##gff-version 3 ##sequence-region P06213 1 1382 P06213 UniProtKB Signal peptide 1 27 . . . . P06213 UniProtKB Chain 28 758 . . . ID=PRO_0000016687;Note=Insulin receptor subunit alpha P06213 UniProtKB Chain 763 1382 . . . ID=PRO_0000016689;Note=Insulin receptor subunit beta P06213 UniProtKB Topological domain 28 758 . . . Note=Extracellular;status=Probable P06213 UniProtKB Topological domain 763 956 . . . Note=Extracellular;status=Probable P06213 UniProtKB Transmembrane 957 979 . . . Note=Helical%3B;status=Potential P06213 UniProtKB Topological domain 980 1382 . . . Note=Cytoplasmic;status=Probable P06213 UniProtKB Domain 622 695 . . . Note=Fibronectin type-III 1 P06213 UniProtKB Domain 757 842 . . . Note=Fibronectin type-III 2 P06213 UniProtKB Domain 850 946 . . . Note=Fibronectin type-III 3 P06213 UniProtKB Domain 1023 1298 . . . Note=Protein kinase P06213 UniProtKB Nucleotide binding 1104 1110 . . . Note=ATP P06213 UniProtKB Nucleotide binding 1163 1164 . . . Note=ATP P06213 UniProtKB Region 733 741 . . . Note=Insulin-binding P06213 UniProtKB Region 999 999 . . . Note=Important for interaction with IRS1%2C SHC1 and STAT5B P06213 UniProtKB Region 1361 1364 . . . Note=PIK3R1-binding P06213 UniProtKB Compositional bias 28 174 . . . Note=Leu-rich P06213 UniProtKB Compositional bias 182 339 . . . Note=Cys-rich P06213 UniProtKB Active site 1159 1159 . . . Note=Proton donor/acceptor P06213 UniProtKB Binding site 1033 1033 . . . Note=ATP P06213 UniProtKB Binding site 1057 1057 . . . Note=ATP P06213 UniProtKB Binding site 1177 1177 . . . Note=ATP P06213 UniProtKB Site 66 66 . . . Note=Insulin-binding;status=Probable P06213 UniProtKB Modified residue 400 400 . . . Note=Phosphoserine P06213 UniProtKB Modified residue 401 401 . . . Note=Phosphotyrosine P06213 UniProtKB Modified residue 407 407 . . . Note=Phosphoserine P06213 UniProtKB Modified residue 992 992 . . . Note=Phosphotyrosine%3B by autocatalysis;status=Probable P06213 UniProtKB Modified residue 999 999 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Modified residue 1011 1011 . . . Note=Phosphotyrosine%3B by autocatalysis;status=Probable P06213 UniProtKB Modified residue 1185 1185 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Modified residue 1189 1189 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Modified residue 1190 1190 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Modified residue 1355 1355 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Modified residue 1361 1361 . . . Note=Phosphotyrosine%3B by autocatalysis P06213 UniProtKB Glycosylation 43 43 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 52 52 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 105 105 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 138 138 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 242 242 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 282 282 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 322 322 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 364 364 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 424 424 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 445 445 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 541 541 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 633 633 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 651 651 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 698 698 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 769 769 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 782 782 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Glycosylation 920 920 . . . Note=N-linked (GlcNAc...) P06213 UniProtKB Glycosylation 933 933 . . . Note=N-linked (GlcNAc...);status=Potential P06213 UniProtKB Disulfide bond 35 53 . . . . P06213 UniProtKB Disulfide bond 153 182 . . . . P06213 UniProtKB Disulfide bond 186 209 . . . . P06213 UniProtKB Disulfide bond 196 215 . . . . P06213 UniProtKB Disulfide bond 219 228 . . . . P06213 UniProtKB Disulfide bond 223 234 . . . . P06213 UniProtKB Disulfide bond 235 243 . . . . P06213 UniProtKB Disulfide bond 239 252 . . . . P06213 UniProtKB Disulfide bond 255 264 . . . . P06213 UniProtKB Disulfide bond 268 280 . . . . P06213 UniProtKB Disulfide bond 286 311 . . . . P06213 UniProtKB Disulfide bond 293 301 . . . . P06213 UniProtKB Disulfide bond 315 328 . . . . P06213 UniProtKB Disulfide bond 331 335 . . . . P06213 UniProtKB Disulfide bond 339 360 . . . . P06213 UniProtKB Disulfide bond 462 495 . . . . P06213 UniProtKB Disulfide bond 551 551 . . . Note=Interchain P06213 UniProtKB Disulfide bond 674 899 . . . . P06213 UniProtKB Disulfide bond 825 834 . . . . P06213 UniProtKB Alternative sequence 745 756 . . . ID=VSP_002898;Note=In isoform Short. P06213 UniProtKB Natural variant 2 2 . . . ID=VAR_058395;Dbxref=dbSNP:rs7508518 P06213 UniProtKB Natural variant 42 42 . . . ID=VAR_004079;Note=In RMS%3B impairs transport to the plasma membrane and reduces the affinity to bind insulin. P06213 UniProtKB Natural variant 55 55 . . . ID=VAR_004080;Note=In LEPRCH%3B Verona-1. P06213 UniProtKB Natural variant 58 58 . . . ID=VAR_004081;Dbxref=dbSNP:rs52836744;Note=In LEPRCH%3B Helmond%3B inhibits processing and transport. P06213 UniProtKB Natural variant 86 86 . . . ID=VAR_015907;Note=In IRAN type A. P06213 UniProtKB Natural variant 89 89 . . . ID=VAR_015908;Note=In IRAN type A. P06213 UniProtKB Natural variant 113 113 . . . ID=VAR_004082;Note=In LEPRCH%3B Atlanta-1%3B abolishes insulin binding. P06213 UniProtKB Natural variant 119 119 . . . ID=VAR_015909;Note=In LEPRCH%3B markedly impairs insulin binding. P06213 UniProtKB Natural variant 120 120 . . . ID=VAR_031518;Note=In LEPRCH%3B inhibits receptor processing. P06213 UniProtKB Natural variant 146 146 . . . ID=VAR_015539;Note=In LEPRCH%3B mild. P06213 UniProtKB Natural variant 167 167 . . . ID=VAR_015910;Note=In IRAN type A. P06213 UniProtKB Natural variant 171 171 . . . ID=VAR_058396;Dbxref=dbSNP:rs1051692 P06213 UniProtKB Natural variant 220 220 . . . ID=VAR_004083;Note=In Ins resistance%3B severe. P06213 UniProtKB Natural variant 228 228 . . . ID=VAR_041429;Note=In a gastric adenocarcinoma sample%3B somatic mutation. P06213 UniProtKB Natural variant 236 236 . . . ID=VAR_004084;Note=In LEPRCH%3B Winnipeg%3B in one patient with in RMS heterozygous compound with S-386%3B may impair receptor processing. P06213 UniProtKB Natural variant 260 260 . . . ID=VAR_004085;Note=In LEPRCH%3B Geldeimalsen. P06213 UniProtKB Natural variant 279 279 . . . ID=VAR_015540;Note=In IRAN type A%3B inhibits receptor internalization. P06213 UniProtKB Natural variant 279 279 . . . ID=VAR_031519;Note=In IRAN type A%3B interferes with receptor processing. P06213 UniProtKB Natural variant 280 280 . . . ID=VAR_015911;Note=In IRAN type A. P06213 UniProtKB Natural variant 301 301 . . . ID=VAR_015912;Note=In LEPRCH. P06213 UniProtKB Natural variant 308 308 . . . ID=VAR_015913;Note=In LEPRCH%3B abolishes insulin binding. P06213 UniProtKB Natural variant 350 350 . . . ID=VAR_015914;Note=In RMS and LEPRCH. P06213 UniProtKB Natural variant 362 362 . . . ID=VAR_015541;Note=In LEPRCH. P06213 UniProtKB Natural variant 386 386 . . . ID=VAR_031520;Note=In RMS%3B may impair receptor processing. P06213 UniProtKB Natural variant 393 393 . . . ID=VAR_004086;Note=In LEPRCH%3B Verona-1. P06213 UniProtKB Natural variant 409 409 . . . ID=VAR_004087;Note=In IRAN type A. P06213 UniProtKB Natural variant 439 439 . . . ID=VAR_015542;Note=In LEPRCH%3B impairs transport of the receptor to the cell surface. P06213 UniProtKB Natural variant 448 448 . . . ID=VAR_015915;Dbxref=dbSNP:rs1051691 P06213 UniProtKB Natural variant 458 458 . . . ID=VAR_031521;Note=In LEPRCH%3B partially inhibits receptor processing and autophosphorylation%3B strongly impairs ERK phosphorylation%3B induces wild-type levels of IRS-1 phosphorylation. P06213 UniProtKB Natural variant 487 487 . . . ID=VAR_004088;Dbxref=dbSNP:rs28933083;Note=In LEPRCH%3B ARK-1. P06213 UniProtKB Natural variant 489 489 . . . ID=VAR_004089;Dbxref=dbSNP:rs28933085;Note=In IRAN type A. P06213 UniProtKB Natural variant 492 492 . . . ID=VAR_015916;Dbxref=dbSNP:rs1131851 P06213 UniProtKB Natural variant 695 695 . . . ID=VAR_041430;Dbxref=dbSNP:rs55906835 P06213 UniProtKB Natural variant 762 762 . . . ID=VAR_004090;Note=In IRAN type A. P06213 UniProtKB Natural variant 811 811 . . . ID=VAR_041431;Dbxref=dbSNP:rs35045353 P06213 UniProtKB Natural variant 830 830 . . . ID=VAR_055986;Dbxref=dbSNP:rs2162771 P06213 UniProtKB Natural variant 858 858 . . . ID=VAR_015917;Dbxref=dbSNP:rs182552223;Note=In NIDDM. P06213 UniProtKB Natural variant 925 925 . . . ID=VAR_015918;Note=In LEPRCH%3B abolishes insulin binding. P06213 UniProtKB Natural variant 926 926 . . . ID=VAR_015919;Note=In LEPRCH%3B markedly impairs insulin binding. P06213 UniProtKB Natural variant 937 937 . . . ID=VAR_015920;Note=In LEPRCH%3B impaired receptor processing. P06213 UniProtKB Natural variant 997 997 . . . ID=VAR_015921;Note=In RMS%3B reduces insulin binding. P06213 UniProtKB Natural variant 1012 1012 . . . ID=VAR_004091;Dbxref=dbSNP:rs1799816;Note=Rare polymorphism. P06213 UniProtKB Natural variant 1020 1020 . . . ID=VAR_004092;Note=In IRAN type A. P06213 UniProtKB Natural variant 1023 1023 . . . ID=VAR_015922 P06213 UniProtKB Natural variant 1035 1035 . . . ID=VAR_004093;Note=In IRAN type A. P06213 UniProtKB Natural variant 1055 1055 . . . ID=VAR_015923;Note=In IRAN type A. P06213 UniProtKB Natural variant 1065 1065 . . . ID=VAR_041432;Dbxref=dbSNP:rs56395521 P06213 UniProtKB Natural variant 1075 1075 . . . ID=VAR_004094;Note=In IRAN type A. P06213 UniProtKB Natural variant 1095 1095 . . . ID=VAR_015924;Note=In a NIDDM subject. P06213 UniProtKB Natural variant 1119 1119 . . . ID=VAR_015925;Note=In LEPRCH. P06213 UniProtKB Natural variant 1143 1143 . . . ID=VAR_015926;Note=In RMS%3B reduces insulin binding. P06213 UniProtKB Natural variant 1158 1158 . . . ID=VAR_015927;Note=In NIDDM. P06213 UniProtKB Natural variant 1158 1158 . . . ID=VAR_015928;Note=In RMS%3B abolishes insulin binding. P06213 UniProtKB Natural variant 1161 1161 . . . ID=VAR_004095;Dbxref=dbSNP:rs28933084;Note=In IRAN type A. P06213 UniProtKB Natural variant 1162 1162 . . . ID=VAR_004096;Note=In IRAN type A%3B impairs proteolytic processing. P06213 UniProtKB Natural variant 1180 1180 . . . ID=VAR_004097;Note=In a patient with insulin resistance. P06213 UniProtKB Natural variant 1191 1191 . . . ID=VAR_004098;Note=In NIDDM. P06213 UniProtKB Natural variant 1201 1201 . . . ID=VAR_015929;Dbxref=dbSNP:rs28933086;Note=In HHF5 and IRAN type A%3B interferes with kinase activation by insulin. P06213 UniProtKB Natural variant 1201 1201 . . . ID=VAR_015930;Note=In LEPRCH and RMS%3B reduces insulin binding possibly due to reduced receptor levels on the cell surface. P06213 UniProtKB Natural variant 1205 1205 . . . ID=VAR_004099;Note=In IRAN type A%3B moderate. P06213 UniProtKB Natural variant 1206 1206 . . . ID=VAR_015931;Note=In IRAN type A%3B accelerates degradation of the protein and impairs kinase activity. P06213 UniProtKB Natural variant 1206 1206 . . . ID=VAR_015932;Note=In LEPRCH. P06213 UniProtKB Natural variant 1220 1220 . . . ID=VAR_004100;Dbxref=dbSNP:rs52800171;Note=In IRAN type A%3B accelerates degradation of the protein and impairs kinase activity. P06213 UniProtKB Natural variant 1227 1227 . . . ID=VAR_004101;Note=In IRAN type A. P06213 UniProtKB Natural variant 1282 1282 . . . ID=VAR_041433;Dbxref=dbSNP:rs55875349 P06213 UniProtKB Natural variant 1361 1361 . . . ID=VAR_015933;Dbxref=dbSNP:rs13306449 P06213 UniProtKB Natural variant 1378 1378 . . . ID=VAR_015934;Dbxref=dbSNP:rs52826008;Note=In IRAN type A. P06213 UniProtKB Mutagenesis 991 991 . . . Note=Reduces interaction with IRS1 but has no effect on interaction with SHC1. P06213 UniProtKB Mutagenesis 992 992 . . . Note=Reduces interaction with IRS1 but has no effect on interaction with SHC1. P06213 UniProtKB Mutagenesis 996 997 . . . Note=Abolishes interaction with IRS1. Severely disrupts%2C but does not abolish interaction with SHC1. P06213 UniProtKB Mutagenesis 996 996 . . . Note=Abolishes interaction with IRS1 and significantly reduces interaction with SHC1. Has no effect on interaction with PIK3R1. P06213 UniProtKB Mutagenesis 997 997 . . . Note=Abolishes interaction with IRS1 and significantly reduces interaction with SHC1. Has no effect on interaction with PIK3R1. P06213 UniProtKB Mutagenesis 998 998 . . . Note=Does not affect interaction with IRS1%2C SHC1 or PIK3R1. P06213 UniProtKB Mutagenesis 999 999 . . . Note=Abolishes interaction with IRS1 and SHC1. P06213 UniProtKB Mutagenesis 999 999 . . . Note=Has no effect on insulin-stimulated autophosphorylation%2C but inhibits the biological activity of the receptor. Abolishes interaction with IRS1 and almost completely prevents interaction with SHC1. Has no effect on interaction with PIK3R1. Abolishes interaction with STAT5B. P06213 UniProtKB Mutagenesis 1000 1000 . . . Note=Severely reduces interaction with SHC1. Has no effect on interaction with IRS1. P06213 UniProtKB Mutagenesis 1002 1002 . . . Note=Reduces interaction with IRS1 but has no effect on interaction with SHC1. P06213 UniProtKB Mutagenesis 1011 1011 . . . Note=Increases kinase activity. P06213 UniProtKB Mutagenesis 1057 1057 . . . Note=Abolishes the kinase activity and abolishes interaction with IRS1%2C SHC1%2C GRB7 and PIK3R1. P06213 UniProtKB Mutagenesis 1057 1057 . . . Note=Abolishes the kinase activity. P06213 UniProtKB Mutagenesis 1159 1159 . . . Note=Loss of kinase activity. P06213 UniProtKB Mutagenesis 1163 1163 . . . Note=Loss of kinase activity. P06213 UniProtKB Mutagenesis 1189 1189 . . . Note=Reduced interaction with GRB7. P06213 UniProtKB Mutagenesis 1190 1190 . . . Note=Strongly reduced interaction with GRB7. P06213 UniProtKB Sequence conflict 601 601 . . . . P06213 UniProtKB Sequence conflict 830 830 . . . . P06213 UniProtKB Sequence conflict 1278 1278 . . . . P06213 UniProtKB Beta strand 33 42 . . . . P06213 UniProtKB Helix 45 50 . . . . P06213 UniProtKB Beta strand 53 65 . . . . P06213 UniProtKB Helix 70 72 . . . . P06213 UniProtKB Turn 73 75 . . . . P06213 UniProtKB Beta strand 83 86 . . . . P06213 UniProtKB Beta strand 88 93 . . . . P06213 UniProtKB Turn 100 102 . . . . P06213 UniProtKB Beta strand 118 124 . . . . P06213 UniProtKB Beta strand 141 149 . . . . P06213 UniProtKB Helix 160 162 . . . . P06213 UniProtKB Beta strand 171 175 . . . . P06213 UniProtKB Helix 176 178 . . . . P06213 UniProtKB Turn 187 192 . . . . P06213 UniProtKB Beta strand 199 201 . . . . P06213 UniProtKB Beta strand 204 206 . . . . P06213 UniProtKB Beta strand 209 211 . . . . P06213 UniProtKB Helix 221 223 . . . . P06213 UniProtKB Beta strand 243 247 . . . . P06213 UniProtKB Beta strand 251 260 . . . . P06213 UniProtKB Beta strand 263 267 . . . . P06213 UniProtKB Beta strand 273 275 . . . . P06213 UniProtKB Turn 276 278 . . . . P06213 UniProtKB Beta strand 279 281 . . . . P06213 UniProtKB Helix 283 295 . . . . P06213 UniProtKB Beta strand 298 300 . . . . P06213 UniProtKB Beta strand 305 307 . . . . P06213 UniProtKB Beta strand 310 314 . . . . P06213 UniProtKB Beta strand 319 321 . . . . P06213 UniProtKB Beta strand 327 330 . . . . P06213 UniProtKB Beta strand 332 334 . . . . P06213 UniProtKB Beta strand 338 348 . . . . P06213 UniProtKB Helix 351 355 . . . . P06213 UniProtKB Turn 356 359 . . . . P06213 UniProtKB Beta strand 361 369 . . . . P06213 UniProtKB Helix 377 385 . . . . P06213 UniProtKB Beta strand 390 393 . . . . P06213 UniProtKB Beta strand 395 399 . . . . P06213 UniProtKB Beta strand 404 406 . . . . P06213 UniProtKB Turn 422 424 . . . . P06213 UniProtKB Beta strand 425 430 . . . . P06213 UniProtKB Turn 441 443 . . . . P06213 UniProtKB Beta strand 452 458 . . . . P06213 UniProtKB Helix 463 472 . . . . P06213 UniProtKB Turn 476 478 . . . . P06213 UniProtKB Turn 481 483 . . . . P06213 UniProtKB Beta strand 486 490 . . . . P06213 UniProtKB Helix 1009 1011 . . . . P06213 UniProtKB Helix 1014 1016 . . . . P06213 UniProtKB Helix 1020 1022 . . . . P06213 UniProtKB Beta strand 1023 1031 . . . . P06213 UniProtKB Beta strand 1033 1043 . . . . P06213 UniProtKB Beta strand 1046 1048 . . . . P06213 UniProtKB Beta strand 1050 1057 . . . . P06213 UniProtKB Helix 1065 1078 . . . . P06213 UniProtKB Beta strand 1089 1093 . . . . P06213 UniProtKB Beta strand 1095 1098 . . . . P06213 UniProtKB Beta strand 1100 1104 . . . . P06213 UniProtKB Helix 1111 1117 . . . . P06213 UniProtKB Beta strand 1119 1121 . . . . P06213 UniProtKB Helix 1133 1152 . . . . P06213 UniProtKB Beta strand 1154 1156 . . . . P06213 UniProtKB Helix 1162 1164 . . . . P06213 UniProtKB Beta strand 1165 1167 . . . . P06213 UniProtKB Beta strand 1173 1175 . . . . P06213 UniProtKB Beta strand 1181 1183 . . . . P06213 UniProtKB Turn 1185 1187 . . . . P06213 UniProtKB Helix 1188 1191 . . . . P06213 UniProtKB Beta strand 1194 1198 . . . . P06213 UniProtKB Helix 1200 1202 . . . . P06213 UniProtKB Helix 1205 1210 . . . . P06213 UniProtKB Helix 1215 1230 . . . . P06213 UniProtKB Turn 1236 1239 . . . . P06213 UniProtKB Helix 1242 1250 . . . . P06213 UniProtKB Helix 1263 1272 . . . . P06213 UniProtKB Helix 1277 1279 . . . . P06213 UniProtKB Helix 1283 1290 . . . . P06213 UniProtKB Helix 1291 1293 . . . . P06213 UniProtKB Helix 1298 1301 . . . . P06213 UniProtKB Turn 1303 1305 . . . . P06213 UniProtKB Helix 1307 1309 . . . .