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EBI Dbfetch

ID   M55994; SV 1; linear; mRNA; STD; HUM; 2394 BP.
XX
AC   M55994; M38549;
XX
DT   05-MAY-1991 (Rel. 28, Created)
DT   07-OCT-2008 (Rel. 97, Last updated, Version 6)
XX
DE   Human tumor necrosis factor receptor II (TNFrII) mRNA, complete cds.
XX
KW   glycoprotein; nerve growth factor receptor related; transmembrane protein;
KW   tumor necrosis factor receptor; tumor necrosis factor receptor II.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-2394
RX   DOI; 10.1073/pnas.87.21.8331.
RX   PUBMED; 2172983.
RA   Kohno T., Brewer M.T., Baker S.L., Schwartz P.E., King M.W., Hale K.K.,
RA   Squires C.H., Thompson R.C., Vannice J.L.;
RT   "A second tumor necrosis factor receptor gene product can shed a naturally
RT   occurring tumor necrosis factor inhibitor";
RL   Proc. Natl. Acad. Sci. U.S.A. 87(21):8331-8335(1990).
XX
DR   MD5; 784b4bcab62fbc9e38a4de7e9056047f.
DR   Ensembl-Gn; ENSG00000028137; homo_sapiens.
DR   Ensembl-Tr; ENST00000376259; homo_sapiens.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..2394
FT                   /organism="Homo sapiens"
FT                   /mol_type="mRNA"
FT                   /cell_line="U937"
FT                   /cell_type="histiocytic lymphoma"
FT                   /db_xref="taxon:9606"
FT   sig_peptide     93..158
FT                   /gene="TNFrII"
FT                   /product="tumor necrosis factor receptor"
FT                   /note="putative"
FT   CDS             93..1478
FT                   /codon_start=1
FT                   /gene="TNFrII"
FT                   /product="tumor necrosis factor receptor"
FT                   /note="603..611 and 669..677 glycosylation site; 861..947
FT                   transmembrane domain; 948..1478 cytoplasmic domain;
FT                   159,,860 extracellular domain"
FT                   /db_xref="GOA:P20333"
FT                   /db_xref="H-InvDB:HIT000195816.14"
FT                   /db_xref="HGNC:HGNC:11917"
FT                   /db_xref="InterPro:IPR001368"
FT                   /db_xref="InterPro:IPR020411"
FT                   /db_xref="PDB:1CA9"
FT                   /db_xref="PDB:3ALQ"
FT                   /db_xref="UniProtKB/Swiss-Prot:P20333"
FT                   /experiment="experimental evidence, no additional details
FT                   recorded"
FT                   /protein_id="AAA36755.1"
FT                   /translation="MAPVAVWAALAVGLELWAAAHALPAQVAFTPYAPEPGSTCRLREY
FT                   YDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQ
FT                   VETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKP
FT                   CAPGTFSNTTSSTDICRPHQICNVVAIPGNASRDAVCTSTSPTRSMAPGAVHLPQPVST
FT                   RSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNC
FT                   VIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDR
FT                   RAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSS
FT                   QASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGM
FT                   KPS"
FT   mat_peptide     159..1475
FT                   /gene="TNFrII"
FT                   /product="tumor necrosis factor receptor"
FT                   /note="putative"
XX
SQ   Sequence 2394 BP; 484 A; 743 C; 739 G; 428 T; 0 other;
     gaattcggcg cagcggagcc tggagagaag gcgctgggct gcgagggcgc gagggcgcga        60
     gggcaggggg caaccggacc ccgcccgcac ccatggcgcc cgtcgccgtc tgggccgcgc       120
     tggccgtcgg actggagctc tgggctgcgg cgcacgcctt gcccgcccag gtggcattta       180
     caccctacgc cccggagccc gggagcacat gccggctcag agaatactat gaccagacag       240
     ctcagatgtg ctgcagcaag tgctcgccgg gccaacatgc aaaagtcttc tgtaccaaga       300
     cctcggacac cgtgtgtgac tcctgtgagg acagcacata cacccagctc tggaactggg       360
     ttcccgagtg cttgagctgt ggctcccgct gtagctctga ccaggtggaa actcaagcct       420
     gcactcggga acagaaccgc atctgcacct gcaggcccgg ctggtactgc gcgctgagca       480
     agcaggaggg gtgccggctg tgcgcgccgc tgcgcaagtg ccgcccgggc ttcggcgtgg       540
     ccagaccagg aactgaaaca tcagacgtgg tgtgcaagcc ctgtgccccg gggacgttct       600
     ccaacacgac ttcatccacg gatatttgca ggccccacca gatctgtaac gtggtggcca       660
     tccctgggaa tgcaagcagg gatgcagtct gcacgtccac gtcccccacc cggagtatgg       720
     ccccaggggc agtacactta ccccagccag tgtccacacg atcccaacac acgcagccaa       780
     ctccagaacc cagcactgct ccaagcacct ccttcctgct cccaatgggc cccagccccc       840
     cagctgaagg gagcactggc gacttcgctc ttccagttgg actgattgtg ggtgtgacag       900
     ccttgggtct actaataata ggagtggtga actgtgtcat catgacccag gtgaaaaaga       960
     agcccttgtg cctgcagaga gaagccaagg tgcctcactt gcctgccgat aaggcccggg      1020
     gtacacaggg ccccgagcag cagcacctgc tgatcacagc gccgagctcc agcagcagct      1080
     ccctggagag ctcggccagt gcgttggaca gaagggcgcc cactcggaac cagccacagg      1140
     caccaggcgt ggaggccagt ggggccgggg aggcccgggc cagcaccggg agctcagatt      1200
     cttcccctgg tggccatggg acccaggtca atgtcacctg catcgtgaac gtctgtagca      1260
     gctctgacca cagctcacag tgctcctccc aagccagctc cacaatggga gacacagatt      1320
     ccagcccctc ggagtccccg aaggacgagc aggtcccctt ctccaaggag gaatgtgcct      1380
     ttcggtcaca gctggagacg ccagagaccc tgctggggag caccgaagag aagcccctgc      1440
     cccttggagt gcctgatgct gggatgaagc ccagttaacc aggccggtgt gggctgtgtc      1500
     gtagccaagg tgggctgagc cctggcagga tgaccctgcg aaggggccct ggtccttcca      1560
     ggcccccacc actaggactc tgaggctctt tctgggccaa gttcctctag tgccctccac      1620
     agccgcagcc tccctctgac ctgcaggcca agagcagagg cagcgggttg tggaaagcct      1680
     ctgctgccat ggtgtgtccc tctcggaagg ctggctgggc atggacgttc ggggcatgct      1740
     ggggcaagtc cctgactctc tgtgacctgc cccgcccagc tgcacctgcc agcctggctt      1800
     ctggagccct tgggtttttt gtttgtttgt ttgtttgttt gtttgtttct ccccctgggc      1860
     tctgccccag ctctggcttc cagaaaaccc cagcatcctt ttctgcagag gggctttctg      1920
     gagaggaggg atgctgcctg agtcacccat gaagacagga cagtgcttca gcctgaggct      1980
     gagactgcgg gatggtcctg gggctctgtg cagggaggag gtggcagccc tgtagggaac      2040
     ggggtccttc aagttagctc aggaggcttg gaaagcatca cctcaggcca ggtgcagtcc      2100
     ctcacgccta tgatcccagc actttgggag gctgaggcgg gtggatcacc tgaggttagg      2160
     agttcgagac cagcctggcc aacatggtaa aaccccatct ctactaaaaa tacagaaatt      2220
     agccgggcgt ggtggcgggc acctatagtc ccagctactc agaagcctga ggctgggaaa      2280
     tcgtttgaac ccgggaagcg gaggttgcag ggagccgaga tcacgccact gcactccagc      2340
     ctgggcgaca gagcgagagt ctgtctcaaa agaaaaaaaa aaaaaaccga attc            2394
//


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