spacer

EBI Dbfetch

ID   AB010091; SV 2; linear; genomic DNA; STD; MUS; 14651 BP.
XX
AC   AB010091; AB010089-AB010090;
XX
DT   31-MAR-1998 (Rel. 55, Created)
DT   18-AUG-2007 (Rel. 92, Last updated, Version 6)
XX
DE   Mus musculus Klotho genes for Klotho protein (membrane and secreted form),
DE   complete cds.
XX
KW   .
XX
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea;
OC   Muridae; Murinae; Mus; Mus.
XX
RN   [1]
RP   1-14651
RA   Shiraki-Iida T.;
RT   ;
RL   Submitted (29-DEC-1997) to the INSDC.
RL   Takako Shiraki-Iida, Tokyo Research Laboratories, Kyowa Hakko Kogyo Co.
RL   Ltd., Anasawa-Iida group; 3-6-6 Asahimachi, Machidashi 194, Japan
RL   (E-mail:takako.iida@kyowa.co.jp, Tel:0427-25-2555, Fax:0427-26-8330)
XX
RN   [2]
RX   DOI; 10.1016/S0014-5793(98)00127-6.
RX   PUBMED; 9537505.
RA   Shiraki-Iida T., Aizawa H., Matsumura Y., Sekine S., Iida A., Anazawa H.,
RA   Nagai R., Kuro-o M., Nabeshima Y.;
RT   "Structure of the mouse klotho gene and its two transcripts encoding
RT   membrane and secreted protein";
RL   FEBS Lett. 424(1-2):6-10(1998).
XX
RN   [3]
RX   DOI; 10.1038/36285.
RX   PUBMED; 9363890.
RA   Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T.,
RA   Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A.,
RA   Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.;
RT   "Mutation of the mouse klotho gene leads to a syndrome resembling ageing";
RL   Nature 390(6655):45-51(1997).
XX
DR   MD5; 541652c89131021796bf1eb97ff086c8.
DR   Ensembl-Gn; ENSMUSG00000058488; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000078856; mus_musculus.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..14651
FT                   /organism="Mus musculus"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:10090"
FT   misc_feature    674
FT                   /note="major transcription start site"
FT   CDS             join(687..1511,1869..2379,3762..4030,9634..10735,
FT                   12353..12690)
FT                   /codon_start=1
FT                   /transl_table=1
FT                   /gene="klotho"
FT                   /product="membrane form of Klotho protein"
FT                   /db_xref="GOA:O35082"
FT                   /db_xref="InterPro:IPR001360"
FT                   /db_xref="InterPro:IPR013781"
FT                   /db_xref="InterPro:IPR017853"
FT                   /db_xref="InterPro:IPR018120"
FT                   /db_xref="InterPro:IPR028546"
FT                   /db_xref="MGI:MGI:1101771"
FT                   /db_xref="UniProtKB/Swiss-Prot:O35082"
FT                   /protein_id="BAA25308.1"
FT                   /translation="MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWA
FT                   RFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPS
FT                   DSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGT
FT                   AGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYA
FT                   ELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVW
FT                   HLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYP
FT                   ESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQL
FT                   LSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYT
FT                   AWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPL
FT                   EGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVD
FT                   FSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVHANITP
FT                   VVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNT
FT                   RNMTYRAGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAER
FT                   VLEFDIGWLAEPIFGSGDYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYT
FT                   TILVDWEKEDPMKYNDYLEVQEMTDITWLNSPSQVAVVPWGVRKVLNWLRFKYGDLPMY
FT                   VTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDINLCGYFAYSLSDRSAPKSGFY
FT                   RYAANQFEPKPSMKHYRRIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQTRKSLLVFIS
FT                   FLVFTFIISLALIFHYSKKGQRSYK"
FT   CDS             join(687..1511,1869..2379,3762..4078)
FT                   /codon_start=1
FT                   /transl_table=1
FT                   /gene="Klotho"
FT                   /product="secreted form of Klotho protein"
FT                   /db_xref="GOA:O35082"
FT                   /db_xref="InterPro:IPR001360"
FT                   /db_xref="InterPro:IPR013781"
FT                   /db_xref="InterPro:IPR017853"
FT                   /db_xref="InterPro:IPR018120"
FT                   /db_xref="InterPro:IPR028546"
FT                   /db_xref="MGI:MGI:1101771"
FT                   /db_xref="UniProtKB/Swiss-Prot:O35082"
FT                   /protein_id="BAA25309.1"
FT                   /translation="MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWA
FT                   RFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPS
FT                   DSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGT
FT                   AGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYA
FT                   ELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVW
FT                   HLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYP
FT                   ESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQL
FT                   LSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYT
FT                   AWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPL
FT                   EGTFPCDFAWGVVDNYVQVSPLTKPSVGLLLPH"
FT   exon            687..1511
FT                   /gene="klotho"
FT                   /number=1
FT   gap             1629..1728
FT                   /estimated_length=unknown
FT   exon            1869..2379
FT                   /gene="klotho"
FT                   /product="Klotho protein"
FT                   /number=2
FT   exon            3762..4078
FT                   /gene="Klotho"
FT                   /product="secreted isoform of Klotho protein"
FT   exon            3762..4030
FT                   /gene="klotho"
FT                   /product="Klotho protein"
FT                   /number=3
FT   misc_feature    4031..4078
FT                   /note="secreted isoform specific translation region"
FT   polyA_signal    8222..8227
FT                   /note="secreted isoform specific polyA signal site"
FT   exon            9634..10735
FT                   /gene="klotho"
FT                   /product="Klotho protein"
FT                   /number=4
FT   gap             11598..11697
FT                   /estimated_length=unknown
FT   exon            12353..14651
FT                   /gene="klotho"
FT                   /number=5
FT   polyA_site      14315
FT   polyA_site      14319
FT   polyA_signal    14632..14637
FT                   /note="polyA signal site for membrane isoform"
FT   polyA_site      14651
XX
SQ   Sequence 14651 BP; 3507 A; 3554 C; 3116 G; 4265 T; 209 other;
     atcattctta gacccactgt gtgttcttgt aggctctgca ggctggggtc tgaggcaagg        60
     cggactctcg ccttctctaa tgggatgggg gactctctta tcagaagaaa actgcctgag       120
     tactcttaaa cctcgcaaag ttccacctga attccccacc ctgccttcct gctgtgttca       180
     gatacagcaa agctctcctg ggatgttctc tgaaagattc ccctggatag agggctcaga       240
     atgggagaaa ggggaaagca ggtgattttc cccactcccc cacccccgag gcgccaaacg       300
     ttgtgcaaag ttgggcagct gtttctgtcc tccaggaaca ccagtcccag gaaggcaaag       360
     ggagtggacg cggggagtgg gcgacgcggg gacatctcag gatggaggcc acaggattgt       420
     gcgatgtgga atagtctgct ccctgagctg gctgcagcag gtgcttgttc tccgacgtcc       480
     ctatgacccc tgctgtgctc tctctgggca ccctggctgg ctgagcccct gtcccgcccc       540
     cgtgccaggc cggagtgggg ggcggcgcct gctctggata atcattgctc gtggggcggc       600
     gggagcgggg gtgggcaccg cgtagggagg gcggcggggc gcgggcatat aggggcgcgg       660
     cgcggtgccc tcccggctcc cgcagcatgc tagcccgcgc ccctcctcgc cgcccgccgc       720
     ggctggtgct gctccgtttg ctgttgctgc atctgctgct gctcgccctg cgcgcccgct       780
     gcctgagcgc tgagccgggt cagggcgcgc agacctgggc tcgcttcgcg cgcgctcctg       840
     ccccagaggc cgctggcctc ctccacgaca ccttccccga cggtttcctc tgggcggtag       900
     gcagcgccgc ctatcagacc gagggcggct ggcgacagca cggcaaaggc gcgtccatct       960
     gggacacttt cacccatcac tctggggcgg ccccgtccga ctccccgatc gtcgtggcgc      1020
     cgtcgggtgc cccgtcgcct cccctgtcct ccactggaga tgtggccagc gatagttaca      1080
     acaacgtcta ccgcgacaca gaggggctgc gcgaactggg ggtcacccac taccgcttct      1140
     ccatatcgtg ggcgcgggtg ctccccaatg gcaccgcggg cactcccaac cgcgaggggc      1200
     tgcgctacta ccggcggctg ctggagcggc tgcgggagct gggcgtgcag ccggtggtta      1260
     ccctgtacca ttgggacctg ccacagcgcc tgcaggacac ctatggcgga tgggccaatc      1320
     gcgccctggc cgaccatttc agggattatg ccgagctctg cttccgccac ttcggtggtc      1380
     aggtcaagta ctggatcacc attgacaacc cctacgtggt ggcctggcac gggtatgcca      1440
     ccgggcgcct ggccccgggc gtgaggggca gctccaggct cgggtacctg gttgcccaca      1500
     acctactttt ggtgagttcg aggggccagg cagggggcca ccttggggga cagagggcct      1560
     cggaagtgcc agagccactt ccagaaatcc ttactcgaac ccatcacgag gtcacacagg      1620
     tctgacacnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      1680
     nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnct agccactgtg      1740
     ttaggtcaga tggtaaccag ccatccagtg gagtggggaa cccagtaaat attgcatgcc      1800
     tcccnccaat acctcctggg agaaatccat gtttgttttt tgttttttgt tttttgtttc      1860
     ctctgtaggc tcatgccaaa gtctggcatc tctacaacac ctctttccgc cccacacagg      1920
     gaggccgggt gtctatcgcc ttaagctccc attggatcaa tcctcgaaga atgactgact      1980
     ataatatcag agaatgccag aagtctcttg actttgtgct aggctggttt gccaaaccca      2040
     tatttattga tggcgactac ccagagagta tgaagaacaa cctctcgtct cttctgcctg      2100
     attttactga atctgagaag aggctcatca gaggaactgc tgactttttt gctctctcct      2160
     tcggaccaac cttgagcttt cagctattgg accctaacat gaagttccgc caattggagt      2220
     ctcccaacct gaggcagctt ctgtcttgga tagatctgga atataaccac cctccaatat      2280
     ttattgtgga aaatggctgg tttgtctcgg gaaccaccaa aagggatgat gccaaatata      2340
     tgtattatct caagaagttc ataatggaaa ccttaaaagg taggctttca agaaaaatcc      2400
     cattgttttg ccaaaattca cacatgcaca ctccccccaa cacacaccac atacaccctc      2460
     cacaatacac cccatacata caacacatac acacatacca cacacacatc atacaccaca      2520
     cacactgtat catacacaca catcatacac atatgcatat catatatgca catgtcacac      2580
     acataccata cacacacatc acacaccaca cacatatcac atgtaacata caccacacat      2640
     atcatacaaa tcacacacac acacacacac acacacacac ataccataac acatatacct      2700
     tttaagacta tctgtaaaat gtgcatatat aattnttgtc aatatgtaaa taatttgagc      2760
     agtagggaga atgtatttat gtaacactgc tctcatttgg gcccttcaga agcttaattt      2820
     tccaagtacc ttaaaaggaa ctttgataat ttgctgataa ggcaataaaa caagattaat      2880
     atttaagaca attgggctcg cagtcgctca tctacattgt tagattatac aacacagatt      2940
     taanagtctc agactatgta gctctctata tatttctagc ccatttgttt tagctgaata      3000
     gcatgttttt ctttaatttt tttattcatt gaaattccat tcatttatac aatgtatgtt      3060
     gattatttat aactaccact agctccctct ttcaacaaca aaatgttttt ttaaagcaag      3120
     aggagtattc atatgacctg gataaactga gctttaaagg ctatgaaagt gggtcagatg      3180
     tagtgtactg gcaccccaag gcctttggtc ccatcgacag cacaagaaaa aacaagacac      3240
     gagtcacagt gtttagtggc caggttagga acaacaagcc accctagcac ctctgggaat      3300
     aagaaactcc actgtgaagg taaaactatc tatgaagaca ttgtctgggg gagtcatcta      3360
     gatttgatga gagccttttg tgaactagaa aaaaagtgtt taccaaataa gaagcattcc      3420
     acctgacttc tgtcttttaa tatttttgag attttattta tttttatttt atgtatgaga      3480
     atttttgact gcatgtgtat gttcatcacg agcatgcaat gcccacagag gccagaagag      3540
     ggcattggat cccttgcact ggaattacag ttgtgagcca ccatgtgggt gctgggagcc      3600
     aaacactgga tcctctagaa gaccggcaag tgcttttaac cattgagcca tctctctaga      3660
     ctcttgcctt gcttctttaa gtggaaaaac ccctctctgc ttgagtcaca caaagcccag      3720
     tgaggggatg acaccactct tgtcctctct tccctctgca gcaatcagac tggatggggt      3780
     cgacgtcatt gggtacaccg cgtggtcgct catggacggt ttcgagtggc ataggggcta      3840
     cagcatccgg cgaggactct tctacgttga ctttctgagt caggacaagg agctgttgcc      3900
     aaagtcttcg gccttgttct accaaaagct gatagaggac aatggctttc ctcctttacc      3960
     tgaaaaccag ccccttgaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa      4020
     ctacgttcaa gtaagtcctt tgacaaaacc cagtgtcggc ctcttgcttc ctcactaagc      4080
     tctggccaag gcacagtgtt gggacgttga gccaaacagg gttccctagt gagcttatga      4140
     actacatagt cctgaacgct tcagtcttca aacatctttc aatctacatc ttgtgctctc      4200
     cattaggtcc aaagggaaac agattcaaac catgaatatg taagctctgt taagacaata      4260
     caaagataag gcacttccct ttggtgttac ggctggggtc cctgctcagg aagttaagtt      4320
     tttcataaat aagattcaac acagaagtcc ggagcatctc agggaagttg ctgagaatgt      4380
     ctggagcatt tagcagattt ctcctcactg taaatgcccc actccaggct catagaaaaa      4440
     aaatctcaag aaagcaaacc attgattcaa tgatctattg atagcaccaa ggcattccaa      4500
     aaatgatcag ttagtattta ctgagcatca aaactgtgta ggaagtcctc aaaaccattt      4560
     tatttttagt ttccccagtg ttaaagtgac ttgtttcttg tggtttgacc aaatacttta      4620
     tgtaagcact tgctgactgc cagttgtgta tgaaacccca tgtgggttgc tgggttccct      4680
     ttgtgaggaa gaccaaagtt cagtatctgt agtcagatct caaggtttag catgctggag      4740
     tctggctcag tggttctcaa ccttcctaat gccaccgccc tttaatacgg gtcctcatgt      4800
     tgtagtgaca ccaaaccata tgattatttt tgttgctacc tcataattgt aagtttgcca      4860
     cggctatgta ttgtaatgta aatatctgtg ttttctgatg gtcttaagca atcctgtgaa      4920
     agggttgttt gaccctcaaa gggccgtgac ccacaggttg agaactactg ttgtagtcca      4980
     gaaggagggg ctacaagttg tagcttcaaa agaaatattc ggaaaaatgc ttaggtccaa      5040
     ggggaggctt cttattggaa tggaattttg gttcctgtag atatcgaaat gctttgtttt      5100
     gttttgaagt acatcgccta tccttgatgt atttctgccc ctgttgatgt aagatgtcct      5160
     tttggctctt agactatgta gctcaatcta gaggtgattt tggacttaag tcctctcctt      5220
     accttcaaaa gacagctgag caatgttgag tggagctcta ttgaggcctg ggatggcacc      5280
     atagggcttc atggtgttgt tttccagctt ggtgctattg acagctagtt gaacagtggg      5340
     gtgctggggt ctactggaag aggtctttag atcacaaagg gcatgtccta aaagagagta      5400
     gtgggacctc aacccctttc tcttcctttt tctctcattt tatcatgaaa caagcagttt      5460
     gtcatactct gtgcccccga ctctggtgtg ccaacttacc acagtcccct aaacagtgag      5520
     gcccattgat tgtttgccgg agcatccaaa gtcatgagcc caaatcagcc ttggctctga      5580
     ttttctcagg tttgctagaa ctgacaggat gttagccaat cagctaacat cagcaccatc      5640
     ctgctcagtg tgaggttatt ttcctgctcc atctccccac ttctctctca gaacaaggct      5700
     atctggattg tcctatccta attcgtcaga gtctacagtg aagtttaggt aggctctaat      5760
     gtggcagaaa tggagatgtc aaaggaggag gaagaagata aatgtgtccc acatcccctc      5820
     cctccttacc ttttttgggg ccaggagtag attagatagc tcctggtctt tgttgtattt      5880
     ccttacctct tgagagtttc ctgctggcca catccctgca ctggaggctc acacacattg      5940
     tctggcatag cagctggagt ctgccaagtg acttcgtgta cagtcagtac tcagactcgc      6000
     atctgtacag cgagacaggg ctgtgtggga aggccatctt cctcccaccc tgctccctaa      6060
     ggatgatttg tgtcttcaca gcgtgaagtg ccagggtttt ggtcgatgtt cttgaaagag      6120
     aagggcaacc ccaatcagaa tcaaaatcat ggcagtgaat aggaaatgtg agggtggggg      6180
     gaggagaagt cttgttttgt ttttgatttt gttatctctt cattttgcag gaccttgtac      6240
     ctgctagtca ctgttactga gtcacaccat ccaactctta aggctgtgtc aggatctcat      6300
     ccgacatcag cgatgcaatg gccccagtcc ctctctctgt ctacattgtt gagatcatct      6360
     actcagggtg tctgacctgc tacatgttca aggccctctg catcctctgt gatcccaacc      6420
     caaatcccaa aatcccatat ctcaaccctg ctgtggttgt aaacgctctg gaagctcccg      6480
     ggtgggaaca ggctatagtt agggtttact tctgtctgcc tgtgctgctg gctttcctct      6540
     aggtcatcag agctcctctc aagacaaccc cctggctgac agcatcagaa cgcctaattt      6600
     gttctctcag tgtgagctgg gtgtctttgt gacaagcagg gctcagcacg tctacaacat      6660
     tatgttacgt tagtgtctca agaagtgatt ttttttaacg aatatttgta ttagttcttg      6720
     ggggattcta tagtgaattt gggtcatatt tacttccttc tattatcccc ctaacttctt      6780
     ccagatccat tcacatcttc ccaaacccca aacttcacat tgtcccccac cttcttcata      6840
     tggacattta ctgtgatttg tattgcccat gcaatcctgg tgggggacca tcctctggaa      6900
     tttggtccac ctacgaagac ctacatcctt aaggaaaatt cactctccct gccctaaaag      6960
     ccattatctt gagcaggtgc tcaagaaccc tattttcttt ctctccctct ttctctttcc      7020
     tccttccctc cttccctcct tctttctttc tttctttctt tctttctttc tttctttctt      7080
     tctttctttc tttctttctt tctttctttc tttcttcctt ccttccttcc ttccttcctt      7140
     ccttccttcc tctctctctt tctctctctt ctctcgccct ctctttctct ctcttctctc      7200
     gccccctctt tctctctcct ccttttatgt tatcatgctg actggcttgc ctctgtgtag      7260
     acaaccccag atgctgtgag ttcatgagta cagaggttct atctctggta ctccccaacc      7320
     tctgctctga caaccttcct gtccttagat ggtccctgag ttgtgagttt ctatgaaacc      7380
     actgttcact gcaccaagaa actttaagaa gtgatttaaa aaaaaaaacc taaagtttct      7440
     cttttccctc ctgggtagtg ctccatactc aagagttggg tcatatattt cacccaaata      7500
     attaaaaata tccccctaag gcaggtgatg gtggtgcaca ctttagtccc agcactcagg      7560
     aggcagaggc gggtggatct ttgtgagttt gaggcagctg gtctgcagag tgagtatcaa      7620
     gacagcaggg gtacacagag aaccctgtct tgaaaaacaa aaaccaaaac aaaacaatgt      7680
     atgtgtgtgt atgggtgtat gtatatgtgt gtatgtgtat acatgtgtgt gtatgtgtgt      7740
     gtgtgtatct ccctagctac acaccacctg ttagaagttt gtagctgggc acatccacat      7800
     gggggaggag tcactttgct caaacccagt gtcccagcnc ctgagtttgc ttgcncatag      7860
     ctactggtgc tgttagttga ccaaaatgaa gcaggttaca tacaacatag agcatcatgg      7920
     ttgtccactg ctgtgaggag agacttttat caataacaaa ttgaatatat gttttgtgct      7980
     caacctccct cagacctatt tttacttttt agtgaaacct aaggcagcga gctgctataa      8040
     ataagttaga ggaacttttg cctgcacact catttctaca tttttcctag tttggagaac      8100
     tgaccctacc atctgcaact ttacatggtc tttcatactt gtttgtagtt agactcaata      8160
     gaaactgtta ttctgggatg gttctggtag agaagttgtg aatttagtac attcagagtt      8220
     gaataaaaat aatccgaaaa atggtgccnc tggccctgaa gactgaanct aaaagactac      8280
     acaggtgagt attttctgca aagctgagag tgtgaaagca ctgtggcgct ggcagtggaa      8340
     gggatnctga caaattccct cagcatcgga aacgtgtgtg ggtgagccag ggtctcagaa      8400
     gtagttcccc agccctattt attatatttt attgctcttc tttgcgaaca caggctcact      8460
     ctgccccttg gagaacagca cgcttacacc tgacaaaacc tgggccagag aatcaagaaa      8520
     cagggcgggt taggtgaagg tacctgttct cacatgacta tttcagagtg aaacccagct      8580
     tagcttgcca ctgcgaggtg ggctggccct ttctgtgcaa gccataaaat ttcctgatgc      8640
     tgcttgcaca cttggcctac atttccnaga gactggtttt tttttttttt tttttttttt      8700
     cattttggag gcttacatat tcatggctga gaagagtcaa accctaaaac acgctttaaa      8760
     agtcccgccc tcaccccgcc cttgcccccc ccccccccag ggtcctctcc tcagccccct      8820
     gcctccaagg gttgatgatg gcactgtctt tttgcataca tataaatcat caggttacat      8880
     tatcaaagtt ttgttttttg gttgtttggg atttggttgt atttggtggt ggtggtttgg      8940
     gtttggttgt ttggtatttt gggacagggt tactctgtgt agctctggct atcctagaac      9000
     tcactctgta gaccgggctg gccttgaact ctgcctctga ctccagagtg ctgagattaa      9060
     agctgtgtgc caccatagcc cagctgtgtt atctaagatt ttcatcatct ctcaagccga      9120
     caaaaggcaa cagttacaca gatttgacaa ccaaaacagg cctcagtaat aattttaaca      9180
     agcacagtta agtaacactt tgtgttactt tgttttctga cctcagacta ctcatgagta      9240
     aattttcttc acttcttatt taaaaaaaaa ttgtttttgt ttgcttcaaa gcagtcttag      9300
     ggctggagac atgactcggt ggttaaaaag cactgactgc ttttacagag aatcctggtt      9360
     tgattcccag cacccacatg acggctcaga actgtctgta attccagttc cagaggatct      9420
     aacgccctct tctggcctct acagccaccg cacacgtttg ttttgttttg ttttgttttg      9480
     ttttgttttg ttttgtaagg ggaatgtttt ctttcttgtg aacagcagtt taagaattca      9540
     gttgtgcacc tcttgcttgc tggagttgtt gaagttatgt ctgcactttt ttgggtccgc      9600
     ccagatagct aacagttgct ctgttctttg taggtggaca ctactctctc tcagtttact      9660
     gacccgaatg tctatctgtg ggatgtgcat cacagtaaga ggcttattaa agtagacggg      9720
     gttgtagcca agaagagaaa accttactgt gttgatttct ctgccatccg gcctcagata      9780
     accttacttc gagaaatgcg ggtcacccac tttcgcttct ccctggactg ggccctgatc      9840
     ttgcctctgg gtaaccagac ccaagtgaac cacacggttc tgcacttcta ccgctgcatg      9900
     atcagcgagc tggtgcacgc caacatcact ccagtggtgg ccctgtggca gccagcagcc      9960
     ccgcaccaag gcctgccaca tgcccttgca aaacatgggg cctgggagaa cccgcacact     10020
     gctctggcgt ttgcagacta cgcaaacctg tgttttaaag agttgggtca ctgggtcaat     10080
     ctctggatca ccatgaacga gccaaacaca cggaacatga cctatcgtgc cgggcaccac     10140
     ctcctgagag cccatgcctt ggcttggcat ctgtacgatg acaagtttag ggcggctcag     10200
     aaaggcaaaa tatccatcgc cttgcaggct gactggatag aaccggcctg ccctttctct     10260
     caaaatgaca aagaagtggc cgagagagtt ttggaatttg atataggctg gctggcagag     10320
     cctatttttg gttccggaga ttatccacgt gtgatgaggg actggctgaa ccaaaaaaac     10380
     aattttcttt tgccctattt caccgaagat gaaaaaaagc tagtccgggg ttcctttgac     10440
     ttcctggcgg tgagtcatta caccaccatt ctggtagact gggaaaagga ggatccgatg     10500
     aaatacaacg attacttgga ggtacaggag atgactgaca tcacatggct caactctccc     10560
     agtcaggtgg cagtggtgcc ttggggcgtg cgcaaagtgc tcaactggct aaggttcaag     10620
     tacggagacc tcccgatgta tgtgacagcc aatggaatcg atgatgaccc ccacgccgag     10680
     caagactcac tgaggatcta ttatattaag aattatgtga atgaggctct gaaaggtgag     10740
     accccgcccc ctcaatcccg gaaatacatc agagcgtgta tcgttcttga tggagaggaa     10800
     gccactgccc atcctgaagg agaactaaag tcagcgagct tccctatggt gaagaagcat     10860
     gctcgggaag ggggaggggt aggaggaggg ggagggggtg gagcccatag tccttagcac     10920
     tgtcctgaat ctgtcaaagc ctagcctctt ctgcttcaaa ggaccccaga acttcccttc     10980
     ctttcttcct tccttccttc cttccttcct tccttccttc ctttcttttt agcttttatc     11040
     atttttttct tcctactttt aaaaatgttt ttgtgcgcat acagaataac ctagttcctt     11100
     ccttatgaga ttttgttcag gtgtgtggag atctcattgt agattgcttt cattcatttc     11160
     tgcctctgcc ctcccttgtc cccctctcta tctcttgata ggcctccctc ctcacaggtt     11220
     atcctagggt ttcttgtcac atttacacat ttgttaatca tttaggtttc ttgagaattt     11280
     catgcacgag tactgtgttt gtattatgtt tcccctttct tccctttcta acttctctgt     11340
     gccccaatat cccctcaaat actgacttct cctttgttta tgagttgtga cacacacaca     11400
     caccacatac acacaccccc acacttcata ccacacatac cacactcata cacatacatc     11460
     acacacatcc acaaacacat accacacaca ccacaacaca cataccacac acggacatat     11520
     acaccacaca catccacaca gacataccac acacacatac ataccacaca cataatacca     11580
     tacacacaca cctatcannn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     11640
     nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnatg     11700
     tatgtatgtg taaatatgtg tatgtgtgta tgtatgtgta tatgtatgta tataagtgtg     11760
     tacgtgtata tgtgtgtatg tgtgcatgta tgtataagga catctctcat ttgtccctct     11820
     ctcaccctta tcctctcttg ttctcaaatc tcctcaattt agatctcttc ctcagcactc     11880
     ataattctat aattactgat ttcatgtcct tgtgagcaca cactcgagca cacacacatg     11940
     taatattcac atgtgtgtgt gtaaatatga gccgtaagag aaaatgtaca atccttgtct     12000
     tgagtctcag ttggatccat tttcctgcaa atggcatcct ttcactcttc acttcaacaa     12060
     aattccagca tgtacatgtg cctttcttta tgtccagttt tgttatcctt tgatctattg     12120
     acatctcata cttgttgtga atggtgcagc tgcccccaca gccattttaa ctgtgtgtgt     12180
     tgtgcatttg cctatttgtt ctggtgtgaa atctttcccg gtgaaatctg atgagtctca     12240
     agtattgttg aacggtatcc aggcttttca ttatctgcca aggctgtgta aaaaggctga     12300
     gttgtgtata aagtatacag tcaaccctct cctgcccttt tcttttctct agcctacgtg     12360
     ttggacgaca tcaacctttg tggctacttt gcgtattcac ttagtgatcg ctcagctccc     12420
     aagtctggct tttatcgata tgctgcgaat cagtttgagc ccaaaccatc tatgaaacat     12480
     tacaggagaa ttattgacag caatggcttc ctgggttctg gaacactggg aaggttttgt     12540
     ccagaagaat acactgtgtg caccgaatgt ggattttttc aaacccggaa gtctttgctg     12600
     gtcttcatct cgtttcttgt ttttactttt attatttctc ttgctctcat ttttcactac     12660
     tccaagaaag gccagagaag ttataagtaa tgtgaacgtc tgcctggcca ttcgctttgg     12720
     gatcaagatg tacacgccgt cagccgtttg cacctctctg tgttgtgagc cgcattccac     12780
     acatttcgat tctagaaaac cctttttgtc atgggtggta gaggttttaa acaggaattg     12840
     gtgagaataa aatattgcag ggtgaatggt atctgaatct gctctctttg gtggcaatta     12900
     cggaattata ctcaccacag tttctacagt gccccggaat ggaaggcata gaatacggta     12960
     gggataacag tgccaagcag acagaagttt aaagaacaac tttagggact tgtttatcca     13020
     tggccatttt taaattcact cctgttgggg agtaacactc tctcaattac catcttaaca     13080
     cctggacttt acctgatcca gttttacaag gtgaagtaga aaaatatcca gtaaaggtgg     13140
     ccaagagccc tgagtccaga gcagcccatt aagaagcact attcctacca aatgctgcta     13200
     atgtcaattt acaaatatac ttagaaagca cattatggac atttgtattc ttgtgaatgt     13260
     ttttgaggtg tgccctaaac cccagatcct tgagggcttt ctcttaccaa ctttcctttc     13320
     agagcctgct tgttggagat tcttccccag cccccttccc ctttccctct tgctctgccc     13380
     cacctcgctc cacccagctt gctccagccc aaagattctt tatttgtttc tcattaccga     13440
     aggttgtgag ccaccatgtg gtttctggga tttgaactca tgacctccgg aggagctgtc     13500
     atgctcttaa ccagcccatg ttgaagattc ttttgataaa tattcacaaa aaataaagat     13560
     gagccatgag ctgttggcct cttcggaagc ggaaactgag tgatttgatt gaacatcctt     13620
     ttatctttga ccagaccttg gaatgaatgc aatgaccttt cccacaggaa gaaggaggag     13680
     ctctcagtca aactgtaaag aatgcctctt cagaatatgc tgtcagtgct tggatgccat     13740
     gatgttcaac tttcttagtc gatccggcag caatcacagt gtgagcacac tgggaacctg     13800
     tccttgcggc cgccgagatc taccgtgtgc ttctgtgaag aggctttgac gtagcccctc     13860
     tttgagctct tacaccatgc tactgacttc tagaaaggct aattaggtct tcttctacac     13920
     ctaataccct aagtcttact gactctcacg ggagaagtct ctgtgctaca cctgagtggt     13980
     cttattgata accctgatac cagatcaggc aagataaatc cgtcatagca ggcatggcta     14040
     cccttgctgc cacagggtca cagcacatag ctcatcaccc tgttattctt catcttgcaa     14100
     tgtggtatgg ttttcctggt gaatgatcag cttttgctgt ggtattcttt atacatctgg     14160
     acttattatt gaaatcaaat gctatagaat caatagttta ttttatgtct atttttcttg     14220
     atcgcagagt aatatatatt aattgtaaaa aatttaagaa acaaaaacta tatgtaaaga     14280
     aaaaattata atataataca gagatgctgc tgacagttcc tatgtgttgt gttttgtata     14340
     ctgagatcat gtgatacgta ggcatacatc ttcttgggtt tttttgtttt tgttttttgt     14400
     tttgttttgt tttgttttgg ttttttgaga tagggtttct ctgtatagcc ctggctgtcc     14460
     tggaactcac tttgcagacc aggctagcct caaactctta ttcattttta ctgaagtaat     14520
     ttttctgtca ttagtcttca agagcaaaac tttaatagtt atggagaata ttgccagaac     14580
     agctcaaaac tgttttattt gttggtccaa tttcccatta attagttcaa taataaatat     14640
     catttagaaa t                                                          14651
//


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