Dbfetch
ID M28583; SV 1; linear; mRNA; STD; HUM; 1033 BP. XX AC M28583; XX DT 02-FEB-1990 (Rel. 22, Created) DT 17-JUN-2008 (Rel. 96, Last updated, Version 20) XX DE Human (clone FJ0-1) MHC class II DR subtype Dw2 mRNA, complete cds, DE haplotype HLA-DR2. XX KW cell surface glycoprotein; class II gene; integral membrane glycoprotein; KW lymphocyte antigen; major histocompatibility complex. XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 1-1033 RX PUBMED; 3571980. RA Wu S.K., Yabe T., Madden M., Saunders T.L., Bach F.H.; RT "cDNA cloning and sequencing reveals that the electrophoretically constant RT DR beta 2 molecules, as well as the variable DR beta 1 molecules, from RT HLA-DR2 subtypes have different amino acid sequences including a RT hypervariable region for a functionally important epitope"; RL J. Immunol. 138(9):2953-2959(1987). XX DR MD5; 654716b2dbb1b63a24b9e183bd2afff0. DR IMGT/HLA; HLA-DRB1*16:01:01; HLA00876. XX CC On Sep 21, 1994 this sequence version replaced gi:341964. XX FH Key Location/Qualifiers FH FT source 1..1033 FT /organism="Homo sapiens" FT /map="6p21.3" FT /mol_type="mRNA" FT /haplotype="HLA-DR2" FT /cell_line="Epstein-Barr virus transformed lymphoblastoid FT cell line LCL" FT /tissue_lib="of Betuel" FT /db_xref="taxon:9606" FT sig_peptide 40..126 FT /gene="HLA-DRB2" FT /note="G00-120-643" FT CDS 40..840 FT /codon_start=1 FT /gene="HLA-DRB2" FT /product="MHC class II DR-beta" FT /db_xref="GOA:Q29974" FT /db_xref="H-InvDB:HIT000195243.14" FT /db_xref="HGNC:HGNC:4948" FT /db_xref="InterPro:IPR000353" FT /db_xref="InterPro:IPR003006" FT /db_xref="InterPro:IPR003597" FT /db_xref="InterPro:IPR007110" FT /db_xref="InterPro:IPR011162" FT /db_xref="InterPro:IPR013783" FT /db_xref="InterPro:IPR014745" FT /db_xref="InterPro:IPR036179" FT /db_xref="UniProtKB/Swiss-Prot:Q29974" FT /protein_id="AAA59680.1" FT /translation="MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQPKRECH FT FFNGTERVRFLDRYFYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAV FT DTYCRHNYGVGESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLN FT GQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS" FT mat_peptide 127..837 FT /gene="HLA-DRB2" FT /product="MHC class II DR-beta" FT /note="G00-120-643" XX SQ Sequence 1033 BP; 217 A; 278 C; 309 G; 229 T; 0 other; cctgcttctc tggcccctgg tcctgtcctg ttctccagca tggtgtgtct gaagctccct 60 ggaggctcct gcatgacagc gctgacagtg acactgatgg tgctgagctc cccactggct 120 ttggctgggg acacccgacc acgtttcctg tggcagccta agagggagtg tcatttcttc 180 aatgggacgg agcgggtgcg gttcctggac agatacttct ataaccagga ggagtccgtg 240 cgcttcgaca gcgacgtggg ggagtaccgg gcggtgacgg agctggggcg gcctgacgct 300 gagtactgga acagccagaa ggacttcctg gaagacaggc gcgccgcggt ggacacctac 360 tgcagacaca actacggggt tggtgagagc ttcacagtgc agcggcgagt ccaacctaag 420 gtgactgtat atccttcaaa gacccagccc ctgcagcacc acaacctcct ggtctgctct 480 gtgagtggtt tctatccagg cagcattgaa gtcaggtggt tcctgaacgg ccaggaagag 540 aaggctggga tggtgtccac aggcctgatc cagaatggag actggacctt ccagaccctg 600 gtgatgctgg aaacagttcc tcgaagtgga gaggtttaca cctgccaagt ggagcaccca 660 agcgtgacaa gccctctcac agtggaatgg agagcacggt ctgaatctgc acagagcaag 720 atgctgagtg gagtcggggg ctttgtgctg ggcctgctct tccttggggc cgggctgttc 780 atctacttca ggaatcagaa aggacactct ggacttcagc caacaggatt cctgagctga 840 aatgcagatg accacattca aggaagaact ttctgccccg gctttgcagg atgaaaagct 900 ttcctgcttg gcagttattc ttccacaaga gagggctttc tcaggacctg gttgctactg 960 gttcggcaac tgcagaaaat gtcctccctt gtggcttcct cagctcctgc ccttggcctg 1020 aagtcccagc att 1033 //