Dbfetch

LOCUS       NM_176113               6520 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster protein kinase N, transcript variant D
            (Pkn), mRNA.
ACCESSION   NM_176113
VERSION     NM_176113.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6520)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6520)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6520)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6520)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6520)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6520)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6520)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6520)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6520)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6520)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6520)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6520)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6520)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6520)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 6520)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6520)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 6520)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   24 (bases 1 to 6520)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033778).
            
            On Dec 17, 2009 this sequence version replaced NM_176113.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6520
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2R"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6520
                     /gene="Pkn"
                     /locus_tag="Dmel_CG2049"
                     /gene_synonym="3-2; CG2049; CG2055; CG8; CT6637; CT6660;
                     Dmel\CG2049; dPKN; Dpkn; DPKN; l(2)06736; l(2)45Ca; Pk45C;
                     Pk?3; PKC-related; pkn; PKN; PRK2; v(2)rG232"
                     /note="Protein kinase N"
                     /map="45C1-45C1"
                     /db_xref="FLYBASE:FBgn0020621"
                     /db_xref="GeneID:35950"
     CDS             498..4766
                     /gene="Pkn"
                     /locus_tag="Dmel_CG2049"
                     /gene_synonym="3-2; CG2049; CG2055; CG8; CT6637; CT6660;
                     Dmel\CG2049; dPKN; Dpkn; DPKN; l(2)06736; l(2)45Ca; Pk45C;
                     Pk?3; PKC-related; pkn; PKN; PRK2; v(2)rG232"
                     /EC_number="2.7.11.1"
                     /note="CG2049 gene product from transcript CG2049-RD;
                     CG2049-PD; Pkn-PD; protein kinase-like 45C; protein kinase
                     related to protein kinase N; complementation group 8;
                     protein kinase c related"
                     /codon_start=1
                     /product="protein kinase N, isoform D"
                     /protein_id="NP_788293.2"
                     /db_xref="FLYBASE:FBpp0087685"
                     /db_xref="GeneID:35950"
                     /db_xref="FLYBASE:FBgn0020621"
                     /translation="MALTMNMVFLKDLRSRLKGYLHGEYIKHPVLYELSHKYGFTENL
                     PESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVLVKKSKSKLA
                     ELKSELQELESQILLTSANTAVNSNGQESITACIDPNGGFLVSGAVGGLGGGNTALEG
                     GAPATANDKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLLAEAHQMLADSKAKI
                     EFLRLRIIKVKQNREQADRLKASRQMIDEHGQTIGGNNSSQPQSLETTLEERIEELRH
                     RLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQE
                     LPADSPAAQQLKTELQIVQLSTSPAPVTYTSLQSGQAGILGGKPYQSVSSLGRCASVT
                     GKLEVRLLGCQDLLEDVPGRSRRDKDNNSSPGDLRSFVKGVTSRSSSKSYSVKDETSI
                     EIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVL
                     RLEEFIDDVRHGMALQLEPQGLLFAEVKFLNPMISQKPKLRRQRMIFNRQQAKNISRA
                     KQMNINVATWGRLLKRNAPNHVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSSD
                     ALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISV
                     LPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPPVLKATSTTPI
                     LDQELQDALHEFDFLSDLDSRPTTLRRLLKEQKMALDAGALENLLLQQQQTEQQALQQ
                     RQRQEQLRLQQFQEAQRQAILDLCVKQREPAEQTSPTLANQTPTFPPLASNQIMPSLN
                     ARPCQSQSPNHNEFQLQPQPPHPAQKPTNPEPPSAVEQQLHRPVLILPPVVLLGGREE
                     DRSVPPSPLVEYPEDDDEYLYRGSNENLGTRLHSSHSSSAGDRFCVEVIPQLGKLYVG
                     SSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPIYANQYEL
                     NVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQPPNAG
                     MLSMDNFRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRI
                     FEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACV
                     VLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFL
                     APEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSL
                     EAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPPFVPTINHL
                     EDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEWC"
ORIGIN      
        1 aaatttgtag aagttttccg atagataaaa attccacata atgtatctca tggatacaga
       61 gcgcacacgt gtcagtatct gtctgcactc gcttcccttt tgcattcgca tgccaatttc
      121 aaatgcgaat ttcgttattt tcttatttat ttttttccga aattatgtgc gcaaatcgaa
      181 aagctttcta atcgcttttc cgccaccaga gcggagcgtt tttccttcct agcattgcag
      241 tttgcgactt ggcagcgcct tgacatcgtc gctttttata ttcgatactc gatgtgtccg
      301 atccatatat atgtacatat gtatgtacat acatataagt gtgtatatat gatgagtccg
      361 tagacgtgga gagtgagcta acgaaaagaa agaaattaac tttaaatata ctgccaatgt
      421 gttactatcg gtgtacgaat atcacattca atgccgtttg tgtgaaataa actaagcaaa
      481 tagaagaaac ccgtactatg gcattgacca tgaacatggt tttcctcaag gacctacgat
      541 cgcgcctcaa gggatatctg cacggcgaat acatcaagca tcccgttctg tacgagctca
      601 gtcacaaata tggtttcaca gagaatctgc cggagagctg tatgtccata cggctggagg
      661 agatcaagga ggccattcgg cgagagatcc gcaaggagct gaagatcaaa gagggcgccg
      721 agaagctccg cgaggtggct aaagatcgac gatccctcag cgatgtggcc gttcttgtca
      781 agaagagcaa aagtaaactt gccgagctga agtccgagtt gcaggagctc gagagtcaaa
      841 tcctcctgac atcggccaac accgccgtca atagtaatgg acaagaatcg atcactgcct
      901 gcattgatcc caatggcggc ttcttggtca gcggtgcagt tggtggcttg ggcggcggaa
      961 acacggctct ggagggcggc gcaccggcca ctgccaatga caaagtgctc gcctcgctgg
     1021 agaagcagct gcagatcgag atgaaggtga agaccggggc ggaaaacatg atccagtcgc
     1081 tgggcatcgg atgcgacaag aagctgctgg cggaagccca ccagatgctg gccgactcga
     1141 aggccaagat tgagtttttg cgcctgcgca tcatcaaggt gaaacagaac cgcgagcagg
     1201 ccgatcgcct caaggcctcg cgccagatga tcgacgagca tggccagacg atcggcggga
     1261 acaacagcag ccagccgcag agcctggaga cgacgctgga ggagcgaatc gaggagctcc
     1321 gccatcgact gcgaatcgag gcagccgtcg tcgatggagc caagaatgtt atacgcacgc
     1381 tgcagacggc gaatagggca ccggacaaga aggctttgca ggaggcccat ggacgtttgt
     1441 cggaatcgtc gcgaaaacta gatctcttgc gctactcctt ggatttacga cgccaggagc
     1501 tgcccgccga ttcgcccgcc gcccagcaat taaaaacgga gctgcagatc gtccagctat
     1561 cgacctcccc agctccggtc acctacacgt cactgcagtc cggacaagcg ggcatactcg
     1621 gcggaaagcc gtaccagtcg gtatcctcgc ttggacgctg tgccagtgtc accggaaaac
     1681 tggaggttcg cttgctgggc tgtcaagatt tgctggaaga tgtgcccggt agatcgagga
     1741 gggacaagga caacaactca agtccgggtg atttacgaag cttcgtcaag ggcgtcacgt
     1801 cgcgcagcag ttcaaagagc tattcggtaa aggatgagac gtccattgag atcatggcgg
     1861 tcatcaagct ggacaatatc accgttggcc agacatcgtg gaagcaatgc tcgcagcagg
     1921 cctgggatca gcgcttctcc atcgatctag accggtcgcg cgaactggag attggagttt
     1981 actggcgcga ctggcgatcc ctgtgcgccg taaaggtgct gcgccttgaa gagttcatcg
     2041 acgatgtacg acatggcatg gcattgcagc tggagccaca aggtctgcta tttgcggagg
     2101 tcaagttctt gaaccccatg atttcacaga agccaaagct gaggcgccag cgtatgatct
     2161 tcaacaggca gcaagcgaag aacatctcgc gggccaagca gatgaacatt aatgtggcca
     2221 catggggccg cctgcttaag cggaatgctc ctaaccatgt gcacatggga tcggcaggat
     2281 caggatcttc tctaaccggt agctcgccta tggtggttgg tgggtctcgc gactctgagt
     2341 ctccgatttc gaggactccc tcatccgacg cactggtgga accggagccc tacacgcccg
     2401 gagagcaggc acagaacttg gaattcgatc ccgatgcagg aattaatgaa cacgtggaga
     2461 cgccaggtga atacccggat ccggcggcca gtggtctgag cggaatgcga cccctgtcca
     2521 tgcacatgca gggaattagt gtgctgcccc cggaatcgcc acccgtggcc accggagcag
     2581 ctggtcggcc caatacgctc agcttacaga tgccgggtgc cagtaaagga caggtgatcc
     2641 aaggcggacg gactgcggcg cctacaacgg cgccaccgcc accacctgtg ctcaaggcga
     2701 catccaccac tccgatattg gatcaggagc tgcaggatgc cctgcacgaa ttcgatttcc
     2761 tgtcggacct ggactcacgt cccaccacgc tgcgtcgcct gctgaaggag cagaagatgg
     2821 cgctggatgc cggcgcgctg gagaatctgc tgctgcagca gcaacagact gagcagcagg
     2881 cactgcagca gcgccagcgc caggagcagc tgcgtctgca gcagtttcag gaggcgcagc
     2941 gccaggcgat cctggacctg tgcgtgaaac agagagagcc cgcggagcag acatcaccca
     3001 cccttgccaa ccaaacgccg acgttcccac cgcttgccag caatcagatc atgccaagct
     3061 taaatgcccg cccttgccaa agccaaagcc caaaccacaa cgaatttcag ttgcagccgc
     3121 agccaccaca tcccgcccag aaaccgacga atcccgaacc accgtccgct gtggaacagc
     3181 agctgcaccg tccggtccta atcctgccgc ccgtggtgct cctgggtggt cgggaggagg
     3241 accgttcggt gccaccatcg ccactagtcg agtatcccga ggacgacgac gagtatctgt
     3301 atcgtggtag caacgaaaac ctgggcacca ggctgcactc cagccacagt tccagtgccg
     3361 gcgatcgttt ctgtgtggag gttataccac agttggggaa gctttacgtg ggcagtagcc
     3421 agcagcagta tgcgcagcag tcatcgccca tcatccagga gccagctact cctactattt
     3481 acggaaacag cgccgcagcc ggagcgccgc agttcccgca gcccgcccaa aggcaagaga
     3541 agcagcctcc gcagcagcag cccatctacg ctaaccagta tgagctgaat gtggccaagg
     3601 cggcagctgc agcatctgtt tactcaccca gctcctccac caccagcaac tccaatcaac
     3661 agcagcagca gcagcgccgg aatgtggccc gtggactgca gtatcgtgaa tctggaggac
     3721 tcgagactgg acgtgctggc aagcagccac ccaatgcggg catgttgtca atggacaact
     3781 tccgtttgct aagcgttctt ggtcgcggcc actttggcaa ggtgattctg tcccaattgc
     3841 gaagcaacaa ccagtactac gctattaagg cactgaagaa gggagacatc attgcccgcg
     3901 acgaagtgga gtccctgctt agcgaaaagc gcatcttcga ggtggccaac gccatgcgcc
     3961 atccgttctt agttaacttg tattcgtgct tccagactga gcaacacgta tgctttgtga
     4021 tggaatacgc tgctggcgga gatttgatga tgcacatcca cacggacgtg ttcctagagc
     4081 cgagagccgt tttctacgcc gcttgtgtgg ttctgggcct gcagtacctg cacgagaaca
     4141 agatcatcta ccgggacctg aagctggaca atttgctttt ggacacggaa ggatatgtga
     4201 aaattgcgga ctttggtttg tgcaaggagg gcatgggctt tggtgatcgc acgggcactt
     4261 tctgtggtac gcccgagttt ctggcaccgg aagtgctcac ggaaacttcc tacacacgag
     4321 ctgtggattg gtggggcttg ggtgtgttga tctttgagat gttggttggt gagtccccat
     4381 tccctggtga cgatgaggag gaagtattcg attcaattgt caacgatgag gtgcgctatc
     4441 cgcgcttcct atcgctggag gccatagccg tgatgcgtag gcttttgcgc aagaatccag
     4501 agagacgtct gggatcttcg gaacgggatg cggaggatgt taagaaacag gcattcttcc
     4561 ggtcaattgt gtgggatgac ctgctcctgc gaaaggttaa accaccattt gtgccgacaa
     4621 ttaaccactt ggaggatgtg tcaaactttg acgaggagtt cacgtcggag aaggctcagc
     4681 ttacgccacc gaaggagccg cgacacttga ccgaggagga gcagttgctc ttccaggact
     4741 tttcatacac ggccgaatgg tgttagaagc tcattcttag ttcaaggatt tactaacggg
     4801 cctagcccga tccttatagc ctatggcctg cttttgcttt tacttgtgta cgaaattggt
     4861 ttcgagtaat tttacttggc ttagtagtcg atgtgagttc aatatttata catgaagaca
     4921 gcatgataat acagatacag gacatatata tttataaact atatctatat agaaaataca
     4981 tctactaacg agagaacttt tgattgttgc tcactggccg agagaccaac acaaaccaaa
     5041 atacctagtt gtccatgttg tggaaaagca agcatttgtc aatcatccat gcaaccggtt
     5101 tagcatacag tgtacccaga aatcatccca cattgtcgtt gcattgtaca gcatatagag
     5161 ttgtttcctt ttccaaacac gagaacgcat tgaatagtct gacaaaccct aggaaagcct
     5221 tatacgccaa gttgtagttt tggaaaccgt tttttaagac cggatacaaa tagattttat
     5281 agatgagaag tgtatgtcta caccccagag cagtcattgc aacctatttt cataatcaac
     5341 atacaagaac aaagatatat tttatacata tattgcatgc acatcccagg aatcgtcttg
     5401 ctaaacgagc tcatcttcta tacgacatac aaacatacat atttatctag taaagtgaga
     5461 gaaagtgaaa tatttacagt tttaacatgt aagccctgta aattgccttt tgccgcgttt
     5521 tatcaactcc ccagcccatt gcccgagttg tgttataatt taaacatatt ttttacgtca
     5581 tatacacacg caaacatttg ttatttatta ttattataac tattatacaa gaaaactgta
     5641 ttgctttgag catttttatt cgacgctaga tcgatgattg taaacaattt gttttgcatg
     5701 cgcggtgtgc tttaaaccag atatgaggat cagaaaacaa ataaccgctc gacgggatag
     5761 aatttggaaa ttccgttgat ggatggcatg caatcggatt gttgtacttc taagatctat
     5821 gttgtattta atgtaacttt tagttcgatt taagcttgta ataatcgatt attgaaacgt
     5881 agtctaagct atcattatgt gaagataatt attgataatt acaattatga taacgatttt
     5941 gcacacctca tgcgaatcga aacgagtata aacaatgcag atcttctatt gtcattttta
     6001 ttatgattat gctcacaact tgcggctata atcatcgatt taattttaaa tctgtaaagt
     6061 cggattggtg cacatccaat cacattgttt agtttcaagt tgcgactgta atttatattt
     6121 atgatatgat tttaaataaa tgtatctatc gctattattt aactgctgtt tttgtcgact
     6181 ggttttcgct gagaccttcg ctcatttggt aatacaaaat attggcggta ttgtccacaa
     6241 cggctaaaaa tatgttgctg atagggaata aagtggttaa aaacataaat attattttca
     6301 taacatttaa tacgcaccgt tttttaagct ttttgtgtaa agattttaca attctaaagt
     6361 cgattgcctt tgtgtgcagc acaggaatat aaacatcatc atttttcatc aaataaaaca
     6421 ctttcagatt tggatcatag ttgggttgga attcggcgct ttcttcctct aatgcataat
     6481 aataaatatt aaattgagaa ttaaatatgc ttgaattacc
//