagaccaac agctttgggc tgggaattcc taggcaggct      7020
     tgaaatcctc agccagacag acatcaggga tggttcaggg aggtgtggtc ccctgggatg      7080
     cctagaattc cttctttgaa agctccggtg acttgatcag ggaagacttg agctgttgga      7140
     atggccaaag gagaggtggt gacgacccct gaaatggtca gaatggaggc agaatgggga      7200
     gaaggtcttg aaatcaatta ttttttcttt ctggattttt ccaagttcta cagagcgaag      7260
     gctccaaaga agacagtact agggctgagg actaggtggg ggatgccatc tgtgtgggtg      7320
     gatagctggt ctccctgggt gagctggaac gcagccccgt ggtacatcga gtgcagccag      7380
     ggttcctgca gccctggata caccatcttc tgggagctga ggagaggcac atggaagggg      7440
     tactgggagg agaagagctg gacctcatgg gccaggtaga gtggggagga ggtggccttg      7500
     ggagagtagg ctttcccaga gaagaccacc tgggagtaga cgaagtagat gccactggtg      7560
     gggaccagga gagaattgtt gctcaaggag aaaccatcct ggaggaaggc acggtccgtg      7620
     tttgctctcc agagcagtga gttctgcttg ctggggtctc ctaggaagag ccatagggga      7680
     tgggggtggg agatcagggg tctggatcag aggtctcaat ccctgaggaa gtgggcactg      7740
     aacaactgag ttcctggggg atggcagggg gaggcatagg agtgggctcc ctctgttttt      7800
     tttagcgtgg gggaagttgg gggagagggg tggatgcttg ggttcctgag gcaggggtag      7860
     gaggagagct ggtggggaca tgtctgggag gtcaggtgga tgtttaccaa tgaggtgagc      7920
     agcaggtttg agggtgctgt gggcaagatg catcttgggg tgctgacggg cagtctgggc      7980
     agctgaaggt gtgaggccaa caccagggag cccctagggg agaacagagt tgaggggggc      8040
     tctagggctc aaggtttggc tgagccaccc cagcagcccc cattctcctg ctgcctcacc      8100
     tgggccccag gcagcagaac cagcagcagc cccagaagga ggaggtgtag ggtggtgcca      8160
     cgcacccttg ggaggaagag acgttcaggt ggtgtcatgg ggagaacctg cagagaaaga      8220
     gagagagaga gagagacagt gagcggggcg gggcacgcgg cggaagacag acctcccgcc      8280
     ctgggagaca gcaccccccg acccccgaga gagagatcga cagagaaggg gacaagatgc      8340
     agtcagagaa accccaaggt gagcagaggg agacagagag agacaggaag ggaacagaga      8400
     ggaatcatgg cagaaacaga gaatgtgtga cagagacaat gagactgaca gatggagagt      8460
     cagagacaga gaaggaaacc aaaaccaaac ccaccaaggc ccaggcccag gcaggccggg      8520
     gatccaggca gcaggtgcag gagggaccga ggcccaggca gagggcagga cactgcgggg      8580
     cggtagtcca aagcacgaag cacgggcagc ccaaggagat ggggcaggag agcctcacct      8640
     gctgtgcgga cccctgggcc cggacgctca ggtcccttta tagaggaagc ggcagtggca      8700
     gcgtggcagg cagcgggcgg gttctaggtc ggggctgggg cccggggaag cccccagggc      8760
     ttagaagata ctgctgtttc agtcaaaggc aggaaaggct gaggcctagg agagaaccac      8820
     aggctggggg ttcaggcgac tgagttctgg gaaagggagt cgggtcaggg gaatcgtggg      8880
     ctgggagggc cagggagtgg ggtcaggcct agagttccaa agaagggaca gtcaattcag      8940
     agaggaggca gttgagcagc tggggtgtga gctggaggcc cggttccctg aagagcaatc      9000
     atatataaca tctctgcacc cttggctgag tacaggcttc tctctttgcc catttccttc      9060
     tcttgtaccc ctgtccttgt cccaaacaac tcaaatcata cttgtcccag tatacggact      9120
     ttccagccca tctggcaggt ttcacatcaa gaaggtccat tatatatccc cttcatcggg      9180
     gacattctgg tgtttgcctc ttgtccaggt gaaaatatta atggatcccc cttccactct      9240
     tgaaagtgtc ctagtttgga agataaattt tttggtcccc ttactcagag atgatgctgg      9300
     acagtcaagt atgatgaggt ctcatctcac tcctgaagga tgccctccat ctcttcctga      9360
     cttcaggtgg cttccacaga acagatttat ataaccccaa ataaacacac attccaggat      9420
     caatgtggca gacaccttcc aaagttttct acaaaggaag tttgcagaat tccacatggg      9480
     tgaggcttaa gggtggtgac ttagggtggg gtggggacag ctaagggact tgttctgaag      9540
     ctgcatttgc agagccaata cattatttta aaattgttcc aggcctggtg cagtggctca      9600
     cacctgtaat cctggcactt tgggagtctg aggtgggcgg attacttgag gtcaggagtt      9660
     tgagaccagc tggccaacat ggtgaaaccc catctctata ataaatacaa aaattagcca      9720
     ggcgtgctgg tgcgcatctg cagtcccagc tactcgggag gctgaggctg gagaattatt      9780
     tgaacctggg aggcggaggc tgcagtgagt caagatcgca ccactgtatt ccagcctggg      9840
     ggacagagca agactctgtc tcaaaaaaaa aaaaaaagtt tccaaaattt ttttcctttt      9900
     tattgatatg taacttaggt atgaggtgga cacctcttaa gtgtacagct gatgaatttt      9960
     tccatctgta tgtagccacc acccagctcc acgtattttc aggtccccag caggttccct     10020
     catgccccct ccctgctgat accctccaaa gataaccaac cactctctca cttttatcac     10080
     catagattat ttcctcctgg tttggggcat catataaatg aaatcacaca gaatgtactc     10140
     atttctgttt gacttctttc agtcagcatt atgtttgtga gattcatata cgtggttgta     10200
     tgtatcagta atgtttttta aaaaaattat gatgtaatat tctattgtat caatatattc     10260
     taatatattc tgttgatggg gatttggttt gtttctagtt tttgtctaac acaaaaatgt     10320
     ctacacgaac attctcatac atgagcccat ttcacttagc ttgcaagtta caaggtttaa     10380
     aaaaagcagt ttctaaagat gactttattc acttttccta agtttgagat aataccaact     10440
     tgtcacctca aatattatta ctgctactca tgtgatttta cttggagagt gttagagggg     10500
     ttggagctgg ggctggtggt gacccggggt aaagcccact gttgcatggg gcagaccact     10560
     tctctcccca ggcacaaggt ccctgagggg tcttggtgta acatggaggg acatgtaagt     10620
     aacattctgg gtgtgtatga gctatttctc ctgttcttct ctacttgagg acctgcccct     10680
     ttgcctttta tgctttacta gtcttagcta ttatttctgt aggggcagaa aggggtgatc     10740
     ccttcctgac ccatcataag ggttatggcc aatactccta taataaaaga cagattaaca     10800
     agagaaaagc ataatacatt tatttaatca aagttttagg tgacatggga gccttcagaa     10860
     atgaagaccc aaggacccag gggaaaacta tttttatgct tagatttgat gaagaatgaa     10920
     cagctgtgca gaaatgtaat tgaacaaaag gagtatcatc taatggtcac agactgggac     10980
     tggggggatc ccagcaaggc ctggccatat tcttcttggt ctctctgtac agcattcctt     11040
     cctcccaggt atagggcaga acctcttctg gaatgagggt cttataacct actatcagat     11100
     gagataagtc agaaaatttc ttttcctttt tttttttttg agacagtttc tcactgtcgc     11160
     acaggctgga gtgcagtggc acgatcttgg ctcactgcaa cctctgcctc ccaggttcaa     11220
     gctattctcc tgcctcagcc tcccgagtag ctgggattac aggcacacgc caccaagccc     11280
     gccaaatttt tttttgtatt tttagtagag acggggtctc accatgttgg ccaggttggt     11340
     cttgaattcc tgaccacagg tgacccacca gccttggcct cccaaagtgc tgggattatg     11400
     ggcgtgagcc actgcgccca accttcttct cattctttta accttattat ctcttgtgtc     11460
     agtgtgggtt tcccttttag cccctgctcc tttctttttc tctgtgttgc cctttctctc     11520
     agggtccttt ttgcttcctg ttgtctcttt ctgcttctct aatggtatga gctgatggac     11580
     tgggacccca gctgagctat attaaaatat aaaatgttat tacaaggcca ggagcagtgg     11640
     cacatgcctg tcatcccagc actttgggag gctgaggcga gcagatcaca aggtcaggag     11700
     atagagacaa tcctggctaa tacggtgaaa ctccatcact gctaaaaata caaaaaatta     11760
     gccgagcatg gtggcacgcg cctgtaatcc tagctactag ggaagctgag gcaggagaac     11820
     tgcttgaacc caggaggcgg aggttgcagt gagccgagat cgtgccactg ccctccagcc     11880
     tgggcaacaa agtgagactc catttcaaac aaaccaacca aaaaacaaaa caaaacaaaa     11940
     caagcaaaca aaaaaaggta ttgcaattaa cagtgagaca cagagagaaa tttaaattaa     12000
     agaggaagaa tgggacattg aaagacaaaa aagggaaggc aagaagggtg atggggagac     12060
     atgagagaca cagaggaagg aagggtaaga ctgggctgag gctcagtgtc acgtgcatgt     12120
     gagatatgcg aaggatgctc cttgagatgg gccaatcttg gtttcaatct cagtttcgga     12180
     ggttgtatga atttggtttc tttcttggca ggccagcagt tggtttggga ctttccctgg     12240
     gtgggagagc tgatgactgg agtcttgtgc cccagactca gggaaataca gtctttatag     12300
     tggtctttgt ggagaaacta gtgaaatctc tgaagcctcc aaatgagact gaaatgacat     12360
     tagcttcaaa cttgaactta gcctcaaaac ctgaattggg atttaatacc aacatcaacc     12420
     ctaacccaaa tttaacctca acccaaatca caactcaaac tcaaccccaa ctgtaaccct     12480
     aacctcaaat ctaaacacat cccaattaat aaccccctaa ataaaacttc tcctctaccc     12540
     caacccaacc ctgtttctag ggctaatctt gaaaccagtt taccaccact cctaacacta     12600
     aacttaaatc tgactctaaa tgtaagtcca atctgagcca caagcctaaa gttgaacttt     12660
     atcctgcttt atgaattatt catccattcc tccatttagt gagtatctgc gtgcctaaca     12720
     catgctgggc attgtcctaa ggcaggaggg acatggaggg caaagggatc agagaaggta     12780
     ccagcacctg tggagcttgt attccagtga ggcccagacg gaaaaagaaa gaaacttgaa     12840
     ggaaggaaat ttggtactat gagaaaataa gacaggctga tgttgtaaga gtggcaggga     12900
     gctactttta aatacagtag tcagcaaaat cctctttgag tgtttgggtg gcactggagc     12960
     tgagacccaa atgacaaaaa atagtgacca ggtaaaagtt tgggagcaaa gcatttcagg     13020
     taaagggagc agctactgca aaggctggaa ggcggaacca agctgggggt gttgacgaca     13080
     aacagaaggc cagtgtggct ggagcagaga gagagactgg gaggcgggtg ggagatgagg     13140
     tcagagagga gggcaggggc caggtcatgc agggccatgc aagaagggta aagcctctag     13200
     atttcatcca gccacaggaa gcctttaaag gtcgtcagag tgtgtggtgc gtgcgtgtgt     13260
     gtgtgtgtgt gtgtgttgca ggggagagag gnggagggag agagagagag agagaagagg     13320
     gaggtgagca gaggtgattg gatttttttt tcttttgaca tggtgtcttg ctctgtggcc     13380
     taggctggag tgcagtggca ccatcatagc ccactgcaac ctcaaaacca tgggctcaag     13440
     tcatccttcc acctcagctt cccaagtatc taggactaca ggtgtgtgcc actgtgcctg     13500
     gctaatttta aaaaatattt taaaattttt gttgagacag ggtctatgct gctcaggctg     13560
     gtctcgaact cctggtttca agtgatctgc ccatcttggc ctcccaaagt ttttttttgt     13620
     tagtttgaga ggcggtttcg ctcgttgccc aggctggagt gcaatgactg atctcatctc     13680
     actgcaacct ctgcctcctg ggttcaagcg attctcctgc ttcagcctcc caagtagctg     13740
     ggattacagg tgcatgccac cattcccggc taattttttg tatttagtag agatggggtt     13800
     caccatgtta gtcaggctga tctcaaactc ctgacctcag gtgatccgcc tgcctcagcc     13860
     tcccaaagtt ttgggattac aggtgtgagc caccatgctg ggccagcctc ccaaagtttt     13920
     gggattacag gcatgagtca ccacactggc cctggatttt ttttctttct tttttttgga     13980
     gacggagtct cactctgttg cccaggctgg agtgcaatgg cgtaatctca gctcactgca     14040
     acctctgctg cccgggttca aacgattctc ctgtcttagc ctcctgagta gctgggatta     14100
     taggtgcatg ccaccatgcc tggctaattt ttgtactttt agtagagaaa gtacaccatc     14160
     ttggccaggc tggtctcgaa ctcctgacct caggtgatcc acttgcgtcg gcctcccaaa     14220
     gtgctgggat tacaggcgtg agacaccgca cccagccttt tttttttttt ttttctttta     14280
     agacagaatc gctctgtcac ccaggctgga gtgcagtggc acaatctcgg ctcactgcaa     14340
     cctctgcctc ccaggtttaa gcaatccacc tatgtcagtc tcccaagtag ctgggattat     14400
     aggtgcatgt caccatgcct ggctaatttt tgtactttta gtatagaaag tacaccatgt     14460
     tggccaggct ggtcttgaac tcctgacctc aagtgatccg cctgcctcag cctcccgaag     14520
     tgctggaatt acagacatgt gccactgcac ccggcctggt tttttttttc taagagatgg     14580
     agtctcactt ttctgcccag gttggagtgc aatggcacca tcatagctca ctgcagcctt     14640
     caactcttgg cctcaggcaa tccttgcacc ttagcctcgc aaagtgttgg gattacaggc     14700
     atgagccact gagccttgcc tggacttttt tttttttttg agatggcgtc tcgctctgtt     14760
     gcccaggttg gagtgctacg gcatgatctt ggctcactgc aacttccacc tcccaggttc     14820
     aagcgattct cttgcctcgg ccccccgagt agctgggatt acagcatgcg ccaccgtgcc     14880
     tggctaattt tggtattttt agtagagata gggtttcatc atgttgggca ggctggtctt     14940
     gaactcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttataggcat     15000
     agccaacgcg cccagcctgg acttgttttt aaaagatcac tgtggctcct gtgtttaggc     15060
     tggctggtag gagacaggtg gcagtgacat tgatggtgaa gagaaaatag tggcagccat     15120
     ggagatggag agaagtagac aagtttggga tatattatac attccagggg tagaaacaac     15180
     aggactagat gatggattga tgggtgggag atgtagatac tgggagagaa gcaggattct     15240
     gatggatgga aaaactaaaa aattctattt tgggtgtggt aagtctaagt ctattagaca     15300
     tgcaagtaga gatgtcactg ggcagataca catctggatt tcaggggcaa ggtccaagct     15360
     agagaaagaa acctgggcat ggtcagcatg aggatggtgt ttaaagccat ggaacttatc     15420
     ttgtgcatcc ctataagacc cctttgaggc acttgtttcc cctcacaatg gatgcagtgc     15480
     atcttccatt ctgaattcca gaggcaacaa cctcctgctc ctagaagcta aactctccag     15540
     acttagtctt ctgaattccc actgggattt aacctccctg gattcaattc cctaccccac     15600
     aaggaccctt ctaccaatcc atttcacaat atttggtgga actcttcaca ttttcaaatc     15660
     ctgtcttcta tgtttgaaag cattttcctc tgggcatttt gaaacctggc tttcccctaa     15720
     tgatgctact cctctctgtg gtgaaggttg ctctttcttc gactccatca ctaggggaat     15780
     gaaggcagaa gagaggggtc gttatcccct ctcccccagg accactgata aactcctcct     15840
     catctcccaa agcacgtgcc ttctggatct gccatgctct ccctgccttc acagcacaat     15900
     cttatccatc aaaatattta ttatgctctt aacaacttgt ataactagct cagtctttct     15960
     ccacatctta tccctaccat catccttgtt tgtttgtttt ttgagacaag gtattgctct     16020
     gtcacccagg ctggagtgca gtggcgtgat cttggctcac tgcagcctcg acctcctggg     16080
     ctcaagtgat cctcccacgt cagcctcctg agtagctagg actacaggcg cataccacca     16140
     tgcccggcta agttttgtat tttttttttt ttccagagat agggttttgc tatgttgcct     16200
     aggctggtct tgaactcctg agctcaagca atccacccgc ctcagcctcc caaagtgctg     16260
     ggattacagg catgacccac cgcacccggc ctcctaccac catctttagt                16310
//