ID   K02800; SV 1; linear; genomic DNA; STD; MUS; 721 BP.
AC   K02800;
DT   02-JUL-1986 (Rel. 09, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 5)
DE   Mouse Ren-1 gene encoding renin-1 isozyme, exon 1 and flanks.
KW   renin; tissue specific regulation.
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
RN   [1]
RP   1-721
RX   PUBMED; 6392850.
RA   Field L.J., Philbrick W.M., Howles P.N., Dickinson D.P., McGowan R.A.,
RA   Gross K.W.;
RT   "Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative
RT   analysis of 5'-proximal flanking regions";
RL   Mol. Cell. Biol. 4(11):2321-2331(1984).
DR   MD5; be3e671248305f37ae613c69b98b069e.
DR   EPD; EP15035; MM_RENI.
DR   EPD; EP15036; MM_RENS.
DR   Ensembl-Gn; ENSMUSG00000070645; mus_musculus.
DR   Ensembl-Gn; MGP_129S1SvImJ_G0016485; mus_musculus_129s1svimj.
DR   Ensembl-Gn; MGP_AJ_G0016468; mus_musculus_aj.
DR   Ensembl-Gn; MGP_BALBcJ_G0016428; mus_musculus_balbcj.
DR   Ensembl-Gn; MGP_C3HHeJ_G0016254; mus_musculus_c3hhej.
DR   Ensembl-Gn; MGP_C57BL6NJ_G0016889; mus_musculus_c57bl6nj.
DR   Ensembl-Gn; MGP_CASTEiJ_G0015834; mus_musculus_casteij.
DR   Ensembl-Gn; MGP_CBAJ_G0016228; mus_musculus_cbaj.
DR   Ensembl-Gn; MGP_DBA2J_G0016333; mus_musculus_dba2j.
DR   Ensembl-Gn; MGP_LPJ_G0016404; mus_musculus_lpj.
DR   Ensembl-Gn; MGP_NODShiLtJ_G0016357; mus_musculus_nodshiltj.
DR   Ensembl-Gn; MGP_NZOHlLtJ_G0016925; mus_musculus_nzohlltj.
DR   Ensembl-Gn; MGP_PWKPhJ_G0015620; mus_musculus_pwkphj.
DR   Ensembl-Gn; MGP_WSBEiJ_G0015896; mus_musculus_wsbeij.
DR   Ensembl-Tr; ENSMUST00000094556; mus_musculus.
DR   Ensembl-Tr; MGP_129S1SvImJ_T0022138; mus_musculus_129s1svimj.
DR   Ensembl-Tr; MGP_AJ_T0022106; mus_musculus_aj.
DR   Ensembl-Tr; MGP_BALBcJ_T0022078; mus_musculus_balbcj.
DR   Ensembl-Tr; MGP_C3HHeJ_T0021884; mus_musculus_c3hhej.
DR   Ensembl-Tr; MGP_C57BL6NJ_T0022591; mus_musculus_c57bl6nj.
DR   Ensembl-Tr; MGP_CASTEiJ_T0021414; mus_musculus_casteij.
DR   Ensembl-Tr; MGP_CBAJ_T0021831; mus_musculus_cbaj.
DR   Ensembl-Tr; MGP_DBA2J_T0021956; mus_musculus_dba2j.
DR   Ensembl-Tr; MGP_LPJ_T0022058; mus_musculus_lpj.
DR   Ensembl-Tr; MGP_NODShiLtJ_T0021942; mus_musculus_nodshiltj.
DR   Ensembl-Tr; MGP_NZOHlLtJ_T0022625; mus_musculus_nzohlltj.
DR   Ensembl-Tr; MGP_PWKPhJ_T0021149; mus_musculus_pwkphj.
DR   Ensembl-Tr; MGP_WSBEiJ_T0021461; mus_musculus_wsbeij.
CC   The Ren-1 structural gene is found in all inbred strains of mice
CC   and encodes the renin-1 protein found in the kidneys.  In addition,
CC   some strains carry a second gene (Ren-2) which encodes the renin-2
CC   protein found in the submaxillary gland.
CC   S1 nuclease and primer extension analysis showed one major and
CC   numerous minor mRNA initiation sites.  Several mRNA initiation
CC   sites are located between positions 358 and 483.  An interesting
CC   feature of the first minor site is the possibility of an additional
CC   23 amino acid residues being added to the protein if translation
CC   begins at the start codon at position 446-448.  No such protein has
CC   yet been identified.
FH   Key             Location/Qualifiers
FT   source          1..721
FT                   /organism="Mus musculus"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:10090"
FT   prim_transcript 358..>721
FT                   /note="renin-1 mRNA (alt.)"
FT   prim_transcript 401..>721
FT                   /note="renin-1 mRNA (alt.)"
FT   prim_transcript 418..>721
FT                   /note="renin-1 mRNA (alt.)"
FT   prim_transcript 446..>721
FT                   /note="renin-1 mRNA (alt.)"
FT   prim_transcript 483..>721
FT                   /note="renin-1 mRNA (alt.)"
FT   CDS             515..606
FT                   /partial
FT                   /codon_start=1
FT                   /gene="ren1"
FT                   /product="renin-1"
FT                   /number=1
FT                   /db_xref="GOA:P06281"
FT                   /db_xref="InterPro:IPR001461"
FT                   /db_xref="InterPro:IPR001969"
FT                   /db_xref="InterPro:IPR012848"
FT                   /db_xref="InterPro:IPR021109"
FT                   /db_xref="InterPro:IPR033121"
FT                   /db_xref="InterPro:IPR034135"
FT                   /db_xref="MGI:MGI:97898"
FT                   /db_xref="PDB:5MKT"
FT                   /db_xref="UniProtKB/Swiss-Prot:P06281"
FT                   /protein_id="AAA40044.1"
FT                   /translation="MDRRRMPLWALLLLWSPCTFSLPTRTATFER"
FT   intron          607..>721
FT                   /note="renin-1 intron A"
SQ   Sequence 721 BP; 199 A; 139 C; 234 G; 149 T; 0 other;
     gacagcaggg gaaggcactg ggtggtctgg cagctggaaa tgctgggagg ccttcttggg        60
     ggagattaga ttaaagctct tcaggggaag gcctattcca tgactccagc atggtgagtc       120
     tagatgaaag gaggtagtct atggttttag agctttattg tagaagagag agagagaagg       180
     tagagaagta gaagccagtc attgccatga agaaggaagg gggagaagga gagcgaaagg       240
     taagagtaag aaaacaagag ctttaggaga gagacaagag agagaggagg aggcaagcag       300
     ccaagtggct ctgggggtgg agtctggaca gcctacatga ctgatggcca cagaattatg       360
     gagctgggtc cttggccaga aaacaggctg cctttcatgg tcccacaggc cctggggtaa       420
     taaatcaaag cagagcctgt gatacatggt gtgtataaaa gaaggctcag ggggtctggg       480
     ctacacagct cttagaaagc cttggctgaa ccagatggac agaaggagga tgcctctctg       540
     ggcactcttg ttgctctgga gtccttgcac cttcagtctc ccaacacgca ccgctacctt       600
     tgaacggtaa cttgggcaga gaaggggtgg cagggtacag gaactggcat cttactaacg       660
     ccctcagctg tctatacgtt ggatcatcca gtccttttgg ccagccagtc agggatgtat       720
     g                                                                       721