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EBI Dbfetch

LOCUS       NP_001075859             127 aa            linear   MAM 24-FEB-2014
DEFINITION  whey acidic protein precursor [Oryctolagus cuniculus].
ACCESSION   NP_001075859
VERSION     NP_001075859.1  GI:126723201
DBSOURCE    REFSEQ: accession NM_001082390.2
KEYWORDS    RefSeq.
SOURCE      Oryctolagus cuniculus (rabbit)
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha;
            Leporidae; Oryctolagus.
REFERENCE   1  (residues 1 to 127)
  AUTHORS   Montazer-Torbati MB, Hue-Beauvais C, Droineau S, Ballester M, Coant
            N, Aujean E, Petitbarat M, Rijnkels M and Devinoy E.
  TITLE     Epigenetic modifications and chromatin loop organization explain
            the different expression profiles of the Tbrg4, WAP and Ramp3 genes
  JOURNAL   Exp. Cell Res. 314 (5), 975-987 (2008)
   PUBMED   18255060
  REMARK    GeneRIF: tight regulation of WAP gene expression parallels
            variations in the chromatin structure and DNA methylation profile
            throughout the Ramp3-WAP-Tbrg4 locus.
REFERENCE   2  (residues 1 to 127)
  AUTHORS   Thepot D, Devinoy E, Fontaine ML, Hubert C and Houdebine LM.
  TITLE     Complete sequence of the rabbit whey acidic protein gene
  JOURNAL   Nucleic Acids Res. 18 (12), 3641 (1990)
   PUBMED   2362817
REFERENCE   3  (residues 1 to 127)
  AUTHORS   Devinoy E, Hubert C, Schaerer E, Houdebine LM and Kraehenbuhl JP.
  TITLE     Sequence of the rabbit whey acidic protein cDNA
  JOURNAL   Nucleic Acids Res. 16 (16), 8180 (1988)
   PUBMED   3419910
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X07943.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X07943.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..127
                     /organism="Oryctolagus cuniculus"
                     /db_xref="taxon:9986"
                     /chromosome="10"
                     /map="10"
     Protein         1..127
                     /product="whey acidic protein precursor"
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1942
     mat_peptide     20..127
                     /product="whey acidic protein"
                     /calculated_mol_wt=11602
     Region          31..67
                     /region_name="WAP"
                     /note="WAP-type (Whey Acidic Protein) 'four-disulfide
                     core'; pfam00095"
                     /db_xref="CDD:249584"
     Region          70..121
                     /region_name="WAP"
                     /note="whey acidic protein-type four-disulfide core
                     domains. Members of the family include whey acidic
                     protein, elafin (elastase-specific inhibitor),
                     caltrin-like protein (a calcium transport inhibitor) and
                     other extracellular proteinase inhibitors. A group of...;
                     cd00199"
                     /db_xref="CDD:238120"
     Site            75..81
                     /site_type="inhibition"
                     /note="inhibitory loop"
                     /db_xref="CDD:238120"
     CDS             1..127
                     /gene="WAP"
                     /coded_by="NM_001082390.2:47..430"
                     /db_xref="GeneID:100009255"
ORIGIN      
        1 mrclislalg llaleaalal apkfiapvqv mcpepsssee tlclsdndcl gstvccpsaa
       61 ggscrtpiiv ptpkagrcpw vqapmlsqlc eelsdcandi ecrgdkkccf srcamrylep
      121 ilestpq
//



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