Dbfetch

ID   AF532989; SV 1; linear; genomic DNA; STD; MUS; 21152 BP.
XX
AC   AF532989;
XX
DT   10-SEP-2002 (Rel. 73, Created)
DT   15-APR-2005 (Rel. 83, Last updated, Version 2)
XX
DE   Mus musculus phosphoinositide 3 kinase P110delta (Pik3cd) gene, complete
DE   cds.
XX
KW   .
XX
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea;
OC   Muridae; Murinae; Mus; Mus.
XX
RN   [1]
RP   1-21152
RX   PUBMED; 12130661.
RA   Okkenhaug K., Bilancio A., Farjot G., Priddle H., Sancho S., Peskett E.,
RA   Pearce W., Meek S.E., Salpekar A., Waterfield M.D., Smith A.J.,
RA   Vanhaesebroeck B.;
RT   "Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase
RT   mutant mice";
RL   Science, e1252229 297(5583):1031-1034(2002).
XX
RN   [2]
RP   1-21152
RA   Okkenhaug K., Vanhaesebroeck B.;
RT   ;
RL   Submitted (26-JUL-2002) to the INSDC.
RL   Cell Signalling, Ludwig Institute for Cancer Research, 91 Riding House
RL   Street, London W1W 7BS, UK
XX
DR   MD5; 5003ac79009dd91b92f683ec4f0e08fa.
DR   Ensembl-Gn; ENSMUSG00000039936; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000105689; mus_musculus.
DR   IMGT/LIGM; AF532989.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..21152
FT                   /organism="Mus musculus"
FT                   /chromosome="4"
FT                   /strain="129P2/OlaHsd"
FT                   /mol_type="genomic DNA"
FT                   /cell_line="ES E14Tg2a"
FT                   /db_xref="taxon:10090"
FT   mRNA            join(<2257..2397,5307..5535,5615..5844,6391..6570,
FT                   6680..6829,7070..7159,8096..8318,8872..8967,9060..9190,
FT                   9962..10012,10092..10256,10344..10465,10633..10776,
FT                   10975..11074,11189..11367,11457..11569,11707..11785,
FT                   12108..12275,12851..12974,13213..13358,13706..13838,
FT                   14813..16427)
FT                   /gene="Pik3cd"
FT                   /product="phosphoinositide 3 kinase P110delta"
FT   CDS             join(2257..2397,5307..5535,5615..5844,6391..6570,
FT                   6680..6829,7070..7159,8096..8318,8872..8967,9060..9190,
FT                   9962..10012,10092..10256,10344..10465,10633..10776,
FT                   10975..11074,11189..11367,11457..11569,11707..11785,
FT                   12108..12275,12851..12974,13213..13358,13706..13838,
FT                   14813..14950)
FT                   /codon_start=1
FT                   /gene="Pik3cd"
FT                   /product="phosphoinositide 3 kinase P110delta"
FT                   /note="signalling"
FT                   /db_xref="GOA:O35904"
FT                   /db_xref="InterPro:IPR000008"
FT                   /db_xref="InterPro:IPR000341"
FT                   /db_xref="InterPro:IPR000403"
FT                   /db_xref="InterPro:IPR001263"
FT                   /db_xref="InterPro:IPR002420"
FT                   /db_xref="InterPro:IPR003113"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR015433"
FT                   /db_xref="InterPro:IPR016024"
FT                   /db_xref="InterPro:IPR018936"
FT                   /db_xref="InterPro:IPR029071"
FT                   /db_xref="MGI:MGI:1098211"
FT                   /db_xref="PDB:2WXF"
FT                   /db_xref="PDB:2WXG"
FT                   /db_xref="PDB:2WXH"
FT                   /db_xref="PDB:2WXI"
FT                   /db_xref="PDB:2WXJ"
FT                   /db_xref="PDB:2WXK"
FT                   /db_xref="PDB:2WXL"
FT                   /db_xref="PDB:2WXM"
FT                   /db_xref="PDB:2WXN"
FT                   /db_xref="PDB:2WXO"
FT                   /db_xref="PDB:2WXP"
FT                   /db_xref="PDB:2WXQ"
FT                   /db_xref="PDB:2WXR"
FT                   /db_xref="PDB:2X38"
FT                   /db_xref="PDB:4AJW"
FT                   /db_xref="PDB:4V0I"
FT                   /db_xref="PDB:4XE0"
FT                   /db_xref="PDB:5AE8"
FT                   /db_xref="PDB:5AE9"
FT                   /db_xref="UniProtKB/Swiss-Prot:O35904"
FT                   /protein_id="AAN05615.1"
FT                   /translation="MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTI
FT                   KQVLWHRAQYEPLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAR
FT                   EGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWL
FT                   QYSFPLQLEPSARGWRAGLLRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALR
FT                   KKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSS
FT                   ILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMK
FT                   LVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVE
FT                   KAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGT
FT                   VRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEELQLREILERR
FT                   GSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVL
FT                   SALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGR
FT                   ALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKAL
FT                   NDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDS
FT                   KMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPY
FT                   GCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAI
FT                   EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVP
FT                   FILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELS
FT                   CSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ"
XX
SQ   Sequence 21152 BP; 4704 A; 5711 C; 5671 G; 5061 T; 5 other;
     gccaccagat gggtaaatgc agcttgtgac attccttttc acgggactga aagacaagaa        60
     cacaaaacat ctgcttgcct cagacccaga cctttgggta gggttcctca gaagcccaag       120
     cctgtattca tgtgaccgaa ggtacccctg aattcccaag cttggaaaga atgcattgta       180
     gatgcaaccc tccagattcc tgcatattcc cntgcccgaa tnttaaatta aaaaaggaaa       240
     actttggcct tagaaagagg aaccccaagt aggacgtggt ttcacagtca gaggaagtag       300
     gtaccagcag ntactggggg tgggggcggn gagatgagag gtgggggcac aggaggcatg       360
     cccggagcag ctgctgccca gtgagtcagg cccagcccag ttggtaccac caccaatagg       420
     gacatctctc ataaccaaat atgtccattt aaatccagga gaatgtgacc ttgtggtagg       480
     catggacatt ttctgttatg ttttggtgtt gggctccaat tcagagcctc aagcatgctg       540
     agctgtcctt gagctacgca ccccaattca caagtctttt tgtctgtctg tctttctttc       600
     tttcttttcc tcctcttttt tttttttttt tttgagatag ggtcttatgt agtcgaggct       660
     ggtcttgaac ttgcaatgta gtagaagatg gcattgaact tctgatcctc ctgtctctgc       720
     ctgctatgag cagggattac agatgtgcag agccgtaccc aatgtgttta tgtggtgttg       780
     gcaagtgaat gcagaggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg gtaagtactc       840
     taccaactga cccacacacc ctcagcctag aattctggtt ttttttaaag aattaaaata       900
     gggcaggcac agtggtgcac tcctttaatc ccagcatttg ggaggttgag gtttcacaga       960
     gtttgaggcc aacctggcct acatagtaga gactctattt caaaaacaaa accaaaaaac      1020
     taatcaaaat aataaagcat aaagtagaca aatttgatta natgaacatt aaagcttctt      1080
     tcagcactaa atgggaaatc ttgtgtcccc cccccccccg tctccccctc ctccaagtct      1140
     gtgcagttgg gggagggggg gagggggagg gggggaggcg aaagcatgcg gaagcccaag      1200
     gctggtgagg agggttgcaa gcaagtgatg ttttcttgat atgatgtggc tgttgcatcc      1260
     agggactcac agaggcagta ggctccttgc aaaggaccta cctgcacaag cctgggtctg      1320
     tgggtgtccc acagcttcgg ctctgaagag tcactaggca ggcaggtttt caaagctcac      1380
     tgaaaatact aggaattgct catgaacgca cactagtaat aagagtatga aaacatgcct      1440
     acagttgatt aagtggctag attccaggtt gcagtgacct ggaaggggga agctggtggc      1500
     gacggggagg gatttggtga ctgggagtgt gggtggtgaa cacaccctgt gtcctgtgat      1560
     ctgttatgtt ttgttattgc tgtggtgctg tggagggggc agggggtggc tgagggttgg      1620
     catgaccgat atcgtaactc cttagataaa gtcatgtatt ctttctccgt gcgtgcgtgc      1680
     gtgcgtgcgt gcgtgcgtgc gtgcgtgcgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga      1740
     gagagagaga gagagagaga gagatctcac ggtcatcaag ctggttttga acttactata      1800
     taaccgaggc tggctttgct ctcctcctga tcagccccct tcacctccca actattggaa      1860
     ttgtaagcag gtgccactgt gctgtggcca gctcgtcagc gctggtttta agctaattgg      1920
     tctctggcca gaacattttt aagaactgaa gagttttatc tttggttttc aagcatctac      1980
     ctgttcttgt ttcccactgt gggtcacctg tcggccacag tgcggtcttt tggcctatgg      2040
     catgtccacc tgtaataaga agcacctcgg cctatagggt ggcttaaatt ggtgggagtc      2100
     acaagccacc tagaggcagg atgctgcctc atgtgtagca agctttgcat gtcctcctgt      2160
     ggcccagatc tggccgtccc attggccaaa gccttagttc atcatgcctt tgcctttccc      2220
     acaggaaaac agacctcaga gaagtaacac aacaggatgc cccctggggt ggactgcccc      2280
     atggagttct ggaccaaaga ggagagccag agcgtggttg ttgacttctt gctgcccaca      2340
     ggggtctact tgaacttccc cgtgtcccgc aatgccaacc tcagcaccat caagcaggta      2400
     gagccatggc cgcttctcac accttgatgc tcaggagaca ctgttcacag acacagaatt      2460
     tcagggcaaa aactgtgtgt gggaactgac cagaggcagg cagccttggc tgccatttct      2520
     caggagcagg gcaccttatt ttcctttccc cctcccctcc cctcccctcc ccctcccgtc      2580
     cccctcctgt ctcctcctcc tcctcctcct cctcctcctc ctcctcctcc ttcttcttct      2640
     tcttctctct ctctctctct ctctctctct ctctctctct ctctcgatat aggatctcac      2700
     tggagtaggc tatactagct ggccagcaag tcaacctttc tccacctctt ccatactggg      2760
     attgcaaaag agtgctatta tccccagcca cttgttttgt ttataattta cttattttta      2820
     tttcatgcat ataggtatcc accatatgtg tgtctggtgt gcaacagggg ccacaatagg      2880
     gctttgggtc ccctgaaacc agagttacag atggctttga gccaccatat tctgccgaga      2940
     attgaacaga ggcagccagt gctcttaact gctgtgtcat ctgtccagtc ccctctgcct      3000
     ctaaaatgtg gattccgagg aactgactct gtcctgatgc ttacaaagca catgtcctac      3060
     ccgctgagcg cttaccctca gctcttaccc tcagccctta gatgtgaagt ctacaagata      3120
     caatttctaa gaattgtctc aaaacctgtg gtttaaactc cacttatcat tccaaagtca      3180
     gcttcccctt taacagtatg catttccctt tactagattg ctagattgcg agccagcttt      3240
     ggggctgcct ctggctgggc tcgcatcccg ctcatgactg ggcggtcatt ttcggaacca      3300
     ctctgtccac agagcaaggg ccttgcaagc caactcgtct ttagagttgt caccccggca      3360
     gtaaacacca ttgttagaaa gaggtttggg gtttgctgaa tcattttcag ggtgatttac      3420
     tgagtgagca tcgcacacat ctggatggca tttggtggtt tctgtctatg acttagacag      3480
     ggctctgcaa cccactaagt gtgggatcta ctggattgtg ttttgagcgg gcgaaggatg      3540
     agaccttacc tcggaatttt aaaagccata aatggaaata ggaaaaccaa ctgcaggaac      3600
     aagaatcatc tttgtgccca ccctagattt cctttaatac tatttttttc ccactatgga      3660
     agcaatatag actcactaaa atttaggaag ataagaaaaa ggcaattagg agtatagctc      3720
     agtcagtaga gggcttgcct acaacacatg gctcgcctac aacacatggc tcacctacaa      3780
     cacatggctt gcctacaaca catgctaccc tgggttctat acccagcaca tcataaactg      3840
     ggtgtggcca tccacacatg gaatcctggc actgggagac tggagggtca ggagttctgg      3900
     gtctcctaag ctacacagtg agttcaagga tattctgggc tcttgtctca aaaaaggaga      3960
     ggaaggcagg ctggcgagat ggctcagcag gtaagggtgc ttccaagccc acaacctgag      4020
     tgtgatcccc aaaaccaaca tggtagaagg agaaagccaa ctcctcagct gtccactgac      4080
     ctctgcacgg gcaccagtag atatgtcctc cctctaccac aataagtcaa caagtgttga      4140
     aaaacagaga aagaaggaaa accatttgtg attgggctac gtgagataat atagtcaata      4200
     cctccactag ttcctggttt tggtttggtt tggtttggtt tggtttggtt ttttgagaca      4260
     gggtttctct gtgtagccct ggctgtcctg gaagtcactt tgcagaccag gctggcctcg      4320
     aaatcagaaa tccccctgcc tctgcttccc gagtgctggg attaaaggca tgggccacca      4380
     cgcccggcgg ttttgttttt taataagaat ttttacattt atttattcac ctgtgtatgc      4440
     cgtggcatgg tttggagatc aggggacaac ttggcggagt ctggcacccc cttctgtcgc      4500
     ttagggatca agttcagatg gtcaggcttg gttacctgtg cgtgtgtacc tgctgggcca      4560
     tcttgctggg gctcccagca catttcatac ctgcacttta gtctcgggat aaatctgacg      4620
     gtgaactttt atgcctcctt tttttttttt tttaagaaaa aaaatttttt ttgaaaatgt      4680
     gtatgagcac cttatctgca aatgtggtcc ggaaaagggt gtgactttca caagaaactc      4740
     cagtttcagg gcatcttgag ctgccacgtg ggtgctagca gctgaagcca ggtcctctgc      4800
     aagagcaaca tgtgctctga acctcagagc cgtccctcca gcccccctgt atctctcaga      4860
     atggacaatg taacacttga tctcggctat aagctttata tagatatact ccatgttggt      4920
     agttcatgcc tgtggtccca gcacttagga agcaggggca gaacaaagat gggtccagcc      4980
     tggtctacaa agggagtaat gatagtggta cccatagtga tcatctggcg gggggggggg      5040
     ggggggttca aaggtcacat atggccatcc ttctcggtag tcaaaggtca tccacaaact      5100
     ccatagagga gataaagggc ccattgccct gcccccacaa tcgccccctg tctcagcaac      5160
     gccccccccc ccacgatgaa ctgagggcag agacaggaag tttatcgaca tggctagtct      5220
     tccggtgtgt gagcttttgt cttctcgggg tctccctctg cccctgtggg agccctgtaa      5280
     gggctaactg tgaccctctc tcccaggtgc tgtggcaccg tgcacagtat gagccactct      5340
     tccacatgct cagtgacccc gaggcctatg tgttcacctg tgtgaaccag acggcggagc      5400
     agcaggagtt ggaggatgag cagcggaggc tgtgcgacat ccagcccttc ctgcccgtgc      5460
     tgcgcctcgt ggcccgagag ggggaccgcg tgaagaagct cattaactcc cagatcagcc      5520
     tcctcattgg caaaggtata cttaccggga gcaggaggct ggccccacgt gccttgacat      5580
     tgtcctgatc tcttcctctc gtcccctcga aaaggtctcc atgagtttga ttccctgcgg      5640
     gacccggaag taaacgactt ccgcactaag atgcgccagt tttgtgaaga ggctgctgct      5700
     caccgccagc agctgggctg ggtggaatgg ctgcagtaca gcttccccct gcagctggag      5760
     ccctcagcaa ggggttggcg ggccggctta ttgcgtgtca gcaaccgagc cctgctggtc      5820
     aacgtgaagt tcgagggcag tgaggtgagc ccctccccca ttccttctcc cagtagcata      5880
     tgagggcatc tgccaggtcc ctgtgcatgc caatgggctt agctaattgt ctcatcgggc      5940
     aaatctggat ttatttttag tttactttat tctatgtgta tgaatgtttt gcttgtgtgt      6000
     atgtaagtgt ctagtgtcta cagaagtcag aagaggatgt cagatcccgt agaactggag      6060
     ttagagacgg ctgtgagcca ccatgtgggt gctgggaacc cacccaagtc ctctgcaagg      6120
     gaagcaaaca atcagaaccg ccaatcatca ggcagatctg acactgcaga gtgcctccct      6180
     ccctccctcc ctccctccct ccctccctcc ctccctccct ccctccctcc ctcccagtgt      6240
     ttcctggatg ttggttgcat cccttgatta gcaaacacct agacatgact tggagatgcg      6300
     gctatctctc ataggcagcc ttaccttacc tctgtgccct agaggcctct cggactgcag      6360
     agcagaaggc tgacctcctt cttcctacag gagagcttca ccttccaggt atccaccaag      6420
     gacatgcccc tggcactgat ggcctgtgcc ctccgaaaaa aggccacagt gttccggcag      6480
     cctctggtgg agcagcctga ggaatatgcc ctgcaggtga acgggaggca cgaatacctc      6540
     tacggcaact acccgctctg ccactttcag gtaagccttc ccgtctgccc gaatgtggtc      6600
     ccgggaacat caagggaacc gacttaggga atgagcgggt gcccccccat cagcagctca      6660
     cccagcccct ctcttccagt acatctgcag ctgcctacac agcgggctga cccctcatct      6720
     gaccatggtc cactcctcct ccatccttgc tatgcgggat gagcagagca atcctgcccc      6780
     ccaagtacag aaaccacgtg ccaaacctcc cccgatccct gccaagaagg tgaggtggtg      6840
     tattcttggt ctgctgggat gaaagcagga gacccatggg ttcaggggcc tgtgattggg      6900
     tgaccagggg cctgttggga tctgtgtgaa ctacagggca gcctccactg tcctcttgtg      6960
     gctcttaggg gtattgggga cccttgtgca tgtgcacaac aggttttctg ataaaaagag      7020
     gagaggtatc ttattctttg ccactcactc cgtctcccta cttccccagc cctcctctgt      7080
     gtccctgtgg tccctggaac agccattctc cattgagctg atcgagggcc gaaaagtgaa      7140
     tgctgacgag cggatgaagg tagggggctc cccggtcaga tgagggagcc actgttttct      7200
     atacaaacaa ggtggctgtg gccaggaggg tggcaagcgg aaggagagtg ggaagatgtc      7260
     acacgaaagc cacctgacca cattacccag cctccctgcc tggagtggtt gtaagctgct      7320
     tcaaaacagg aagggggagt ggggtgggcc agccagccag agactgattc gtggaaaccc      7380
     gggcagagca gatttctgtg tatttgactt tggtggaggt tgtggggatg aaagaggcat      7440
     ccggggaggt gtgagaggtg caaggaagga gcctgctgca agctggtctg ggtatggctg      7500
     cagcctggat gggtagctgc cttatcccct ggggtctgaa gacagtgggc gggagtgagg      7560
     aggcacatgg taccctttgg tttctttaaa aacacttcca cacgcatcac atctgccttc      7620
     caggtgcagg tgttattgtt ccatctgtgg aacaggaagc ccacagacag ttctggctaa      7680
     attaactcca taactttaca aacttggagg gttgggtact tgggtatggg atgatgggta      7740
     aggttcaaaa aagggcaggc agtcttaggt agagccaggg agttgtggaa ttaccatctt      7800
     ctattgaaga aactgaggtc tggatgggaa ggggcatgcc ttgggctatc aatgcactgt      7860
     ggcctcccct gccccatggc ttcttgtcct acttgactag tggctttccc tctaagaagc      7920
     acacacacac acacacacac acacacacac acacacacac accacgagaa agtagattca      7980
     gacccattta agaatgagga cacttgagga gaacattgtt gtgagtagcc tggtgagaag      8040
     agagaaggga tggagcccgg ggcctctcct cccattaatt caccccgacc cccagctggt      8100
     tgttcaggcc gggctcttcc atggcaatga gatgctgtgc aagactgtgt caagctcgga      8160
     ggtgaatgta tgctcagagc ccgtgtggaa gcagcgactg gagttcgata tcagcgtctg      8220
     tgacctcccg cgcatggctc gactctgttt tgctctctat gccgtcgtgg agaaggctaa      8280
     gaaggcacgc tccacaaaga agaagtctaa gaaggcggtg agtattggct ggctggggag      8340
     gagcctaggc ctcccttcag tgccccaagc cgcaggcagg caggcaggtt gaggacaggg      8400
     gtcctggggg accctaaacc ccaagcttct ccaccatctt ggatccctac acactctagg      8460
     gatagcctgt gaacggcctg cttgggctat ctgctctgga cctgtaggcc agtaggcttt      8520
     tgtaggcagc tccctgggta gaaagtatcc tcagagggac taaagggcct gggccagcgg      8580
     ctgtcttgag tggctgggcc cctagtcacc aattccagta tttaaagtgg ctctcactct      8640
     cactctgccg atgcatactg ggtgtgagcc aggagccgag atgcagcctg ggctcgtttt      8700
     gtcactaggg caaggcagtt ggtcctccct cttctcaaac agggtcttcc cttgagtcta      8760
     tctgggagtc cacccttgaa gcccagatcc cctccccaat tggccttccc tccgaggtca      8820
     gcaaatgggg cttttgtgcc tggccctaac ccgctggtgt ccttccccaa gactgcccca      8880
     tcgcttgggc caacctcatg ctattcgact acaaagatca gctcaagacg ggggagcgct      8940
     gcctctacat gtggccctct gtcccaggtg ggcccagccc caggggagca gctaacaggg      9000
     ggtagaggtc cccaagcaag tgacttgaca cacaccgctg catctgtccc tgtgtccaga      9060
     tgagaaggga gagctgctga atcctgcggg tacagtgcgc gggaacccca acacggagag      9120
     tgccgctgcc ctggtcatct acctgcctga ggtggccccc caccctgtgt acttccccgc      9180
     tctggagaag gtcagtgaag accctttcct tctagccccc tgggtctcaa tcctaatgct      9240
     gcgacccttt agtacatgtg gtggtcaccc ccaccataga ttatttttat tgctacttca      9300
     taaatgttat tttgctaatt tttttaagaa ttaaaagaaa aagatttatg tatatgagta      9360
     cactgtatct gccttcagac acaccagaag aggcatcagc tcctattaca gatggttgtg      9420
     agccaccatg tggttgctgg gaattgaact caggacctct ggaagagcag tgagtgctct      9480
     taaccactga gccatctctc gagccccatt tgctattgtt acgaatcgtc atgtaaatac      9540
     tctatatttt cagatggtct taggttaccc ctgtgaaagg tgtgttggac atcccccaga      9600
     gggctcctga cccaggttga gagccatggt tctagacttt tcctagtcca gtgtttcagt      9660
     tcttcagaga gttagaccct ggccaccctg ggattcgcct gctgctaggg taatgtcgtt      9720
     ctgccaattc agggttttct aagagccctt tgagctgcca ttcggtaacg tttgatgtgg      9780
     aaaggatgtt cctggtatgt tgtagcttca agctaggatg ctggtaaaga ctgtgcaaaa      9840
     tacccaaaat acatcctcca gtgaggatga catgttaggt ctgaggtgta gcttcctgct      9900
     ttggggcctg acagggactg ccctacgccc aggataagtg agagcctcat ccattctgca      9960
     gatcctggag ctggggcgtc acggggagcg tgggcgcatc acggaggagg aggtgagctc     10020
     cgtcttggaa tgggggagct gggattgggc gtggagcttg gaggcctcac cctgtctgcg     10080
     cccctcagca gctgcagctg cgggagatcc tggaacggcg gggatccggg gaactgtacg     10140
     aacatgagaa ggacctggtg tggaagatgc gccacgaagt ccaggagcat ttcccagagg     10200
     cgctggcccg cctgctgctg gtcaccaagt ggaataaaca cgaggatgtg gcccaggtga     10260
     gtagagaggg gggttcggga agacagcccc ggggcagatg gacagttccc gcccacccct     10320
     acctgaccac caagctgtcc cagatgctct atttgctgtg ctcctggccc gagctgcctg     10380
     tgctgagcgc cctggaactt ctggacttta gctttcccga ctgctacgtg ggctccttcg     10440
     ccatcaagtc ccttcggaag ctgacgtgag tcccagctgg tgctacccct ggggcccaca     10500
     gactccctgc tcttccggaa ggcagctttg ccccaagcat ttggaagtgg gtgctgggtt     10560
     gggatgaatc tggcctctgc ctcttactct gccaccgccc agctgtagac caccgacttt     10620
     ccttctcttc agggacgatg agctcttcca gtaccttctg cagctggtgc aagtgctcaa     10680
     atatgagtcc tacctggact gcgagctgac caaattcttg ctgggccgag ccctggctaa     10740
     ccgcaagatc ggacacttcc tgttctggca cctccggtag ttgaacacac aacagcctat     10800
     tccttggaaa tcctatgagg gtcacgggga agtgagaact caggattctg agatcttgct     10860
     gaactcctgt ttccagcagg ctcagatgtc ctgatgctct gggtcccacc taggctgcgg     10920
     gcagggggtg tgagaccctg actggcaaga ctcagtacca ttttttcccc ccagctctga     10980
     gatgcacgta ccatcagtgg ctctgcggtt tggtctcatc atggaagcct actgcagagg     11040
     cagcacccac cacatgaagg tgctgatgaa gcaggtaagg cttggtcagt ttctgcttac     11100
     aagctttaga aggctctcac tggaccatcc tcccacctgt ggctggcacc caccaccact     11160
     tatcaccacc acccgttatc accaccaggg ggaagcactg agcaagctta aggcactgaa     11220
     tgactttgtg aaggtgagct cccagaagac caccaagccc caaaccaagg agatgatgca     11280
     tatgtgcatg cgccaggaga cctacatgga ggccctgtcc cacctgcagt ctccactcga     11340
     ccccagcacc ctgctggagg aagtctggtg agccccatgc ctgacccacc agggctcctc     11400
     ccaacctccc tgggcctgcg gaggagcccc tgtcgaccct actctctggc cagcagtgtg     11460
     gagcagtgca ccttcatgga ctccaaaatg aaacccctgt ggatcatgta cagcagcgag     11520
     gaggcgggca gtgctggcaa cgtgggcatc atctttaaga acggggatgg tgagcaggcg     11580
     ggctagggag tctgcagagg cctaaccgtc cctgtgccat cctgaggggt ggtcctggga     11640
     cctaagaacg gatacccagt gggagaagag aacccaccag acactggtct ccttcccaca     11700
     ctgcagacct ccgccaggac atgctgactc tgcagatgat ccagctcatg gacgtcctgt     11760
     ggaagcagga gggcctggac ctgaggttgg ggcccatcct gtaactgttg tgctctgggt     11820
     cagcccttag agctgtgctt tggaagggga gccaaactat cctcctcgtg tgggtgggaa     11880
     agggctgatc ccaggagagg cgagggtagg gagggcagcc aagcacttgt cttgttccct     11940
     tctgtatttc ccggcccctt gtgtagagga agcagcagct tcccccaaac cctcatcttg     12000
     ggtaccagga gcctccgagt ccttcctcct cctcctcagc cacttgagtg tggcatctcc     12060
     aggaacagcc tttgatcgtg acgttctgct ggcctttctc tcactaggat gacgccctac     12120
     ggctgcctcc ccaccgggga ccgcacaggt ctcatcgagg tggtcctcca ctcggacacc     12180
     atcgccaaca tccagctgaa caaaagcaac atggcggcca cagctgcctt caacaaggac     12240
     gccctgctca actggctcaa gtccaagaac cctgggtagg tttcaagcct tctcctcctg     12300
     ggaggtgtga cgtgggaagg gttggcctat cagagacaag atgagaggga agggctgtga     12360
     tcttctctga ctagttggct ctgctgtggg gccggcctga atctgagtca gcatagcggt     12420
     tcttgtgtct cagttgccag tggttgtgtg tgataccact caaagcttcc gaccttagac     12480
     atctgctgct gtgaatctcg ggatactata cgtgccttgc ttgggacaac tcaagtcatc     12540
     tgggacttct cccaaacctg gagggtctaa gatggagtcc actgaatgcc cagagcctga     12600
     agtcagctat acctctcttc ttggcctctg cttgtgcagg ccggtcctca gcctttcccc     12660
     acggtgcgcc taggtggtgg ggataggctc cagatcagag aggtatttta ggcctaagct     12720
     ctgggactat atactttaca tctgttgagt aaagcatgcc aaaaggctag actcagagaa     12780
     agagaggcag acccccttct ggtaaagggt tgcagtctgg tgtgccatga cctccaatct     12840
     tccccctcag ggaggccctg gatcgggcca ttgaggaatt caccctctcc tgtgctggct     12900
     actgtgtggc cacatatgtg ctgggcatcg gtgaccggca cagtgacaac atcatgatca     12960
     gagagagtgg gcaggtaggg gcgtgtggct gggtggcttt gctatagggc tgacgtcccg     13020
     tctggcctgc tggccccttt gctctgggtt tggtggcccc gcgaacgctg tgagccctgc     13080
     tggtgtcttc ttcgcctggg tctctcaagg ggcatggaag ctccctgttc tctgctttct     13140
     cttcctccct gcggctcccg gggttggatc cctgctcact cgaggctaag ggctccactt     13200
     cgtccccgtc agctcttcca cattgatttt ggccactttc tggggaactt caagaccaag     13260
     tttggaatca accgagagcg cgtccccttc attctcacct acgactttgt ccacgtgatc     13320
     cagcagggga agactaacaa cagtgagaag tttgaaaggt gagggctctg cccttgatta     13380
     tctgtccggg atgccaggaa cgctgggttc aagaacgagg ctggagacgg tggtcggtcc     13440
     tgctcccgcc ccctcccctg gatgttgatg gattgggatg agtgacctcc aaacctgttt     13500
     ggcctccttg ggccatgggg gaggaggttt gtgtctccag caggaggcag agggaggtca     13560
     tcttgaagaa ctagccaacg gtggataacc ttcaacaaca accttcagca acagctcggg     13620
     gggggggggg tggggggggg aggtgggggt ggggtgggaa ggtgaacacc caggacctta     13680
     cctgccccgc ctccctcacc tgcaggttcc gcggctactg tgaacgagcc tacaccatcc     13740
     tgcggcgcca cgggctgctt ttcctccatc tcttcgccct gatgcgggcc gcaggtctgc     13800
     ctgagcttag ctgctccaaa gatatccagt atctcaaggt aagtgtcccc gtgggggtcc     13860
     cttctgctat gataaaagcc atcaaaagca gcgtgggcag aaaagggttt atttcaactt     13920
     gtggtcgcag cagtcacatc atgaagaggg atcaagggca ggcattgaac cagaagcaat     13980
     ggtttgttca gactaccttc ttttacaacc caggaccact tgcctagggg atggcaccac     14040
     ccacagtggg ctgaaccctt ctttatcagt cactgatcca aaaaataaaa tgccccaagg     14100
     gcttaactac aggcaatctg atgaaggcgt ttcctcagtt gaggaaattt cctttttccc     14160
     agatgactcc agtttgtatc aagttggcag aaaaccacca acacagtagg tcaagccagg     14220
     gccgagtcag ggctgacccc atggctgtat acttcctaca gcctgcctgg gaggtctgga     14280
     tcctagtagg gccccttctg gtagactttc agcggtactg atggttgtgg ggtcctcatg     14340
     gcatccttgt cctagcagtg ggcagggcca gagtggtcca gtttgctggg cctacttatg     14400
     ctgggtggca gatacgtggt aaccttcctt agtcaatcca tgtgtccctc ataggtgtcc     14460
     acgcacgcac gcacacacac acacacacac acacacacac acacacacgt acattcctgc     14520
     tcagtctgtg tgagctaagg ttccttgcac attgtgtaaa tgctttcgtc ccacgtcctc     14580
     catctgtgat aactggagca gagagtgaca ggccaccagc ctaaccaggg catcccctga     14640
     aggtcacaat gacatgctaa ggcatctgac atttgagtca agtgggtgga ccatctgggt     14700
     ttgggggtct gaatacagag agaatttagc atcctattgg gcttcattct ggattgcgta     14760
     acagagagca aagtccctca gtgtcactct gctgtgtgtg gtgtttgtcc aggactctct     14820
     ggcactgggg aagacggagg aagaggcgct aaagcacttc cgggtgaagt tcaacgaagc     14880
     tctcagagaa agctggaaaa ccaaagtcaa ctggctggcg cacaatgtgt ccaaggataa     14940
     ccgacagtag gaggcgcccc ctggtggtca tacggcggtt ccctcctggc tttcagccct     15000
     agaggtaaaa ggacagtcct ggagaccagg catgtccagt ggtcaccaaa gggaccccag     15060
     agcctgaact gtccctcatg gggaagaacc acaccactgc ttcttgttta cactggtaat     15120
     ttatttatga ctcgaaatgt ttaaggaaca gaatagccat aaatggaagt gcatttctgt     15180
     gcagggaggg tgatgtcctc atgatgtcat cccgggtcag cactgtaata gcaccttgag     15240
     gatcgaaccc ctagtcttcc aacctgtggg tcttggccca gcaaggacag ttcttggggc     15300
     cttcttccca ggctcccagc aggctgcctg gaacaagcct ggcggtcacc tggtgcctcc     15360
     atcctcagct cacctccggc caccgttgtg tggcctaccc aaccaagcct ccggcagctc     15420
     ttgaggaagc caggagcttc cctctagact caggcacact tgctcggcac tgctgaagcg     15480
     acctcttggg tttgggtaca ggaatgccct cacctctcat ttgcgggtaa gaacacgata     15540
     tgtagactct gtcccttacc ccgatggctg gggtaaggga cctggcctcc actacagtta     15600
     gtgtattcca ggccttgaag cactcagacc ggtgccccat ttagctctgt gtggtcacga     15660
     atcaagacga agggccagcc agaatggaag tcctcttcgc agttcatgtg aggggcacac     15720
     aaggcagctt tatggacgga caggactgat ctcttccaga gctgaaatcg cagaaggcag     15780
     ctggggagct aggctcgaca agtgtgagca aggacaagaa cggaattcag tgcagtctgg     15840
     gcagtcagag gaactcgaga aacgcagtct cggcctcctc ccggggagcc aaacgccagc     15900
     cacccgcccg gcttttagag agcccagctc aggggtcgca cgtgcttatc gtcccacccc     15960
     aagcacatct ccatgtatca gctgccacct caggacctgg atctcccggt agcattctga     16020
     gactttgaga accatcaccg ctgtctcgcc agcagcccag aacatggctc aaggagcccc     16080
     ttcatgttga tgagcccagg gtccagcagt gagcggtggt gcctccgcag cacccgctga     16140
     acccctagtc tgccccacca actctgaaat aggaaacgtg tctgtgtgtg tgtatgtatg     16200
     tatgccatgt tatttattga aaagagtcta ggtgctctct ggtgtggctg cagattctgc     16260
     acaggctcgg cctttctggg ttgggtgtgt ggcctgtgta cttggctgga agacgggttt     16320
     tttgttaagt tttttcctct cactgatggg ggctgagacc agtttgtgca accttgacac     16380
     aacaggtaaa gacaggtgaa aagaaataaa aacgttttta tgttcttaag ttcttggctc     16440
     aaataacaag gggacttggg gggatacagt gtactggttg agcccttgtc tgcgaagtgc     16500
     aaagcctcgg gtacattcct tagtaccata aaaattaata atccttgccc ggcatggtgg     16560
     acatctgtaa tcccagcact gagcaggcag aggcaggagg attgctttaa gtttgagccc     16620
     agcctatctt cataaatccc tcaacccctg ccccaacccg tacccaacaa acatgaaaga     16680
     atggacccca ctcaggctgg agttagaacc agaactttat tataacgcat acactttctg     16740
     acctatgtcg atatacacat cttaaagggg aaccctgcgg ctactgacac gacaggccct     16800
     ttctccgtta gcctgttcca tctaagaaag cagctacagg gacaggacat gggagggcgg     16860
     ccacagacag cacggcggcg aggactggga tgtcccagct ggagcagtct aaactcttga     16920
     ctgtgaatga agagctgtgc tgtgtgggtg gtacctgctg tctcctatct gctgggtctt     16980
     agatcttagc ccaaacccaa cagcacgcgg catcccatgg ggcctctggg gaggagagaa     17040
     aagattgttc tggagcattg tagcagtttg tctttgggcc tcgggggtct ccttttggtg     17100
     ctgttgtgca gacttgctca gaatcgtggt cttccaagca aggagctgac cgcctgcacc     17160
     tttgctgtcc gttcccagct acaccatttc accaacaggg agactcacgt taataagcag     17220
     aaaccacgtg gctgccagtc acaggcgtgt acaggaaagg ccagggcttt ggcaacatcc     17280
     tggctgttcc cagcctctaa tgtggttgga ggcgcgtggg gctgcccccc ccccccagac     17340
     agcacttgaa agccatggcc ccggccacgt ggctgtacgg aaaccctagc aagggtgggc     17400
     cccagtgact tgggcctctc caacctggtt tcttgggagg gaagagggag gaagaggtcc     17460
     tcctggcccc gcattctgac tttacattcc tgtcctggac tactagcaca gaggacacac     17520
     agaatcccaa tttatttaca aaatattaaa aagtcggttg gccatctaca tattaacccc     17580
     ctctgctctc ccactttata catgcactag tttgggaaaa aaaaataaaa aaacttttaa     17640
     aaataaagaa gagaaatggt tactgactgc gtgggagtaa tttttcaccc tctgtcgaca     17700
     agtccgctca gtgcggcttc tctggaggtc ccaggtgctg gtgtcctctc cctggccaac     17760
     aggggctcca gacacacttg gggtctgagg tgctgtgggg cccctgccct ggggaggaag     17820
     cgccagcttc tagcaaaact gcaatggtga tgggcgggga gggtggagcc ggtggtccca     17880
     cacaccaagc acgggaggac tttgagcagt gggggaaggg tctgcagacc tgctggtcaa     17940
     aatgattttg tacatcgtgg acccgtgggg ctgggagaga gtctggagag caggcgctga     18000
     gtgcgggttt agtagctgag tgtggagtca tcccattcca gctgtcgggt ggcattctgg     18060
     ccgtccccgg ggcctccttc ctcctcctca ctgctctcag actcggcact ggtgatgtct     18120
     tcctcttcct ccccatcttc gctctcctcc tcctcctcct cctcttcctc ctcctcactg     18180
     ctgtgctggt cctcatacgt ctggcaaaga gacgacggcg taaatctagc ctgtggcccc     18240
     atcgcccagt gtctatctac taaaagccac aaaggaaaac acagccaacc ccacagtgac     18300
     agaagggcct gagtggtact gggagtcgcc tcgccaaagt gacccggcag gtgacgctct     18360
     cattagcaac atggatacca ctcacatggg atggggtgct caatgcagag gggcggagct     18420
     tagtcctgtc ataccacgga catcttgggg taaagaagcc aagagcgtca gttgcctgcc     18480
     tatgctactc acggaggcct tcagcaaggg cttcctcatc tgaaggtgac ccccctaatc     18540
     taatctcact gacccaacct gcaagcacgt gaccagggtc tgggtctccg tggcgctttg     18600
     tggttggccc ttctgtgcct acctccatgg ggttgacggt gatggtcaag gcagagtcat     18660
     cccagtccat ctcattctcc ttccccgtgt cctggtcccg catcgttcgc tgatgtgcag     18720
     cccggatccg aaacaccccc aggatgatca tgaaaaccag gaagctgaca cacaccacaa     18780
     tcaccactgt cgccgtgctg gggataactg ccatggggtt tgaagaccag acacacagct     18840
     tttgtgatgc tgcttacacc caaagagctc cccccatccc atccctcctt ggcctcctca     18900
     actactctag gtaggtcaaa tggaatgtgt cagagtgctt cctgactcct aaaccctagg     18960
     aggaagccct aagcctgcct tcgctcactg gctgctctgt ggcagtggtg agcgagcttc     19020
     cttgtgtaag tgacagcatt ggggtagttg atgggcagta gttgtgagct acgcttgcta     19080
     ccaggtttgt gtgtatgtgt gtgtgtgtgt gtgtgtgtgt ctgtctgtct gtctgtctat     19140
     ccatctggac cctacatacc acagcatcct gacccacgtt ctttcccccg tcctacctgc     19200
     aaacgggtga ggattggcca ggttgtgacc agacaggtcc acaaaggatc gatgttcagg     19260
     gtggacgaac tgtggctggg cagccatgtg gttggcatgt tccacggggt tggctgtgtg     19320
     gatcacattc acctacagca gagagagtgt cactaggcac cccaagtgta cctgacaggt     19380
     gaatagacgg tcggcagtgc tgcttcccag tctcccagct ccaggctggg ggcaaacagt     19440
     gaccagaaaa acatcacctg tttacaacag tgtgacagtg tcacatatcc cagaaacagt     19500
     gtgtccgatg gctcatttgt aatgtagctt acaaaagaag gcattcacat cagagtagga     19560
     agccaccctg gccttaggcg acagctcaga tcacctcttc ccattcttct caccagccac     19620
     cctttggctc gagtacattt agtctcctcc gcccaccact tggatcaagg tggagatggc     19680
     gggcgggttg ctcagaattt atttcttcag acctcggagg cgctggccca tgaagtcagc     19740
     tgcggcagag gccactgaag gtgtcagggc agagtgtact gtcctttagc tgctgtggcc     19800
     tcagagtgac tgtggcagtg ttggcactca acaacccggg acccaaatgt ccctgtcaac     19860
     ggggccggtg gtctgacaca gccaccaaga ccacttggtt tcctgggggc tcgttcacag     19920
     acactctgtc gtcacactcc aactctgctc ctcaaggcct gtatgtctac cctgtggaca     19980
     cagccagcca gccctgctct gagcctaaat aagtcgccgc catgaacatc tgaaaccttg     20040
     ggagcccgag tcaggacatc tgattactta atgttcgccc tttgcggtgg gcgccctgga     20100
     ctcacctcca ccttgaactc attgctgagg tagcgaccat ttagttctga gcaaatgagc     20160
     ttgaacttgc gatccagcag ggactggtgt gccaattccg atagcgaagg aggtgcaaaa     20220
     cctcctcgta gcttgccatg gtctccacgc ttgtagggtg ttgagggtga gcagcttaag     20280
     tctggagccc aggtgggccc ttgggtcagc caagctgagg gctacaactc tgtgactttc     20340
     agagtcaggg aactaaagca aagcaagcag gcatttctcc atctggggca tgagctgttt     20400
     gttatgtgcc cagccccacc ctgcacaaag cactgcccgt gccccctcca tgtgcagaag     20460
     ggtgccagtg tgaggcggat gcaccagtgc gcatttgtag gcaatgggca ggccgaagcc     20520
     ttcccctcac ctgtgaagac cacacccagg tcagagtggc ttgcttcgat gcccttctgc     20580
     tggaggcggg tcacgtctac ctccaggctc tcctgctctg cgttcagctc atccccttcc     20640
     actgtgacct cacaggtgtc caggtcatgc acaatttcct ctgacaccag ggattcttgc     20700
     ctgcaaaaaa aaaaaaagag agagaccaga aatagcagag gctgcaggtg acataaatac     20760
     cccacccacc caccccccac ccccacccca cccacccacc gtgctgccac atttcaaaac     20820
     cacagtcaag tgtaaggacc aagcatggga gagtcatctt caagacttgg gggctgagag     20880
     tgtagtcagt ggtagagtat atgattagca tgttgaaggc ccaggcccag tcccagctca     20940
     gtcaataaat atcacttagt aagttcccgg taagaatgga gggatacttc ctttgagctg     21000
     gccctcaagc taaatcttaa aacccaacac cagctacagc caagttccag acacagactc     21060
     aagtgttaaa acattaaaac ctccaaaacc agccgagcag tggtggcgca cgcctttaat     21120
     cccagcactt gggaggcaga ggcaggtgga tc                                   21152
//