LOCUS       AC_000022              16300 bp    DNA     circular ROD 28-AUG-2012
DEFINITION  Rattus norvegicus strain Wistar mitochondrion, complete genome.
ACCESSION   AC_000022
VERSION     AC_000022.2  GI:110189662
DBLINK      Project: 12455
            BioProject: PRJNA12455
KEYWORDS    RefSeq.
SOURCE      mitochondrion Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 16300)
  AUTHORS   Gadaleta,G., Pepe,G., De Candia,G., Quagliariello,C., Sbisa,E. and
            Saccone,C.
  TITLE     The complete nucleotide sequence of the Rattus norvegicus
            mitochondrial genome: cryptic signals revealed by comparative
            analysis between vertebrates
  JOURNAL   J. Mol. Evol. 28 (6), 497-516 (1989)
   PUBMED   2504926
REFERENCE   2  (bases 1 to 16300)
  AUTHORS   Grosskopf,R. and Feldmann,H.
  TITLE     Analysis of a DNA segment from rat liver mitochondria containing
            the genes for the cytochrome oxidase subunits i, ii, iii, atpase
            subunit 6, and several tRNA genes
  JOURNAL   Curr. Genet. 4, 151-158 (1981)
REFERENCE   3  (bases 1 to 16300)
  AUTHORS   Grosskopf,R. and Feldmann,H.
  TITLE     tRNA genes in rat liver mitochondrial DNA
  JOURNAL   Curr. Genet. 4, 191-196 (1981)
REFERENCE   4  (bases 1 to 16300)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2008) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 16300)
  AUTHORS   Saccone,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JAN-1995) Dipartimento di Biochimica e Biologia
            Molacolare, Via Amendola 165/A, 70126 Bari, Italy
REFERENCE   6  (bases 1 to 16300)
  AUTHORS   Saccone,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-MAR-1989) Dipartimento di Biochimica e Biologia
            Molacolare, Via Amendola 165/A, 70126 Bari, Italy
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X14848.
            On Jul 6, 2006 this sequence version replaced gi:58615676.
            Sequence Note:  NC_001665.2 represents the reference sequence for
            the rat mitochondrial genome. In July 2006 the underlying sequence
            was updated to represent the Brown Norway strain based on the
            recommendation of the Rat Genome Sequencing Consortium that
            BN/SsNHsdMCW should be the reference sequence.  In conjunction with
            this update, an alternate accession AC_000022.2 was updated to
            continue to represent the the Wistar strain sequence that was
            previously considered to be the reference standard.
            for seqs get included see V00681, K00434, J01436, X07479, X07482.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..16300
                     /organism="Rattus norvegicus"
                     /organelle="mitochondrion"
                     /mol_type="genomic DNA"
                     /strain="Wistar"
                     /db_xref="taxon:10116"
                     /clone="pSF2124."
     tRNA            1..67
                     /product="tRNA-Phe"
     rRNA            69..1025
                     /product="s-rRNA"
                     /note="12S ribosomal RNA"
     STS             901..1616
                     /standard_name="PMC316374P5"
                     /db_xref="UniSTS:272966"
     tRNA            1026..1094
                     /product="tRNA-Val"
     rRNA            1095..2653
                     /product="l-rRNA"
                     /note="16S ribosomal RNA"
     STS             2340..2525
                     /standard_name="RH136367"
                     /db_xref="UniSTS:210357"
     tRNA            2654..2728
                     /product="tRNA-Leu"
                     /codon_recognized="UUR"
     gene            2729..3685
                     /gene="ND1"
                     /db_xref="GeneID:7066247"
     CDS             2729..3685
                     /gene="ND1"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 1"
                     /protein_id="AP_004892.1"
                     /db_xref="GI:110189663"
                     /db_xref="GOA:P03889"
                     /db_xref="InterPro:IPR001694"
                     /db_xref="UniProtKB/Swiss-Prot:P03889"
                     /db_xref="GeneID:7066247"
                     /translation="MYFINILTLLIPILIAMGLLTLVERKILGYMQLRKGPNNEGPYG
                     KLQPFADAMKLFMKEPMRPLTTSMSLFIIAPTLSLTLALSLWIPLPMPHPLINLNLGM
                     PFILATSSLSVYSILWSGWASNSKYSLFGALRAVAQTISYEVTMALYLLSVLLMSGSF
                     SLQMLITTQEHIWLLIPAWPMAMMWYISTLAETNRAPFDLTEGESELVSGFNVEYAAG
                     PFALFFMAEYTNIILMNALTSIVFLGPLYHINYPELYSTSFMTETLLLSTTFLWIRAS
                     YPRFRYDQLMHLLWKNFLPLTLAFCMWYISLPIFLAGIPPYT"
     tRNA            3684..3752
                     /product="tRNA-Ile"
     tRNA            complement(3750..3820)
                     /product="tRNA-Gln"
     tRNA            3824..3891
                     /product="tRNA-Met"
     gene            3892..4929
                     /gene="ND2"
                     /db_xref="GeneID:7066248"
     CDS             3892..4929
                     /gene="ND2"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 2"
                     /protein_id="AP_004893.1"
                     /db_xref="GI:110189664"
                     /db_xref="GOA:P11662"
                     /db_xref="InterPro:IPR000652"
                     /db_xref="InterPro:IPR001750"
                     /db_xref="InterPro:IPR003917"
                     /db_xref="InterPro:IPR010933"
                     /db_xref="UniProtKB/Swiss-Prot:P11662"
                     /db_xref="GeneID:7066248"
                     /translation="MNPITLTIIYLTTFKGRLITTLSTNLPPMWVGLEMSLLAIIPLL
                     ANKKSPRSTEAATKYFLTQATASMIILLVIILNYKQSGMWTLQQQTNNMLLNMMLISL
                     AMKLGLAPFHYWLPEVTQGIPLHIGLILLTWQKIAPLSILYQFYQLLNPTITTILAIS
                     SVFVGAWGGLNQTQTRKIMAYSSIAHMGWMTAILPYNPNLTLLNLTIYILLTVPMFNY
                     IMTNSATTINTLSLAWNKTPMILTMASIILLSLGGLPPLTGFLPKWAIISELLKNNCS
                     TLSTLMAIMALLSLFFYTRLIYSMSLTTFPTNNNSKMISHHQNPKHNFILPTLTVLST
                     LTLPLSSQLIT"
     tRNA            4928..4993
                     /product="tRNA-Trp"
     tRNA            complement(4995..5063)
                     /product="tRNA-Ala"
     tRNA            complement(5066..5139)
                     /product="tRNA-Asn"
     rep_origin      5140..5170
                     /note="origin of light strand replication"
     tRNA            complement(5171..5238)
                     /product="tRNA-Cys"
     tRNA            complement(5242..5307)
                     /product="tRNA-Tyr"
     gene            5309..6853
                     /gene="COX1"
                     /db_xref="GeneID:7066249"
     CDS             5309..6853
                     /gene="COX1"
                     /codon_start=1
                     /transl_table=2
                     /product="cytochrome c oxidase subunit I"
                     /protein_id="AP_004894.1"
                     /db_xref="GI:110189665"
                     /db_xref="GOA:P05503"
                     /db_xref="InterPro:IPR000883"
                     /db_xref="UniProtKB/Swiss-Prot:P05503"
                     /db_xref="GeneID:7066249"
                     /translation="MFVNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQP
                     GALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSF
                     WLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGVSVDLTIFSLHLAGVSSILG
                     AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT
                     FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWT
                     MMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKW
                     SPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAG
                     FVHWFPLFSGYTLNDTWAKAHFAIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTW
                     NTVSSMGSFISLTAVLVMIFMIWEAFASKREVLSISYSSTNLEWLHGCPPPYHTFEEP
                     SYVKVK"
     tRNA            complement(6850..6919)
                     /product="tRNA-Ser"
                     /codon_recognized="UCN"
     tRNA            6922..6989
                     /product="tRNA-Asp"
     gene            6991..7674
                     /gene="COX2"
                     /db_xref="GeneID:7066250"
     CDS             6991..7674
                     /gene="COX2"
                     /codon_start=1
                     /transl_table=2
                     /product="cytochrome c oxidase subunit II"
                     /protein_id="AP_004895.1"
                     /db_xref="GI:110189666"
                     /db_xref="GOA:P00406"
                     /db_xref="InterPro:IPR001505"
                     /db_xref="InterPro:IPR002429"
                     /db_xref="InterPro:IPR008972"
                     /db_xref="UniProtKB/Swiss-Prot:P00406"
                     /db_xref="GeneID:7066250"
                     /translation="MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISSLVLYIISL
                     MLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGH
                     QWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVL
                     HSWAIPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKY
                     FENWSASMI"
     tRNA            7678..7741
                     /product="tRNA-Lys"
     gene            7743..7946
                     /gene="ATP8"
                     /db_xref="GeneID:7066251"
     CDS             7743..7946
                     /gene="ATP8"
                     /codon_start=1
                     /transl_table=2
                     /product="ATP synthase F0 subunit 8"
                     /protein_id="AP_004896.1"
                     /db_xref="GI:110189667"
                     /db_xref="GOA:P11608"
                     /db_xref="InterPro:IPR001421"
                     /db_xref="UniProtKB/Swiss-Prot:P11608"
                     /db_xref="GeneID:7066251"
                     /translation="MPQLDTSTWFITIISSMATLFILFQLKISSQTFPAPPSPKTMAT
                     EKTNNPWESKWTKIYLPLSLPPQ"
     gene            7904..8584
                     /gene="ATP6"
                     /db_xref="GeneID:7066252"
     CDS             7904..8584
                     /gene="ATP6"
                     /codon_start=1
                     /transl_table=2
                     /product="ATP synthase F0 subunit 6"
                     /protein_id="AP_004897.1"
                     /db_xref="GI:110189668"
                     /db_xref="GOA:P05504"
                     /db_xref="InterPro:IPR000568"
                     /db_xref="UniProtKB/Swiss-Prot:P05504"
                     /db_xref="GeneID:7066252"
                     /translation="MNENLFASFITPTMMGLPIVVTIIMFPSILFPSSERLISNRLHS
                     FQHWLIKLIIKQMMLIHTPKGRTWALMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMDL
                     SMAIPLWAGAVILGFRHKLKNSLAHFSPQGTPISLIPMLIIIETISLFIQPMALAVRL
                     TANITAGHLLMHLIGGATLVLMDISPPTATITFIILLLLTVLEFAVALIQAYVFTLLV
                     SLYLHDNT"
     gene            8584..9367
                     /gene="COX3"
                     /db_xref="GeneID:7066253"
     CDS             8584..9367
                     /gene="COX3"
                     /note="TAA stop codon is completed by the addition of 3' A
                     residues to the mRNA"
                     /codon_start=1
                     /transl_except=(pos:9367,aa:TERM)
                     /transl_table=2
                     /product="cytochrome c oxidase subunit III"
                     /protein_id="AP_004898.1"
                     /db_xref="GI:110189669"
                     /db_xref="GOA:P05505"
                     /db_xref="UniProtKB/Swiss-Prot:P05505"
                     /db_xref="GeneID:7066253"
                     /translation="MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLS
                     LGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFY
                     HSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMN
                     QALLITILLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVC
                     LLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS"
     tRNA            9368..9435
                     /product="tRNA-Gly"
     gene            9436..9783
                     /gene="ND3"
                     /db_xref="GeneID:7066254"
     CDS             9436..9783
                     /gene="ND3"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 3"
                     /protein_id="AP_004899.1"
                     /db_xref="GI:110189670"
                     /db_xref="GOA:P05506"
                     /db_xref="InterPro:IPR000440"
                     /db_xref="UniProtKB/Swiss-Prot:P05506"
                     /db_xref="GeneID:7066254"
                     /translation="MNLPIIITINITLSFILISIAFWLPQMNLYSEKANPYECGFDPT
                     SSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAIQTTNTTTMMATAFILVTILSLGL
                     AYEWTQKGLEWTE"
     tRNA            9785..9852
                     /product="tRNA-Arg"
     gene            9855..10151
                     /gene="ND4L"
                     /db_xref="GeneID:7066255"
     CDS             9855..10151
                     /gene="ND4L"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 4L"
                     /protein_id="AP_004900.1"
                     /db_xref="GI:110189671"
                     /db_xref="GOA:P05507"
                     /db_xref="UniProtKB/Swiss-Prot:P05507"
                     /db_xref="GeneID:7066255"
                     /translation="MTSAFLNLTMAFTLSLLGTFMFRSHLMSTLLCLEGMMLSLFVMT
                     STSTLNSNSMISMTIPITILVFAACEAAVGLALLVKISNTYGTDYVQNLNLLQC"
     gene            10145..11522
                     /gene="ND4"
                     /db_xref="GeneID:7066256"
     CDS             10145..11522
                     /gene="ND4"
                     /note="TAA stop codon is completed by the addition of 3' A
                     residues to the mRNA"
                     /codon_start=1
                     /transl_except=(pos:11522,aa:TERM)
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 4"
                     /protein_id="AP_004901.1"
                     /db_xref="GI:110189672"
                     /db_xref="GOA:P05508"
                     /db_xref="InterPro:IPR000260"
                     /db_xref="InterPro:IPR001750"
                     /db_xref="InterPro:IPR003918"
                     /db_xref="InterPro:IPR010227"
                     /db_xref="UniProtKB/Swiss-Prot:P05508"
                     /db_xref="GeneID:7066256"
                     /translation="MLKIIFPSIMLLPLTWLSANKKIWTNVTSYSFLVSLLSLSLLWQ
                     NDENYLNFSVMFSSDPLSTPLIILTTWLLPLMMLASQNHMKKENMMHQKLYISMLISL
                     QILLIMTFSATELILFYILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPL
                     LIALISIQNSMGTLNFLILSLTTHPLPSTWSNTILWLACMMAFMIKMPLYGVHLWLPK
                     AHVEAPIAGSMILAAILLKLGGYGMMRVSIILDPLTKSLAYPFIILSLWGMIMTSSIC
                     LRQTDLKSLIAYSSVSHMALVITAIMIQTPWSFMGATMLMIAHGLTSSLLFCLANTNY
                     ERIHSRTMIMARGLQMIFPLMATWWLLASLANLALPPLINLMGELFIVMATFSWSNPS
                     IILMATNIVITGMYSMYMIITTQRGKLTSHMNNLQPSHTRELTLMALHIIPLMLLTIN
                     PKLITGLTM"
     tRNA            11523..11590
                     /product="tRNA-His"
     tRNA            11591..11650
                     /product="tRNA-Ser"
                     /codon_recognized="AGY"
     tRNA            11650..11720
                     /product="tRNA-Leu"
                     /codon_recognized="CUN"
     gene            11721..13553
                     /gene="ND5"
                     /db_xref="GeneID:7066257"
     CDS             11721..13553
                     /gene="ND5"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 5"
                     /protein_id="AP_004902.1"
                     /db_xref="GI:110189673"
                     /db_xref="GOA:P11661"
                     /db_xref="InterPro:IPR001516"
                     /db_xref="InterPro:IPR001750"
                     /db_xref="InterPro:IPR003916"
                     /db_xref="InterPro:IPR003945"
                     /db_xref="InterPro:IPR010934"
                     /db_xref="UniProtKB/Swiss-Prot:P11661"
                     /db_xref="GeneID:7066257"
                     /translation="MNMMTILILMILDLLTTPITFSMTILTKLMYFRHMLITSIKFSF
                     LLSLLPLLLFFHHNTEYMITNWHWLTINSIKLTMSFKIDYFSILFLSVSLFVTWSIMQ
                     FSSWYMHSDPHINRFIKYLMMFLNNMLILTSANNLFQLFIGWEGVGIMSFLLIGWWYG
                     LADANTAALQAILYNRVGDIGFILAMTWFCLNMNSWELQQIFLTNTNNNLVPLTGLLI
                     AATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFHPLTSNNSTIMTA
                     MLCLGAITTLFTAICALTQNDIKKIVAFSTSSQLGLMMVTLGINQPYLAFLHICTHAF
                     FKAMLFMCSGSIIHILNDEQDIRKMGNMMKAMPFTSSCLIIGSLALTGMPFLTGFYSK
                     DLIIEAINTCNTNAWALMITLIATSMTAVYSMRIIYFVTMTKPRYSPLITINENNPNL
                     INPIKRLALGSILAGFLISLNIPPTNIQILTMPWHLKMTALLITILGFAIALELNNLT
                     LNLSMSKPTKLSSFSTSLGYYPPIMPRIIPQKTLNSSYKLSLNLLDLIWSEKTIPKST
                     SITQTQLSKMMSNQKGLIKLYFLSFLITISLIFILHTLNPEWFQ"
     gene            complement(13531..14049)
                     /gene="ND6"
                     /db_xref="GeneID:7066258"
     CDS             complement(13531..14049)
                     /gene="ND6"
                     /codon_start=1
                     /transl_table=2
                     /product="NADH dehydrogenase subunit 6"
                     /protein_id="AP_004903.1"
                     /db_xref="GI:110189674"
                     /db_xref="GOA:P03926"
                     /db_xref="InterPro:IPR001457"
                     /db_xref="UniProtKB/Swiss-Prot:P03926"
                     /db_xref="GeneID:7066258"
                     /translation="MTNYMFILSLLFLTGCLGLALKPSPIYGGFGLIVSGCIGCLMVL
                     GFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWFIFSFFVLGLFMELVV
                     FYLFSLNNKVELVDFDSLGDWLMYEIDDVGVMLEGGIGVAAIYSCATWMMVVAGWSLF
                     AGIFIIIEITRD"
     tRNA            complement(14050..14118)
                     /product="tRNA-Glu"
     gene            14124..15266
                     /gene="CYTB"
                     /db_xref="GeneID:7066259"
     CDS             14124..15266
                     /gene="CYTB"
                     /codon_start=1
                     /transl_table=2
                     /product="cytochrome b"
                     /protein_id="AP_004904.1"
                     /db_xref="GI:110189675"
                     /db_xref="GOA:P00159"
                     /db_xref="UniProtKB/Swiss-Prot:P00159"
                     /db_xref="GeneID:7066259"
                     /translation="MTNIRKSHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQ
                     ILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLQANGASMFFICLFLHVGRGL
                     YYGSYTFLETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTL
                     VEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSDADKI
                     PFHPYYTIKDLLGVFMLLLFLMTLVLFFPDLLGDPDNYTPANPLNTPPHIKPEWYFLF
                     AYAILRSIPNKLGGVVALILSILILAFLPFLHTSKQRSLTFRPITQILYWILVANLLV
                     LTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIVEDKMLKWN"
     tRNA            15268..15334
                     /product="tRNA-Thr"
     tRNA            complement(15336..15403)
                     /product="tRNA-Pro"
     D-loop          15404..16300
     STS             15765..16119
                     /standard_name="PMC139749P2"
                     /db_xref="UniSTS:270889"
ORIGIN