Dbfetch
ID AF240469; SV 1; linear; mRNA; STD; MUS; 2250 BP. XX AC AF240469; XX DT 11-SEP-2000 (Rel. 65, Created) DT 23-SEP-2008 (Rel. 97, Last updated, Version 2) XX DE Mus musculus nicastrin mRNA, complete cds. XX KW . XX OS Mus musculus (house mouse) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. XX RN [1] RP 1-2250 RX DOI; 10.1038/35024009. RX PUBMED; 10993067. RA Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A., RA Song Y.-Q., Rogaeva E., Chen F., Kawarai T., Supala A., Levesque L., Yu H., RA Yang D.S., Holmes E., Milman P., Liang Y., Zhang D.M., Xu D.H., Sato C., RA Rogaev E., Smith M., Janus C., Zhang Y., Aebersold R., Farrer L., Sorbi S., RA Bruni A., Fraser P.E., St George-Hyslop P.H.; RT "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction RT and betaAPP processing"; RL Nature 407(6800):48-54(2000). XX RN [2] RP 1-2250 RA Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A., RA Song Y.-Q., Rogaeva E., Kawarai T., Supala A., Aebersold R., Sorbi S., RA Bruni A., Fraser P.E., St George-Hyslop P.H.; RT ; RL Submitted (02-MAR-2000) to the INSDC. RL Dept. of Medicine, Centre for Research in Neurodegenerative Diseases, RL University of Toronto and University Health Network, Rm. 118, Tanz RL Neuroscience Bldg., 6 Queen's Park Crescent West, Toronto, Ontario M5S 3H2, RL Canada XX DR MD5; a32efe92b08c7468989513fe82fd14d8. DR Ensembl-Gn; ENSMUSG00000003458; mus_musculus. DR Ensembl-Gn; MGP_129S1SvImJ_G0016776; mus_musculus_129s1svimj. DR Ensembl-Gn; MGP_AJ_G0016755; mus_musculus_aj. DR Ensembl-Gn; MGP_AKRJ_G0016721; mus_musculus_akrj. DR Ensembl-Gn; MGP_BALBcJ_G0016716; mus_musculus_balbcj. DR Ensembl-Gn; MGP_C3HHeJ_G0016540; mus_musculus_c3hhej. DR Ensembl-Gn; MGP_C57BL6NJ_G0017178; mus_musculus_c57bl6nj. DR Ensembl-Gn; MGP_CASTEiJ_G0016120; mus_musculus_casteij. DR Ensembl-Gn; MGP_CBAJ_G0016514; mus_musculus_cbaj. DR Ensembl-Gn; MGP_DBA2J_G0016621; mus_musculus_dba2j. DR Ensembl-Gn; MGP_FVBNJ_G0016618; mus_musculus_fvbnj. DR Ensembl-Gn; MGP_LPJ_G0016692; mus_musculus_lpj. DR Ensembl-Gn; MGP_NODShiLtJ_G0016645; mus_musculus_nodshiltj. DR Ensembl-Gn; MGP_NZOHlLtJ_G0017214; mus_musculus_nzohlltj. DR Ensembl-Gn; MGP_PWKPhJ_G0015906; mus_musculus_pwkphj. DR Ensembl-Gn; MGP_WSBEiJ_G0016182; mus_musculus_wsbeij. DR Ensembl-Tr; ENSMUST00000003550; mus_musculus. DR Ensembl-Tr; MGP_129S1SvImJ_T0023537; mus_musculus_129s1svimj. DR Ensembl-Tr; MGP_AJ_T0023500; mus_musculus_aj. DR Ensembl-Tr; MGP_AKRJ_T0023470; mus_musculus_akrj. DR Ensembl-Tr; MGP_BALBcJ_T0023479; mus_musculus_balbcj. DR Ensembl-Tr; MGP_C3HHeJ_T0023283; mus_musculus_c3hhej. DR Ensembl-Tr; MGP_C57BL6NJ_T0023989; mus_musculus_c57bl6nj. DR Ensembl-Tr; MGP_CASTEiJ_T0022828; mus_musculus_casteij. DR Ensembl-Tr; MGP_CBAJ_T0023230; mus_musculus_cbaj. DR Ensembl-Tr; MGP_DBA2J_T0023348; mus_musculus_dba2j. DR Ensembl-Tr; MGP_FVBNJ_T0023362; mus_musculus_fvbnj. DR Ensembl-Tr; MGP_LPJ_T0023455; mus_musculus_lpj. DR Ensembl-Tr; MGP_NODShiLtJ_T0023326; mus_musculus_nodshiltj. DR Ensembl-Tr; MGP_NZOHlLtJ_T0024028; mus_musculus_nzohlltj. DR Ensembl-Tr; MGP_PWKPhJ_T0022552; mus_musculus_pwkphj. DR Ensembl-Tr; MGP_WSBEiJ_T0022846; mus_musculus_wsbeij. XX FH Key Location/Qualifiers FH FT source 1..2250 FT /organism="Mus musculus" FT /map="near looptail (Lp) locus" FT /mol_type="mRNA" FT /db_xref="taxon:10090" FT CDS 18..2144 FT /codon_start=1 FT /product="nicastrin" FT /function="modulates beta-APP processing and Notch/Glp1 FT signal transduction" FT /note="type 1 transmembrane protein; similar to Homo FT sapiens and Drosophila melanogaster nicastrin encoded by FT GenBank Accession Numbers AF240468 and AF240470; interacts FT with presenilin proteins PS1, PS2, S182, and E5-1" FT /db_xref="GOA:P57716" FT /db_xref="InterPro:IPR008710" FT /db_xref="InterPro:IPR041084" FT /db_xref="MGI:MGI:1891700" FT /db_xref="UniProtKB/Swiss-Prot:P57716" FT /protein_id="AAG11413.1" FT /translation="MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNK FT TAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTR FT DVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLW FT NELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHA FT VISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRL FT DSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSS FT RMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLAT FT LEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDT FT AENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTV FT TRLLYGFLVKANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGK FT ATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFE FT LSQWSSTEYSTWAESRWKDIQARIFLIASKKLEFITLIVGFSILIFSLIVTYCINAKAD FT VLFVAPREPGAVSY" XX SQ Sequence 2250 BP; 535 A; 612 C; 563 G; 539 T; 1 other; cccagcggag aggcaacatg gctacgacta ggggcggctc tgggcctgac ccaggaagtc 60 ggggtcttct tcttctgtct ttttccgtgg tactggcagg attgtgtggg ggaaactcag 120 tggagaggaa aatctacatt cccttaaata aaacagctcc ttgtgtccgc ctgctcaacg 180 ccactcatca gattggctgc cagtcttcaa ttagtgggga tacaggggtt atccacgtag 240 tggagaaaga agaagacctg aagtgggtgt tgaccgatgg ccccaacccc ccttacatgg 300 ttctgctgga gggcaagctc ttcaccagag atgtaatgga gaagctgaag ggaacaacca 360 gtagaatcgc tggtcttgcc gtgactctag ccaagcccaa ctcaacttca agcttctctc 420 ctagtgtgca gtgcccaaat gatgggtttg gtatttactc caactcctac gggccagagt 480 ttgctcactg caagaaaaca ctgtggaatg aactgggcaa cggcttggct tatgaagact 540 ttagtttccc catctttctt cttgaagatg agaacgaaac caaggtcatc aagcagtgct 600 atcaagatca caacctgggt cagaatggct ctgcaccaag cttcccattg tgtgctatgc 660 agctcttctc acacatgcac gccgtcatca gcactgccac ctgcatgcgg cgcagcttca 720 tccagagcac cttcagcatc aacccagaaa tcgtctgtga ccccttatct gactacaacg 780 tatggagcat gcttaagcct ataaatacat ctgtgggact agaacctgac gtcagggttg 840 tggttgcggc cacacggctg gatagccggt cctttttctg gaatgtggcc ccaggggctg 900 aaagtgctgt agcctccttt gtcactcagc tggctgcagc tgaagctttg cacaaggcac 960 ctgatgtgac cactctatcc cgaaatgtga tgtttgtctt cttccagggg gaaacttttg 1020 actacattgg cagctcacgg atggtctatg atatggagaa cggcaagttt cccgtgcggc 1080 tcgagaacat cgactccttc gtggagctgg gacaggtggc cctaagaact tcactagatc 1140 tctggatgca cacagatccc atgtctcaga aaaatgagtc tgtgaaaaac caggtggagg 1200 atcttctggc cactctggag aagagcggtg ctggtgtccc tgaagttgtc ctgaggagac 1260 tggcccagtc ccaggccctt ccaccttcat ctctacaacg atttcttcgg gctcgaaaca 1320 tctctggcgt ggtcctggct gaccactctg gctccttcca caatcggtat taccagagca 1380 tttatgacac ggctgagaac attaatgtga cctatcctga gtggcagagc ccagaagagg 1440 acctcaactt tgtgacagac actgccaagg cactggcgaa tgtggccaca gtgctggcgc 1500 gtgcactgta tgagcttgca ggaggaacca acttcagcag ctccatccag gctgatcccc 1560 agacagttac acgtctgctc tatgggttcc tggttaaagc taacaactca tggtttcagt 1620 cgatcctgaa acatgaccta aggtcctatt tggatgacag gcctcttcaa cactacatcg 1680 ccgtctccag ccctaccaac acgacttacg ttgtgcagta cgccttggca aacctgactg 1740 gcaaggcgac caacctcacc cgagagcagt gccaggatcc aagtaaagtc ccaaatgaga 1800 gcaaggattt atatgaatac tcgtgggtac aaggcccttg gaattccaac aggacagaga 1860 ggctcccaca gtgtgtgcgc tccacagtgc gactggccag ggccttgtcc cctgcctttg 1920 aactgagtca gtggagctcc acagaatact ctacgtgggc ggagagccgc tggaaagaca 1980 tccaagctcg gatattccta attgccagca aaaagcttga gttcatcacg ctgatcgtgg 2040 gcttcagcat ccttatcttc tctctcatcg tcacctactg catcaatgcc aaagccgacg 2100 tccttttygt tgctccccga gagccaggag ctgtgtctta ctgaagagga ctctagctct 2160 ccctgcctgc tctgaacttt acttcccaga ccaggtgtcc ggctgggaac aaaccactaa 2220 tttgtcactg gactgtctct gggcctgctt 2250 //