Dbfetch

LOCUS       NM_206051               8512 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster corin, transcript variant B (Corin), mRNA.
ACCESSION   NM_206051
VERSION     NM_206051.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8512)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8512)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8512)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8512)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8512)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8512)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8512)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8512)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8512)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8512)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8512)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8512)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8512)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8512)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 8512)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8512)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 8512)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   24 (bases 1 to 8512)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033778).
            
            On Jul 15, 2014 this sequence version replaced NM_206051.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8512
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2R"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8512
                     /gene="Corin"
                     /locus_tag="Dmel_CG2105"
                     /gene_synonym="CG2105; corin; Dmel\CG2105; SP75"
                     /map="43D3-43D7"
                     /db_xref="FLYBASE:FBgn0033192"
                     /db_xref="GeneID:35691"
     CDS             1138..5331
                     /gene="Corin"
                     /locus_tag="Dmel_CG2105"
                     /gene_synonym="CG2105; corin; Dmel\CG2105; SP75"
                     /EC_number="3.4.21.-"
                     /note="CG2105 gene product from transcript CG2105-RB;
                     CG2105-PB; Corin-PB; DCorin"
                     /codon_start=1
                     /product="corin, isoform B"
                     /protein_id="NP_995773.1"
                     /db_xref="FLYBASE:FBpp0087983"
                     /db_xref="GeneID:35691"
                     /db_xref="FLYBASE:FBgn0033192"
                     /translation="MNALDMNKQFLSVSQDHQHQTSVADQRSRSRSERASSLALPLNS
                     LLDFYDKQQEQCKSVTLLPLPSNSGSISESSSLSSSNSIVRRHSSHYYPMLEDKQKPS
                     QLPQAATEMLVNMTEQKYCQSAHQGASIAGGRQVHHQQQHLVRVDTPVTPPPPIPRRL
                     LRGKSAWQASSPHPLPLSAGGQDGAHGTGTGTVFVYPQPENVTAEAVVRGSGDGQGGG
                     GAGLQSALLVDIATRPASGYADADGISDDDRMSLENSVFDESLTSTPVKVAGYLAGRY
                     AGLSHMAKRAQRSSSSTVDSAYGSSLGGHSERFASSSTSVDFRSRFSSVDTQSSLDEK
                     PLSSSIDSPLARDPRDAYRERAVLNDAMHKLNNNNTSLGLALYSASNNNNGSSVASDG
                     SQLPVVPARKQPPPVKGSSNSSNSIGETQSQSSKEPSSVSASASTSSAASAGSSTISS
                     GTMSSMSGPCPAVVPPTDAITKRPGPPEPPLRQANVFDPVETGSRGHPPPPLTVRNKL
                     GRNKPPPITYPRMQQRQDSTLSSDSYSISSSPGYNSKLMEAPLLGSQQGGRKSNAPGS
                     AQRQTPLMDLAPTRFLGGAGGGTGSGKQGPAMPPPRSKINFRQDSTISSDSFSQTSSP
                     GYNPKLMEAPLLPSLSAKRLCSAPAPIVCRQGVQHEPIEELEPPQTISPLHKAAGQPS
                     SLQTIVRFQNGAPHTMSLQHQIINRRKSSNPYITNGRLKFRLFQILINAFALLAIAGG
                     LAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTV
                     FPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLC
                     TETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQ
                     CDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPY
                     GQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAV
                     NATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNY
                     ECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASH
                     CVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQL
                     ATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPII
                     TRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSW
                     GIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRVNKYDLHPGGPDILSKIATD
                     PMREGAPHHYTHSRTSSKN"
ORIGIN      
        1 gcagtgcgta ggcggttgtc gttgactgac gtcgtggcca acagcacgtg ctaaccgagg
       61 cggcgcgtgc agcaaaaagt agtagcagaa gctgtagtgg cccacaacaa cagcacaaca
      121 acggcatcag cagccgagca gccagttgaa aagctacaca cggaatatac aacacacagc
      181 tctagtatca caacaactaa cgctttgggc taggcagaga gaagggagtg ggcgagcggg
      241 gagagagttt aacttgagtg aaatttaaag cagttgaaga agaggaagca gcaggacaat
      301 acaccaatgc aggctaactg taaaagtgtg tgaaagcata gtgagtgagc aagaggaacg
      361 gggaaaggga tagaggctga gagtgagtga gtaggaatga caatgcgaca ataaattagc
      421 tgtaaactgc accttgttat ttgcacctga atcgaaagtg gattatatat tttgctatag
      481 tattaataac aacaacacac aaaaggaggc cagaacaacc agccagccag taatcaaagt
      541 taatttacca acacaagaaa cgtaaacgtg agttctattg acgcaaataa gaagaagagg
      601 aaaagcgggc gaataagtag gcaacagaag aattaggagc agcaaccgga ggagcaggca
      661 gcgcgcaaac aggatactta aaatatcaag gcaaacacac acacacacag agacatacac
      721 aaacaggagt acacacgcac acgcacttgc ccgaaggagg ttcatatttt tggcgaaaaa
      781 acacaaaacc accgcacgaa ataaataaaa tataaaccca accacgttga ggtgtatggc
      841 ccaaaggcaa ggcaaacaaa cagagctgaa atcgaggaga agaagcagcg aaacataaag
      901 atgccaaaat gctggacgga gattgatgct ggctgccgaa gaacagcacc cactacaaca
      961 accacaagca cagcagcagc agcagcaaca actgcaataa caataataag gccgagacaa
     1021 acgacaagcg agaacaacag caacaagagc aacaacagca gcgacaaccg ccaaatgtga
     1081 gcagacaagc gacaccaatt gagatatatt gatttcgaag tacgacgcga ttaagccatg
     1141 aacgcactcg atatgaataa acaatttctg agcgtctccc aggaccatca gcatcagacc
     1201 tcggtggcag atcaaaggag tcgctcaaga tcggaacgcg cctccagcct ggcgctgccc
     1261 ctcaattcgc tgctggactt ctacgacaag cagcaggagc agtgcaagtc cgtcaccctg
     1321 ctgcccttgc ccagcaactc cggcagcatc agtgagagca gcagcctctc cagcagcaac
     1381 agcatcgtgc gccgacactc ctcccactat tatcccatgc tcgaggacaa gcagaagccg
     1441 tcgcagctgc cccaggcagc caccgaaatg cttgtaaaca tgacggagca gaaatattgc
     1501 cagtcagcgc atcagggtgc ctccatcgcg ggaggaaggc aggtccacca ccagcagcag
     1561 cacttagtgc gggtggacac cccagtgacg cccccacctc ccattccgcg gcgactactg
     1621 cgcggcaagt ccgcctggca ggcgtcgagt ccacacccac ttccactctc ggctggcgga
     1681 caggatggcg cccacggcac gggcacgggc actgtgtttg tttatccgca gccagaaaac
     1741 gtgaccgcag aggcagtggt ccgaggatcg ggcgacggac aggggggcgg aggtgccggg
     1801 ctgcaatcag cactgcttgt tgacatagcc acacgtccgg cgtccggata tgcggatgcc
     1861 gatgggattt ccgatgacga ccgcatgagt ctggagaact ccgtgttcga cgagtcgcta
     1921 acctccacgc ccgtcaaggt cgccggctat ttggccggcc gctatgccgg gctgagtcac
     1981 atggccaagc gggcgcagcg ttcctccagc agcaccgtgg actccgccta cggctcatcg
     2041 ctgggcggcc acagtgagcg gttcgctagc agctcgacca gcgtggactt tcgcagtcgc
     2101 ttctcctcgg tggacaccca gtcctcgctc gatgagaagc cgctgtctag ctcgattgac
     2161 tcgccgctgg ccagggatcc cagggatgcg tacagggaac gtgctgtgct caacgatgcc
     2221 atgcataagc tgaacaacaa taacaccagc ctgggactgg ccctctactc ggccagcaat
     2281 aacaacaacg gcagtagcgt ggcaagcgat ggttcccagc taccagtggt tcctgcccga
     2341 aagcagccgc cgccagtgaa gggcagcagc aacagcagca actcaatcgg cgaaactcag
     2401 tcgcagagct ccaaggaacc aagcagcgtg tcggcctcgg cctccacttc gtccgccgcc
     2461 tccgcaggtt ccagcactat atccagcggc accatgtcat ctatgtcagg gccatgtcca
     2521 gccgttgtgc cgcccacaga tgccattacc aaacgtccag ggccgccaga gccaccatta
     2581 cggcaggcca acgtgtttga tccagtggag acgggatcgc ggggtcaccc gccacctcca
     2641 ttgactgtgc ggaacaagct cgggcgcaat aaaccgccac cgataacgta tcctcggatg
     2701 caacagcgcc aggactccac gctgtccagc gacagctact cgatcagctc cagtccgggc
     2761 tacaactcca agcttatgga agcgccactg ctgggttccc agcagggggg acgtaagtct
     2821 aatgcacccg gcagcgcaca gcgccagact ccgctcatgg acttggcccc cacccgcttt
     2881 ctgggcggcg ccggcggagg aaccggaagc ggaaagcagg gtcctgcaat gccgccaccg
     2941 aggagtaaga tcaacttccg gcaggactcg accatctcca gcgacagctt tagccagacg
     3001 tccagtccgg gatacaatcc taagctcatg gaggcgccgc tgctgccctc gttgtccgcc
     3061 aagcggctgt gcagtgcgcc agccccgatc gtgtgccgtc agggagttca gcacgagccc
     3121 atcgaggaac tagaaccgcc gcagacgatc tcgccgcttc ataaggcggc cggccagccc
     3181 agcagcctgc agacgattgt ccgctttcaa aatggagcac cgcacaccat gtccttgcag
     3241 catcagatta ttaaccggcg caagagctcc aatccgtaca tcacaaacgg ccgcctaaag
     3301 ttccgcctgt tccagatttt gatcaacgca ttcgccctgc tggctatcgc cggcggtctg
     3361 gctgcctact ttaatgcgta tccgactata aagttcgtga acaagactat catcaacacg
     3421 atccacgtgg aggacaccac aagttttggc aagaatccag ccccaggcac ctgcctgccc
     3481 atcatagtcc ggttttgtca aggtccacag attccctaca actacaccgt gtttcccaac
     3541 tatatcggtc actttggaca gctggagact caaacggact tggattccta tgaggccctg
     3601 gtggatgtgc gatgttacga gctcgtttcc ctgtttctct gcacactttt cgtgccgaag
     3661 tgcggacaga gcggggccac cgtgccacct tgcaagaccc tctgtacgga gacgatgcgc
     3721 cgctgtggct tcttcttcga cgttttcgga ctgagtctgc ccgagtacct gaactgcaaa
     3781 ctcttcaagg actttccgag ttccgaggac tgcgtgggtt tggatgaggt tcgcgaggtg
     3841 atgagagccg ccacgcatcc caagtgcgat gggttccagt gcgaccagaa ccgttgtctg
     3901 ccgcaggagt acgtgtgcga tggccacctg gactgcatgg accaggcaga cgaggccaag
     3961 tgcgagcgtt gtggaccgga cgagatctac tgcggcgaca gccagtgcat tggaaccaag
     4021 cacatatgcg acggtatcat cgactgtccc tacggccagg atgagcgcaa ctgcttgagg
     4081 ctaagtgagc ggaacggcga tgtgggcacc ggtgtcctgg aggtctatcg cataggccag
     4141 cggcagtgga tgcccgcgtg tgtgaagaac tgggatcggg cagtatcgcc cagcgctgtg
     4201 tgttccattc tgggctactc ggccgtgaat gccaccagtg tcctgaccca acttactcac
     4261 cgcccactgc tagccacggt aaatgtgtcc acagatatat ggaaaatgta cgccaaacga
     4321 aagtcgacct tgatgcagga gtttgccaac tgcaaaaaga cagaggatta tccaatggcc
     4381 gatctaacgt gctccaatta tgagtgcggc cgagtaaagc ggggtagaca caagccatcg
     4441 agacgcatca ttggaggaac ccaagccagt cccggcaatt ggccattcct ggccgcaatt
     4501 ttgggcggtc cggagaagat tttctactgc gctggcgttc taatctcgga tcaatgggtg
     4561 ctcacagcct cccactgcgt gggaaattat agcgtgatcg acttggagga ttggaccatt
     4621 cagctgggcg tgacgcgtcg caactctttc acctactcgg gtcagaaggt caaggtcaag
     4681 gccgtaattc cgcatccgca atacaacatg gctattgccc acgacaatga catagccctc
     4741 ttccaacttg ccacgcgtgt tgctttccat gaacacctat tgcccgtatg tttgccgccg
     4801 ccaagcgtga ggaatctgca tcctggcacc ctgtgcaccg tcatcggatg gggaaagcgg
     4861 gaggacaagg atcccaaatc cacgtacgag tacatagtca acgaggtgca agtgcccatc
     4921 atcacgcgta atcagtgcga cgaatggctg gacaacctga cggtgtcgga gggcatggtc
     4981 tgtgccgggt tcgatgacgg aggcaaggat gcctgtcagg gtgattcggg cggtccgctg
     5041 ctgtgtccgt atcccgggga gaagaatcgc tggtttgtgg gcggcatagt ctcctggggc
     5101 attatgtgtg cgcatccccg tctgccgggc gtatatgcaa acgtggtgca atatgtgccc
     5161 tggatacagg agcagatcgc gaagcattcg cgtcccatta aagaggaccg cgttaacaag
     5221 tatgacctgc atcccggagg acccgatata ctatccaaaa tagccactga ccctatgcgc
     5281 gagggtgcac cacaccacta cactcattcc aggacgtcgt ccaaaaatta atcctgacca
     5341 cggctttatg ccgtgactct tctataagaa gagtcaccac agtcgtcagg tgattctgga
     5401 accgagcata tccatgaaac aattgcacaa attacgaaag tcaaacggaa cagatggatc
     5461 ctgtaggata catacatata ttttgctact gaacttaggg tattagccag ccggctagca
     5521 ccgatttggg caacataatc atgtgtcaat ttgccgaatt tatttgtcaa tttttttaca
     5581 aagagatttt tatgaaccta aaccgcagac attttataac ccagacaaac cgaaaaaggg
     5641 ggtgcaaaca tatgtcaata catattgcaa gagcgattta tatattacca cgtaaatgga
     5701 aagtaaccgt tatgtaccca aaatctaaat aattgataat tgtgtctaaa taccccgaaa
     5761 cccagaatat aattcaattt tgtagctgaa ttttgtgttg aaaatgaacc ctgtattatt
     5821 ataagtacga gtattactcc actggaaaaa ttatgataat cgaagaagaa ttcagaaaaa
     5881 tattgtgaag tataaatagt agaatcccag ctattgagtg ttgaaaatta atgcaggaaa
     5941 taagaaaatc aattgtagaa actaatgtat aactataacc aaaccaaatc aaagaaaaca
     6001 aggaatcatt gctgatcttg ggcatttgat ggacgtagca gtaggctctt ctccaaaccc
     6061 aaatatgctg tcttacaaca acaatgaatc taaaaaacaa taagaaagtg tgcagttgac
     6121 aataatgaga aatgcacaat aagcaactaa atgcgattag atataagcca tgaaaataat
     6181 aactacaatg cgtgggtttc agctttaaag aacacaaacg aatggcaagt cgtttagtct
     6241 ggctaaagtc agatcaaaag gattaggatc aggggataat aaggatcata cttatacacc
     6301 tagcatacga atcgactatt tacgcggtga actacagaag gtacgatagt actcgcttcg
     6361 atagtggata tgtcaatgta acttaatatt tagaactatt tacacgccaa cgccgcacct
     6421 cgtttgtcac gcccacttag actggccgct tgggtcgaag ctcgaggtat tgtcccgatt
     6481 tagatctcta ctcatccata aaccaggtct ggtatcgtac gatctggaag atacaatgct
     6541 tgagtgctga cattcgtagg cacaactatt ttgcagagga atcgcacgta atgaatgtaa
     6601 aatacgcgta actaaagact caaaatcggt tgtttcaaca cacagaacac acacaaacac
     6661 accagagctt cgcgatgtgt acagctttga tattgttttc gagtcgaaac cggaacatga
     6721 accggaagtg ggtcggattt ccggtagcta catgtttttg acttatcgtt tctagtttct
     6781 agcaaaaacc tgttgaaatg ctttagacaa gagattgcaa atgtataacc gatcactact
     6841 agatctagtt ggtcatatta tgcctaccaa tatatatata tatatatata tatatatata
     6901 tatatataca tatatgcatg ttttgtacaa tcagtttaca agtggaaaag tattattagt
     6961 cttaacgggg ggttaaatga agcgcatatt acacaaggca cacgatgttt taggcggaac
     7021 atgaacacaa accaatatgt aactgaaata tatacaagaa atatacatat aacggataca
     7081 tatattctat atatatattg tagtgctagc aattaagcag atgtgatggt gtctaaattt
     7141 atacatgcat attatcaagc gaaagtggaa agcttagatt atactcgaga caaatctgtg
     7201 ggctgttgta gatcgagcat actagctata atgacagagt acagatccag gacaatacaa
     7261 acttataaag atatacccat atcatagaaa ctatgcttac ttcaatatcg tgcagtgcat
     7321 gaacacaagc ccgagttttc ctgaaactct caggggtttt actactaagc ttcaaatgca
     7381 ttgacgtgaa atcactgacg acttcaggac cacatcggat ggatatagtt tgtgcttgaa
     7441 ctcaggcagg actcctttgc tgttgctttg gacagtaagc caccacacct ttcacccttt
     7501 cagttttctg gggttcactc tccttgtgca tttacgatca ttcggatcat ggcgagctat
     7561 ttttatacac cccatgctcc aggctactat caaaacgctt agctttatgt acatttagtc
     7621 taaatcgaat acaacccata tattatatat attgtagatg taaaatgctt agcattggcg
     7681 atcggagtga gtgaaataat ttacacgtgg catgaactgc agaatagata attactaagt
     7741 acaatacgca aacagttgac actcaaactc agaatcgcac aagccccaca tcctagttga
     7801 aattctgcgc ttaacgggga tcgtccccaa ggattcgatt cagtttcgca tgctccatgt
     7861 gcatggaggg acacactaca caaagtacat aagaacaggc cctattaaac aaagaacaca
     7921 agaatttgta gcgaaaagtt atgtgtaaaa tgtagcaaaa tccaaaaacc agaagctgat
     7981 aaacaaacta gttgaattta catgtgtcgc gcattataaa gatgaagcat agtatatgta
     8041 ctcacgtatc agaatattat atgtaaatgt ttaaagatga taatttgatg aaaagcactt
     8101 gttatctatg cacagacgga actttgtgaa gaatttacaa taacaacctt tgacaataaa
     8161 gacaaactga atttgttttc ctgtgagcta gacaagcgca tcggaggcat tgagaattta
     8221 tgaaaagttt tacattcaga tcttgaagtt ttgacgcaaa tcgaacaata ttgttgaaca
     8281 tttatttttg aaaactcaga gagtaccaaa accatgacaa taaagccggc atttggccaa
     8341 tgtccgacaa taactgggaa agtgcagtaa actaaatgta actacataaa gtacacgcag
     8401 acacacgtat aaccaactaa atgctaaaag caacatgtca taccaaacat gatatatacc
     8461 tacaaacata tattatataa atgttaaaaa ataaatgtat aaaaccacat ac
//