spacer

EBI Dbfetch

ID   AY323833; SV 1; linear; genomic DNA; STD; MUS; 12503 BP.
XX
AC   AY323833;
XX
DT   30-NOV-2003 (Rel. 78, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 3)
XX
DE   Mus musculus guanylyl cyclase-B1, B2, and B3 isoforms (Npr2) gene, exons 3
DE   through 22, and complete cds, alternatively spliced.
XX
KW   .
XX
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea;
OC   Muridae; Murinae; Mus; Mus.
XX
RN   [1]
RP   1-12503
RX   DOI; 10.1074/jbc.M308680200.
RX   PUBMED; 14514678.
RA   Tamura N., Garbers D.L.;
RT   "Regulation of the guanylyl cyclase-B receptor by alternative splicing";
RL   J Biol Chem 278(49):48880-48889(2003).
XX
RN   [2]
RP   1-12503
RA   Tamura N., Garbers D.L.;
RT   ;
RL   Submitted (14-JUN-2003) to the INSDC.
RL   Howard Hughes Medical Institute and Pharmacology, University of Texas
RL   Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX
RL   75390-9051, USA
XX
DR   MD5; 7ceee7f6cce7e01e6d4a0d13ddfe90b9.
DR   Ensembl-Gn; ENSMUSG00000028469; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000030191; mus_musculus.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..12503
FT                   /organism="Mus musculus"
FT                   /strain="129/SvEvTac"
FT                   /mol_type="genomic DNA"
FT                   /sex="male"
FT                   /tissue_type="spleen"
FT                   /db_xref="taxon:10090"
FT   gene            order(AY323832.1:384..8065,1..11009)
FT                   /gene="Npr2"
FT   mRNA            join(AY323832.1:<384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1353,1576..1660,3082..3202,3363..3437,
FT                   3635..3712,4112..4216,4337..4408,6572..6731,6947..7102,
FT                   7180..7348,7502..7648,8108..8231,8378..8446,10180..10354,
FT                   10425..10523,10739..10830,10944..>11009)
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B3 isoform"
FT   mRNA            join(AY323832.1:<384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1040,1221..1353,1576..1660,3082..3202,
FT                   3363..3437,3635..3712,4112..4216,4337..4408,6572..6731,
FT                   6947..7102,7180..7348,7502..7648,8108..8231,8378..8446,
FT                   10180..10354,10425..10523,10739..10830,10944..>11009)
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B1 isoform"
FT   mRNA            join(AY323832.1:<384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1040,1221..1353,1576..1660,3082..3202,
FT                   3635..3712,4112..4216,4337..4408,6572..6731,6947..7102,
FT                   7180..7348,7502..7648,8108..8231,8378..8446,10180..10354,
FT                   10425..10523,10739..10830,10944..>11009)
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B2 isoform"
FT   CDS             join(AY323832.1:384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1040,1221..1353,1576..1660,3082..3202,
FT                   3363..3437,3635..3712,4112..4216,4337..4408,6572..6731,
FT                   6947..7102,7180..7348,7502..7648,8108..8231,8378..8446,
FT                   10180..10354,10425..10523,10739..10830,10944..11009)
FT                   /codon_start=1
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B1 isoform"
FT                   /function="generates cGMP from GTP"
FT                   /note="GC-B1; C-type natriuretic peptide receptor; activity
FT                   is increased by C-type natriuretic peptide binding;
FT                   membrane protein; alternatively spliced"
FT                   /db_xref="GOA:Q6VVW5"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR001054"
FT                   /db_xref="InterPro:IPR001170"
FT                   /db_xref="InterPro:IPR001245"
FT                   /db_xref="InterPro:IPR001828"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR018297"
FT                   /db_xref="InterPro:IPR028082"
FT                   /db_xref="MGI:MGI:97372"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q6VVW5"
FT                   /protein_id="AAQ02634.1"
FT                   /translation="MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRV
FT                   GPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYP
FT                   AASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWT
FT                   ARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGR
FT                   IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQE
FT                   QAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDG
FT                   ILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGD
FT                   LDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAI
FT                   VALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTL
FT                   SLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQF
FT                   NHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLH
FT                   NSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSG
FT                   NPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSID
FT                   RTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNL
FT                   EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFT
FT                   ALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEI
FT                   ARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASR
FT                   KESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKGPPGLL"
FT   CDS             join(AY323832.1:384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1040,1221..1353,1576..1660,3082..3202,
FT                   3635..3712,4112..4216,4337..4408,6572..6731,6947..7102,
FT                   7180..7348,7502..7648,8108..8231,8378..8446,10180..10354,
FT                   10425..10523,10739..10830,10944..11009)
FT                   /codon_start=1
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B2 isoform"
FT                   /function="generates cGMP from GTP"
FT                   /note="GC-B2; C-type natriuretic peptide receptor; activity
FT                   is not increased by C-type natriuretic peptide binding;
FT                   membrane protein; alternatively spliced"
FT                   /db_xref="GOA:Q6VVW5"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR001054"
FT                   /db_xref="InterPro:IPR001170"
FT                   /db_xref="InterPro:IPR001245"
FT                   /db_xref="InterPro:IPR001828"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR018297"
FT                   /db_xref="InterPro:IPR028082"
FT                   /db_xref="MGI:MGI:97372"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q6VVW5"
FT                   /protein_id="AAQ02635.1"
FT                   /translation="MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRV
FT                   GPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYP
FT                   AASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWT
FT                   ARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGR
FT                   IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQE
FT                   QAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDG
FT                   ILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGD
FT                   LDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAI
FT                   VALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTL
FT                   SLGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPR
FT                   GSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
FT                   TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIAL
FT                   RSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPD
FT                   FGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQI
FT                   LPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAI
FT                   IDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLR
FT                   LRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRKESNGQALKIHVSSTTKDALDELGC
FT                   FQLELRGDVEMKGKGKMRTYWLLGEQKGPPGLL"
FT   CDS             join(AY323832.1:384..1050,AY323832.1:1724..1929,167..280,
FT                   563..698,946..1079)
FT                   /codon_start=1
FT                   /gene="Npr2"
FT                   /product="guanylyl cyclase-B3 isoform"
FT                   /note="GC-B3; extracellular ligand-binding domain; contains
FT                   no transmembrane segments; alternatively spliced"
FT                   /db_xref="GOA:Q6VVW5"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR001054"
FT                   /db_xref="InterPro:IPR001170"
FT                   /db_xref="InterPro:IPR001245"
FT                   /db_xref="InterPro:IPR001828"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR018297"
FT                   /db_xref="InterPro:IPR028082"
FT                   /db_xref="MGI:MGI:97372"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q6VVW5"
FT                   /protein_id="AAQ02636.1"
FT                   /translation="MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRV
FT                   GPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYP
FT                   AASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWT
FT                   ARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGR
FT                   IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQE
FT                   QAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDG
FT                   ILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGD
FT                   LDSGDFQVMGERTGRRDWS"
FT   exon            167..280
FT                   /gene="Npr2"
FT                   /number=3
FT   exon            563..698
FT                   /gene="Npr2"
FT                   /number=4
FT   exon            946..1040
FT                   /gene="Npr2"
FT                   /number=5
FT   exon            1221..1353
FT                   /gene="Npr2"
FT                   /number=6
FT   exon            1576..1660
FT                   /gene="Npr2"
FT                   /number=7
FT   exon            3082..3202
FT                   /gene="Npr2"
FT                   /number=8
FT   exon            3363..3437
FT                   /gene="Npr2"
FT                   /number=9
FT   exon            3635..3712
FT                   /gene="Npr2"
FT                   /number=10
FT   exon            4112..4216
FT                   /gene="Npr2"
FT                   /number=11
FT   exon            4337..4408
FT                   /gene="Npr2"
FT                   /number=12
FT   exon            6572..6731
FT                   /gene="Npr2"
FT                   /number=13
FT   exon            6947..7102
FT                   /gene="Npr2"
FT                   /number=14
FT   exon            7180..7348
FT                   /gene="Npr2"
FT                   /number=15
FT   exon            7502..7648
FT                   /gene="Npr2"
FT                   /number=16
FT   exon            8108..8231
FT                   /gene="Npr2"
FT                   /number=17
FT   exon            8378..8446
FT                   /gene="Npr2"
FT                   /number=18
FT   exon            10180..10354
FT                   /gene="Npr2"
FT                   /number=19
FT   exon            10425..10523
FT                   /gene="Npr2"
FT                   /number=20
FT   exon            10739..10830
FT                   /gene="Npr2"
FT                   /number=21
FT   exon            10944..11009
FT                   /gene="Npr2"
FT                   /number=22
XX
SQ   Sequence 12503 BP; 2746 A; 3184 C; 3186 G; 3386 T; 1 other;
     atgtgtgtgt gcatgtgcgt gtgcgtgtgc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt        60
     gcgcgcatgt gtgtgcgtgt gtgtgtgcat gtgtgtgtgt ttacccactt ttcctatggt       120
     ggtccttccc ctcctgctca ccccgagtcc tgtttccatg gtgcagactg tattggtgat       180
     cacataccga gaacccccaa atcctgagta tcaggagttt cagaatcgcc tgctgatcag       240
     agcccgggaa gactttggtg tggagctggc cccatccctg gtgagtagat ctctgagggt       300
     cagaacaggc tacgaggaag ggacttctca cagagtcctt gatcatggag caagccccat       360
     ttcaggctgt gacttccatc caggctacta ccctttgacc ccgggaccgg gggtggggga       420
     ggggatggca tgataggggt ggggggaggg aggaagtaag ccaagaaagt ggggaggcgt       480
     ggggacacgc aggggtggga gagtgaacca ggaaggggac ctcaggggac atttggagag       540
     tgttgctgct tgctgtctcc agatgaacct tattgctggc tgcttctatg atgggatcct       600
     gctctatgcc caagtcctga atgagactat acaggaaggg ggtaccaggg aagatggact       660
     tcgaattgtg gagaagatgc agggacgaag ataccatggt aatgaagggt gggggagtgg       720
     aggcctgggg gctgacgcca ggctcaggag tgcagtgggc agaagacagc tactccaggc       780
     actgcaaggg aagagtcact gggggtcagg aacagtcaga gtggacacac gtcactgtgg       840
     gcagagactc tgagacagtg agatgggggg ggggtacggg ggacgacaga aggagagtgg       900
     ccagggttag atctcaaaag tgagggacac tcttttttat cttaggtgta actggactgg       960
     ttgtcatgga caagaacaat gaccgcgaga ctgatttcgt cctgtgggcc atgggagact      1020
     tggattctgg ggactttcag gtgatggggg agaggacagg gaggagggat tggtcctaag      1080
     atccagaggg gacagaatcc tttgctctgg ggggcaggag cttactccct gctgggcctt      1140
     catcacggtg ggggcgcagg gagaaggctg cgcatgcgca cgtggcaggc ctgtgggccc      1200
     agcgttctgc ttcctcacag cccgcagccc attactctgg agcagagaag cagatttggt      1260
     ggacaggccg gccaattccc tgggtgaagg gggccccacc tttggacaat cccccctgtg      1320
     cctttgactt ggacgaccca tcctgtgata aaagtgggtg tgtgcaggga ctgggagcag      1380
     tccccccttt accctgcccc tgcgctctgc ccctacctca ctgacaccca ttcccactcc      1440
     tggctatgcc ttctctctgt ctgcagctct ctctctttcc gtcaagaacg ctctgcacct      1500
     cctgcgcctg tgtctctctg ccctcagcca ctccagtctt tctcagggcc tctcttctct      1560
     cttcctctcc ttcagctcca ctttccactc tggcaatcgt ggccctgggc acgggagtca      1620
     ccttcatcat gtttggtgtt tccagtttcc taattttccg gtgagttctg ggttttccta      1680
     tcctcatggc gcctcttgct gcatggcctc tggctgaggc aggggtccct gtcgtgtggc      1740
     tggcaagtct cctaacccgg tgtgggtttc ttggactggc agctttctct ctggcctttg      1800
     aatttggtcc cccttcatcc taggtattta tcttgctttt gtttgtaacc tgggtagact      1860
     agttgttggt ttggttattg ttgctgttgt tttttgtttg tttgtttgtt tgtttgtttt      1920
     gtgacaaagt cttgctaagt agcccagact ggccttgaac tcaagagtct actccctcac      1980
     actcctgagt attgggttta cagatgtgtg tcatggagcc ttatttgaat actgtttttg      2040
     tgtttgtgat aaggtttcgt tgtagagctc tggcctgtct ggaacccact atgtagacta      2100
     ggctgccctt taacttctca gggttttgcc tacctctgcc tttcaagtgc tggaattaaa      2160
     gacctcctcc accatgcctt atctctgaat aaggattttt taaaaaagaa gtagttttta      2220
     tttatatatc tcctgtatgt ctgtgtaaat gtataccacc acacacatgt gtaggtgcct      2280
     atagaggcta gaagaggcca tcggatcctc tggagcctga gttacaggtg gttgtgagca      2340
     gcgcaggatg ggtgcttgga attgaacttg ggtcttctgg aagagcagca ggtgctccta      2400
     accacttagg ctcatctcca gccctggagt actgactttg ggtagagttt gggtcaaagg      2460
     tgaatttcta tacactgctt gccacccccc ccccccctcc tcacctcatt cccactgaag      2520
     tgcaaacaaa ttctcacagt tctggatagg tgggagatct gagatcaagt ctgcaacagc      2580
     ttctgtgtct ggtgagggtg cacgttctga tttgtggaaa gtaatgtttc actgtgtctt      2640
     cacagagtgg aagactggct gtcctgactt agctataggc tggggatgga gcagcaccct      2700
     ggtagagtat ttgcctagca tgttcaaggc catagattta atctctagcc tggaagaggg      2760
     gaatgaagag agaggagaga ggagggaaga aggggagaga gagagagcga gcaagagaga      2820
     gagagagaga actagagttg tgtggtggta tatatctaca atcccaacat ttggaaggct      2880
     gaagcaggaa gaccatcatt agtttaaggc ctacctgtgc tctgtctcaa aaccaaatga      2940
     aaccaaacca accaaaccaa accactttgc ctgtgacact gagtgttcat gtcccagtcc      3000
     ggtggcagtt gcagcttcct ggaagcttag tgggtggcag gacagggctt gtccgtcggc      3060
     tgagatgtgc agtccttaca ggaagctgat gctggagaag gagctggcta gcatgctatg      3120
     gcgcattcgc tgggaagaac tgcagtttgg caactcggat cgctatcaca agggtgcagg      3180
     cagtcgcctg acgctgtcgc tggtgagccc ttggccctcc gtcttcctct gacttcctgt      3240
     tctctcttac cctggacctt tcccccccgc acactggcct gtaatgatag acccttgcac      3300
     caccaccacc accatctaat gttcctttca tccttccgcc tccatgttgc ccttggcccc      3360
     agcggggatc cagttacggc tcgctcatga cagcccatgg gaaataccag atctttgcca      3420
     acaccggtca cttcaaggtg aagagtcatc tgcttgttct ggttcccgac catttcattg      3480
     tgtctcatcc ccatcatgcc acctctgccc ctgaacctct gccccctcac agtccccgct      3540
     gtcttcccag cgaggttctt gggagctctc agttctctag catctcagat acccctgagg      3600
     ctcagggtct ttgtctgttt ccaccccacc ttagggaaat gttgttgcca tcaaacacgt      3660
     gaataagaag cgcatcgagc tgacccggca agttctgttt gaactcaaac acgtacgtac      3720
     ttgggtatga gtgggaggtg agggtggaca gggaagagga aatgagggga ccatggttcc      3780
     ctggctaacg ggataagggg cttatttatc actgattccc agttgcaggt gtatgtaaga      3840
     gaaatgtcat tgctcacagt ggtatttctg tatttccgta tttatttatt tagagacata      3900
     gtctctctgt gtaacagctc tggctatcct ggaacttact atgtagacca ggctggccct      3960
     gaactcacag agatcctact gcttctgcct ccccagtgct ggggttaaag gtgtgcgcca      4020
     ccatgtttgg cctctgtatt taagctttag ggctgcccat tctcttgttt tgtttgtttg      4080
     tttgtttgtt tgttttgttt tgttttggta gatgagagat gtccagttca accatcttac      4140
     tcgcttcatc ggagcctgca tagaccctcc caacatctgc attgtcaccg agtattgtcc      4200
     tcgtgggagc ttacaagtga gggacagggg taggagactg tggtagggtg ggggtggagg      4260
     ttccaaagtc accttgtgtc aaagggtagc ccgtgagact ggggacagac cctgatctct      4320
     aacgtgtcac tgtcaggata ttctagaaaa tgacagcatc aatttggact ggatgtttcg      4380
     ctactcgctc atcaatgacc ttgtgaaggt aagtcttccc cgccatgtaa aatgtctcag      4440
     tccctcaatc ttcgctgcag tttctctcct ggatctctaa cagccaagct ctttcccagc      4500
     cctctcctcc cgtgactggg tgatgcagcg gtcctatgtc ccgagaggtt cttgtcctcc      4560
     tgtcccagat atctttaatg tttctctagt gtctctttac ctcaaagggt tcccctgtag      4620
     tagaatccta tagctgggca tgccatcata tgggaggttg aggcaggggg ctgctctgac      4680
     ttggagcttg accaaaggct tcagagtgag tttcaggcta gtgtggacta cataacaaga      4740
     tcctatccag aaaaagaaga caattaaacc aaaccgaaca gtgacgaggc atcccttagc      4800
     tgggtgtggg tagtgcacat gtgtaatccc agaactcgct gagacaggag gattgggtgt      4860
     tcgagaacag cctgagcatc agtaagaatc tgtctcaaaa caaacaaatg aagacgtcga      4920
     atgaggtctc cgtgcactcg tctcctgtaa tttcatgctt taaccaatat tccccatgcc      4980
     tgtaactaac tgcggaagag gtctctagtc tttaacattt ctaaatttaa ctgcttgttt      5040
     ctggagactg ggtctctctg tgttgccttg gctgacctgg aagtatctct ctgtggacca      5100
     ggctgacctt gaactcaaga gatctacctg ccccggctcc tctgtactgg gattaatggc      5160
     aggggacaac acttgtagct ttgatttctt ttagagacag ggtttcatgt tgcctagaca      5220
     ggcctcaaac ttactatgta gccagaaatt gctttgaact cctgactttc ccatctctac      5280
     ttccccaatg ctaacattgt aggtgtgcac caccatcgta cctggtcaga gactgaaacg      5340
     tatttgtatg ttaacctaag agagaggaag gaaacttgca ctaaatctgt ttccattcta      5400
     acggccaacc attttaaaat gactcagagg cctgcagatg gctgaagcac actgatgaat      5460
     cttgtatggc ttagacagtg ttcagaagca ggtctcatca gcctactcat gagaccgcct      5520
     gactgtgcct gacactggct ctgattttct gctaagtttt cagaaagttt tttttaaaat      5580
     taatttatgc atatgaaagt ttgccatcaa gtgagagagg aaactattag ggaaagccaa      5640
     tgtagttttg gacaggagat gtggggataa acatgaaacc caggggtaaa ttcaccagct      5700
     taggcattcc ttcctaaagg cctcgagctg ctcaaagcaa taaagaggag gaactcgaag      5760
     gccttggacc tgttcaaggc cagagcttag cggttacacc cttgtgattc tggtccacag      5820
     cagagccttc tagcctctgt ctgaccacct gcaccgacta gggagggctt ccagagtttc      5880
     tctttgggga aacactgcct tgccctccca agaccggcct tttcatctcc tgggggcagt      5940
     gttctgacat ctctgcctct aggaagccat gcttccacga tgacttgact gttggttgcc      6000
     cacctctgtc tatttttttc aaactttgtc ttcactactg tgtggtctag cattcctcta      6060
     atagacccca ttctgctccc accatgacct ggatcctatg cacagccata cacaagagtt      6120
     acaagtggct ggctttctat ggagcaccta gagcctagcc atgtcttaag tcgtgtcctc      6180
     ctaaacagta gctaggagtg tgaagtcggt tcaggtgccg agctggttct ggctgctccc      6240
     ttcactgctc agcaagccgc cattctcagg gaaactaccg atggctcgcc tcatccctct      6300
     tcataagtat ctccgcctat cccttgtgcc ttgtagttcg atgctgttta catgggaagt      6360
     gatggctttc ccattctgcc tgcttcctcc agtcgaggct ctacaggaga catcatctca      6420
     attcagcttg ttttttcggt cttaagatcc tttaatctct aatgatttgg ggttggtggt      6480
     ctgaatatct ttatgaagtt agctggatca tgccatggac tgaggttgcc taagccagat      6540
     acaatccaga cacttactct gtatcctgca gggtatggcc tttctccaca acagcattat      6600
     ttcatctcat ggaagcctca agtcctccaa ctgtgtggtg gatagtcgat ttgtgctcaa      6660
     aataacagat tacggtctgg ctagtttccg atcaactgct gaaccggacg acagccatgc      6720
     cctctatgcc agtgagactg ctccctgcac ccccctcccc ccaagccatc ccctccccca      6780
     cacctcctcc ctctgccgcc taccttttat gtcacccttc aagccttggt cgtttcttcc      6840
     cggggagggg gtaagaggga gaccagtagt agcaacatgg ggctgagccc aggtggcatc      6900
     caagatgctg tttggggaac ctagccagcc tgttcactct ttgcagagaa gctgtggact      6960
     gccccagaac tgcttagcgg gaaccccttg ccaaccacag gcatgcagaa agcagatgtc      7020
     tacagctttg ccatcattct acaggaaata gcacttcgaa gtggtccttt ctacttggaa      7080
     ggcctggacc tcagtcccaa gggtgagcga gtccgttgct acacagtcgc ttctgctagg      7140
     gaaacctgag tcttcatcca aacttcctgt cacccttaga gattgtccag aaggtgcgga      7200
     atggtcagag gccgtatttc cggccaagca ttgaccggac acaactgaat gaagagttag      7260
     ttttgctgat ggagagatgc tgggcccagg acccaacaga acgtccagac tttgggcaaa      7320
     tcaagggctt cattcgccgg tttaacaagt gagaggtcac ccaggctcag aggctcccgg      7380
     gggacagaaa cattatcatt ctcagtggat gcggctggtg tgcctcaggg gtgggttaga      7440
     taggaagcct tgtcattctt gagcaccttg gagcaggtgt gatagcctgg cctccctgca      7500
     gggaaggtgg taccagcata ttggacaacc tcttgctgcg catggaacag tatgctaata      7560
     acctggaaaa gctggtggag gaacgcacac aggcctatct agaggagaaa cgcaaagcgg      7620
     aggccctgct gtaccaaatt ctaccccagt aagacctttg tcccccttct ccgagaattt      7680
     cctcacattc tagctcatcc atcttctgag aatttgtttg ccaccctggg aaccctgggt      7740
     gacgtcttgc cacagtaagc cctcctggct acaggcagaa tgctctcact tggtctccat      7800
     atgggctgtg ctgtcatctt tcagtttcca gtccctcctt cttggggcac tgttctttct      7860
     cacctttgtc tgaccaagta tatgcagaac gatttcaact ggaaccactt atccccacgg      7920
     gagtcccctc gcagtgccgg ccacttttgc acccggatgt gcactgagct aggtgacatc      7980
     gtctcagctg ctttcctttt cttccaccaa agccaacttc cattctaagg cttggctgtg      8040
     ccacataccc caccctctcc ctccttctct ctcagagcgg ggctgagggg acactcttgc      8100
     ttcctagttc tgtagcagag cagttaaagc ggggagagac ggttcaggcg gaggccttcg      8160
     acagcgtcac catctacttc agtgacatcg tgggcttcac agcgctgtca gctgagagca      8220
     cccccatgca ggtgagarcc gtgaggggag cgggcatggg agtgctggga gagcctcgat      8280
     ggactagttt gctctagagc tcttttgtct ttcagcttga gaatttttta ggaacttggg      8340
     cactaatttc agagcctctg ctttcccgtc ctgttaggtg gtgacacttc ttaatgacct      8400
     ttatacctgc tttgatgcca ttatcgacaa ctttgatgtc tacaaggtga gagctggagc      8460
     tgacctcctt ctaagaccca tttcaaaccc agtttcctga accccacaga ccttatccac      8520
     tccacagtca gcgctcccta agtttctcca gcgtcctagt gttctaatgg gtgtgagtct      8580
     agcaggcgtg gacactggca caacacccgt ggctcccagg cttcctgatc acgagcttta      8640
     gtcccttcct ctctggggta ttagtgatac agacgcctgg tctctccttc cagaacagtc      8700
     cgaggatgcg ggcacagcct gactatggat ggggtggggg aaatacatgt tacaaagctc      8760
     tttgttaaag tcattgtcgg gttataaagt catttggtta aggggctaac ttgcccttgg      8820
     gcgtaaatgt gctgcatttg catatggatt ttatagctaa ttatgtggcc ttaggcaggg      8880
     tcaggatttc tctgagcttt ggttgttgca gcaatagttt agttatcatg caaactgatg      8940
     ggccagcaag agggcttggt gggtaagggc ggcaagcctg gtgtcttagg ctcagtgcct      9000
     ggaatcccta tgatggaagg agagaagtga tacccacagg tgtcctctga cttccacatt      9060
     catgtgcgtg tgggcgtgca cgcacaaata aatgtgagac ctattttttt ttagatgttc      9120
     ctaacatgta gtgtggttgt ggcaggtaac aatattgggc atggtgagac ctgcctgtca      9180
     tcccagtatt taggagctgg gacagacgga tcacgagttt aagattagtc ttggctatac      9240
     aacgggaccc tacctaaaca taaaagagga ccttttaaag cttactttac cctttctgat      9300
     gtttctctaa caaaattccc ataaaccctt tacttaaatc catcaattat ttttatttcc      9360
     tcctacttat tttatacgtc tccttccctc tctggaacgt ttgggaatca agcctccagc      9420
     ttttctcacg ctgctctgtt ctaatgctga ctacatccct ggccttatta ttttttttaa      9480
     aattcatata aaaattcata tattctggaa aatttgagag taagttttag ataaagtacc      9540
     cctttatccc taaattctaa gtgtgggctc cctccagact tcactgtgag ccacaggttg      9600
     gtacagccac cagcgtcggg agctgcttct tccctgacag ccaggccatc tggtccatgc      9660
     tacggagcat acgctactct ctttgtgctt ctgggttctt tggactggga ctgggatcct      9720
     gtccacttgt tcagcaaatg ccactgagga ctccccaggg gctggggtcg cgaggaagag      9780
     tcaagtattc ccctgtctgg cctcctctta ctcccagatt ctcagggcca tggcatgtag      9840
     tccctcgtct ctctggtcag tcatggtctc ccaagctgtc aggatgaccc ctgctgtcca      9900
     gctaacctcc tttctcgctc tccccgagac agctggagat gacctcttaa aactagtttt      9960
     attattttac ttatgtgtgt gtacctatct gagtatgtgc cacatgggtg cagttgctgt     10020
     ggaggccaca agagggtgcc atatccccta gaactggagt tacagggagt ttgagctgct     10080
     acatggatgc tgggaactga actcaggtcc tctggaggaa cagtcagtgt tctaatgact     10140
     gagactacag gtgaccttct aatctcccct ttaaatcagg tggaaaccat tggggatgcc     10200
     tacatggtgg tatctggcct tccaggccga aacggtcagc gccatgcacc agaaattgct     10260
     cgaatggccc tagcattgct agatgctgtc tcttccttcc gcatccgcca tcgaccccat     10320
     gaccagctga ggttacgcat aggtgtccat actggtaagg ctgattctca cctggcccta     10380
     gtgtctactt ttccagatct ttcccaacca gtttgttttt acagggccag tctgtgctgg     10440
     ggtggttggc ctgaagatgc cccggtactg tctttttgga gacacagtaa acactgcttc     10500
     tcgaaaggag tcgaatggcc aaggtaagga caacagcttt taactccaaa cttgacctgt     10560
     cttactcttt tcttttcgga gttcttccat atctctttgt tggatggtcc tgaagtgccc     10620
     cattcttggt cttatgttga ttcttataat tacgctctgg caggactggt gacaattctt     10680
     ctcttgtctt ttcttgaatt tttctttctc cctctgcccc tggtctacat caccctagct     10740
     ctaaagatcc atgtctcctc gaccaccaag gacgccctgg atgagctggg atgcttccag     10800
     ctcgagctcc gtggggatgt ggagatgaag gtgatggcag gctgtggggg agtggatcat     10860
     gggaggatga tggtgggggg agagagggag acaaagacac taacacacaa gagtctgaac     10920
     tgtgctcatc cccctgcctc cagggaaaag gaaaaatgcg aacttactgg ctcttgggag     10980
     agcaaaaggg acctcccgga ctcctgtaaa gcccaggccg gccatcttct gctgctggta     11040
     cttggatggg caatggtcac tgtgtttcca cacagcaaaa acagacgtag ccatatcaga     11100
     tggaaaacat gcatagacac aaaccccctg ccttatgtgg aaatcatagc cccctgccgc     11160
     tcagccttgt acatagacct atccctccct gccctggtcc tcttcctgcc tcctgtaaat     11220
     atctgtatct agaccagaat attttgtcca agtataaaac aacaacaaca aaaaatcatg     11280
     gtgtcattgt ctggggtcca ggccatccca agagaagaat actggttgtg gacacagtta     11340
     ctcacagaat caatgaatta gcagcttgag gatgagagtg ctttatgtaa aacccctcat     11400
     cggggacaga gaatcaactc catccaatct acctctgtag tataaacaga aactgatttc     11460
     aaatcccacg tctgcttctc tcctcgattc ttagattgga gttgttttcg tccttccaca     11520
     cccctgccct cctccctgac aggcaaggga agatattacc cccacttggt gggggccgct     11580
     ctcaagctcg taaggcaagg gctgccccag cgacaagggc acgggcgtcg agaagctgca     11640
     gttcttccgg aatggtgtgt ccagtgtcct gatgtcactg acaccctggg ggagtaccag     11700
     gatacagatg ccacccttac ccaagccaga acataagagc ctctcccaca ccccagtacc     11760
     tagtcgccca cacacaccgg tagccgtgct gcccgctgaa tccagaaggt ttcaggctgc     11820
     tcctggcggt aatcatgagg ctgtgaggga agaggtactg aactcctggc ctttggcact     11880
     ctctaaactt ccaggattgc tgctctccca ctcctaggca gagcagagct gtgcaagaag     11940
     ggcaggctgg gttctcacct ttgttgaggc aggaggcgct gctcgtacca gctccactct     12000
     gtagtcatgg tgtgttaccg actcggtctc aaagagcttc cttgcaggtt cctgctctgc     12060
     ctgcacctct ttactatgta gccatgtgag aggtcaagac catccccctg gtttctctcc     12120
     tcccctcccc ccttcccagg ctctcaccag atctggtgtc gcaggagcat ctccagcatg     12180
     gcttcacgct tccctgggag aggacagaag agaaatctag tcaggaacta gcgtcagaaa     12240
     tgagttgagc aaagaagggg aatcttgggg tttgccctta tagccaccaa acaatccaca     12300
     atcccaccag gaagtccggt ctcccttttc tgtctcctgg gctctttctg gtcccccatc     12360
     tctcatgctt cacacctcga agtggctgac agatgtgtct tgggagctgg tatgagtctc     12420
     tctgggtggt gctagaagac atgggtgact ggggctgcgt ggtcagcaga ccctggtgtc     12480
     cgggtcggaa gaagtaactc tca                                             12503
//


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