ID AH001842; SV 2; linear; genomic DNA; STD; MUS; 3604 BP.
XX
AC AH001842; J00348; M16381-M16395;
XX
DT 13-JUN-2016 (Rel. 129, Created)
DT 13-JUN-2016 (Rel. 129, Last updated, Version 1)
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DE Mus musculus alpha-fetoprotein (Afp) gene, complete cds.
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KW alpha-fetoprotein; fetoprotein.
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OS Mus musculus (house mouse)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
XX
RN [1]
RP 1-3604
RX PUBMED; 6161929.
RA Gorin M.B., Cooper D.L., Eiferman F., van de Rijn P., Tilghman S.M.;
RT "The evolution of alpha-fetoprotein and albumin. I. A comparison of the
RT primary amino acid sequences of mammalian alpha-fetoprotein and albumin";
RL J Biol Chem 256(4):1954-1959(1981).
XX
RN [2]
RP 40-165,280-331,446-566,674-885,993-1125,1233-1330,1438-1567,1675-1889,
RP 1997-2129,2237-2334,2442-2580,2695-2918,3026-3158,3268-3322,3437-3484
RX DOI; 10.1038/291201a0.
RX PUBMED; 6164927.
RA Law S.W., Dugaiczyk A.;
RT "Homology between the primary structure of alpha-fetoprotein, deduced from
RT a complete cDNA sequence, and serum albumin";
RL Nature 291(5812):201-205(1981).
XX
RN [3]
RP 1-172,273-287,324-338,439-452,558-573,674-682,878-892,993-999,1117-1125,
RP 1226-1241,1323-1337,1438-1444,1559-1574,1675-1683,1882-1889,1990-2003,
RP 2121-2136,2237-2245,2327-2334,2435-2448,2572-2587,2688-2703,2911-2918,
RP 3019-3032,3150-3165,3266-3329,3430-3604
RX DOI; 10.1038/294713a0.
RX PUBMED; 6172714.
RA Eiferman F.A., Young P.R., Scott R.W., Tilghman S.M.;
RT "Intragenic amplification and divergence in the mouse alpha-fetoprotein
RT gene";
RL Nature 294(5843):713-718(1981).
XX
RN [4]
RP 3268-3322
RX PUBMED; 2452956.
RA Minghetti P.P., Law S.W., Dugaiczyk A.;
RT "The rate of molecular evolution of alpha-fetoprotein approaches that of
RT pseudogenes";
RL Mol. Biol. Evol. 2(4):347-358(1985).
XX
DR MD5; 468dc243f444c12467dd95c2c6dec3a9.
XX
CC On or before Jun 10, 2016 this sequence version replaced gi:191747,
CC gi:476713, gi:191749, gi:191750, gi:191751, gi:191752, gi:191753,
CC gi:191754, gi:191755, gi:191756, gi:191757, gi:191758, gi:191759,
CC gi:191760, gi:191761, gi:476714.
XX
FH Key Location/Qualifiers
FH
FT source 1..3604
FT /organism="Mus musculus"
FT /mol_type="genomic DNA"
FT /db_xref="taxon:10090"
FT gene 37..3576
FT /gene="Afp"
FT exon 37..165
FT /gene="Afp"
FT /number=1
FT CDS join(81..165,280..331,446..566,674..885,993..1125,
FT 1233..1330,1438..1567,1675..1889,1997..2129,2237..2334,
FT 2442..2580,2695..2918,3026..3158,3268..3312)
FT /codon_start=1
FT /gene="Afp"
FT /product="alpha-fetoprotein"
FT /note="precursor"
FT /protein_id="AAA37189.1"
FT /translation="MKWITPASLILLLHFAASKALHENEFGIASTLDSSQCVTEKNVLS
FT IATITFTQFVPEATEEEVNKMTSDVLAAMKKNSGDGCLESQLSVFLDEICHETELSNKY
FT GLSGCCSQSGVERHQCLLARKKTAPASVPPFQFPEPAESCKAHEENRAVFMNRFIYEVS
FT RRNPFMYAPAILSLAAQYDKVVLACCKADNKEECFQTKRASIAKELREGSMLNEHVCSV
FT IRKFGSRNLQATTIIKLSQKLTEANFTEIQKLALDVAHIHEECCQGNSLECLQDGEKVM
FT TYICSQQNILSSKIAECCKLPMIQLGFCIIHAENGVKPEGLSLNPSQFLGDRNFAQFSS
FT EEKIMFMASFLHEYSRTHPNLPVSVILRIAKTYQEILEKCSQSGNLPGCQDNLEEELQK
FT HIEESQALSKQSCALYQTLGDYKLQNLFLIGYTRKAPQLTSAELIDLTGKMVSIASTCC
FT QLSEEKWSGCGEGMADIFIGHLCIRNEASPVNSGISHCCNSSYSNRRLCITSFLRDETY
FT APPPFSEDKFIFHKDLCQAQGKALQTMKQELLINLVKQKPELTEEQLAAVTADFSGLLE
FT KCCKAQDQEVCFTEEGPKLISKTRDALGV"
FT sig_peptide 81..140
FT /gene="Afp"
FT mat_peptide join(141..165,280..331,446..566,674..885,993..1125,
FT 1233..1330,1438..1567,1675..1889,1997..2129,2237..2334,
FT 2442..2580,2695..2918,3026..3158,3268..3309)
FT /gene="Afp"
FT /product="alpha-fetoprotein"
FT intron 166..>172
FT /gene="Afp"
FT /number=1
FT gap 173..272
FT /estimated_length=unknown
FT intron <273..279
FT /gene="Afp"
FT /number=1
FT exon 280..331
FT /gene="Afp"
FT /number=2
FT intron 332..>338
FT /gene="Afp"
FT /number=2
FT gap 339..438
FT /estimated_length=unknown
FT intron <439..445
FT /gene="Afp"
FT /number=2
FT exon 446..566
FT /gene="Afp"
FT /number=3
FT intron 567..>573
FT /gene="Afp"
FT /number=3
FT gap 574..673
FT /estimated_length=unknown
FT exon 674..885
FT /gene="Afp"
FT /number=4
FT intron 886..>892
FT /gene="Afp"
FT /number=4
FT gap 893..992
FT /estimated_length=unknown
FT exon 993..1125
FT /gene="Afp"
FT /number=5
FT gap 1126..1225
FT /estimated_length=unknown
FT intron <1226..1232
FT /gene="Afp"
FT /number=5
FT exon 1233..1330
FT /gene="Afp"
FT /number=6
FT intron 1331..>1337
FT /gene="Afp"
FT /number=6
FT gap 1338..1437
FT /estimated_length=unknown
FT exon 1438..1567
FT /gene="Afp"
FT /number=7
FT intron 1568..>1574
FT /gene="Afp"
FT /number=7
FT gap 1575..1674
FT /estimated_length=unknown
FT exon 1675..1889
FT /gene="Afp"
FT /number=8
FT gap 1890..1989
FT /estimated_length=unknown
FT intron <1990..1996
FT /gene="Afp"
FT /number=8
FT exon 1997..2129
FT /gene="Afp"
FT /number=9
FT intron 2130..>2136
FT /gene="Afp"
FT /number=9
FT gap 2137..2236
FT /estimated_length=unknown
FT exon 2237..2334
FT /gene="Afp"
FT /number=10
FT gap 2335..2434
FT /estimated_length=unknown
FT intron <2435..2441
FT /gene="Afp"
FT /number=10
FT exon 2442..2580
FT /gene="Afp"
FT /number=11
FT intron 2581..>2587
FT /gene="Afp"
FT /number=11
FT /note="putative"
FT gap 2588..2687
FT /estimated_length=unknown
FT intron <2688..2695
FT /gene="Afp"
FT /number=11
FT exon 2695..2918
FT /gene="Afp"
FT /number=12
FT gap 2919..3018
FT /estimated_length=unknown
FT intron <3019..3025
FT /gene="Afp"
FT /number=12
FT exon 3026..3158
FT /gene="Afp"
FT /number=13
FT intron 3159..>3165
FT /gene="Afp"
FT /number=13
FT gap 3166..3265
FT /estimated_length=unknown
FT intron <3266..3267
FT /gene="Afp"
FT /number=13
FT exon 3268..3322
FT /gene="Afp"
FT /number=14
FT intron 3323..>3329
FT /gene="Afp"
FT /number=14
FT gap 3330..3429
FT /estimated_length=unknown
FT intron <3430..3436
FT /gene="Afp"
FT /number=14
FT exon 3437..3576
FT /gene="Afp"
FT /number=15
XX
SQ Sequence 3604 BP; 645 A; 494 C; 525 G; 540 T; 1400 other;
acaggatata aaaggacttc agcaggactg ctcgaaacat cccacttcca gcactgcctg 60
cggtgaagga acaagcagcc atgaagtgga tcacacccgc ttccctcatc ctcctgctac 120
atttcgctgc gtccaaagca ttgcacgaaa atgagtttgg gataggtaag atnnnnnnnn 180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnttttcagc ttccacgtta gattcctccc 300
agtgcgtgac ggagaagaat gtgcttagca tgtaagttnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnct tgcagagcta ccatcacctt tacccagttt gttccggaag 480
ccaccgagga ggaagtgaac aaaatgacta gcgatgtgtt ggctgcaatg aagaaaaact 540
ctggcgatgg gtgtttagaa agccaggtga gtgnnnnnnn nnnnnnnnnn nnnnnnnnnn 600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660
nnnnnnnnnn nnnctatctg tgtttctgga tgaaatttgc catgagacgg aactctctaa 720
caagtatgga ctctcaggct gctgcagcca aagtggagtg gaaagacatc agtgtctgct 780
ggcacgcaag aagactgctc cggcctctgt cccacccttc cagtttccag aacctgccga 840
gagttgcaaa gcacatgaag aaaacagggc agtgttcatg aacaggtaag gannnnnnnn 900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngttcatct atgaagtgtc aaggaggaac 1020
cccttcatgt atgccccagc cattctgtcc ttggctgctc agtacgacaa ggtcgttctg 1080
gcatgctgca aagctgacaa caaggaggag tgcttccaga caaagnnnnn nnnnnnnnnn 1140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200
nnnnnnnnnn nnnnnnnnnn nnnnncatct agagagcatc cattgcaaag gaattaagag 1260
aaggaagcat gttaaatgag catgtatgtt cagtgataag aaaatttgga tcccgaaacc 1320
tccaggcaac gtaagtannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnaac 1440
cattattaag ctaagtcaaa agttaactga agcaaatttt actgagattc agaagctggc 1500
cctggatgtg gctcacatcc acgaggagtg ttgccaagga aactcgctgg agtgtctgca 1560
ggatggggta ggagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngaaaaa 1680
gtcatgacat atatatgttc tcaacaaaat attctgtcaa gcaaaatagc agagtgctgc 1740
aaattaccca tgatccaact aggcttctgc ataattcacg cagagaatgg cgtcaaacct 1800
gaaggcttat ctctaaatcc aagccagttt ttgggagaca gaaattttgc ccaattttct 1860
tcagaggaaa aaatcatgtt catggcaagn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnna tttaagcttt cttcatgaat actcaagaac tcaccccaac cttcctgtct 2040
cagtcattct aagaattgct aaaacgtacc aggaaatatt ggagaagtgt tcccagtctg 2100
gaaatctacc tggatgtcag gacaatctgg taggttnnnn nnnnnnnnnn nnnnnnnnnn 2160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnngaag aagaattgca gaaacacatc gaggagagcc aggcactgtc 2280
caagcaaagc tgcgctctct accagacctt aggagactac aaattacaaa atctnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncttcaa ggttccttat tggttacacg 2460
aggaaagccc ctcagctgac ctcagcagag ctgatcgacc tcaccgggaa gatggtgagc 2520
attgcctcca cgtgctgcca gctcagcgag gagaaatggt ccggctgtgg tgagggaatg 2580
gtgagtgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnntta acaggccgac 2700
attttcattg gacatttgtg tataaggaat gaagcaagcc ctgtgaactc tggtatcagc 2760
cactgctgca actcttcgta ttccaacagg aggctatgca tcaccagttt tctgagggat 2820
gaaacctatg cccctccccc attctctgag gataaattca tcttccacaa ggatctgtgc 2880
caagctcagg gcaaagccct acagaccatg aaacaagann nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnnnnnnnnn nnnnnnnnac cccaggcttc tcattaacct ggtgaagcaa aagcctgaac 3060
tgacagagga gcagctggcg gctgtcactg cagatttctc gggccttttg gagaagtgct 3120
gcaaagccca ggaccaggaa gtctgtttca cagaagaggt gcgtannnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnagggt ccaaagttga tttccaaaac tcgtgatgct 3300
ttgggcgttt aaacatctcc aggtaagaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnna ttgcagaagg aagagtggac aaaaaaatgt gttgacgctt tggtgtgagc 3480
cttttggctt aactgtaact gctagtactt taaccacatg gtgaagatgt ccatgtgaga 3540
tttctatacc ttaggaataa aaacttttca actatttctc ttctcctagt ctgctttttt 3600
ttat 3604
//
