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EBI DbfetchID AM419948; SV 1; linear; genomic DNA; STD; HUM; 10278 BP. XX AC AM419948; XX DT 13-MAR-2007 (Rel. 91, Created) DT 13-MAR-2007 (Rel. 91, Last updated, Version 1) XX DE Homo sapiens HLA-DRB1 gene for MHC class II antigen, HLA-DRB1*010101 DE allele, exons 1-6 XX KW HLA-DRB1 gene; HLA-DRB1*010101 allele; human leucocyte antigen; KW major histocompatibility complex; MHC class II antigen. XX OS Homo sapiens (human) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. XX RN [1] RP 1-10278 RA Von Salome J.K.; RT ; RL Submitted (14-DEC-2006) to the INSDC. RL Von Salome J.K., Department of Genetics and Pathology, Medical Genetics, RL Dag Hammarskjolds vag 20, Rudbeck Laboratory, SE-751 85 Uppsala, SWEDEN. XX RN [2] RX DOI; 10.1007/s00251-007-0196-8. RX PUBMED; 17345114. RA von Salome J., Gyllensten U., Bergstrom T.F.; RT "Full-length sequence analysis of the HLA-DRB1 locus suggests a recent RT origin of alleles"; RL Immunogenetics 59(4):261-271(2007). XX DR Ensembl-Gn; ENSG00000196126; homo_sapiens. DR Ensembl-Tr; ENST00000360004; homo_sapiens. DR EuropePMC; PMC2442840; 18534008. XX FH Key Location/Qualifiers FH FT source 1..10278 FT /organism="Homo sapiens" FT /chromosome="6" FT /map="6p21.3" FT /serotype="HLA-DRB1*010101" FT /mol_type="genomic DNA" FT /country="Sweden" FT /db_xref="taxon:9606" FT CDS join(1..100,5373..5642,7872..8153,8855..8965,9453..9476, FT 10265..10278) FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /product="MHC class II antigen" FT /db_xref="GOA:P04229" FT /db_xref="HGNC:HGNC:4948" FT /db_xref="InterPro:IPR000353" FT /db_xref="InterPro:IPR003006" FT /db_xref="InterPro:IPR003597" FT /db_xref="InterPro:IPR007110" FT /db_xref="InterPro:IPR011162" FT /db_xref="InterPro:IPR013783" FT /db_xref="InterPro:IPR014745" FT /db_xref="PDB:1AQD" FT /db_xref="PDB:1DLH" FT /db_xref="PDB:1FYT" FT /db_xref="PDB:1HXY" FT /db_xref="PDB:1JWM" FT /db_xref="PDB:1JWS" FT /db_xref="PDB:1JWU" FT /db_xref="PDB:1KG0" FT /db_xref="PDB:1KLG" FT /db_xref="PDB:1KLU" FT /db_xref="PDB:1LO5" FT /db_xref="PDB:1PYW" FT /db_xref="PDB:1R5I" FT /db_xref="PDB:1SEB" FT /db_xref="PDB:1SJE" FT /db_xref="PDB:1SJH" FT /db_xref="PDB:1T5W" FT /db_xref="PDB:1T5X" FT /db_xref="PDB:2FSE" FT /db_xref="PDB:2G9H" FT /db_xref="PDB:2IAM" FT /db_xref="PDB:2IAN" FT /db_xref="PDB:2ICW" FT /db_xref="PDB:2IPK" FT /db_xref="PDB:2OJE" FT /db_xref="PDB:2XN9" FT /db_xref="PDB:3L6F" FT /db_xref="PDB:3PDO" FT /db_xref="PDB:3PGC" FT /db_xref="PDB:3PGD" FT /db_xref="PDB:3QXA" FT /db_xref="PDB:3QXD" FT /db_xref="PDB:3S4S" FT /db_xref="PDB:3S5L" FT /db_xref="PDB:4AEN" FT /db_xref="PDB:4AH2" FT /db_xref="PDB:4E41" FT /db_xref="PDB:4FQX" FT /db_xref="PDB:4GBX" FT /db_xref="UniProtKB/Swiss-Prot:P04229" FT /protein_id="CAL99240.1" FT /translation="MVCLKLPGGSCMTALTVTLMVLSSPLALAGDTRPRFLWQLKFECH FT FFNGTERVRLLERCIYNQEESVRFDSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAV FT DTYCRHNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRN FT GQEEKAGVVSTGLIXNGXWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSE FT SAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPRGFLS" FT exon 1..100 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=1 FT intron 101..5372 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=1 FT exon 5373..5642 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=2 FT intron 5643..7871 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=2 FT exon 7872..8153 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=3 FT intron 8154..8854 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=3 FT exon 8855..8965 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=4 FT intron 8966..9452 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=4 FT exon 9453..9476 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=5 FT intron 9477..10264 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=5 FT exon 10265..10278 FT /gene="HLA-DRB1" FT /allele="HLA-DRB1*010101" FT /number=6 XX SQ Sequence 10278 BP; 2733 A; 2013 C; 2482 G; 3032 T; 18 other; atggtgtgtc tgaagctccc tggaggctcc tgcatgacag cgctgacagt gacactgatg 60 gtgctgagct ccccactggc tttggctggg gacacccgac gtaagtgcac attgcgggtg 120 ctgagctact atggggtggg gaaaataggg agttttgtta acattgtgcc caggccatgt 180 cccttaagaa attgtgacgt tttcttcaga gattgcccat ctttatcatt ggatcccaaa 240 ttatttcctc cataaaagga gcttgggtac ttgccctctt catgagactt gtgtaagggg 300 cctttgcaca agtcatttct tttcaaatct ccaccaataa aacctttgca tcacatgtcc 360 tcagggtctt tagaggattt agaaataagg attctaaaat aaattcccca tacagcactt 420 ccctttatta tgttgactta tgtcagacaa aaggaggttc ttactgaaaa ttttgtggga 480 gtcaagggaa ttcaaagggt ctctcctaga cgatccagtg ttaggttccc cacaggacct 540 ttggtgttgg ccatagtcct catatgtgag gatggaccca gtggcctccc cattatctcc 600 tttcttttct tgctgaactc caatgtttat aaggcctgta tccctgtagc gtatgtaggt 660 tctctgacag aagttatact tagtgctctt cctttcttgt ggggaaaagt ccctggaact 720 gaagctgaga ttgttagtac ttggagtcac cttacagata cagagcattt atgaggtatt 780 ctttggtgcc taaagaactt aaggcatcct ctgaaaaact agcccaggtt cgtgttcatt 840 atgaatcttt tttaaccttt ctgtacttgt ttctcttgca tctcctatgt gcnctaacta 900 gacatgacag aagagattta actaatgtat aaattatatg aaattctatt ttttnagtca 960 aaaataatca actatcagaa atttaataat gttcaaacta tatactctgt gtggggttac 1020 cgagatgatg tgaacattgt tcacgtctca tagggctgaa agtcaatggg caagtcttgg 1080 gaactcattg tcttactggg gtcttgtcct aaatttccta ggttcaccca tcatgccctc 1140 agctttcctt aactagccat gtctgcttac ctcttcctcc agtttctatt tttccccagc 1200 tatgttgtca tcatttccag aaatctctaa agcttgcaca gaaccttagc actatgcgat 1260 tcattgaaag agactttttt tctctttttg aggtagggcc tggctctgtc acccagtcta 1320 tagctcagtg gtgtgatcga ggctcactgc aacctctgcc acccatgctc aagtgatcct 1380 ccctcctcag gctccagagt agctgggaat acaggcaggc aaccacgccc agctaatttt 1440 tgtaattttg gtagacatga gattttgcca tgttgcccag gctggtctta aactgctggt 1500 ttcaagcaat cctcctgcct tggcctccca acatgctagg attatagatg tgagccactg 1560 tgcccaggca aaaagaaatg actcttaata aaaaaatntc ctttttctta aatcactgtt 1620 tctttatctg tgaattcttc ttccaactag aaggaggaga aaaaagaagt ttgcctgtat 1680 ttctcaccag gaggagaagg ggtctagtgt gacattaaaa tgaaagggtg ctggagcttg 1740 agcccctnct tgctttccag gatccctaca gtgatcagtt cccataccct ggtttattca 1800 tgtaaaccac acttattttt ctcagcagct actctttact gggctccatt ctaggttcaa 1860 atcattctat ttgattaagt tagagagcgt ccctactctc atggaagtta cacaagagta 1920 gaggagacag acactaaccc aataagcatt taacaaagaa gataatgtta gagagtcata 1980 gtgcactgaa gaaaagacat caggtttgtg aaaaagagag acatggattc acctacttta 2040 gttcatatgt tagggagctc cacctgagaa agtgacatnc agctgagaca acaaaataag 2100 tagacagtcg tgaagatcta agggatgaaa gttccaggga gaccaaatgg cgggaaagcc 2160 ctggtgtggg aaactatgtg gagggagaga aagaaagcta gaggggctga agtatagaaa 2220 gcaacgaaat ggagaggcag aagatgaggt aggacacaga gaggaagtca ggagcctcat 2280 cattataggc tctgatgtcc acggtaaaaa aaatttgaat tttattattt atttacctat 2340 ttatttgttt atttatttta ttttattttg tgatggagtc tctctctgtt gcccaggcta 2400 gatggcagtg gcacaatctc ggctcactgc aacctccgcc tcctgggttc aagcaattct 2460 cctgcctcag cctcccaatt agctggggcc acaggtgcat gccaccacac ctggctaatt 2520 ttttgtattt ttagtaggga taggatttca ccgtgttagc caggatggtc tcgatctcct 2580 gacctcgtga tccgcccgcc ttggcctccc aaagtgctgg gattataggc gtgagccact 2640 gcacccggcc tatattcaat ttttaaaact aattctagct actctgtggg gattggattg 2700 ttggggttca cnagtggtta ggaagactat ttaggagcac agcagggaat tctccaggga 2760 aaacaagctt gtggcttcat ggagtgcatt agtgataaag acggtgaaga agataaagtg 2820 gacagactcg gcatgtattt ttgcttagct tgttaatgaa ttactgtaaa gggggtagag 2880 cttattccta aggattttct tttgacaaat aagtgggtgg tagtgttgtt tattgagata 2940 ggaaaaacta tgggaggaaa tgatttgaag tgggtggttt gaaataaaag ttttgtttaa 3000 atatgagatg attgactgac atttatgtgg agcaatcaga aggtcaatgg catttaagag 3060 actcatggtg aggctagggc ttcaggtatt tatgttggag gcatcaatac gtgtagtgtg 3120 ttaaattcca gggagtggaa gaggatacat agggagatgg attgtgtgga gaaacaagaa 3180 gagggcacag gccagcaaag ggggctgaga aagagcccag ggatgttgga gaaaaaccaa 3240 gagaacatca tgtatgtaag tcaaggaaaa cagatttttt tcaaggagaa gggagaggcc 3300 aattgtggtg agtaccacta agaggagggg gaagtgagaa tatgacagag aagcaagtgc 3360 tgggattggt ggagttgata tttgcagtca atggagtatc cagggaggaa actggattgg 3420 accatttgga gagcaaataa aagtgaggac gaggttaagg ttgactgttc tgtgtagaga 3480 gcttcaggga aggattgttc tctgggttca gggagccagc tgaacctaaa ggaaaaggct 3540 aaagaagctg aagagaagga ggaggacctg tgaaccagag atgctcagcc attattagca 3600 aggaaataca agagagcccc tgtgtgcagt ggtgactact catgcaaaat gtcacacagc 3660 caatatttaa cacagccagg atttcacaca gccaatattt attagtgaca tagaatatat 3720 ttgttattgc tctaggtcat gagaatggag tgacaaaatg aatccggtcg ccatcagtat 3780 atgccacata acattttgca gtgactgtgt gccaggccta tgaatttcag tattcaattt 3840 caataatgat cctgttgtat ctgtggtatt taaaaacata tacatctctg taatctaaaa 3900 ttgagaggtt ataagtaaaa cccagtatta caaatttagt gctggaaatt gattgcagtt 3960 taaatctgag catatagaaa gtccctttct tctatgtcag cagatgcctt ttgtgtgagg 4020 tttaggtata ctgcattatt agacataaac cagtgtttct gccctatgtt ttcagaatga 4080 caattcttta tgaaactaat agaagaacag aagacaattg caaaatcatg atgaagatac 4140 taattgcttt agaattaagg aatacaaata atgtgagctg cagttatagg gatcaaaaaa 4200 gttacaatgg gaatgtattt gagtgtttat tatgtgatca gtgctaagaa gtgtcatcat 4260 ttaattttac acttaacagt aatcctgtga ggattatgct attattaaat gcacttgata 4320 cattacaaaa aggcttatgg ttgatataaa ttgacccaag tagaagagat catgttttta 4380 ttcaggtttt ctgattctag agtttgagag tttgaccatc attagtgagt agtgactata 4440 ttgtgtctga attattgaca gaatttctga tattcatatg taccaggttg tttcttagag 4500 tgggagcaga gatgcaaggg ctgctagttc cgatgtgtag gagaaactat cattcatttt 4560 gcatttatca ttttaaacgt tctatatgtc tatcctgggc atgtgttgaa gaacacaagg 4620 aagtattaaa tcactccttc ttctgaagtt tgactggcaa aattgggcta gagttacgaa 4680 ataaaataca ggttcctagt gaaatctgaa tttcagatac acaaccataa tttattggaa 4740 atccaaattt aactggatat cttctattat tctctgttct agaactccac acttctaaca 4800 tttctcattc ctgtctaagc tcttgtgtgt ttggtttttg gccatcgctt tcactgctct 4860 ttaagctccc ccagtagagt ggagaggnct gttttccctc gtttggattc ctacaggcag 4920 cgcaggcctg gcacaaggtc atcactaagg aagtgttcac agggtgaagg cggtgggtgc 4980 tgttgaagga accggtaaag cctgtgggat gagagaagga gcagagagtg tttttggggt 5040 ggaggctccc aggaggaggc gggacgggct gcggtgctgg gcggatcctc ctccagctcc 5100 tgcttggagg tctccagaac aggctggagg cagggagggg gtcccaaaag cctggggatg 5160 agaaggggtt ttcccgcatg gtcccccagg cccccgttcg cctcaggaag acggaggatg 5220 agctcctggg ctgctggtgg tgggcgttgc gggtggggcc ggttaaggtt cccagtgccc 5280 gcaccctgcc cagggagccc cggatggtgg cgtcgctgtc agtgtcttct caggaggctg 5340 cccgtgtgac cggatccttc gtgtccccac agcacgtttc ttgtggcagc ttaagtttga 5400 atgtcatttc ttcaatggga cggagcgggt gcggttgctg gaaagatgca tctataacca 5460 agaggagtcc gtgcgcttcg acagcgacgt gggggagtac cgggcggtga cggagctggg 5520 gcggcctgat gccgagtact ggaacagcca gaaggacctc ctggagcaga ggcgggccgc 5580 ggtggacacc tactgcagac acaactacgg ggttggtgag agcttcacag tgcagcggcg 5640 aggtgagcgc ggcgcggggc ggggcctgag tccctgtaag cggagaatct gagtgtgtgt 5700 gtgtgtgtgt gtgtgtgtgt gtgtaagaaa gagagagagc gcgccatctg tgagcattta 5760 gaatcctctc aatccccagc aagcagttct gagagcacag gtgtgtgtgt agagtgtgga 5820 tttgtctggg tatgtctgtt gtgggagggg aggcaggagg gggctgattc ttatccttgg 5880 agacctctgt ggggaggtga caagggaggt gggtgctggg ggctggagag agaggagacc 5940 ttgattgtct cgggtcctta gagatgcggg gaagggaaat gtaaggggtg tgtgattggg 6000 gtgaaggttt aggggaggac tgctgagggg taaggaaggt ttgggataat gtgaggaggc 6060 cggttccaga ctctccctgg catacaccct tcgtgtaatc tctgaaataa aagtgtgtgc 6120 tgtttgtttg taaaagcatt agattaattt ctagaggaac tgagtagacc tctgaggcac 6180 tccngaagct tctttatatc taaatttctt gctagttttt tgggtttttt tagtgtgtat 6240 atttttacat agtagaaatg actgtgaaac taactttttg aattaaagtt ttaacacagt 6300 tactatttta ttataatgct agttttctag tagttacata ttattctttt atatataata 6360 gttatgacac aactcacctc actttcccct ttgttgacct ttattatgac attcaccaaa 6420 agttgaaaat gtatgtttct ggttaatttt taatttatat ttttnatttg taattgcttt 6480 gaattatttt gacctattta ttggcggatt ataattattg ctctaagaat tccctattgt 6540 atttggtagg caatggacaa tgatctatgg tctgatatct tgagggctta gtatttttct 6600 cagtgacttt gtgggttctt tgtgctataa gattattaac actttattga tatttgatcc 6660 agcatttgct tcagtttgtg gtttgtatgt ggattttgaa agttcttttc catgttaaga 6720 atttgaactt tttatttaat aaaatatatt gcaaaatttt tattaatgat ttacaatcca 6780 tcttaaatct gccattttgt ggcattgttg tctccaggtt cctccttact tctaaaaaaa 6840 atagttgtat ttattgagag tatgctagtg ttggggattt tcctgggcat aagcacccca 6900 agtaacaagt cccagacact gccttaatcc aaatgtgact ctggaaagaa aaatcatttt 6960 acaatgatag gcctaataat aattatgctt gtgttacacg ggagatgcat tgatcagcta 7020 aatgtaaata taagaacttt caaaactaaa atgacattcc ctaatccttt tctctgcttc 7080 gggactcatg cttttctagg aacgtaaaaa tttggagaat catttctgtc tgtcccacat 7140 tcccaggggc agaacaattt ctgttttgtt ctaaggtgtg agtgcatggc agtagtattc 7200 ctaaaattca tactcggttt cctcatgtac ccaattctgt ccctttatct atgcatattt 7260 ctttaaatca tatttttctg tcatggggta caaggatgat aaataggtgc caagtggagc 7320 acccaagtgt gatgagcgcc ctcacagtgg aatggagtga gaagctttct gaccttataa 7380 actgaaggct atcttcagtc attgttttat atattttaca tgcattaatc ctcatataac 7440 cccaagaggt aaattagtat aattatcctt cattgtaggt gacaaagttg agacacagaa 7500 gaatcaaaaa actcttccag gatcaaccag taaaaggcag accttggatt cgaaccaagc 7560 aacctggctc aaatatcagt tttaattact acactctata ctttccaaga tttgtaaaca 7620 gtttgacaat gcatgccaat ttaaagctat gaagaaacaa acacaatttt tcacaacacc 7680 tctcaaatct aatgggtcct cactgtcaag attaaattcc aggctgatga cactgtaagg 7740 tcacatggcc agctgtgcta taggcctggt caaggtcaga gcctgggttt gcagagaagc 7800 agacacacag ccaaaccagg agacttactc tgtcttcctg actcattctc tctacatttg 7860 ttttctccta gttgagccta aggtgactgt gtatccttca aagacccagc ccctgcagca 7920 ccacaacctc ctggtctgct ctgtgagtgg tttctatcca ggcagcattg aagtcaggtg 7980 gttccggaac ggccaggaag agaaggctgg ggtggtgtcc acaggcctga tccanaatgg 8040 agantggacc ttccagaccc tggtgatgct ggaaacagtt cctcggagtg gagaggttta 8100 cacctgccaa gtggagcacc caagtgtgac gagccctctc acagtggaat ggagtgagca 8160 gctttctgac ttcataaatt tctcacccac caagaagggg actgtgctaa tccctgagtg 8220 tcaggtttct cctctcccac acccnatttt catttgctcc atgttctcat ctccatcagc 8280 acaggtcact gggggtagcc ctgtaggtgt ttctagaaac acctgtacct cctggagaag 8340 cagtctcacc tgccaggcag gagagactgt ccctcttttg aacctcccca tgatttcgca 8400 ggtcagggtc acccactctc cccaggctcc aggccctgct tctgggtctg agactgagtt 8460 tctggtgctg ttgctctgag ttatttnttg tgatctggga agaggagaag tgtaggggcc 8520 tncctgacat gaggggantc caatctcagc nctgcctttt attagctctg tcactctaga 8580 caaactactt agcntcattg agtctcaggc tttctgttga tcagatgttg aacgcttgcc 8640 ttacatcaag gctgtaatat ttgaatgagt ttgatgtctg aacatcgtaa ctgttcagcg 8700 tgatttgaaa tccttttttt ctcctgaaat ggctagttat tttaattctt gtggggcagg 8760 cttctgcccc attttcaaag ctctgaatct tagagtctca attaaagagg ttcaatttgg 8820 aataagcatc actaaacctg gattcctctc tcaggagcac ggtctgaatc tgcacagagc 8880 aagatgctga gtggagtcgg gggcttcgtg ctgggcctgc tcttccttgg ggccgggctg 8940 ttcatctact tcaggaatca gaaaggtgag gagcctttgg gagctgactc tctccatagg 9000 cttttctgga ggaggaacca tggttttgct gagaggttag ttctcagtat acgagtggcc 9060 ctgaataaag cctttctttc cccaaacggc tctaatgtcc tgctaatcca gaaatcatca 9120 gtgcatggtt actatgtcaa agcataatag cttgtggcct gcagagacaa gaggaaggtt 9180 aacaagtagg ggtccttttg tttgagatcc tggagcaaat taaggaagag ccactaaggc 9240 taatggaatt acactggatc ctgtgacaga cacttcaggc ttcatgggtc acatggtctg 9300 tctctgctcc tttctgcccc tttctgccct ggttggtgcg ggttgtggtg ttagagaaat 9360 ctcaggtggg agatctgcgg ctgggacatt gtgttggagg acagatttgc ttccataaat 9420 tttaagtgta tatattttcc tctttttccc aggacactct ggacttcagc caagaggtaa 9480 taccttttaa tcctctttta gaaacagata cggtttccct agtgaggggt gaagccagct 9540 ggacttctgg gtcgggtagg gacttgcaga actttcctgt cttaggagag gtttctaaat 9600 gcaccaatca gtgctctgta aaaacacacc aattggcact ctgtggctag atagatgttt 9660 gtaaaatgga ctaatcagca ctctgtaaaa tggagcaatc cacactctgt aaaatggacc 9720 aaccaatgct ctttaaaatg gaccaatcag caggacatgg gcggggacaa ataagggaat 9780 acaagctggc caccccagcc agcagcagca acccgctcag gtcgccttcc atgctgtgga 9840 agctttgttc ttttgctctt cacaataaat cttgctgttg ctcactcttc gggtctgtgc 9900 cacctttaag agctgtaaca ctcactgtga agattcgcgg cttcattctt gaagtcagcg 9960 aaaccacgaa cccaccggaa ggaacaaact ctggacacac tagaattgat ggtagaggtg 10020 ataaagcatg agacagaaat aataggaaag actttggatc caaatttctg atcaggcaat 10080 ttacaccaaa actcctcctc tccacttaga aaaggcctgt gctctgtggg actattggct 10140 ctgggagact caggaacttg tttttcttct tcctgcagtg ctctcatntg agtccctgaa 10200 agagaggaaa agaaactgtt agtagagtca ggttgaaaac aacactctcc tctgtctttt 10260 gcaggattcc tgagctga 10278 // |
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