spacer

EBI Dbfetch

ID   AF182509; SV 1; linear; genomic DNA; STD; MUS; 18541 BP.
XX
AC   AF182509;
XX
DT   09-NOV-1999 (Rel. 61, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 3)
XX
DE   Mus musculus clusterin gene, complete cds.
XX
KW   .
XX
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea;
OC   Muridae; Murinae; Mus; Mus.
XX
RN   [1]
RP   1-18541
RA   Zhu G., Ley-Ebert C., Barrie A.M.III., Witte D.P., Rosenberg M.,
RA   Harmony J.A.K., Aronow B.J.;
RT   "Clusterin Gene Locus Structure and Function in Development, Homeostasis,
RT   and Tissue Injury";
RL   (in) Landes R.G. (Eds.);
RL   CLUSTERIN IN NORMAL BRAIN FUNCTIONS AND DURING NEURODEGENERATION.:1-16;
RL   Springer-Verlag, Austin, TX (1999)
XX
RN   [2]
RP   1-18541
RX   DOI; 10.1172/JCI9037.
RX   PUBMED; 11067863.
RA   McLaughlin L., Zhu G., Mistry M., Ley-Ebert C., Stuart W.D., Florio C.J.,
RA   Groen P.A., Witt S.A., Kimball T.R., Witte D.P., Harmony J.A.K.,
RA   Aronow B.J.;
RT   "Apolipoprotein J/clusterin limits the severity of murine autoimmune
RT   myocarditis";
RL   J. Clin. Invest. 106(9):1105-1113(2000).
XX
RN   [3]
RP   1-18541
RA   Jordan-Starck T.C., Ley-Ebert C., Zhu G., Johnson J.A., Harmony J.A.K.,
RA   Aronow B.J.;
RT   ;
RL   Submitted (02-SEP-1999) to the INSDC.
RL   Molecular Developmental Biology, Children's Hospital Research Foundation &
RL   University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
XX
DR   MD5; 6458ea0c9488c1acf0dffedd4589ef56.
DR   Ensembl-Gn; ENSMUSG00000022037; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000022616; mus_musculus.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..18541
FT                   /organism="Mus musculus"
FT                   /strain="SvJ/129"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:10090"
FT   repeat_region   969..1065
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="TATG"
FT   repeat_region   1066..1421
FT                   /rpt_family="ORR1A3"
FT                   /rpt_type=DISPERSED
FT   repeat_region   1422..1449
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="TATG"
FT   misc_feature    1507..1527
FT                   /note="AT-rich region"
FT   repeat_region   1665..1738
FT                   /rpt_family="ID4"
FT                   /rpt_type=DISPERSED
FT   repeat_region   2787..2838
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="GT"
FT   repeat_region   3089..3301
FT                   /rpt_family="B4"
FT                   /rpt_type=DISPERSED
FT   repeat_region   4165..4201
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="CT"
FT   repeat_region   4204..4319
FT                   /rpt_family="B1_MM"
FT                   /rpt_type=DISPERSED
FT   misc_feature    4660..4738
FT                   /note="CT-rich region"
FT   mRNA            join(5558..5602,8620..8740,10164..10312,11597..11767,
FT                   12333..12744,13615..13719,16352..16585,17475..17646,
FT                   17905..18140)
FT                   /product="clusterin"
FT   repeat_region   6669..6741
FT                   /rpt_family="MER5A"
FT                   /rpt_type=DISPERSED
FT   repeat_region   6812..6863
FT                   /rpt_family="MIR"
FT                   /rpt_type=DISPERSED
FT   repeat_region   7660..7712
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="TG"
FT   repeat_region   7930..7952
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="TGGGGG"
FT   CDS             join(8647..8740,10164..10312,11597..11767,12333..12744,
FT                   13615..13719,16352..16585,17475..17646,17905..17914)
FT                   /codon_start=1
FT                   /product="clusterin"
FT                   /note="apolipoprotein J; SGP-2; TRPM-2"
FT                   /db_xref="GOA:Q549A5"
FT                   /db_xref="InterPro:IPR000753"
FT                   /db_xref="InterPro:IPR016014"
FT                   /db_xref="InterPro:IPR016015"
FT                   /db_xref="InterPro:IPR016016"
FT                   /db_xref="MGI:MGI:88423"
FT                   /db_xref="UniProtKB/TrEMBL:Q549A5"
FT                   /protein_id="AAF06365.1"
FT                   /translation="MKILLLCVALLLIWDNGMVLGEQEVSDNELQELSTQGSRYINKEI
FT                   QNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKKEDALEDTRDSEMKLKAFPEVCNET
FT                   MMALWEECKPCLKHTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWMNGDRIDSLLE
FT                   SDRQQSQVLDAMQDSFARASGIIDTLFQDRFFARELHDPHYFSPIGFPHKRPHFLYPKS
FT                   RLVRSLMSPSHYGPPSFHNMFQPFFEMIHQAQQAMDVQLHSPAFQFPDVDFLREGEDDR
FT                   TVCKEIRRNSTGCLKMKGQCEKCQEILSVDCSTNNPAQANLRQELNDSLQVAERLTEQY
FT                   KELLQSFQSKMLNTSSLLEQLNDQFNWVSQLANLTQGEDKYYLRVSTVTTHSSDSEVPS
FT                   RVTEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSRAE"
FT   sig_peptide     8647..8697
FT   repeat_region   9294..9438
FT                   /rpt_family="L1MA9"
FT                   /rpt_type=DISPERSED
FT   repeat_region   10539..10581
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="TG"
FT   repeat_region   10790..10973
FT                   /rpt_family="MER44A"
FT                   /rpt_type=DISPERSED
FT   repeat_region   11048..11106
FT                   /rpt_type=TANDEM
FT                   /rpt_unit_seq="CA"
FT   misc_feature    12597^12598
FT                   /note="alpha and beta subunits cleavage site"
FT   repeat_region   13879..13946
FT                   /rpt_family="ID3"
FT                   /rpt_type=DISPERSED
FT   repeat_region   14183..14267
FT                   /rpt_family="SINE/MIR"
FT                   /rpt_type=DISPERSED
FT   repeat_region   14491..14595
FT                   /rpt_family="PB1D10"
FT                   /rpt_type=DISPERSED
FT                   /note="SINE/Alu"
FT   repeat_region   15152..15279
FT                   /rpt_family="MER20"
FT                   /rpt_type=DISPERSED
FT   repeat_region   17129..17268
FT                   /rpt_family="B1_MM"
FT                   /rpt_type=DISPERSED
FT                   /note="SINE/Alu"
FT   repeat_region   18339..18411
FT                   /rpt_family="B4A"
FT                   /rpt_type=DISPERSED
XX
SQ   Sequence 18541 BP; 4494 A; 4358 C; 4769 G; 4920 T; 0 other;
     gaattcccaa acctcgtgtg cttgggaaca ggagaaaagt ggacacttgt aactgtggca        60
     ggggactcct tatctccctc tccccggatc ccctacttct gctgactaag gcacatcttc       120
     ctgcctaatc tccaaaggag aacttttaga gactcggtgc tgagctcaca gagccggcta       180
     atggcagggc tgtgggggtg tacaggaaag gcagctgtct ttaaaaaggg acagcaatct       240
     atcttttact tacatgtttg tttgcccaca cacatactat tctagaagca tgaaattcag       300
     gagaagctga cagtaagaca gatagggtga ttggttactg actgtatatt catttttttt       360
     tccttaaatc tccaagggaa tttggagcca gcaacgtctg catgtttgta tctccaagcc       420
     ggccccacag gtcagcttac atcggtgtga ggaacacagt attgtttaac accatacaaa       480
     agtgagcaga gacagggttc atgaaatcac aaatcgaaag tgtttgctac tgttgttacc       540
     tggtcaccca aacaggtgtc ccgtatttag tttaaaagcc acacagaaag acaaaatgga       600
     gcatgtttgg ggtagggatg aagagagtga ggtatttggc atcctatgtg agaagtaggt       660
     tgagggaaac atgggtaaga tcagatacaa tttgggtttt cggctgtttg aggagttggc       720
     ttgtagaaga aaggactctg tatcggatat tgtctcagga ataagacaca ggaggccgct       780
     gtatggagga aactgcaggg gcttcagcca gagagagcaa acacctgcca gagatcttct       840
     gagtcccctt cccccatgct ctctgtagag agagtaacac tgtgatacag agaagatcaa       900
     acacagtaga gcataagcca gcactttgca aattgtgttc ccaaactgcg gctgctttta       960
     cttggctctg tgtgtgtgtg tacgtgctta tgtatgcatg tgtataatgt gtatataata      1020
     tattaataag ttacatatgt attaatataa gacatgttgt atatatgtgg tggtttgaat      1080
     aagattggac cagggagtgg cactattaag aggtgtggtc ttattggcgt aggtgtgacc      1140
     ttgttggaag aaatgtgtca ctttgtgggt gggctttgag accctcttcc tagctgcctg      1200
     gaagagagat agccttttct cctggctacc ttggatcaag atgtagaact cttagctctt      1260
     tcaccagtac catgcctgcc tagacactgc catgcttcct gccttgatga tgatgaactg      1320
     aacctctgaa actgtaagcc agccccgatt aaatgttgtt ctttataaga gttaccttgg      1380
     tcatggtgtc tcttcacagc aataaaaccc taagtaagac agtgtatata ttaactatat      1440
     atgtatctag atgctgtgac agattaaacc aaatatctct gatggggagg actcatctat      1500
     tggtagtttt aatataattt aattaaaatg tttagacaga atcttatata tttcaggctg      1560
     gcctcaaact tgttatagag ctaaagatga tcttggaatc ttgcttctct tgcctgtgcc      1620
     tcctgagagc tgggttctag gcatgtgcca tcacaactgg agtatgtggt tctgcgaatt      1680
     gtaccaagat cctcatgcac gttaggcaag cctgccagct aagctatgtc cctggtcctc      1740
     attggtaata tttagagcta ccaagtaatc ttttggttag ccattgactg gttccacagc      1800
     aaagcacata tatgaagtaa taattgggtg ctaagtgatt atagaagtag tcttgatttg      1860
     aagcagatct gtgggtcaat ttttttcaag gcccattagc ttaacgtttg gagataaagg      1920
     ctgtgactga gaagtttcaa agtgaaatcc agaaagcata gcctgtccac agcatgagga      1980
     aagctaaaga tggtttaagg accatcatct tttcccaggc atgtgataag tcattcaggc      2040
     ttgagtagcc actaaccttt ctcctgggga agtcccagat gagaaggacc aaccgatgaa      2100
     ttgtttctag agctcacaga tgcccaagaa aagacctaag gggtcttcct ctacctttgg      2160
     cagagtcaat tatttatgat tttattatcc gtgattcttt atgtgattga ttcaatgtgc      2220
     ccttaaataa tcactgctaa agactggttc ttagtgaggg tcacgggatt ctgcttgtgt      2280
     ccatgtctgc attgctgtgt tggtagctga agctgcctgg ctgcgtgctg agctcactga      2340
     gccggctaat ggcagggctg tggaggtgta caggaaagga caccaagtag acactcagat      2400
     gcaaagacat ttgggcagcc agagatgctg agcaaagctt aaagggggaa aaaattagat      2460
     ccccacgaag ctctgcactt accccaacac tcttccccaa gaccacagag caaagaaacc      2520
     aggctgaagc tgtcacagct gcacgtgtcc cgtgactcag ctcccagctc aaggccaatg      2580
     tggagtatgc aggataagga agtgggtgct cctactctgc tctacatggc caggtcactc      2640
     ctggcattga caaacgcaga gctgggtttg gggggtttca agagcatcaa ggtcagaagg      2700
     ccaaagcctg gaggagtctg cagatgaaga caagcaatga gcttctggtt ccaggccttc      2760
     agggggagca gatttgggag atataagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt      2820
     gtgtgtgtgt gtgtgtgtct ctgaggacag aattgggctc agggccagcc ctttacagga      2880
     accagggagc tccggcaaag atggctttcc taaagaatta attgcttgca aggaaaatac      2940
     ccagttctca ggttgggaac atccaaatag aagtaggaga actcctgggg gttgaggagt      3000
     tgctgatata caagtaggaa gagggtcaac caggtcttat actggaaact cagggtggga      3060
     gatgaggtgg tgggtaaggc agaagctcag gatctgagtt ggatccctgg tacccgtcta      3120
     aaacgtggcc tatagttata accccagagc tgggaaggca ggcacaggat cttatggatt      3180
     gttgtacagc tggtgagttc catgccagtg agagagcctg cctaaggtac gaacagttgg      3240
     aaggcacctt tggaggaaca cctgaggttg tcctgtggtc tcacacgtgc acatgtatgc      3300
     aagtgcacac acatgcccac gggcacacac gtgaatcaag aggtgcattc aagatttgtg      3360
     tccgtttgct caaggctgag ttcccaaacc tcgtgtgctt gggaacagga gaaaagtgga      3420
     cacttgtaac tgtggcaggg gactccttat ctccctctcc ccggatcccc tacttctgct      3480
     gactaaggca catcttcctg cctaatctcc aaaggagaac ttttagagac tttgctattg      3540
     taccctgtgc ccatgacagg caacagggag ggaactgcta tatcagaaaa acattacaag      3600
     gacatcggtg tccatagaaa atgtagctat tactgataat tctttctttt tatttttctt      3660
     tataaagaaa acaaaaagaa gatttggggg tggggtgggg ggaacattcc tccaagtttc      3720
     tgttgactct gtttttctgg ttagttatct tcccagactt ggcattgaat caggttaggc      3780
     taaagaaagc cttagtgagg actcatttca gattcatctt tcccagacgg aagaaactaa      3840
     ggcccaaggg cagagtggtt tgtctaaagg cactgggtgc ctcagggaac agctgggact      3900
     gtagccagcc ttagcccagt tctgaccatt cctagacatt tcctgtaggc tgccttttgg      3960
     gaaagtacca aatcaccata gtctctgggc cttgagcaaa tggaaatctg gccctatggc      4020
     tgctccttta aagatctgaa cgggaaacag acctcgacca cacatttctc cttcaagtct      4080
     gtttctttta catagttttc aaggcctgcc acccaaactg tgttacctac attggttcct      4140
     cgacagcttg agggggatgc caggctctct ctctctctct ctctctctct ctctctctct      4200
     cggtttttcg agacagggct tctctgtgta gctctggctg tcctggaact taactttgta      4260
     gaccaggctg gcctcgaact cagaaatccg cctgcctctg cctcccgagt gctgggattt      4320
     gatacacgga tgttccaggg ttcagagtgg gaagctcagc ttctcccccg agaagtagca      4380
     tggtgggggc ttctaggttg tcccttcttc ccagagatgc ccataacagg tgtccctgtt      4440
     ctcagcaaaa agcagctagg gtgcctctca gcacctctgg tcacagaccc agctactcag      4500
     cagcagggct ccacggagaa cttccaccat aggctccttg ttcagaaacc agtgtgagtt      4560
     cccaagtctg ggacaaagta gtttttgttt aaaaaattga attagtatat attaattata      4620
     cataatgagt ttaagaatgg catagtcata tatatatatt cccctccttc atttctcttt      4680
     cgtgtcctct ttgtcctctt cttcctccca ttatctcttc tctctctctc ttcctctcat      4740
     aaatttcatt agtgttgccc acaggagcat gcggtgagca gttatttaca gaaacataga      4800
     caccttacca ttggctctat cacctaagaa aatggggtag tatacttgaa aacaggtgtg      4860
     agggtcctag gtccagaggc agtgaagccc accctgcttg actgggtccc aagtgcgtgg      4920
     gagccatgct taggctttac gaattcaggg acagcagagg ccttcgggat tactgatgta      4980
     tcattgtctc attcttaacc cgcttctgtt tcctccatct gtctgccaag ggaccagcaa      5040
     gcagcccagt gcagcgttta gggagccaag tacttcgtgt atactcttcc ctagcacaat      5100
     gcctacgcca tcttctatgt ttctgttact ctcccattaa aatgggagca aagaaaagga      5160
     gtgaacgatg tggaaggatg tggaagatga acatgcaata aggtgggcgt cgggcggtgg      5220
     aatcctgtgc cagttctggc tgagcagtcc agtgtagtgt gtgatccttg tctctaagct      5280
     ctcttgggcc tgattgagag gttttggtag ctgctcaagg gattagagcc accaatttag      5340
     gggccctaca gcaaccaatg cggtcatttg tgatgcccat gcgccccctg gtgcccccgc      5400
     tgggtgctgc gcctcttacc cccacctcta ggcttccaga aagctcctgg tgcattctcc      5460
     ggcattctct gggcgtgagt cacgcaggtt tgcagccagc caaagggggt gtacttgagc      5520
     agagcgctat aaatagggcg cttccccggt gctcaccacc cgcgtcacca ggaggagcgc      5580
     actggagcca agccgcagac cggtgagaca gctgcacctt tcctacccca gcgccgctga      5640
     agccacaccg gagggatggg agggcaaggg tagcagctag gtggaaagct gcgcagggtg      5700
     gggaagtggg aggtgactag agcccatcac cagacagccg agcatggggt tgggtagggg      5760
     gtgcacgctg gctcagacac gggagtctcc gtgttcttta atccggatca caatttcaca      5820
     gctgttcaat aggccacata caaagatctt ccttttgcaa aaatggggaa actgaggctt      5880
     gaagcctgcc gtacgatgcg ggaggcgcag gggtgcgagt ggctcagcgc cgcgactagg      5940
     tgcggatctc tgtagtggct gttgtctttt gggcatgagt cattgcattt tgacctccct      6000
     ttcagttcct gggacagcgc ataataaata agatgttgtg tatttaaaga cgtgctgcag      6060
     acatccagac ccgttttgct gagctgactg cattcatcca gttctttaga gaaatgctcc      6120
     accaggccga gacgtctgat cccaccggat cactttatag atggtaatct gaggcctgga      6180
     gaccattaga ggctcagcct ccaaacgtta tatgaataag aaactgaagc cctttggctt      6240
     ttccagaatt tctgggccca gttttaaaaa tggtgctggt gctgttttta aaggaagaag      6300
     ttaggaattc aagagtctat acaagttctc ttaacaggat catacaattt agtgcccgac      6360
     cctgtgagaa tagtaaaaca aactgcaaat ggtagtcaat caatggaata ttaggcagca      6420
     gcaaatgtgt gacttttaaa aatatttaaa aacaggacct atgaagggat ggtttataaa      6480
     aatgcattgg aaaaaaatgg agaaaatacg ccacaatggg agaggctatg ttttcctact      6540
     agataaggag gtcttgggct ggtgggtgat gcacccaggg ctagttggca gccaggcagt      6600
     aggccaggcc tccaaaagaa gacaggaagt aagtcagtgt agagggaagg cagcgggctg      6660
     aactgagcag cgttgtcctt ggaacaacaa caccacagcg ccgggaaact tgggagacta      6720
     gcagattctg acccgagtcc atattaccag cagacctaga gggagtctgt tcttagcttt      6780
     actgaataga ggatcgcttc tttgaggtct gtatcaggtc cattttacag ataaagaaac      6840
     caagccggag agatttagga ctttttattg tcaaggaaag aatattaaaa tgaggtttca      6900
     gagggctgca ttcttcctgg ggggtggaga gtgggggtgg gggttggcta ctggcttgca      6960
     gtgtgtcttg gggagcctgg caggtgtctg ggcgttggca ttctctagaa gggcccaggc      7020
     tgaagagcaa gcaaccctcc ctttcttatt tgggaacttg gtggctctcc agaccccagg      7080
     tctcctttgg caagccccaa gctccctgct ccctgtagct catcttgata ctgcttcgcc      7140
     tcccattcaa ttgtcttcct tggctgccct gccctgctgc ctcttcctgc ctcggatcag      7200
     aagccatttc caaggctgtt aaatggcttt tcccaaaatg gtcatgcttg aggctactcc      7260
     cacctacaga tatttctgtg gctttgtctc tgatgtgtca agggtctgta ggcctcacct      7320
     ggctagcatt tcagagactc cacgtgagca cctgggaggt ctatgagatc agggccttcc      7380
     tagtggatca tgaaccaggc tggctgagcc acctacctat ccctgggaag tctcttctcc      7440
     cacaccactc ctcctctgct ctccccccgt aattaagctc agcagaggcc ttgccctatt      7500
     aatgatctgc ccagtgtgtt gatgggcctg cctagctgag agcaggtttt aagagtgagc      7560
     cattccagga agagagatcg tcccttttcc ctgttcctgt gggtatagga agttggtgag      7620
     cccagataag ctatctgggc agcgttggag atgcaagtgg tgtgtgtgtg tgtgtgtgtg      7680
     tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgaggatcca accaatcagc ttaggaagat      7740
     catggtatac tgctctgaaa gatcattgtg taatactgga cttcgagcct gtgtccctgg      7800
     ctcaggcagc cgcccagtgg tgcagaggcc ccttggcaga gtatgctagt tcagcttaga      7860
     ggcaacaggc atgtgaaagg aatttgctgg accaatgggc ttgtcctcct gaaagggctt      7920
     tctggggcgg ggggtggggg tggggatggg ggctcactgc taatctcagg ctttgtcctt      7980
     cccctttcta gttctgcctt ctctgcagtc ctaaattcct tcccttccca ttttgctttt      8040
     accccacccc ctccccaatc catactcagc ctggtggcac agcgttgccc agagatggtg      8100
     agatggattg aatttcccgt gctgatggaa gggtgtgcat attaccacag gctcacttgg      8160
     atagccttgg gaggctgagg gcccctaagg ggagcccagg gctgtgcagt gagtggggat      8220
     gcagtaccat ggaaggggat aggcgaggga tgtttgcatg tttcgggaga ggtatcttta      8280
     gtatttggca tgttaaatat gctctggaga cacaggaaat tcatctgccc tgcctcagag      8340
     ctcgtccctt ccactccaga tagcctggct cctctgtggg gccgggccat ggttcttccc      8400
     agggcctcgt ctgtccagtg tctatagaag gggtcagttt aatcttggct ttcttcccca      8460
     gttcttgaga agtagattgc agtgatgcca gatgaggaga cagatgaggg ccgcgtgttc      8520
     caatcccacc ccacctcccc tctcagggag ctgtagcagg gtgcagaaaa ccctgaagct      8580
     gcccaggggt tgccatgaca catctgctgt tgtttccagg actccagatt ccaaggaggc      8640
     cacgccatga agattctcct gctgtgcgtg gcactgctgc tgatctggga caatggcatg      8700
     gtcctgggag agcaggaggt ctctgacaat gagctccaag gtaggctagg ctgagactgt      8760
     tcctctggtg gatgctatag ggcccagggc agggccattc ctcaaagctc agtccccaag      8820
     tgctgagggc tgttttcatt ctacatcctg ggtctgtcca tgccctctgc cctctctagg      8880
     tcctgtcttg atgtttttgt ggtcaggtga cttctagaca ttgccctctg tctcaagccc      8940
     ctctgttggc tgcctgtcat tcctttgtca ttactggtcc cctcacctgg ctctcttact      9000
     cttctcccaa agccgtgccc tagacccttt gaaactttgt cagtcttccc tttgtgtgac      9060
     atccagggtt cttaccgatg tgtctccaca ccaacccctc ctggaaagcc atatccacca      9120
     atttcctcct ctggaaaaag ggcaatgcaa tttgacatga agtagtcacc tgagagcacc      9180
     ctctcccttc ctccccactc ttcaagcggc ttttctggaa acccaccttt tctcccttct      9240
     tctctcctaa cctcttgctc atagctgacc agttctgggg gggggggtct tcgttaaaga      9300
     caatgtgatc agattctttg atgtggatac acacggtgaa atgattgctg ttgtcaagct      9360
     attagctgtc catcacctca acttatcatt gggttcagac acttaaaata tgttctctag      9420
     cacacttcaa gggtagaacg agctcttgtg ttgctacatc attgaagctc ttgcccttgg      9480
     ctcagcagtc ccccctcccg cttctctttg gatgtgtctg gcaaccgcat caggtagaaa      9540
     acagcagagg tgtgggaaat ggcacttgac acaggataag taagtggtac accgtgacat      9600
     gatgtgtcat tgccttcgtc acctggggcc gtgtcatggc tatggtctcc atggtgaatg      9660
     cagctcttca tttatcgtcc gtctctcatg gtgtcatggt gctatctgtc acctgaccct      9720
     gtgcgtgtag caaagaagtg cagaatggta cctgaggctc acagagatat tcaaagagca      9780
     ctttatacac ctgatgctta tatcgcgttg ttttgttttg ttttctgttt tccttgaaat      9840
     attctctgtg gctgttggct ctccagggtg gcatggtggc gtcagtcata gtatggctgc      9900
     ccctctctgc accactcact cctgagtttc tgagctgtga cttggagtct accatgagcc      9960
     ctttgatggg acatagaggc aggactgagc cattggtggt gccattcccc ttcggatggg     10020
     taatagtgat ggtgtctcag cttagcgccc ccagcactcc ccatcaaagc atggcttctc     10080
     accgtccccc tggcacccag gctatttctc cagccattcc tccccgcccc cctcaactca     10140
     ctgtaccttc ctctctctca cagaactgtc cactcaaggg agtaggtata ttaataagga     10200
     gattcagaac gccgtccagg gagtgaagca cataaaaact ctcatagaaa aaaccaacgc     10260
     agagcgcaag tccttgctca acagtttaga ggaagccaag aagaagaaag aggtagggcc     10320
     aagccttggc tgagcccagg ctctccctgc tggaggggag gaggggacat ggtgagcagg     10380
     tgcctttctg ggttgccatg gtgtcctaag gcggtcctcg aagggttcgc taatgctgga     10440
     ctgaggagcc agggaaagca caggcctgaa gcctagattc agatcaatag gtttttctaa     10500
     cccttgcgtg tgggtagggc atggtgcagg actcagcggt gtgtgtgtgt gtgtgtgtgt     10560
     gtgtgtgtgt gtgtgtgtgt gatatgagca tccagacatt tcccattctt ttcttctgta     10620
     ttcaaaatga cttttaacat gaaagttctt attgaaatat tttaaaatca atgtaaaatt     10680
     cttgtaatct atccttagac atccatccat tcattcattc ccactcagat ataggggagg     10740
     ggggcagttt tcaaaaccct tagtagaagc tgcagagatt gtgcttctgt aatttataaa     10800
     ttacagacag taaggtatga gcagccacaa taaaatagag caattataat gctataccag     10860
     ttataccata cagaaggcta cgcagatgtg atttctccca cacaaaatat ctcaattcct     10920
     cagcttccac aatactattt ttagactggt tgaccatgga tagctaagaa ctgataacaa     10980
     gggactgccc tgttaccatt tgtttaattt gtcatctaca tttgaacatc aagtttgact     11040
     ctggtcaaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca     11100
     cacacaaact tatccacaga ttcatccatc cacttaatta ttttccatat tgatatgtag     11160
     acacacacat ttgctataaa ctagtatctc ttcaggcgga gaatttaaat ttttcatttt     11220
     agcaatcccc agagccaatg actgggtcag gggcatggta atgagtttga tggttgattt     11280
     gactggatag cttcgattta cattgtcaga gcacagtcta cagaagtaga ctgtctcttg     11340
     gagatgagag acgtggtgtt agagagtggc tagaggaacg tcagagcagc agatcagagt     11400
     gagatcagag tggacaggga agcttaggga atggctgggc cttgaagaag gagaggctcc     11460
     tgagagcgtg gctggggagg cccaacagaa gggctagagc gaagctgtgg gcaccaggag     11520
     caaccttgta ctcagatcgg ggagaccggc tgggtctctg tgtgggtcac ctggccttct     11580
     tgtcatctcc ctgaaggatg ctctggagga cactagggat tctgaaatga agctgaaggc     11640
     attcccggaa gtgtgtaacg agaccatgat ggccctctgg gaggagtgca agccctgcct     11700
     gaagcatacc tgcatgaagt tctatgcacg tgtctgcagg agcggctcag ggctggtcgg     11760
     ccagcaggtg agaaggagag atgtccacag cctgggttct ggatggggaa tgtggagaat     11820
     ccatgaaata ggcctcattc catatgctgg gtacagttga ttagcattgc ttgactgcac     11880
     atcgttctag tgtcatggtc gattggtgat gtctgcttgg caggtaccat ctctttcaag     11940
     acctttaact ggttgggtaa aatggcctta tgggatggta gaatcctgtg ttagaatagg     12000
     aaaagggaat taaaaaatat ttagtctatt gcattaattc tatccctacc tgtgagattc     12060
     acttggttgg aactcagtaa aattcactgt ttcctcaagg ctgagcagct aagcaggagt     12120
     ggctatttat tctttatggc ccaaggtgag acttgggaac ctccgagttt cgccatgaga     12180
     aatggatttg gggggcggcg gcggggggac gggggtgctg acagggtacc caggaggcag     12240
     aacagtggga acttgggtca gtttctgtgt ggccacaggg ggatacaggc tggagtacac     12300
     acaatgcctt actctacttc tctgggtccc agctagagga gtttctaaac cagagctcac     12360
     ccttctactt ctggatgaac ggcgaccgca tcgactccct gctggagagt gaccggcagc     12420
     agagccaagt cctggatgcc atgcaggaca gctttgctcg ggcatctggc atcatagaca     12480
     cgctctttca ggaccggttc ttcgcccgtg agcttcatga cccccactac ttctccccca     12540
     tcggcttccc acacaagagg cctcatttct tatatcccaa gtcccgcttg gtccgcagcc     12600
     tcatgtctcc ctcccactat gggcctccga gcttccacaa catgttccag cctttctttg     12660
     agatgatcca ccaggctcaa caggccatgg atgtccagct ccacagccca gccttccagt     12720
     tcccagacgt ggatttctta agaggttaga aagcaattgc tttctttcta agtaggaatg     12780
     tgaatgtccc agatgtctag gctcttccag ggcttgacct gtgctggttt tatgttccta     12840
     gaagcctcag aggctggtat ttcctccatt tgtagggtaa aggagctagg atgggggcaa     12900
     agaaatgcag gtaaatgtgg gggggcgcag ttcaattagc atttgtagag attggagctc     12960
     ttgtgtttgt tacagtgaac tcagggtgtg atctggggct gtgcctccta taggatccca     13020
     gatattattt cttgggaact tttgagggtg tggtgtgaga ggcccgccct tccaggcaat     13080
     gagtctgtgt catcttaaag aagatgttca tggctgtgac cttagcgtgt aatgcctgta     13140
     agatgaaata tcacgtggac acgagaaacc ggtgtctgag gagtgatttt ttttttccat     13200
     tagtgccttg ggtcttaata ccatgtccta catgtatggt ttgcattaga aatagaagaa     13260
     gtcttggcat ccaacacaca tctactgtag ctcccattgt ctaaagatgg tttatgttgt     13320
     cagacacact tgtgctctct ggggcttgaa ggccagttag ggagtaccat cagtcaagga     13380
     gaacaaagaa cagccatgat gtcagaaggc acacagctga ggggatgtgg caggagagat     13440
     ctcctcagat ggagatggtg ggaagcgagg caggacctgc tgagagccgt gggaatatcc     13500
     tcagccacag ggaagtccca tggcactgag cagaggtgtg gaaggctgtc gggtgggcat     13560
     ccttctgatg tgccatgtgt ctaatcctgc ccctctttcc cctcatgtgt ccagaaggtg     13620
     aagatgaccg cactgtgtgc aaggagatcc gccgcaactc cacaggatgc ctgaagatga     13680
     agggccagtg tgaaaagtgc caggagatct tgtctgtggg tgagtccggg aaccagtggt     13740
     catctgactg tgggtctcca gtgactcact ggcactatcc ttttccaaag actagctctc     13800
     tgcctgggaa ctcttaatcc ccgggagact cctcaccctg gtgcacagcc tactctcctc     13860
     ttatctagag cttcattatt tgggagctgg ggtaggaccc agtgcctcct gcatgttagg     13920
     tgaacgctct accactgagc cacatcaatt ttactcagaa tcaagttcag gtgcagattg     13980
     ttctcatata gatgaggtgg agctaaagtg cccaccacca cccctgtggc tcactggcaa     14040
     acctgcagtc cacggtggaa ttacactgta tcgaccagta agccacagct cgttcccctg     14100
     gctactttgt tccacagtgc caagtactgt agaccctgat tttgaacttc tgattatgaa     14160
     atctttgaca acatgcgttt tgtttaacaa gtgctcgcca catgccaggc actgctgcaa     14220
     acacgtcaca ggtgtctgtt cgcagaatga tcctgtgagc tgggtacagc ttctttccgt     14280
     cttgctggat ggctaagtga cttatctaag attacgtgac acgaggcttc tcacttaggc     14340
     tgtgctcata aacagcaccc tggggtttct ccctggggac cttgagctat gtccttgtga     14400
     tggtggtcct tggtatcctg gccgcattct ttttggtgaa ctagtccctc agaaaaggac     14460
     tatttttcct tcatcagttc cccaggcaat ctgggtatgg tgacatatcc ctataatccc     14520
     aacatttggg aggctgaggt aggagggtgg tgaatccgag gccagcggcg aggttctgtc     14580
     tcaatgaaaa caaaacaaaa tacagcaaac ccaaaactgt tccccacaga tttgtcaggt     14640
     ctggctatca agccaatgcc ccgccttcag cctggtcttt acagtggctc acagtacacg     14700
     gtgctacctg ctcagatcac cctctttatt ggccgggaca gacctttaga gtctggttaa     14760
     atattcccag cctcattcct gcaatgttag gaggctagga aaaaaaaact agtgctttca     14820
     aaggtatagt gtgacattat aaacaaatat gggccacacc tgtaggcttt cccttatagt     14880
     tgaaagatgg ggtgcctgag ccaagagaag ccagtcacct tatagactgg atctcttaca     14940
     tcagacttag cgatcctctc aacagtcacc cgttagctct tatttacggt gcttataatg     15000
     gtatcctctc agcagtcacc gtttctgtca cccgttagct cttatgtaca gtcacttaca     15060
     atggcatgga taggcttcac agagacctct cgcctgggac atctgctcag ctcagcacta     15120
     gtagcgtggg cagagactga catgctgagc attaacaaca ttttggctcc aacctaccat     15180
     ctaccaagag caaccctccc tccactgtac aatcagaaac atcttcagat tgtctggact     15240
     gtctcctggt gggtggtgtg gtcccaggtt gagaaccacg ttctactctg tccttctctc     15300
     aggactttct tgtttgggct aatcagtggt tagagtgctc cggttattcc tggaagattt     15360
     cttctcattt ctgcttctgg tctccaatcc tgtgtcttgc cccatgcaac attatatctt     15420
     attttaagta tgaacaattg tagtagccac atagggccca gaaggcatct ctcttgtctt     15480
     gcttagtttg gatatagcct ctcatagatg tttaaaaaat aattgaggag gggggaggcg     15540
     ttgttaaaca ctggttttca gaagcatgag cactttgttg gtctcagtag cctgatgcct     15600
     gcagtgcact cttgcagaag agaggatgcc agagttccta tttcctcctg gtcatcctgg     15660
     gtggacaagg gcaggcaagg actgaccctt gggcaccaaa cacctgtgtt ttgtagactc     15720
     gggacctggc tgtcttctgc aggtttggtt ctgggaaaat ggtcttgccg aatctgtcaa     15780
     attatgttca aaaataagtt tggagaatat tctagaaccc tggtctcagg ggctcaggtt     15840
     gaggagtgaa agatggggct tcaatcctgg ttccacagat cgcttcctct atagatctga     15900
     gcaaggtcca cctaagtaaa taatgatcct gttctttgtg gggtgtccag tgccacagta     15960
     gcttctccta ttttggaaat gagtcctgga gaggagctca gggagcaaga gtaagtccag     16020
     gaacatgggg tagtcagcat aggtgctccc cagagcaccg tcagcagcat tgtgacaggt     16080
     caccaagact ggtcatgtct accgcccaaa gaagactcag ccacgctgct ctgacacagt     16140
     ttagcacagc taagccattg tatcccaaag cacgaagggg gcagcacctt ggtttcgtgt     16200
     ccggggaact gtaagagctg atctgtagcc ctccctggaa gagttcctct gcttcagatt     16260
     gtggctgctg cagctggttc ccaggggcgt gtccgtcccc tttaccctcc ctttcatgct     16320
     tctgccttct gcttctttct tctctgggca gactgttcaa ccaacaatcc tgcccaggct     16380
     aacctgcgcc aggagctgaa cgactcgctc caggtggccg agaggctgac agagcagtac     16440
     aaggagctgc tgcagtcctt ccagtcgaag atgctcaaca cctcatccct gctggagcag     16500
     ctgaacgacc agttcaactg ggtgtcccag ctggctaacc tcacacaggg cgaagacaag     16560
     tactaccttc gggtctccac cgtgagttgt atccagtcat ttgatgaggc tgagacccgg     16620
     gtgtatccag aggtgatgtg tgtctcttag agatgtggtg ggacaaaggt ccccatagga     16680
     tttacaccag cagggactag gaaaaccgta tgcacgttgt agcattgaaa tgcctttgcc     16740
     ccgtcaaata tccaagtctc attgtcaaga tgaggaaaga gagaggttct gtggtttgct     16800
     aagaacagac agttttgggc aacttccctg ggtcagcctg tcagcctggc tgtaacagtg     16860
     cttctgccca ggcactctga gtcgccatag atggttccat gttacgagtg agcatcggtc     16920
     ttagtttgcg caccactctg ccagctgcta cttgcacgat gtgcagtgtg tgtcgtctgt     16980
     acgacgctga gactagcgag atagagagct tgagcctggc tgactatata gtgacagctc     17040
     tccacagcac aagacacaca gagaacatca aaatcatttc aagtttctgg agtgcctact     17100
     tggctagtca tttttaagta acattaaagc gtggtggcgc acgcctttaa tcccagcact     17160
     cgggaggcag aggcaggtgg atttctgagt tcgaggccag cctggtctac agagtgagtt     17220
     ccaggatagc cagggctata cagagaaacc ctgtctcgaa aaaacaaaca aagaagcaag     17280
     caagcaaaca aacacacaaa caaaaaaacc gagatagttt tgctcggaat tctctaggca     17340
     tccagaaatg acagataacc cgcagatcca tatctggctg aagggggcaa agggcagttc     17400
     catatccttt gacagagaag ggtgcactct gcagccatcc cgtagagaca cttctcctgc     17460
     cttcctctag gtgaccaccc attcctctga ctcagaggtc ccctcccgtg tcactgaggt     17520
     ggtggtgaag ctgtttgact ctgaccccat cacagtggtg ttaccagaag aagtctctaa     17580
     ggataaccct aagtttatgg acacagtggc ggagaaggcg ctacaggaat accgcaggaa     17640
     aagccggtaa gcgggcagct ttctgtgacc aggactgtaa acaagactgg aggctgaagt     17700
     ctcagagtca gacaagaaca gactatgcat tctggcacgt gctatcctga ggccagagcc     17760
     acggggaagc taggaaaacc ccggggattt tactttcttt gctctgggaa atgtttttct     17820
     tgatggttaa ggatgtgggt gttggcggct gcttctgggg gcatactgat tctcttatcc     17880
     actctcctct tttttttttt caagtgcgga atgagataga agcatcacct tcctatatgt     17940
     aggagtgtct gggagggaat ctcccagctc cccgaggtgg ctgcagaccc ctagagaact     18000
     ccacatgtct ccaggcgagt aggcctcacc caagcagcct gcccttcctc tggattctgt     18060
     acactaatgc ctgcacttgc tgctctcggg aagaactgat tcccccacgc aactaatcca     18120
     ataaaagccg ccttgcgata cgtgtccttg ggtctgtttt ttatttaatc tctgcaggct     18180
     gcacatcttg gtttggtatg gaggggaaac aaggataata gccgggtcag ttgctaaagc     18240
     acttgccaca cgaacgacag tagttgaaag tcagcatggt gcacctcttg tatttaacct     18300
     cggtgctatc agaacagaga aagagaactt gctggtgttc ggtgagcctc aggttccagt     18360
     gagagatctt gtctcagaac acatgggtag aaagagacca aagagcgaca cgaggtcatg     18420
     catataaaaa tgaacagctg agactatata ggggtctcca tacactgtag agtactcatg     18480
     acaattgggg caccttcagc tttgagagag gtatgttcca atgagccacg gaggtgaatt     18540
     c                                                                     18541
//


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