Dbfetch
ID AF532989; SV 1; linear; genomic DNA; STD; MUS; 21152 BP. XX AC AF532989; XX DT 10-SEP-2002 (Rel. 73, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 2) XX DE Mus musculus phosphoinositide 3 kinase P110delta (Pik3cd) gene, complete DE cds. XX KW . XX OS Mus musculus (house mouse) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. XX RN [1] RP 1-21152 RX PUBMED; 12130661. RA Okkenhaug K., Bilancio A., Farjot G., Priddle H., Sancho S., Peskett E., RA Pearce W., Meek S.E., Salpekar A., Waterfield M.D., Smith A.J., RA Vanhaesebroeck B.; RT "Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase RT mutant mice"; RL Science, e1252229 297(5583):1031-1034(2002). XX RN [2] RP 1-21152 RA Okkenhaug K., Vanhaesebroeck B.; RT ; RL Submitted (26-JUL-2002) to the INSDC. RL Cell Signalling, Ludwig Institute for Cancer Research, 91 Riding House RL Street, London W1W 7BS, UK XX DR MD5; 5003ac79009dd91b92f683ec4f0e08fa. DR Ensembl-Gn; ENSMUSG00000039936; mus_musculus. DR Ensembl-Gn; MGP_129S1SvImJ_G0029144; mus_musculus_129s1svimj. DR Ensembl-Gn; MGP_AJ_G0029109; mus_musculus_aj. DR Ensembl-Gn; MGP_AKRJ_G0029057; mus_musculus_akrj. DR Ensembl-Gn; MGP_BALBcJ_G0029125; mus_musculus_balbcj. DR Ensembl-Gn; MGP_C3HHeJ_G0028846; mus_musculus_c3hhej. DR Ensembl-Gn; MGP_C57BL6NJ_G0029574; mus_musculus_c57bl6nj. DR Ensembl-Gn; MGP_CASTEiJ_G0028259; mus_musculus_casteij. DR Ensembl-Gn; MGP_CBAJ_G0028808; mus_musculus_cbaj. DR Ensembl-Gn; MGP_DBA2J_G0028957; mus_musculus_dba2j. DR Ensembl-Gn; MGP_FVBNJ_G0028921; mus_musculus_fvbnj. DR Ensembl-Gn; MGP_LPJ_G0029047; mus_musculus_lpj. DR Ensembl-Gn; MGP_NODShiLtJ_G0028948; mus_musculus_nodshiltj. DR Ensembl-Gn; MGP_NZOHlLtJ_G0029606; mus_musculus_nzohlltj. DR Ensembl-Gn; MGP_PWKPhJ_G0027979; mus_musculus_pwkphj. DR Ensembl-Gn; MGP_WSBEiJ_G0028339; mus_musculus_wsbeij. DR Ensembl-Tr; ENSMUST00000105689; mus_musculus. DR Ensembl-Tr; MGP_129S1SvImJ_T0069360; mus_musculus_129s1svimj. DR Ensembl-Tr; MGP_AJ_T0069424; mus_musculus_aj. DR Ensembl-Tr; MGP_AKRJ_T0069331; mus_musculus_akrj. DR Ensembl-Tr; MGP_BALBcJ_T0069344; mus_musculus_balbcj. DR Ensembl-Tr; MGP_C3HHeJ_T0069001; mus_musculus_c3hhej. DR Ensembl-Tr; MGP_C57BL6NJ_T0069836; mus_musculus_c57bl6nj. DR Ensembl-Tr; MGP_CASTEiJ_T0069481; mus_musculus_casteij. DR Ensembl-Tr; MGP_CBAJ_T0068947; mus_musculus_cbaj. DR Ensembl-Tr; MGP_DBA2J_T0069085; mus_musculus_dba2j. DR Ensembl-Tr; MGP_FVBNJ_T0068986; mus_musculus_fvbnj. DR Ensembl-Tr; MGP_LPJ_T0069160; mus_musculus_lpj. DR Ensembl-Tr; MGP_NODShiLtJ_T0069005; mus_musculus_nodshiltj. DR Ensembl-Tr; MGP_NZOHlLtJ_T0070022; mus_musculus_nzohlltj. DR Ensembl-Tr; MGP_PWKPhJ_T0068963; mus_musculus_pwkphj. DR Ensembl-Tr; MGP_WSBEiJ_T0068167; mus_musculus_wsbeij. DR IMGT/LIGM; AF532989. XX FH Key Location/Qualifiers FH FT source 1..21152 FT /organism="Mus musculus" FT /chromosome="4" FT /strain="129P2/OlaHsd" FT /mol_type="genomic DNA" FT /cell_line="ES E14Tg2a" FT /db_xref="taxon:10090" FT mRNA join(<2257..2397,5307..5535,5615..5844,6391..6570, FT 6680..6829,7070..7159,8096..8318,8872..8967,9060..9190, FT 9962..10012,10092..10256,10344..10465,10633..10776, FT 10975..11074,11189..11367,11457..11569,11707..11785, FT 12108..12275,12851..12974,13213..13358,13706..13838, FT 14813..16427) FT /gene="Pik3cd" FT /product="phosphoinositide 3 kinase P110delta" FT CDS join(2257..2397,5307..5535,5615..5844,6391..6570, FT 6680..6829,7070..7159,8096..8318,8872..8967,9060..9190, FT 9962..10012,10092..10256,10344..10465,10633..10776, FT 10975..11074,11189..11367,11457..11569,11707..11785, FT 12108..12275,12851..12974,13213..13358,13706..13838, FT 14813..14950) FT /codon_start=1 FT /gene="Pik3cd" FT /product="phosphoinositide 3 kinase P110delta" FT /note="signalling" FT /db_xref="GOA:O35904" FT /db_xref="InterPro:IPR000341" FT /db_xref="InterPro:IPR000403" FT /db_xref="InterPro:IPR001263" FT /db_xref="InterPro:IPR002420" FT /db_xref="InterPro:IPR003113" FT /db_xref="InterPro:IPR008290" FT /db_xref="InterPro:IPR011009" FT /db_xref="InterPro:IPR015433" FT /db_xref="InterPro:IPR016024" FT /db_xref="InterPro:IPR018936" FT /db_xref="InterPro:IPR029071" FT /db_xref="InterPro:IPR035892" FT /db_xref="InterPro:IPR036940" FT /db_xref="InterPro:IPR037703" FT /db_xref="InterPro:IPR042236" FT /db_xref="MGI:MGI:1098211" FT /db_xref="PDB:2WXF" FT /db_xref="PDB:2WXG" FT /db_xref="PDB:2WXH" FT /db_xref="PDB:2WXI" FT /db_xref="PDB:2WXJ" FT /db_xref="PDB:2WXK" FT /db_xref="PDB:2WXL" FT /db_xref="PDB:2WXM" FT /db_xref="PDB:2WXN" FT /db_xref="PDB:2WXO" FT /db_xref="PDB:2WXP" FT /db_xref="PDB:2WXQ" FT /db_xref="PDB:2WXR" FT /db_xref="PDB:2X38" FT /db_xref="PDB:4AJW" FT /db_xref="PDB:4V0I" FT /db_xref="PDB:4XE0" FT /db_xref="PDB:5AE8" FT /db_xref="PDB:5AE9" FT /db_xref="PDB:5I4U" FT /db_xref="PDB:5I6U" FT /db_xref="PDB:5IS5" FT /db_xref="PDB:5L72" FT /db_xref="PDB:5NCY" FT /db_xref="PDB:5NCZ" FT /db_xref="PDB:5NGB" FT /db_xref="PDB:5O83" FT /db_xref="PDB:5T27" FT /db_xref="PDB:5T28" FT /db_xref="PDB:5T2B" FT /db_xref="PDB:5T2D" FT /db_xref="PDB:5T2G" FT /db_xref="PDB:5T2I" FT /db_xref="PDB:5T2L" FT /db_xref="PDB:5T2M" FT /db_xref="PDB:5T7F" FT /db_xref="PDB:5T8I" FT /db_xref="PDB:6DGT" FT /db_xref="PDB:6EZ6" FT /db_xref="PDB:6GY0" FT /db_xref="PDB:6MUL" FT /db_xref="PDB:6MUM" FT /db_xref="UniProtKB/Swiss-Prot:O35904" FT /protein_id="AAN05615.1" FT /translation="MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTI FT KQVLWHRAQYEPLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAR FT EGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWL FT QYSFPLQLEPSARGWRAGLLRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALR FT KKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSS FT ILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMK FT LVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVE FT KAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGT FT VRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEELQLREILERR FT GSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVL FT SALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGR FT ALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKAL FT NDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS FT KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPY FT GCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAI FT EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVP FT FILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELS FT CSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ" XX SQ Sequence 21152 BP; 4704 A; 5711 C; 5671 G; 5061 T; 5 other; gccaccagat gggtaaatgc agcttgtgac attccttttc acgggactga aagacaagaa 60 cacaaaacat ctgcttgcct cagacccaga cctttgggta gggttcctca gaagcccaag 120 cctgtattca tgtgaccgaa ggtacccctg aattcccaag cttggaaaga atgcattgta 180 gatgcaaccc tccagattcc tgcatattcc cntgcccgaa tnttaaatta aaaaaggaaa 240 actttggcct tagaaagagg aaccccaagt aggacgtggt ttcacagtca gaggaagtag 300 gtaccagcag ntactggggg tgggggcggn gagatgagag gtgggggcac aggaggcatg 360 cccggagcag ctgctgccca gtgagtcagg cccagcccag ttggtaccac caccaatagg 420 gacatctctc ataaccaaat atgtccattt aaatccagga gaatgtgacc ttgtggtagg 480 catggacatt ttctgttatg ttttggtgtt gggctccaat tcagagcctc aagcatgctg 540 agctgtcctt gagctacgca ccccaattca caagtctttt tgtctgtctg tctttctttc 600 tttcttttcc tcctcttttt tttttttttt tttgagatag ggtcttatgt agtcgaggct 660 ggtcttgaac ttgcaatgta gtagaagatg gcattgaact tctgatcctc ctgtctctgc 720 ctgctatgag cagggattac agatgtgcag agccgtaccc aatgtgttta tgtggtgttg 780 gcaagtgaat gcagaggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg gtaagtactc 840 taccaactga cccacacacc ctcagcctag aattctggtt ttttttaaag aattaaaata 900 gggcaggcac agtggtgcac tcctttaatc ccagcatttg ggaggttgag gtttcacaga 960 gtttgaggcc aacctggcct acatagtaga gactctattt caaaaacaaa accaaaaaac 1020 taatcaaaat aataaagcat aaagtagaca aatttgatta natgaacatt aaagcttctt 1080 tcagcactaa atgggaaatc ttgtgtcccc cccccccccg tctccccctc ctccaagtct 1140 gtgcagttgg gggagggggg gagggggagg gggggaggcg aaagcatgcg gaagcccaag 1200 gctggtgagg agggttgcaa gcaagtgatg ttttcttgat atgatgtggc tgttgcatcc 1260 agggactcac agaggcagta ggctccttgc aaaggaccta cctgcacaag cctgggtctg 1320 tgggtgtccc acagcttcgg ctctgaagag tcactaggca ggcaggtttt caaagctcac 1380 tgaaaatact aggaattgct catgaacgca cactagtaat aagagtatga aaacatgcct 1440 acagttgatt aagtggctag attccaggtt gcagtgacct ggaaggggga agctggtggc 1500 gacggggagg gatttggtga ctgggagtgt gggtggtgaa cacaccctgt gtcctgtgat 1560 ctgttatgtt ttgttattgc tgtggtgctg tggagggggc agggggtggc tgagggttgg 1620 catgaccgat atcgtaactc cttagataaa gtcatgtatt ctttctccgt gcgtgcgtgc 1680 gtgcgtgcgt gcgtgcgtgc gtgcgtgcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga 1740 gagagagaga gagagagaga gagatctcac ggtcatcaag ctggttttga acttactata 1800 taaccgaggc tggctttgct ctcctcctga tcagccccct tcacctccca actattggaa 1860 ttgtaagcag gtgccactgt gctgtggcca gctcgtcagc gctggtttta agctaattgg 1920 tctctggcca gaacattttt aagaactgaa gagttttatc tttggttttc aagcatctac 1980 ctgttcttgt ttcccactgt gggtcacctg tcggccacag tgcggtcttt tggcctatgg 2040 catgtccacc tgtaataaga agcacctcgg cctatagggt ggcttaaatt ggtgggagtc 2100 acaagccacc tagaggcagg atgctgcctc atgtgtagca agctttgcat gtcctcctgt 2160 ggcccagatc tggccgtccc attggccaaa gccttagttc atcatgcctt tgcctttccc 2220 acaggaaaac agacctcaga gaagtaacac aacaggatgc cccctggggt ggactgcccc 2280 atggagttct ggaccaaaga ggagagccag agcgtggttg ttgacttctt gctgcccaca 2340 ggggtctact tgaacttccc cgtgtcccgc aatgccaacc tcagcaccat caagcaggta 2400 gagccatggc cgcttctcac accttgatgc tcaggagaca ctgttcacag acacagaatt 2460 tcagggcaaa aactgtgtgt gggaactgac cagaggcagg cagccttggc tgccatttct 2520 caggagcagg gcaccttatt ttcctttccc cctcccctcc cctcccctcc ccctcccgtc 2580 cccctcctgt ctcctcctcc tcctcctcct cctcctcctc ctcctcctcc ttcttcttct 2640 tcttctctct ctctctctct ctctctctct ctctctctct ctctcgatat aggatctcac 2700 tggagtaggc tatactagct ggccagcaag tcaacctttc tccacctctt ccatactggg 2760 attgcaaaag agtgctatta tccccagcca cttgttttgt ttataattta cttattttta 2820 tttcatgcat ataggtatcc accatatgtg tgtctggtgt gcaacagggg ccacaatagg 2880 gctttgggtc ccctgaaacc agagttacag atggctttga gccaccatat tctgccgaga 2940 attgaacaga ggcagccagt gctcttaact gctgtgtcat ctgtccagtc ccctctgcct 3000 ctaaaatgtg gattccgagg aactgactct gtcctgatgc ttacaaagca catgtcctac 3060 ccgctgagcg cttaccctca gctcttaccc tcagccctta gatgtgaagt ctacaagata 3120 caatttctaa gaattgtctc aaaacctgtg gtttaaactc cacttatcat tccaaagtca 3180 gcttcccctt taacagtatg catttccctt tactagattg ctagattgcg agccagcttt 3240 ggggctgcct ctggctgggc tcgcatcccg ctcatgactg ggcggtcatt ttcggaacca 3300 ctctgtccac agagcaaggg ccttgcaagc caactcgtct ttagagttgt caccccggca 3360 gtaaacacca ttgttagaaa gaggtttggg gtttgctgaa tcattttcag ggtgatttac 3420 tgagtgagca tcgcacacat ctggatggca tttggtggtt tctgtctatg acttagacag 3480 ggctctgcaa cccactaagt gtgggatcta ctggattgtg ttttgagcgg gcgaaggatg 3540 agaccttacc tcggaatttt aaaagccata aatggaaata ggaaaaccaa ctgcaggaac 3600 aagaatcatc tttgtgccca ccctagattt cctttaatac tatttttttc ccactatgga 3660 agcaatatag actcactaaa atttaggaag ataagaaaaa ggcaattagg agtatagctc 3720 agtcagtaga gggcttgcct acaacacatg gctcgcctac aacacatggc tcacctacaa 3780 cacatggctt gcctacaaca catgctaccc tgggttctat acccagcaca tcataaactg 3840 ggtgtggcca tccacacatg gaatcctggc actgggagac tggagggtca ggagttctgg 3900 gtctcctaag ctacacagtg agttcaagga tattctgggc tcttgtctca aaaaaggaga 3960 ggaaggcagg ctggcgagat ggctcagcag gtaagggtgc ttccaagccc acaacctgag 4020 tgtgatcccc aaaaccaaca tggtagaagg agaaagccaa ctcctcagct gtccactgac 4080 ctctgcacgg gcaccagtag atatgtcctc cctctaccac aataagtcaa caagtgttga 4140 aaaacagaga aagaaggaaa accatttgtg attgggctac gtgagataat atagtcaata 4200 cctccactag ttcctggttt tggtttggtt tggtttggtt tggtttggtt ttttgagaca 4260 gggtttctct gtgtagccct ggctgtcctg gaagtcactt tgcagaccag gctggcctcg 4320 aaatcagaaa tccccctgcc tctgcttccc gagtgctggg attaaaggca tgggccacca 4380 cgcccggcgg ttttgttttt taataagaat ttttacattt atttattcac ctgtgtatgc 4440 cgtggcatgg tttggagatc aggggacaac ttggcggagt ctggcacccc cttctgtcgc 4500 ttagggatca agttcagatg gtcaggcttg gttacctgtg cgtgtgtacc tgctgggcca 4560 tcttgctggg gctcccagca catttcatac ctgcacttta gtctcgggat aaatctgacg 4620 gtgaactttt atgcctcctt tttttttttt tttaagaaaa aaaatttttt ttgaaaatgt 4680 gtatgagcac cttatctgca aatgtggtcc ggaaaagggt gtgactttca caagaaactc 4740 cagtttcagg gcatcttgag ctgccacgtg ggtgctagca gctgaagcca ggtcctctgc 4800 aagagcaaca tgtgctctga acctcagagc cgtccctcca gcccccctgt atctctcaga 4860 atggacaatg taacacttga tctcggctat aagctttata tagatatact ccatgttggt 4920 agttcatgcc tgtggtccca gcacttagga agcaggggca gaacaaagat gggtccagcc 4980 tggtctacaa agggagtaat gatagtggta cccatagtga tcatctggcg gggggggggg 5040 ggggggttca aaggtcacat atggccatcc ttctcggtag tcaaaggtca tccacaaact 5100 ccatagagga gataaagggc ccattgccct gcccccacaa tcgccccctg tctcagcaac 5160 gccccccccc ccacgatgaa ctgagggcag agacaggaag tttatcgaca tggctagtct 5220 tccggtgtgt gagcttttgt cttctcgggg tctccctctg cccctgtggg agccctgtaa 5280 gggctaactg tgaccctctc tcccaggtgc tgtggcaccg tgcacagtat gagccactct 5340 tccacatgct cagtgacccc gaggcctatg tgttcacctg tgtgaaccag acggcggagc 5400 agcaggagtt ggaggatgag cagcggaggc tgtgcgacat ccagcccttc ctgcccgtgc 5460 tgcgcctcgt ggcccgagag ggggaccgcg tgaagaagct cattaactcc cagatcagcc 5520 tcctcattgg caaaggtata cttaccggga gcaggaggct ggccccacgt gccttgacat 5580 tgtcctgatc tcttcctctc gtcccctcga aaaggtctcc atgagtttga ttccctgcgg 5640 gacccggaag taaacgactt ccgcactaag atgcgccagt tttgtgaaga ggctgctgct 5700 caccgccagc agctgggctg ggtggaatgg ctgcagtaca gcttccccct gcagctggag 5760 ccctcagcaa ggggttggcg ggccggctta ttgcgtgtca gcaaccgagc cctgctggtc 5820 aacgtgaagt tcgagggcag tgaggtgagc ccctccccca ttccttctcc cagtagcata 5880 tgagggcatc tgccaggtcc ctgtgcatgc caatgggctt agctaattgt ctcatcgggc 5940 aaatctggat ttatttttag tttactttat tctatgtgta tgaatgtttt gcttgtgtgt 6000 atgtaagtgt ctagtgtcta cagaagtcag aagaggatgt cagatcccgt agaactggag 6060 ttagagacgg ctgtgagcca ccatgtgggt gctgggaacc cacccaagtc ctctgcaagg 6120 gaagcaaaca atcagaaccg ccaatcatca ggcagatctg acactgcaga gtgcctccct 6180 ccctccctcc ctccctccct ccctccctcc ctccctccct ccctccctcc ctcccagtgt 6240 ttcctggatg ttggttgcat cccttgatta gcaaacacct agacatgact tggagatgcg 6300 gctatctctc ataggcagcc ttaccttacc tctgtgccct agaggcctct cggactgcag 6360 agcagaaggc tgacctcctt cttcctacag gagagcttca ccttccaggt atccaccaag 6420 gacatgcccc tggcactgat ggcctgtgcc ctccgaaaaa aggccacagt gttccggcag 6480 cctctggtgg agcagcctga ggaatatgcc ctgcaggtga acgggaggca cgaatacctc 6540 tacggcaact acccgctctg ccactttcag gtaagccttc ccgtctgccc gaatgtggtc 6600 ccgggaacat caagggaacc gacttaggga atgagcgggt gcccccccat cagcagctca 6660 cccagcccct ctcttccagt acatctgcag ctgcctacac agcgggctga cccctcatct 6720 gaccatggtc cactcctcct ccatccttgc tatgcgggat gagcagagca atcctgcccc 6780 ccaagtacag aaaccacgtg ccaaacctcc cccgatccct gccaagaagg tgaggtggtg 6840 tattcttggt ctgctgggat gaaagcagga gacccatggg ttcaggggcc tgtgattggg 6900 tgaccagggg cctgttggga tctgtgtgaa ctacagggca gcctccactg tcctcttgtg 6960 gctcttaggg gtattgggga cccttgtgca tgtgcacaac aggttttctg ataaaaagag 7020 gagaggtatc ttattctttg ccactcactc cgtctcccta cttccccagc cctcctctgt 7080 gtccctgtgg tccctggaac agccattctc cattgagctg atcgagggcc gaaaagtgaa 7140 tgctgacgag cggatgaagg tagggggctc cccggtcaga tgagggagcc actgttttct 7200 atacaaacaa ggtggctgtg gccaggaggg tggcaagcgg aaggagagtg ggaagatgtc 7260 acacgaaagc cacctgacca cattacccag cctccctgcc tggagtggtt gtaagctgct 7320 tcaaaacagg aagggggagt ggggtgggcc agccagccag agactgattc gtggaaaccc 7380 gggcagagca gatttctgtg tatttgactt tggtggaggt tgtggggatg aaagaggcat 7440 ccggggaggt gtgagaggtg caaggaagga gcctgctgca agctggtctg ggtatggctg 7500 cagcctggat gggtagctgc cttatcccct ggggtctgaa gacagtgggc gggagtgagg 7560 aggcacatgg taccctttgg tttctttaaa aacacttcca cacgcatcac atctgccttc 7620 caggtgcagg tgttattgtt ccatctgtgg aacaggaagc ccacagacag ttctggctaa 7680 attaactcca taactttaca aacttggagg gttgggtact tgggtatggg atgatgggta 7740 aggttcaaaa aagggcaggc agtcttaggt agagccaggg agttgtggaa ttaccatctt 7800 ctattgaaga aactgaggtc tggatgggaa ggggcatgcc ttgggctatc aatgcactgt 7860 ggcctcccct gccccatggc ttcttgtcct acttgactag tggctttccc tctaagaagc 7920 acacacacac acacacacac acacacacac acacacacac accacgagaa agtagattca 7980 gacccattta agaatgagga cacttgagga gaacattgtt gtgagtagcc tggtgagaag 8040 agagaaggga tggagcccgg ggcctctcct cccattaatt caccccgacc cccagctggt 8100 tgttcaggcc gggctcttcc atggcaatga gatgctgtgc aagactgtgt caagctcgga 8160 ggtgaatgta tgctcagagc ccgtgtggaa gcagcgactg gagttcgata tcagcgtctg 8220 tgacctcccg cgcatggctc gactctgttt tgctctctat gccgtcgtgg agaaggctaa 8280 gaaggcacgc tccacaaaga agaagtctaa gaaggcggtg agtattggct ggctggggag 8340 gagcctaggc ctcccttcag tgccccaagc cgcaggcagg caggcaggtt gaggacaggg 8400 gtcctggggg accctaaacc ccaagcttct ccaccatctt ggatccctac acactctagg 8460 gatagcctgt gaacggcctg cttgggctat ctgctctgga cctgtaggcc agtaggcttt 8520 tgtaggcagc tccctgggta gaaagtatcc tcagagggac taaagggcct gggccagcgg 8580 ctgtcttgag tggctgggcc cctagtcacc aattccagta tttaaagtgg ctctcactct 8640 cactctgccg atgcatactg ggtgtgagcc aggagccgag atgcagcctg ggctcgtttt 8700 gtcactaggg caaggcagtt ggtcctccct cttctcaaac agggtcttcc cttgagtcta 8760 tctgggagtc cacccttgaa gcccagatcc cctccccaat tggccttccc tccgaggtca 8820 gcaaatgggg cttttgtgcc tggccctaac ccgctggtgt ccttccccaa gactgcccca 8880 tcgcttgggc caacctcatg ctattcgact acaaagatca gctcaagacg ggggagcgct 8940 gcctctacat gtggccctct gtcccaggtg ggcccagccc caggggagca gctaacaggg 9000 ggtagaggtc cccaagcaag tgacttgaca cacaccgctg catctgtccc tgtgtccaga 9060 tgagaaggga gagctgctga atcctgcggg tacagtgcgc gggaacccca acacggagag 9120 tgccgctgcc ctggtcatct acctgcctga ggtggccccc caccctgtgt acttccccgc 9180 tctggagaag gtcagtgaag accctttcct tctagccccc tgggtctcaa tcctaatgct 9240 gcgacccttt agtacatgtg gtggtcaccc ccaccataga ttatttttat tgctacttca 9300 taaatgttat tttgctaatt tttttaagaa ttaaaagaaa aagatttatg tatatgagta 9360 cactgtatct gccttcagac acaccagaag aggcatcagc tcctattaca gatggttgtg 9420 agccaccatg tggttgctgg gaattgaact caggacctct ggaagagcag tgagtgctct 9480 taaccactga gccatctctc gagccccatt tgctattgtt acgaatcgtc atgtaaatac 9540 tctatatttt cagatggtct taggttaccc ctgtgaaagg tgtgttggac atcccccaga 9600 gggctcctga cccaggttga gagccatggt tctagacttt tcctagtcca gtgtttcagt 9660 tcttcagaga gttagaccct ggccaccctg ggattcgcct gctgctaggg taatgtcgtt 9720 ctgccaattc agggttttct aagagccctt tgagctgcca ttcggtaacg tttgatgtgg 9780 aaaggatgtt cctggtatgt tgtagcttca agctaggatg ctggtaaaga ctgtgcaaaa 9840 tacccaaaat acatcctcca gtgaggatga catgttaggt ctgaggtgta gcttcctgct 9900 ttggggcctg acagggactg ccctacgccc aggataagtg agagcctcat ccattctgca 9960 gatcctggag ctggggcgtc acggggagcg tgggcgcatc acggaggagg aggtgagctc 10020 cgtcttggaa tgggggagct gggattgggc gtggagcttg gaggcctcac cctgtctgcg 10080 cccctcagca gctgcagctg cgggagatcc tggaacggcg gggatccggg gaactgtacg 10140 aacatgagaa ggacctggtg tggaagatgc gccacgaagt ccaggagcat ttcccagagg 10200 cgctggcccg cctgctgctg gtcaccaagt ggaataaaca cgaggatgtg gcccaggtga 10260 gtagagaggg gggttcggga agacagcccc ggggcagatg gacagttccc gcccacccct 10320 acctgaccac caagctgtcc cagatgctct atttgctgtg ctcctggccc gagctgcctg 10380 tgctgagcgc cctggaactt ctggacttta gctttcccga ctgctacgtg ggctccttcg 10440 ccatcaagtc ccttcggaag ctgacgtgag tcccagctgg tgctacccct ggggcccaca 10500 gactccctgc tcttccggaa ggcagctttg ccccaagcat ttggaagtgg gtgctgggtt 10560 gggatgaatc tggcctctgc ctcttactct gccaccgccc agctgtagac caccgacttt 10620 ccttctcttc agggacgatg agctcttcca gtaccttctg cagctggtgc aagtgctcaa 10680 atatgagtcc tacctggact gcgagctgac caaattcttg ctgggccgag ccctggctaa 10740 ccgcaagatc ggacacttcc tgttctggca cctccggtag ttgaacacac aacagcctat 10800 tccttggaaa tcctatgagg gtcacgggga agtgagaact caggattctg agatcttgct 10860 gaactcctgt ttccagcagg ctcagatgtc ctgatgctct gggtcccacc taggctgcgg 10920 gcagggggtg tgagaccctg actggcaaga ctcagtacca ttttttcccc ccagctctga 10980 gatgcacgta ccatcagtgg ctctgcggtt tggtctcatc atggaagcct actgcagagg 11040 cagcacccac cacatgaagg tgctgatgaa gcaggtaagg cttggtcagt ttctgcttac 11100 aagctttaga aggctctcac tggaccatcc tcccacctgt ggctggcacc caccaccact 11160 tatcaccacc acccgttatc accaccaggg ggaagcactg agcaagctta aggcactgaa 11220 tgactttgtg aaggtgagct cccagaagac caccaagccc caaaccaagg agatgatgca 11280 tatgtgcatg cgccaggaga cctacatgga ggccctgtcc cacctgcagt ctccactcga 11340 ccccagcacc ctgctggagg aagtctggtg agccccatgc ctgacccacc agggctcctc 11400 ccaacctccc tgggcctgcg gaggagcccc tgtcgaccct actctctggc cagcagtgtg 11460 gagcagtgca ccttcatgga ctccaaaatg aaacccctgt ggatcatgta cagcagcgag 11520 gaggcgggca gtgctggcaa cgtgggcatc atctttaaga acggggatgg tgagcaggcg 11580 ggctagggag tctgcagagg cctaaccgtc cctgtgccat cctgaggggt ggtcctggga 11640 cctaagaacg gatacccagt gggagaagag aacccaccag acactggtct ccttcccaca 11700 ctgcagacct ccgccaggac atgctgactc tgcagatgat ccagctcatg gacgtcctgt 11760 ggaagcagga gggcctggac ctgaggttgg ggcccatcct gtaactgttg tgctctgggt 11820 cagcccttag agctgtgctt tggaagggga gccaaactat cctcctcgtg tgggtgggaa 11880 agggctgatc ccaggagagg cgagggtagg gagggcagcc aagcacttgt cttgttccct 11940 tctgtatttc ccggcccctt gtgtagagga agcagcagct tcccccaaac cctcatcttg 12000 ggtaccagga gcctccgagt ccttcctcct cctcctcagc cacttgagtg tggcatctcc 12060 aggaacagcc tttgatcgtg acgttctgct ggcctttctc tcactaggat gacgccctac 12120 ggctgcctcc ccaccgggga ccgcacaggt ctcatcgagg tggtcctcca ctcggacacc 12180 atcgccaaca tccagctgaa caaaagcaac atggcggcca cagctgcctt caacaaggac 12240 gccctgctca actggctcaa gtccaagaac cctgggtagg tttcaagcct tctcctcctg 12300 ggaggtgtga cgtgggaagg gttggcctat cagagacaag atgagaggga agggctgtga 12360 tcttctctga ctagttggct ctgctgtggg gccggcctga atctgagtca gcatagcggt 12420 tcttgtgtct cagttgccag tggttgtgtg tgataccact caaagcttcc gaccttagac 12480 atctgctgct gtgaatctcg ggatactata cgtgccttgc ttgggacaac tcaagtcatc 12540 tgggacttct cccaaacctg gagggtctaa gatggagtcc actgaatgcc cagagcctga 12600 agtcagctat acctctcttc ttggcctctg cttgtgcagg ccggtcctca gcctttcccc 12660 acggtgcgcc taggtggtgg ggataggctc cagatcagag aggtatttta ggcctaagct 12720 ctgggactat atactttaca tctgttgagt aaagcatgcc aaaaggctag actcagagaa 12780 agagaggcag acccccttct ggtaaagggt tgcagtctgg tgtgccatga cctccaatct 12840 tccccctcag ggaggccctg gatcgggcca ttgaggaatt caccctctcc tgtgctggct 12900 actgtgtggc cacatatgtg ctgggcatcg gtgaccggca cagtgacaac atcatgatca 12960 gagagagtgg gcaggtaggg gcgtgtggct gggtggcttt gctatagggc tgacgtcccg 13020 tctggcctgc tggccccttt gctctgggtt tggtggcccc gcgaacgctg tgagccctgc 13080 tggtgtcttc ttcgcctggg tctctcaagg ggcatggaag ctccctgttc tctgctttct 13140 cttcctccct gcggctcccg gggttggatc cctgctcact cgaggctaag ggctccactt 13200 cgtccccgtc agctcttcca cattgatttt ggccactttc tggggaactt caagaccaag 13260 tttggaatca accgagagcg cgtccccttc attctcacct acgactttgt ccacgtgatc 13320 cagcagggga agactaacaa cagtgagaag tttgaaaggt gagggctctg cccttgatta 13380 tctgtccggg atgccaggaa cgctgggttc aagaacgagg ctggagacgg tggtcggtcc 13440 tgctcccgcc ccctcccctg gatgttgatg gattgggatg agtgacctcc aaacctgttt 13500 ggcctccttg ggccatgggg gaggaggttt gtgtctccag caggaggcag agggaggtca 13560 tcttgaagaa ctagccaacg gtggataacc ttcaacaaca accttcagca acagctcggg 13620 gggggggggg tggggggggg aggtgggggt ggggtgggaa ggtgaacacc caggacctta 13680 cctgccccgc ctccctcacc tgcaggttcc gcggctactg tgaacgagcc tacaccatcc 13740 tgcggcgcca cgggctgctt ttcctccatc tcttcgccct gatgcgggcc gcaggtctgc 13800 ctgagcttag ctgctccaaa gatatccagt atctcaaggt aagtgtcccc gtgggggtcc 13860 cttctgctat gataaaagcc atcaaaagca gcgtgggcag aaaagggttt atttcaactt 13920 gtggtcgcag cagtcacatc atgaagaggg atcaagggca ggcattgaac cagaagcaat 13980 ggtttgttca gactaccttc ttttacaacc caggaccact tgcctagggg atggcaccac 14040 ccacagtggg ctgaaccctt ctttatcagt cactgatcca aaaaataaaa tgccccaagg 14100 gcttaactac aggcaatctg atgaaggcgt ttcctcagtt gaggaaattt cctttttccc 14160 agatgactcc agtttgtatc aagttggcag aaaaccacca acacagtagg tcaagccagg 14220 gccgagtcag ggctgacccc atggctgtat acttcctaca gcctgcctgg gaggtctgga 14280 tcctagtagg gccccttctg gtagactttc agcggtactg atggttgtgg ggtcctcatg 14340 gcatccttgt cctagcagtg ggcagggcca gagtggtcca gtttgctggg cctacttatg 14400 ctgggtggca gatacgtggt aaccttcctt agtcaatcca tgtgtccctc ataggtgtcc 14460 acgcacgcac gcacacacac acacacacac acacacacac acacacacgt acattcctgc 14520 tcagtctgtg tgagctaagg ttccttgcac attgtgtaaa tgctttcgtc ccacgtcctc 14580 catctgtgat aactggagca gagagtgaca ggccaccagc ctaaccaggg catcccctga 14640 aggtcacaat gacatgctaa ggcatctgac atttgagtca agtgggtgga ccatctgggt 14700 ttgggggtct gaatacagag agaatttagc atcctattgg gcttcattct ggattgcgta 14760 acagagagca aagtccctca gtgtcactct gctgtgtgtg gtgtttgtcc aggactctct 14820 ggcactgggg aagacggagg aagaggcgct aaagcacttc cgggtgaagt tcaacgaagc 14880 tctcagagaa agctggaaaa ccaaagtcaa ctggctggcg cacaatgtgt ccaaggataa 14940 ccgacagtag gaggcgcccc ctggtggtca tacggcggtt ccctcctggc tttcagccct 15000 agaggtaaaa ggacagtcct ggagaccagg catgtccagt ggtcaccaaa gggaccccag 15060 agcctgaact gtccctcatg gggaagaacc acaccactgc ttcttgttta cactggtaat 15120 ttatttatga ctcgaaatgt ttaaggaaca gaatagccat aaatggaagt gcatttctgt 15180 gcagggaggg tgatgtcctc atgatgtcat cccgggtcag cactgtaata gcaccttgag 15240 gatcgaaccc ctagtcttcc aacctgtggg tcttggccca gcaaggacag ttcttggggc 15300 cttcttccca ggctcccagc aggctgcctg gaacaagcct ggcggtcacc tggtgcctcc 15360 atcctcagct cacctccggc caccgttgtg tggcctaccc aaccaagcct ccggcagctc 15420 ttgaggaagc caggagcttc cctctagact caggcacact tgctcggcac tgctgaagcg 15480 acctcttggg tttgggtaca ggaatgccct cacctctcat ttgcgggtaa gaacacgata 15540 tgtagactct gtcccttacc ccgatggctg gggtaaggga cctggcctcc actacagtta 15600 gtgtattcca ggccttgaag cactcagacc ggtgccccat ttagctctgt gtggtcacga 15660 atcaagacga agggccagcc agaatggaag tcctcttcgc agttcatgtg aggggcacac 15720 aaggcagctt tatggacgga caggactgat ctcttccaga gctgaaatcg cagaaggcag 15780 ctggggagct aggctcgaca agtgtgagca aggacaagaa cggaattcag tgcagtctgg 15840 gcagtcagag gaactcgaga aacgcagtct cggcctcctc ccggggagcc aaacgccagc 15900 cacccgcccg gcttttagag agcccagctc aggggtcgca cgtgcttatc gtcccacccc 15960 aagcacatct ccatgtatca gctgccacct caggacctgg atctcccggt agcattctga 16020 gactttgaga accatcaccg ctgtctcgcc agcagcccag aacatggctc aaggagcccc 16080 ttcatgttga tgagcccagg gtccagcagt gagcggtggt gcctccgcag cacccgctga 16140 acccctagtc tgccccacca actctgaaat aggaaacgtg tctgtgtgtg tgtatgtatg 16200 tatgccatgt tatttattga aaagagtcta ggtgctctct ggtgtggctg cagattctgc 16260 acaggctcgg cctttctggg ttgggtgtgt ggcctgtgta cttggctgga agacgggttt 16320 tttgttaagt tttttcctct cactgatggg ggctgagacc agtttgtgca accttgacac 16380 aacaggtaaa gacaggtgaa aagaaataaa aacgttttta tgttcttaag ttcttggctc 16440 aaataacaag gggacttggg gggatacagt gtactggttg agcccttgtc tgcgaagtgc 16500 aaagcctcgg gtacattcct tagtaccata aaaattaata atccttgccc ggcatggtgg 16560 acatctgtaa tcccagcact gagcaggcag aggcaggagg attgctttaa gtttgagccc 16620 agcctatctt cataaatccc tcaacccctg ccccaacccg tacccaacaa acatgaaaga 16680 atggacccca ctcaggctgg agttagaacc agaactttat tataacgcat acactttctg 16740 acctatgtcg atatacacat cttaaagggg aaccctgcgg ctactgacac gacaggccct 16800 ttctccgtta gcctgttcca tctaagaaag cagctacagg gacaggacat gggagggcgg 16860 ccacagacag cacggcggcg aggactggga tgtcccagct ggagcagtct aaactcttga 16920 ctgtgaatga agagctgtgc tgtgtgggtg gtacctgctg tctcctatct gctgggtctt 16980 agatcttagc ccaaacccaa cagcacgcgg catcccatgg ggcctctggg gaggagagaa 17040 aagattgttc tggagcattg tagcagtttg tctttgggcc tcgggggtct ccttttggtg 17100 ctgttgtgca gacttgctca gaatcgtggt cttccaagca aggagctgac cgcctgcacc 17160 tttgctgtcc gttcccagct acaccatttc accaacaggg agactcacgt taataagcag 17220 aaaccacgtg gctgccagtc acaggcgtgt acaggaaagg ccagggcttt ggcaacatcc 17280 tggctgttcc cagcctctaa tgtggttgga ggcgcgtggg gctgcccccc ccccccagac 17340 agcacttgaa agccatggcc ccggccacgt ggctgtacgg aaaccctagc aagggtgggc 17400 cccagtgact tgggcctctc caacctggtt tcttgggagg gaagagggag gaagaggtcc 17460 tcctggcccc gcattctgac tttacattcc tgtcctggac tactagcaca gaggacacac 17520 agaatcccaa tttatttaca aaatattaaa aagtcggttg gccatctaca tattaacccc 17580 ctctgctctc ccactttata catgcactag tttgggaaaa aaaaataaaa aaacttttaa 17640 aaataaagaa gagaaatggt tactgactgc gtgggagtaa tttttcaccc tctgtcgaca 17700 agtccgctca gtgcggcttc tctggaggtc ccaggtgctg gtgtcctctc cctggccaac 17760 aggggctcca gacacacttg gggtctgagg tgctgtgggg cccctgccct ggggaggaag 17820 cgccagcttc tagcaaaact gcaatggtga tgggcgggga gggtggagcc ggtggtccca 17880 cacaccaagc acgggaggac tttgagcagt gggggaaggg tctgcagacc tgctggtcaa 17940 aatgattttg tacatcgtgg acccgtgggg ctgggagaga gtctggagag caggcgctga 18000 gtgcgggttt agtagctgag tgtggagtca tcccattcca gctgtcgggt ggcattctgg 18060 ccgtccccgg ggcctccttc ctcctcctca ctgctctcag actcggcact ggtgatgtct 18120 tcctcttcct ccccatcttc gctctcctcc tcctcctcct cctcttcctc ctcctcactg 18180 ctgtgctggt cctcatacgt ctggcaaaga gacgacggcg taaatctagc ctgtggcccc 18240 atcgcccagt gtctatctac taaaagccac aaaggaaaac acagccaacc ccacagtgac 18300 agaagggcct gagtggtact gggagtcgcc tcgccaaagt gacccggcag gtgacgctct 18360 cattagcaac atggatacca ctcacatggg atggggtgct caatgcagag gggcggagct 18420 tagtcctgtc ataccacgga catcttgggg taaagaagcc aagagcgtca gttgcctgcc 18480 tatgctactc acggaggcct tcagcaaggg cttcctcatc tgaaggtgac ccccctaatc 18540 taatctcact gacccaacct gcaagcacgt gaccagggtc tgggtctccg tggcgctttg 18600 tggttggccc ttctgtgcct acctccatgg ggttgacggt gatggtcaag gcagagtcat 18660 cccagtccat ctcattctcc ttccccgtgt cctggtcccg catcgttcgc tgatgtgcag 18720 cccggatccg aaacaccccc aggatgatca tgaaaaccag gaagctgaca cacaccacaa 18780 tcaccactgt cgccgtgctg gggataactg ccatggggtt tgaagaccag acacacagct 18840 tttgtgatgc tgcttacacc caaagagctc cccccatccc atccctcctt ggcctcctca 18900 actactctag gtaggtcaaa tggaatgtgt cagagtgctt cctgactcct aaaccctagg 18960 aggaagccct aagcctgcct tcgctcactg gctgctctgt ggcagtggtg agcgagcttc 19020 cttgtgtaag tgacagcatt ggggtagttg atgggcagta gttgtgagct acgcttgcta 19080 ccaggtttgt gtgtatgtgt gtgtgtgtgt gtgtgtgtgt ctgtctgtct gtctgtctat 19140 ccatctggac cctacatacc acagcatcct gacccacgtt ctttcccccg tcctacctgc 19200 aaacgggtga ggattggcca ggttgtgacc agacaggtcc acaaaggatc gatgttcagg 19260 gtggacgaac tgtggctggg cagccatgtg gttggcatgt tccacggggt tggctgtgtg 19320 gatcacattc acctacagca gagagagtgt cactaggcac cccaagtgta cctgacaggt 19380 gaatagacgg tcggcagtgc tgcttcccag tctcccagct ccaggctggg ggcaaacagt 19440 gaccagaaaa acatcacctg tttacaacag tgtgacagtg tcacatatcc cagaaacagt 19500 gtgtccgatg gctcatttgt aatgtagctt acaaaagaag gcattcacat cagagtagga 19560 agccaccctg gccttaggcg acagctcaga tcacctcttc ccattcttct caccagccac 19620 cctttggctc gagtacattt agtctcctcc gcccaccact tggatcaagg tggagatggc 19680 gggcgggttg ctcagaattt atttcttcag acctcggagg cgctggccca tgaagtcagc 19740 tgcggcagag gccactgaag gtgtcagggc agagtgtact gtcctttagc tgctgtggcc 19800 tcagagtgac tgtggcagtg ttggcactca acaacccggg acccaaatgt ccctgtcaac 19860 ggggccggtg gtctgacaca gccaccaaga ccacttggtt tcctgggggc tcgttcacag 19920 acactctgtc gtcacactcc aactctgctc ctcaaggcct gtatgtctac cctgtggaca 19980 cagccagcca gccctgctct gagcctaaat aagtcgccgc catgaacatc tgaaaccttg 20040 ggagcccgag tcaggacatc tgattactta atgttcgccc tttgcggtgg gcgccctgga 20100 ctcacctcca ccttgaactc attgctgagg tagcgaccat ttagttctga gcaaatgagc 20160 ttgaacttgc gatccagcag ggactggtgt gccaattccg atagcgaagg aggtgcaaaa 20220 cctcctcgta gcttgccatg gtctccacgc ttgtagggtg ttgagggtga gcagcttaag 20280 tctggagccc aggtgggccc ttgggtcagc caagctgagg gctacaactc tgtgactttc 20340 agagtcaggg aactaaagca aagcaagcag gcatttctcc atctggggca tgagctgttt 20400 gttatgtgcc cagccccacc ctgcacaaag cactgcccgt gccccctcca tgtgcagaag 20460 ggtgccagtg tgaggcggat gcaccagtgc gcatttgtag gcaatgggca ggccgaagcc 20520 ttcccctcac ctgtgaagac cacacccagg tcagagtggc ttgcttcgat gcccttctgc 20580 tggaggcggg tcacgtctac ctccaggctc tcctgctctg cgttcagctc atccccttcc 20640 actgtgacct cacaggtgtc caggtcatgc acaatttcct ctgacaccag ggattcttgc 20700 ctgcaaaaaa aaaaaaagag agagaccaga aatagcagag gctgcaggtg acataaatac 20760 cccacccacc caccccccac ccccacccca cccacccacc gtgctgccac atttcaaaac 20820 cacagtcaag tgtaaggacc aagcatggga gagtcatctt caagacttgg gggctgagag 20880 tgtagtcagt ggtagagtat atgattagca tgttgaaggc ccaggcccag tcccagctca 20940 gtcaataaat atcacttagt aagttcccgg taagaatgga gggatacttc ctttgagctg 21000 gccctcaagc taaatcttaa aacccaacac cagctacagc caagttccag acacagactc 21060 aagtgttaaa acattaaaac ctccaaaacc agccgagcag tggtggcgca cgcctttaat 21120 cccagcactt gggaggcaga ggcaggtgga tc 21152 //