LOCUS       NP_001075859             127 aa            linear   MAM 04-FEB-2024
DEFINITION  whey acidic protein precursor [Oryctolagus cuniculus].
ACCESSION   NP_001075859
VERSION     NP_001075859.1
DBSOURCE    REFSEQ: accession NM_001082390.2
KEYWORDS    RefSeq.
SOURCE      Oryctolagus cuniculus (rabbit)
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha;
            Leporidae; Oryctolagus.
REFERENCE   1  (residues 1 to 127)
  AUTHORS   Montazer-Torbati,M.B., Hue-Beauvais,C., Droineau,S., Ballester,M.,
            Coant,N., Aujean,E., Petitbarat,M., Rijnkels,M. and Devinoy,E.
  TITLE     Epigenetic modifications and chromatin loop organization explain
            the different expression profiles of the Tbrg4, WAP and Ramp3 genes
  JOURNAL   Exp Cell Res 314 (5), 975-987 (2008)
   PUBMED   18255060
  REMARK    GeneRIF: tight regulation of WAP gene expression parallels
            variations in the chromatin structure and DNA methylation profile
            throughout the Ramp3-WAP-Tbrg4 locus.
REFERENCE   2  (residues 1 to 127)
  AUTHORS   Thepot,D., Devinoy,E., Fontaine,M.L., Hubert,C. and Houdebine,L.M.
  TITLE     Complete sequence of the rabbit whey acidic protein gene
  JOURNAL   Nucleic Acids Res 18 (12), 3641 (1990)
   PUBMED   2362817
REFERENCE   3  (residues 1 to 127)
  AUTHORS   Devinoy,E., Hubert,C., Schaerer,E., Houdebine,L.M. and
            Kraehenbuhl,J.P.
  TITLE     Sequence of the rabbit whey acidic protein cDNA
  JOURNAL   Nucleic Acids Res 16 (16), 8180 (1988)
   PUBMED   3419910
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X07943.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X07943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN07985527, SAMN15222339
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..127
                     /organism="Oryctolagus cuniculus"
                     /db_xref="taxon:9986"
                     /chromosome="10"
                     /map="10"
     Protein         1..127
                     /product="whey acidic protein precursor"
                     /calculated_mol_wt=11602
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1942
     mat_peptide     20..127
                     /product="whey acidic protein"
                     /calculated_mol_wt=11602
     Region          70..121
                     /region_name="WAP"
                     /note="whey acidic protein-type four-disulfide core
                     domains. Members of the family include whey acidic
                     protein, elafin (elastase-specific inhibitor),
                     caltrin-like protein (a calcium transport inhibitor) and
                     other extracellular proteinase inhibitors. A group of...;
                     cd00199"
                     /db_xref="CDD:238120"
     Site            75..81
                     /site_type="inhibition"
                     /note="inhibitory loop"
                     /db_xref="CDD:238120"
     CDS             1..127
                     /gene="WAP"
                     /coded_by="NM_001082390.2:47..430"
                     /db_xref="GeneID:100009255"
ORIGIN