Dbfetch
LOCUS NM_168290 3226 bp mRNA linear INV 26-DEC-2023 DEFINITION Drosophila melanogaster paramyosin, transcript variant B (Prm), mRNA. ACCESSION NM_168290 VERSION NM_168290.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 3226) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3226) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3226) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 3226) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 3226) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 3226) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 3226) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 3226) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 3226) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 3226) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 3226) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 3226) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 3226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (10-NOV-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 21 (bases 1 to 3226) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 22 (bases 1 to 3226) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 23 (bases 1 to 3226) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 24 (bases 1 to 3226) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 25 (bases 1 to 3226) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_168290.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3226 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="3L" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..3226 /gene="Prm" /locus_tag="Dmel_CG5939" /gene_synonym="0106/05; CG5939; Dmel\CG5939; l(3)10631; l(3)S010605; mPM; Para; pm; PM; PM/mPM; prm" /note="Paramyosin" /map="66D12-66D12" /db_xref="FLYBASE:FBgn0003149" /db_xref="GeneID:39002" CDS 226..2865 /gene="Prm" /locus_tag="Dmel_CG5939" /gene_synonym="0106/05; CG5939; Dmel\CG5939; l(3)10631; l(3)S010605; mPM; Para; pm; PM; PM/mPM; prm" /note="CG5939 gene product from transcript CG5939-RB; CG5939-PB; Prm-PB; paramyosin/miniparamyosin; lethal (3) S010605" /codon_start=1 /product="paramyosin, isoform B" /protein_id="NP_729405.1" /db_xref="FLYBASE:FBpp0076321" /db_xref="GeneID:39002" /db_xref="FLYBASE:FBgn0003149" /translation="MSSSQAVRSSKYSYRATSTGPGTADVNIEYIQDLSSLSRLEDKI RLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLK LRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYEL LSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTK DVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQL EEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIE SLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDET IILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNR RLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEK DEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTN IDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDS ANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISD ERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKR IISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDAL DKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRT FVTTSTVPGSQVYIQETTRTITE" ORIGIN 1 aatactcttt attcgaacga caacgggatc tcttgttcag tagatcacca gccttactcc 61 gacgtttatt acgaattttc tcggtgactc ggtgacaact acaaaactgc gtgcggtgct 121 gtatagattt tcgcttgaga ggaacacaca aatcataata ctagatacgc gaaccgatcg 181 cacattaatt tatagaacca aaatcgaaaa tctgacctag caaacatgtc gtcatcgcag 241 gctgtccgct cctcgaaata ctcctaccgt gccacgtcca ccggacccgg taccgccgat 301 gtgaacatcg agtacatcca ggacctgagc tcgctctccc gcttggagga caagatccgt 361 ttgctccaag atgatcttga agttgaacgt gagttgcgcc aaaggatcga gcgcgagaaa 421 gccgatctca gcgttcaggt cattcagatg tccgagcgtc tcgaggaggc cgagggtggt 481 gctgaacatc aatttgaagc caaccgcaag cgcgacgctg agctgctgaa gctgcgcaag 541 ctgcttgagg atgttcatct tgagtcggag gagaccactt tgcttttgaa gaaaaagcac 601 aacgaaatta tcacggattt ccaggaacag gttgaaatcc taacgaaaaa caaggccaga 661 gccgaaaagg acaaggccaa attccagacc gaagtctacg agctgctctc ccagatcgag 721 tcctacaaca aggagaagat cgtgtcggag aagcacatct ccaaactgga ggtctcgatc 781 tccgagctca acgtgaagat cgaggagctt aaccgcaccg ttatcgacat tagctcccac 841 cgatcccgcc tctcgcagga gaacattgag ctgaccaagg acgtccaaga tctgaaggtt 901 cagctggaca cggtctcgtt ctccaagagc caggtcattt cccagctgga ggacgcccgc 961 cgtcgcttgg aggacgagga ccgtcgtcgc tcgctgctcg aatcctctct gcatcaggtt 1021 gagatcgaat tggactcggt tcgtaatcaa ctcgaggagg agtccgaggc ccgcatcgac 1081 ttggaacgtc agttggtcaa ggccaatgcc gatgccacct cctggcagaa caagtggaac 1141 tccgaggtgg ctgcccgcgc cgaggaggtc gaggagatcc gtcgcaagta ccaggtccgc 1201 atcaccgagc tggaggagca catcgagtcc ctcatcgtca aggtcaacaa tctggagaag 1261 atgaagacgc gcctggccag cgaagtggag gtgctcatca tcgatctgga gaagtcgaac 1321 aacagctgcc gcgagctgac caagtcggtc aacaccctcg agaagcacaa cgttgagctg 1381 aagagccgtc tggacgagac catcatcctg tacgagacca gccagcgcga cctgaagaac 1441 aagcacgccg acctcgtccg cactgtccac gaactggaca aggtcaagga caacaacaac 1501 cagctgaccc gcgagaacaa gaaactggga gatgatcttc atgaggccaa gggtgccatc 1561 aacgaactga accgtcgtct gcacgaattg gaactggagc tgcgtcgtct ggagaacgag 1621 cgtgatgagc tgaccgctgc ctacaaggaa gccgaggctg gccgcaaggc tgaggagcag 1681 cgcggacagc gcctggccgc cgacttcaac cagtaccgcc acgacgccga gcgtcgtctg 1741 gccgagaagg atgaggagat cgaggccatt cgcaagcaga cctcgatcga gatcgagcag 1801 ctcaatgccc gcgtcatcga ggcggagacc cggctgaaga ccgaggtgac ccgcatcaag 1861 aagaagctgc agatccagat caccgagctg gagatgtcgc tggatgtggc caacaagacc 1921 aacatcgatc tgcagaaggt gatcaagaag cagtcgctgc agctgaccga actgcaggcc 1981 cactacgagg atgtccagcg ccagttgcag gccaccttgg accagtatgc cgttgcccag 2041 cgccgtctgg ccggtctcaa tggcgagctg gaggaggtgc gctcgcacct ggacagcgcc 2101 aaccgtgcca agcgcaccgt ggagctgcag tacgaggagg ctgcctcccg catcaacgaa 2161 ctgaccaccg ccaatgtcag cctcgtctcc atcaagtcca agctggagca ggagctctcc 2221 gtggtcgcct ccgactacga ggaggtgtcc aaggagctgc gcatcagcga cgagcgctac 2281 cagaaggtcc aggtggagct caagcatgtc gtcgagcagg tgcatgagga gcaggagcgc 2341 atcgttaagc tggagaccat caagaagtcc ttggaagtcg aagtcaagaa cttgtccatc 2401 cgcttggagg aggtcgagct gaacgccgtc gccggcagca agcgcatcat cagcaagctg 2461 gaagcccgca tccgcgatct ggagctggag ctggaggagg agaagcgccg ccacgccgag 2521 accatcaaga ttctgcgcaa gaaggagcgc accgtcaagg aggtgctggt gcagtgcgag 2581 gaggaccaga agaacctcat cctgctgcag gacgcgctgg acaagtccac tgccaagatc 2641 aacatctacc gccgccagct gtccgagcag gagggtgtct cccagcagac caccacccgt 2701 gtgcgccgct tccagcgcga gctggaggct gccgaggatc gcgccgacac cgccgagtcc 2761 agcctgaaca tcatccgcgc caagcaccgc acattcgtca ccacctcgac ggtgcccgga 2821 tcccaggtgt acatccagga gaccacaagg acgatcaccg aatagagccc cacgctccgc 2881 accgagatca tttcattatc aaacgctaac cgaagaaccg aacacaacca atcccgaacc 2941 catgaagaag accatctggc ggagggcaga gttcagagtg caggacgaga acgagaattg 3001 cgtgagaaag tttttataat ttaaattttt ttgtcaaacc cccaaaacgc cgcggcagcg 3061 attagaaccc agtggacttc ggcgggggct cgtataggct acacactata aatacataac 3121 actacacatc ctatctatat aataataata ctattttgaa gttcatgtaa tttaattaaa 3181 ataatgaacc tgaaaaacct aaaaacaaaa taaaaacaaa ccaacg //