Dbfetch
ID AB010088; SV 1; linear; mRNA; STD; MUS; 5825 BP. XX AC AB010088; XX DT 30-MAR-1998 (Rel. 55, Created) DT 23-SEP-2008 (Rel. 97, Last updated, Version 6) XX DE Mus musculus mRNA for secreted isoform of Klotho protein, complete cds. XX KW secreted isoform of Klotho protein. XX OS Mus musculus (house mouse) OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. XX RN [1] RP 1-5825 RA Shiraki-Iida T.; RT ; RL Submitted (29-DEC-1997) to the INSDC. RL Takako Shiraki-Iida, Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. RL Ltd., Anasawa-Iida group; 3-6-6 Asahimachi, Machidashi 194, Japan RL (E-mail:takako.iida@kyowa.co.jp, Tel:0427-25-2555, Fax:0427-26-8330) XX RN [2] RX DOI; 10.1016/S0014-5793(98)00127-6. RX PUBMED; 9537505. RA Shiraki-Iida T., Aizawa H., Matsumura Y., Sekine S., Iida A., Anazawa H., RA Nagai R., Kuro-o M., Nabeshima Y.; RT "Structure of the mouse klotho gene and its two transcripts encoding RT membrane and secreted protein"; RL FEBS Lett. 424(1-2):6-10(1998). XX RN [3] RX DOI; 10.1038/36285. RX PUBMED; 9363890. RA Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., RA Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., RA Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.; RT "Mutation of the mouse klotho gene leads to a syndrome resembling ageing"; RL Nature 390(6655):45-51(1997). XX DR MD5; f9d72c482922713def69dc1e9ada8c8f. DR Ensembl-Gn; ENSMUSG00000058488; mus_musculus. DR Ensembl-Gn; MGP_129S1SvImJ_G0030414; mus_musculus_129s1svimj. DR Ensembl-Gn; MGP_AJ_G0030387; mus_musculus_aj. DR Ensembl-Gn; MGP_AKRJ_G0030314; mus_musculus_akrj. DR Ensembl-Gn; MGP_BALBcJ_G0030396; mus_musculus_balbcj. DR Ensembl-Gn; MGP_C3HHeJ_G0030110; mus_musculus_c3hhej. DR Ensembl-Gn; MGP_C57BL6NJ_G0030851; mus_musculus_c57bl6nj. DR Ensembl-Gn; MGP_CASTEiJ_G0029512; mus_musculus_casteij. DR Ensembl-Gn; MGP_CBAJ_G0030088; mus_musculus_cbaj. DR Ensembl-Gn; MGP_DBA2J_G0030232; mus_musculus_dba2j. DR Ensembl-Gn; MGP_FVBNJ_G0030186; mus_musculus_fvbnj. DR Ensembl-Gn; MGP_LPJ_G0030319; mus_musculus_lpj. DR Ensembl-Gn; MGP_NODShiLtJ_G0030222; mus_musculus_nodshiltj. DR Ensembl-Gn; MGP_NZOHlLtJ_G0030881; mus_musculus_nzohlltj. DR Ensembl-Gn; MGP_PWKPhJ_G0029226; mus_musculus_pwkphj. DR Ensembl-Gn; MGP_WSBEiJ_G0029589; mus_musculus_wsbeij. DR Ensembl-Tr; ENSMUST00000078856; mus_musculus. DR Ensembl-Tr; MGP_129S1SvImJ_T0076104; mus_musculus_129s1svimj. DR Ensembl-Tr; MGP_AJ_T0076181; mus_musculus_aj. DR Ensembl-Tr; MGP_AKRJ_T0076086; mus_musculus_akrj. DR Ensembl-Tr; MGP_BALBcJ_T0076121; mus_musculus_balbcj. DR Ensembl-Tr; MGP_C3HHeJ_T0075744; mus_musculus_c3hhej. DR Ensembl-Tr; MGP_C57BL6NJ_T0076596; mus_musculus_c57bl6nj. DR Ensembl-Tr; MGP_CASTEiJ_T0076293; mus_musculus_casteij. DR Ensembl-Tr; MGP_CBAJ_T0075707; mus_musculus_cbaj. DR Ensembl-Tr; MGP_DBA2J_T0075856; mus_musculus_dba2j. DR Ensembl-Tr; MGP_FVBNJ_T0075748; mus_musculus_fvbnj. DR Ensembl-Tr; MGP_LPJ_T0075905; mus_musculus_lpj. DR Ensembl-Tr; MGP_NODShiLtJ_T0075771; mus_musculus_nodshiltj. DR Ensembl-Tr; MGP_NZOHlLtJ_T0076830; mus_musculus_nzohlltj. DR Ensembl-Tr; MGP_PWKPhJ_T0075746; mus_musculus_pwkphj. DR Ensembl-Tr; MGP_WSBEiJ_T0074876; mus_musculus_wsbeij. XX FH Key Location/Qualifiers FH FT source 1..5825 FT /organism="Mus musculus" FT /mol_type="mRNA" FT /db_xref="taxon:10090" FT misc_feature 1 FT /note="transcription start site" FT CDS 14..1666 FT /codon_start=1 FT /transl_table=1 FT /product="secreted isoform of Klotho protein" FT /db_xref="GOA:O35082" FT /db_xref="InterPro:IPR001360" FT /db_xref="InterPro:IPR017853" FT /db_xref="InterPro:IPR028546" FT /db_xref="InterPro:IPR033132" FT /db_xref="MGI:MGI:1101771" FT /db_xref="UniProtKB/Swiss-Prot:O35082" FT /protein_id="BAA25307.1" FT /translation="MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWA FT RFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPS FT DSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGT FT AGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYA FT ELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVW FT HLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYP FT ESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQL FT LSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYT FT AWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPL FT EGTFPCDFAWGVVDNYVQVSPLTKPSVGLLLPH" FT regulatory 5810..5815 FT /regulatory_class="polyA_signal_sequence" FT polyA_site 5825 FT /note="27 A nucleotides" XX SQ Sequence 5825 BP; 1311 A; 1492 C; 1317 G; 1703 T; 2 other; cggctcccgc agcatgctag cccgcgcccc tcctcgccgc ccgccgcggc tggtgctgct 60 ccgtttgctg ttgctgcatc tgctgctgct cgccctgcgc gcccgctgcc tgagcgctga 120 gccgggtcag ggcgcgcaga cctgggctcg cttcgcgcgc gctcctgccc cagaggccgc 180 tggcctcctc cacgacacct tccccgacgg tttcctctgg gcggtaggca gcgccgccta 240 tcagaccgag ggcggctggc gacagcacgg caaaggcgcg tccatctggg acactttcac 300 ccatcactct ggggcggccc cgtccgactc cccgatcgtc gtggcgccgt cgggtgcccc 360 gtcgcctccc ctgtcctcca ctggagatgt ggccagcgat agttacaaca acgtctaccg 420 cgacacagag gggctgcgcg aactgggggt cacccactac cgcttctcca tatcgtgggc 480 gcgggtgctc cccaatggca ccgcgggcac tcccaaccgc gaggggctgc gctactaccg 540 gcggctgctg gagcggctgc gggagctggg cgtgcagccg gtggttaccc tgtaccattg 600 ggacctgcca cagcgcctgc aggacaccta tggcggatgg gccaatcgcg ccctggccga 660 ccatttcagg gattatgccg agctctgctt ccgccacttc ggtggtcagg tcaagtactg 720 gatcaccatt gacaacccct acgtggtggc ctggcacggg tatgccaccg ggcgcctggc 780 cccgggcgtg aggggcagct ccaggctcgg gtacctggtt gcccacaacc tacttttggc 840 tcatgccaaa gtctggcatc tctacaacac ctctttccgc cccacacagg gaggccgggt 900 gtctatcgcc ttaagctccc attggatcaa tcctcgaaga atgactgact ataatatcag 960 agaatgccag aagtctcttg actttgtgct aggctggttt gccaaaccca tatttattga 1020 tggcgactac ccagagagta tgaagaacaa cctctcgtct cttctgcctg attttactga 1080 atctgagaag aggctcatca gaggaactgc tgactttttt gctctctcct tcggaccaac 1140 cttgagcttt cagctattgg accctaacat gaagttccgc caattggagt ctcccaacct 1200 gaggcagctt ctgtcttgga tagatctgga atataaccac cctccaatat ttattgtgga 1260 aaatggctgg tttgtctcgg gaaccaccaa aagggatgat gccaaatata tgtattatct 1320 caagaagttc ataatggaaa ccttaaaagc aatcagactg gatggggtcg acgtcattgg 1380 gtacaccgcg tggtcgctca tggacggttt cgagtggcat aggggctaca gcatccggcg 1440 aggactcttc tacgttgact ttctgagtca ggacaaggag ctgttgccaa agtcttcggc 1500 cttgttctac caaaagctga tagaggacaa tggctttcct cctttacctg aaaaccagcc 1560 ccttgaaggg acatttccct gtgactttgc ttggggagtt gttgacaact acgttcaagt 1620 aagtcctttg acaaaaccca gtgtcggcct cttgcttcct cactaagctc tggccaaggc 1680 acagtgttgg gacgttgagc caaacagggt tccctagtga gcttatgaac tacatagtcc 1740 tgaacgcttc agtcttcaaa catctttcaa tctacatctt gtgctctcca ttaggtccaa 1800 agggaaacag attcaaacca tgaatatgta agctctgtta agacaataca aagataaggc 1860 acttcccttt ggtgttacgg ctggggtccc tgctcaggaa gttaagtttt tcataaataa 1920 gattcaacac agaagtccgg agcatctcag ggaagttgct gagaatgtct ggagcattta 1980 gcagatttct cctcactgta aatgccccac tccaggctca tagaaaaaaa atctcaagaa 2040 agcaaaccat tgattcaatg atctattgat agcaccaagg cattccaaaa atgatcagtt 2100 agtatttact gagcatcaaa actgtgtagg aagtcctcaa aaccatttta tttttagttt 2160 ccccagtgtt aaagtgactt gtttcttgtg gtttgaccaa atactttatg taagcacttg 2220 ctgactgcca gttgtgtatg aaaccccatg tgggttgctg ggttcccttt gtgaggaaga 2280 ccaaagttca gtatctgtag tcagatctca aggtttagca tgctggagtc tggctcagtg 2340 gttctcaacc ttcctaatgc caccgccctt taatacgggt cctcatgttg tagtgacacc 2400 aaaccatatg attatttttg ttgctacctc ataattgtaa gtttgccacg gctatgtatt 2460 gtaatgtaaa tatctgtgtt ttctgatggt cttaagcaat cctgtgaaag ggttgtttga 2520 ccctcaaagg gccgtgaccc acaggttgag aactactgtt gtagtccaga aggaggggct 2580 acaagttgta gcttcaaaag aaatattcgg aaaaatgctt aggtccaagg ggaggcttct 2640 tattggaatg gaattttggt tcctgtagat atcgaaatgc tttgttttgt tttgaagtac 2700 atcgcctatc cttgatgtat ttctgcccct gttgatgtaa gatgtccttt tggctcttag 2760 actatgtagc tcaatctaga ggtgattttg gacttaagtc ctctccttac cttcaaaaga 2820 cagctgagca atgttgagtg gagctctatt gaggcctggg atggcaccat agggcttcat 2880 ggtgttgttt tccagcttgg tgctattgac agctagttga acagtggggt gctggggtct 2940 actggaagag gtctttagat cacaaagggc atgtcctaaa agagagtagt gggacctcaa 3000 cccctttctc ttcctttttc tctcatttta tcatgaaaca agcagtttgt catactctgt 3060 gcccccgact ctggtgtgcc aacttaccac agtcccctaa acagtgaggc ccattgattg 3120 tttgccggag catccaaagt catgagccca aatcagcctt ggctctgatt ttctcaggtt 3180 tgctagaact gacaggatgt tagccaatca gctaacatca gcaccatcct gctcagtgtg 3240 aggttatttt cctgctccat ctccccactt ctctctcaga acaaggctat ctggattgtc 3300 ctatcctaat tcgtcagagt ctacagtgaa gtttaggtag gctctaatgt ggcagaaatg 3360 gagatgtcaa aggaggagga agaagataaa tgtgtcccac atcccctccc tccttacctt 3420 ttttggggcc aggagtagat tagatagctc ctggtctttg ttgtatttcc ttacctcttg 3480 agagtttcct gctggccaca tccctgcact ggaggctcac acacattgtc tggcatagca 3540 gctggagtct gccaagtgac ttcgtgtaca gtcagtactc agactcgcat ctgtacagcg 3600 agacagggct gtgtgggaag gccatcttcc tcccaccctg ctccctaagg atgatttgtg 3660 tcttcacagc gtgaagtgcc agggttttgg tcgatgttct tgaaagagaa gggcaacccc 3720 aatcagaatc aaaatcatgg cagtgaatag gaaatgtgag ggtgggggga ggagaagtct 3780 tgttttgttt ttgattttgt tatctcttca ttttgcagga ccttgtacct gctagtcact 3840 gttactgagt cacaccatcc aactcttaag gctgtgtcag gatctcatcc gacatcagcg 3900 atgcaatggc cccagtccct ctctctgtct acattgttga gatcatctac tcagggtgtc 3960 tgacctgcta catgttcaag gccctctgca tcctctgtga tcccaaccca aatcccaaaa 4020 tcccatatct caaccctgct gtggttgtaa acgctctgga agctcccggg tgggaacagg 4080 ctatagttag ggtttacttc tgtctgcctg tgctgctggc tttcctctag gtcatcagag 4140 ctcctctcaa gacaaccccc tggctgacag catcagaacg cctaatttgt tctctcagtg 4200 tgagctgggt gtctttgtga caagcagggc tcagcacgtc tacaacatta tgttacgtta 4260 gtgtctcaag aagtgatttt ttttaacgaa tatttgtatt agttcttggg ggattctata 4320 gtgaatttgg gtcatattta cttccttcta ttatccccct aacttcttcc agatccattc 4380 acatcttccc aaaccccaaa cttcacattg tcccccacct tcttcatatg gacatttact 4440 gtgatttgta ttgcccatgc aatcctggtg ggggaccatc ctctggaatt tggtccacct 4500 acgaagacct acatccttaa ggaaaattca ctctccctgc cctaaaagcc attatcttga 4560 gcaggtgctc aagaacccta ttttctttct ctccctcttt ctctttcctc cttccctcct 4620 tccctccttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttctt 4680 tctttctttc tttctttctt tcttccttcc ttccttcctt ccttccttcc ttccttcctc 4740 tctctctttc tctctcttct ctcgccctct ctttctctct cttctctcgc cccctctttc 4800 tctctcctcc ttttatgtta tcatgctgac tggcttgcct ctgtgtagac aaccccagat 4860 gctgtgagtt catgagtaca gaggttctat ctctggtact ccccaacctc tgctctgaca 4920 accttcctgt ccttagatgg tccctgagtt gtgagtttct atgaaaccac tgttcactgc 4980 accaagaaac tttaagaagt gatttaaaaa aaaaaaccta aagtttctct tttccctcct 5040 gggtagtgct ccatactcaa gagttgggtc atatatttca cccaaataat taaaaatatc 5100 cccctaaggc aggtgatggt ggtgcacact ttagtcccag cactcaggag gcagaggcgg 5160 gtggatcttt gtgagtttga ggcagctggt ctgcagagtg agtatcaaga cagcaggggt 5220 acacagagaa ccctgtcttg aaaaacaaaa accaaaacaa aacaatgtat gtgtgtgtat 5280 gggtgtatgt atatgtgtgt atgtgtatac atgtgtgtgt atgtgtgtgt gtgtatctcc 5340 ctagctacac accacctgtt agaagtttgt agctgggcac atccacatgg gggaggagtc 5400 actttgctca aacccagtgt cccagcncct gagtttgctt gcncatagct actggtgctg 5460 ttagttgacc aaaatgaagc aggttacata caacatagag catcatggtt gtccactgct 5520 gtgaggagag acttttatca ataacaaatt gaatatatgt tttgtgctca acctccctca 5580 gacctatttt tactttttag tgaaacctaa ggcagcgagc tgctataaat aagttagagg 5640 aacttttgcc tgcacactca tttctacatt tttcctagtt tggagaactg accctaccat 5700 ctgcaacttt acatggtctt tcatacttgt ttgtagttag actcaataga aactgttatt 5760 ctgggatggt tctggtagag aagttgtgaa tttagtacat tcagagttga ataaaaataa 5820 tccga 5825 //