Dbfetch
LOCUS NM_138194 11261 bp mRNA linear INV 26-DEC-2023 DEFINITION Drosophila melanogaster homeodomain interacting protein kinase, transcript variant A (Hipk), mRNA. ACCESSION NM_138194 VERSION NM_138194.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 11261) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 11261) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 11261) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 11261) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 11261) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 11261) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 11261) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 11261) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 11261) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 11261) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 11261) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 11261) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 11261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (10-NOV-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 21 (bases 1 to 11261) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 22 (bases 1 to 11261) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 23 (bases 1 to 11261) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 24 (bases 1 to 11261) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 25 (bases 1 to 11261) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_138194.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..11261 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="3L" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..11261 /gene="Hipk" /locus_tag="Dmel_CG17090" /gene_synonym="CG17090; dhipk2; DHIPK2; Dmel\CG17090; hipk; hipK; HipK; HIPK; HIPK2" /note="Homeodomain interacting protein kinase" /map="61C3-61C5" /db_xref="FLYBASE:FBgn0035142" /db_xref="GeneID:38070" CDS 438..4460 /gene="Hipk" /locus_tag="Dmel_CG17090" /gene_synonym="CG17090; dhipk2; DHIPK2; Dmel\CG17090; hipk; hipK; HipK; HIPK; HIPK2" /EC_number="2.7.11.1" /note="CG17090 gene product from transcript CG17090-RA; CG17090-PA; Hipk-PA; Homeodomain-interacting protein kinase 2; homeodomain interacting protein kinase; homeodomain interactin protein kinase" /codon_start=1 /product="homeodomain interacting protein kinase, isoform A" /protein_id="NP_612038.2" /db_xref="FLYBASE:FBpp0072451" /db_xref="GeneID:38070" /db_xref="FLYBASE:FBgn0035142" /translation="MKTSYPPKASDFVDYAVAGGGGSGFCSGLGAGLSVRATSFYGDQ TVTATTDGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDCGC VDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHA NTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQN LYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYR VKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWP LYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAE TNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERR LTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSS TENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVS NILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTN RVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEIYPKHHLNLPRNDLK KESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAH HNCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHI VSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTAV ITISDSEDEGGEAGGAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRSSAHQQPHPHPQ QQQQQQINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQP PPQQVLPQPQPSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEP AEFYPEYAAAPPQQLDTKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAP PLAHSKSSSASSSSSISAATAAAAAAAAAAAASVGPPSWGPPQVYRQPSQPPPGSVGL PGSTQPPPSSVAPHPHHHSHGHHHHQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRP TVFVSQAAPSYAYANRAVVAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQ VAASKHAAHFAPTNIWYGAE" ORIGIN 1 cagagtctcc acaaacggct tcgcgagcgg acgttgcagc cacagaagat acagccacgg 61 ccgtcgagga agtggcagct acagaaagcc aagatatata tctgcatata catatgactg 121 gcgaagctgc tgcgaaaaag attctctttt aatttggcat aaattgtatt tgtcttgaaa 181 aaagcatatt cttgtaaata tatcctcttc gtaaaatatt ttacttaaaa gccttaaaat 241 attgaattca cgtgaaattt caaacggtgt cactcgaaat tcgccagtga ctcgccgcca 301 cgttttgtac aaacatagtt tgtaaacata agtttgtaag cggccggaaa aaggcgaacg 361 gaacccaaaa accccaatgc aagccaactg agtgcaaggg agacagccga ccacgtcgag 421 cgggatagca tgcgccaatg aaaacgtcct accccccaaa agcgtccgat ttcgttgact 481 acgccgttgc cgggggcggg ggatccggat tctgttcggg attaggagcg ggactttcag 541 tcagggcgac gtccttctac ggcgatcaaa cggtaacggc aactacggac gggacgcgtc 601 accaggaaca acaacaacaa caactgcagc agcagcaaca gcagcatatc ctaaggcaac 661 ctgcaacatc cgcatcgact tcatcggtag ctgcagcagc aaccagcaag cgaaaacgtc 721 aaacagattg tgattgcggc tgcgtcgact catataactc cagccacggc ccgccagtgc 781 agcaggactc ttcagcagca gcgggagcgg gatctgtggg atcgaaagcg ggatcaggac 841 caggaccaga cggaatcggg cccatcagca gcctcaaaac ggcgcacaca aaggtcgcca 901 cctcgggggg tcatgccaac acgcagcccc ccagcaaaag gtcgagcagt ggagcggatg 961 gcgactacca gctggtgcag cacgaggtgc tctattccct atcggcggaa tatgaggtcc 1021 ttgagttctt gggccgcggc acctttggcc aggtggtcaa gtgctggaag cgcggcacct 1081 ccgagatcgt ggccatcaag atcctgaaga accatccttc gtatgcgcgg cagggccaga 1141 tcgaggtatc gatcctttcg cgcctcagcc aggagaatgc cgacgagttc aattttgtgc 1201 gggcctttga gtgctttcag cacaagaacc acacctgcct ggtctttgag atgctggagc 1261 agaaccttta cgattttctc aagcagaaca agttttcgcc gctgccgctc aagtacataa 1321 ggcccattct ggagcaggta ttgactgccc tgttgaagct gaaacaactg ggtctgatcc 1381 atgccgacct gaagcccgag aacatcatgc tggtggaccc agtgcgtcag ccctaccgcg 1441 tcaaggtgat cgactttggt agcgcctctc acgtgagcaa aacggtctgc aacacgtatc 1501 tgcagtcgcg ctactatcgt gctcccgaaa tcatactggg cctgcccttc tgtgaggcga 1561 tcgatatgtg gtcactgggc tgcgtggtgg cagagctctt cctcggctgg ccgctctatc 1621 cgggcagctc ggagttcgac cagatccgct acatctcgca gacacaggga ttgcccacag 1681 agcacatgct gaacagtgcc tcgaagacct ccaagttctt ctaccgcgac gtggactcaa 1741 cgtatccctt ttggcgcctg aagaccaccg aggaacatga ggcggagaca aacacgaaga 1801 gcaaggaggc gcgcaagtac atcttcaact gtcttgatga cattgggcag gtcaatgtgc 1861 ccactgattt ggagggcggt cagttgctgg cagagaagac ggacaggcga gagtttattg 1921 atctgcttaa acgcatgctg accattgatc aagagcggcg actcacgcca gcagaagcgt 1981 tgaaccactc gtttacacgg ctgacccatc tggttgacta tgtctactgc aacaatgtca 2041 aggcatccgt gcagatgatg gaggtgtgcc gccgaggcga tttccacact gtgcagcctg 2101 cgtcgacgct ggtgactaat tttgtgccct cgagcacaga gaacatgacg ttcacgatca 2161 acaaccagtt gaccagccag gtgcagcgcc ttgtgcgcga tgggcgtcct ttggcttacg 2221 agggactcta ccagatctac aacggacgca gcgtggcccg acagtatccg cagacgcgga 2281 ctgatagctt ccagcaccag ctggtctcga acatcctgtg cccgccctcg taccagacga 2341 tgcccagtcc cactaaacat gtggtggtgg gcagtgcaac catgcagcca ccgttgcagg 2401 tcccgccgca gcagtacgtt aatgtgcccg taccagtttc catggtggag ccaacatctg 2461 gtcagagaat gcttctaacg aaccgtgtgc aggccagcgg agtagcctgg ccacaaactg 2521 gacggcagat ggccttggtg ccgtcgtggc cccagcaggc gcccgcccac tcgctcatcg 2581 tggactcgac gcctcttttt aatgtggagg agatctatcc caagcaccac ctcaacttgc 2641 cacgcaacga tctcaagaag gagtcgccgg ctcatcatat tgccaagggg aactcttatc 2701 gcgtgccgcg ccacgagaag aaggagcacc agcagttgtc gccggtgaag aagcgggtga 2761 aggaaagctc gccgccccac cagcagcggt accagcgcgc tgcacacgtt tcgccgcagt 2821 atcacgcgca ccacaactgc aactacggga atggcagtgg ttacagcgcc agtgccggat 2881 cggtggtggc ctcctcggct gcctcctcta gcaacattgt gaatggaagc tcgtcgagtt 2941 cgcaccatca tcacgtcccc gtcgcccatg cccagcccta cagtagctcc tcaggtcacc 3001 acattgtaag caactgcaac gccaacggag gagcaggagg agcagtggtt taccaacagc 3061 caccggctca tgcccatcag cagcatgggc agcagccgca tccgcagagt tcgcagcatc 3121 cgcagcacgt caagcagccg acaataacca tccacgacac gccctcgccc acggctgtga 3181 taacgatctc ggacagtgag gacgagggcg gagaggctgg aggagctcag gtaccggtgc 3241 taaagcaacg ggcgcatgcc cagtcgcaga ccagtggtag tctgctacag cacgcaccaa 3301 gctcgtcctg tagcaggagc agcgcccacc agcagccgca tccacatccc cagcagcaac 3361 agcagcagca gataaactat ggtgatcatg atccggaaga tgcccgccgt cgtcatcatg 3421 ccgccgccgc agccgccgtg ggaagtccca agcatcacca tcatcagcag caacagcaac 3481 ctgctcctcc tccacagcag caacagcagc agtatcagcc acagccaccg ccgcagcagg 3541 tgttgcccca gccacagccc agcatcaagt atgagcccgg ccagtcgcaa aagaaacgca 3601 tcttggccat ggctcaaagc gaatgtggct accaacctca ggttcccagc cagccgtcgt 3661 cttcggccag tttgccgcac attcccacca agcaggagcc agccgaattt tatccggagt 3721 atgcagctgc tccgccgcaa cagttagaca caaagcgctc ctcctgggca cctacatctt 3781 cgggatcagg agtgtccgct ctcccgcttg ctcatccaaa gcgagaggcc ccctctgtag 3841 ctcccataag ctatgtagcc ccgtctgtgg ctccgccatt agcccactcc aagagcagtt 3901 ccgcatcatc atcgtcgtcg ataagcgctg cgactgccgc agcagctgct gcagctgcag 3961 cggcggcggc cagcgttggt cctccatcgt ggggtcctcc acaggtctat cgtcagccat 4021 cacagccgcc tccgggcagc gtgggactac caggaagcac tcagccgccg ccgtcgagtg 4081 tggccccgca tccgcatcac cacagtcatg gacatcatca tcaccaggcc ggaacaccgc 4141 tgggcggatc gccatcatca acggcggcgg ccgctttgtt gcagcccgat atttatgcgc 4201 aaggcgacat ttaccgccgg cccacagttt tcgtatcaca ggcggccccc agctatgcct 4261 acgccaaccg ggcggtggtg gctccacctc cggcccacaa cagctccagt cgtcaggtga 4321 taccatcgca tccgctgcca gctcacattc agatacccac acagtacagc cagtttggac 4381 cgctcagtcc tgcccaggta gccgccagca aacacgcggc gcactttgcg cccaccaaca 4441 tatggtatgg ggctgagtag accgacgatg ggagttgacg gggagagggg cgatgaggag 4501 agacgcggga cgaggatgtg cacccaccca gaaccaagaa ccacccaact acacaccgca 4561 caacaccacc atcaccactg ttgttatgat cttgagctag agcccgatcg aatgattcaa 4621 cgctcgaatc ttttgtagcc tcgggcgagg caggcgacaa tccggagcaa agccaagagc 4681 tgcagcaaca tcagctgcag ctaactcagt gctggtggtt catgctactc atgcagcaga 4741 ctataatcca gaacaactcc atattccaag cgggcagcga cgacgccgca gcaacggcag 4801 cagcatcctc agacacaacc acaacacgta aagcacgacg gcaacattaa gcaaagtcca 4861 agtcccctaa ctcattgcca cttcttagct tatttttttt cggggtcccg cgggatctca 4921 tttctgctac tattaatttt tattattttt tttaaataat attaaatata aatgtaaagc 4981 actcctacac gcagctgggt gtacagtgct caggcaaact tttggcaagt tgtgcatcag 5041 cacaatttcg cacccacaca cactacagct atagcttcta taccctcgaa atatgccagt 5101 tagatgcata tcgagagatg tttttcttcg aaacgaaagc gttttataaa tgtgtgtttt 5161 attgataatt tccaaataat attctctata atctacttat atattatata catgcatatg 5221 taacactatt attatgaata ctatatatca agagaaagct aaacaaaact agagtttacg 5281 gcacgtcgac aactgcaaca ttaggccaga gagccagtaa gagaaagctt cgaaattccc 5341 tagcaagtac ctcagaaaat caaaaaccta gcagcagcag cagcaacaac agcaaccaga 5401 taagaaaata aacaacattg ttatgcaatt tgccttttac acaaaacaag caacaaaaga 5461 aattgagatg acgaaagacg ttgaagatta tgattatgat gcaggagtag agttagacga 5521 ggttagtaga gaaccacaac aaattgaata ccgcaaaaac cttactagca aacaaacaaa 5581 caaataaaat agatacccta ggagatatca acaaagagaa cttaacaatt acatagctca 5641 tagatttagt ggatagaacg ggagaaggtc aaagggcgaa cgttttttac acactcgtaa 5701 ctcactcata ggaatagccg agaaaagaat tacaactaac aactaacaga taacaattct 5761 aaattatgtt taacgagcaa caacaaataa ttataggagc aagtgtacat aatacgcata 5821 tacttacata tatcggtact aaaattagcc ggagcccaac aaaaagccga ttttaaaact 5881 gatcagttgt taaagtcagg tcagcgaagc cagttagtct gcggtacgct taatttttag 5941 acttcacatt tcgttttacc ccatctgtgt cctggaagaa gatctgcgtt ttggttattc 6001 ttttaaatag gaaagcgcat aggaaagttt actaaagtac aaaaccaaac aaaaataata 6061 agcaatctag cagtttaggc ttttagtgtt tgtcccacta caaccccttg ttttagactt 6121 ttccccagag aaattgtaat atatagaatc ccattttgat atgtacaaac ctggcttact 6181 ttaactcgcc tactatagat ccttaatata aaataataaa aaaaaaaaaa ctaaatcttg 6241 ttaaataggt ttcctaaagt acttcgtagt tagaattaaa cttaactttc gcgataaaat 6301 aaccaagcag caactaattt ttcgccctcc tggggtcgat tactcggttg tcccaaccga 6361 gaatttatta aaatcggtcc ttcgagggag gcacttccta tataatgaat tacatgctga 6421 tacaaagcag aaatatttaa accatccttc gccccttcct agatcagctg tgtacagtag 6481 gctattttgg gatcgggatc gagatgaatc aactccgacg attggaaaag atctagcata 6541 taattattgt gatgtagttt ttaacgagga gcagagaagt ccgcaaacgt tttttgtcag 6601 tcgtcgtcgt cgtcgtcggc gaatagaaat tacctaaaat tacgaataac caattgcgat 6661 acggatacgg aatatgcatc tatatgttaa ctaattagtg tgcaggattc aatagcgtta 6721 gcacgacaac aaaacgtttt tttaaccaag caagtacatt tttaaaaagc gagtaataac 6781 actttttgta gtaggaaaag gagaacaatt gtagcataca tagacgtaat taagaaacgt 6841 tagtgttgtg aatatatacg agtaattaca aaaacataga gaactagatt ctacccgtgg 6901 ttcgagtaca tttatattat ggatatattt tgtgtataaa caataacggc aaccagcagc 6961 taacaattgt aattgtaata aacaataaac gaaaaccaca actcggcaga tttaagattc 7021 ttgtttaaag tcgagagaac cgtatctaga taatagtctt agatgtattc agcaagttct 7081 ttttttatag aaattttatg gaccattcaa ctaaagcata tagtcaaata agcatgaata 7141 ttgtataaaa acagctgtgt gaccgtttag atgtcagcgg aaagttgcga tctgtgtttc 7201 cgatttgtgt ttcttgtcct gcacccactc agtgtgcgaa cttatactta tattatatgt 7261 aaatgtatat gctaaatatc tgcgagggca gacgaacttt tcttctcttt ctactcaata 7321 tttaggagca tcaaccagaa agcaaaaccg agaaaaaaaa acaagaaaac aaatcatgaa 7381 cgctttaaat gtaacaaaaa cgaaacgtta atagacttat gaaaacaaca aacaaattaa 7441 atttatatta aacgacaaaa aaataaattt atattaacaa acaaacaaat tacatttata 7501 tttaaagaaa atcaacaaca aattaaagtt atattaaaca aactcacact caacaaataa 7561 ataagcaggc aggtggacca cggtcgttag cagacttttg tggcccactg tcggaggact 7621 tgtatttagg aggaactctg ggtggctttc accaccagcg aaatgcggag agatccgcac 7681 aaacactcta atatacgtat atatttaaat gagaaatgtt ttaactgtgt agccttagta 7741 tttgtactcg tcgtcctctc gatttccgac aaaaatatga tgatatacga tactgtaggg 7801 caagcaatgc cgatcgatgt ttactaatat atttcatatg tacttgttta atcgtactga 7861 gttcggatga gttgccccta ctactttact cttttaaccg tttaaattta cttttaattt 7921 actttgtttc tttgcttaac tttgttttat aatggaacat agccacaaca tataccatat 7981 atattgctta tatttactta tgtcctacaa aatatagaaa tcgtaaatat acataacaga 8041 tatcgcaatt ttcgtttttc tttagttctt tagtctctta ttatttcgtt ttctagtgct 8101 ttaagaacaa cttaatcaaa agcaaacgga gaagatgatg atgaacaaca acaaatacaa 8161 catatatccc accaaattac aaaggagtaa ataattttta agtttaaacg attagtgaat 8221 taacttaata ataatcgtag ttattgtgca ataatatcga taacgattag ccattcaaag 8281 caaattgtgc aaacaattta attttagtat tggggaccta gtagtctagt tgctccccgc 8341 aagaggctag cttcagctga tttagattta gttcaagacc aaccaggttt ctgcagatta 8401 tagattgatt tcgcacgccc cgccccgcca cacccctcga actttgaacc accccccacg 8461 aagttgtttg attgaccaac aattgatgag cttttaccgg aaagtaaaga tattttgttt 8521 tgcatttacc aaaacagagc aagcgaaacc gaaaacgcac cgaaccggaa ccggaaattc 8581 aaaaccaatc tgtaacagat gggttgaggg agattagagg agttgacaaa caagattgat 8641 aagaacccgt ccataattag atttctttcg tttgagctgg acctgaacaa actgaaacac 8701 gcacttcgga cagctggagc gagatccaaa aacttagcag gggccctctc ctacttaatg 8761 atagcataat tttacgaatg cggataatac cgacttagta ggctaccagt aacttaatta 8821 cgatattgat aaccccttcg tgtttccttc acttgaagaa ctttctaaac tctcttaaaa 8881 attgcggttc ggatcgacat tagaagtttt taatacacac acagaatata tgtatatgcg 8941 gatatatttt attaactaag aaattatttc ctaggcaaga ggagagatca taacgataac 9001 cgaaatgttg atgtgtgaaa tttataagac tagcatattt cctacctaca gaaaaccaaa 9061 taacagaaca atatgtgtta tatatactcg tatacacgaa atatgataaa tagcagctag 9121 agctgagatc atactcacag tcgtacatat aagcgctaag gcaaatacag ataattataa 9181 tgagatattg aatttaaatg atcgtacctt ttgctgattt caaaacaagc cagaatttga 9241 aaaggccaga gcaaagcgga gtcattgggt gatgaaaacg taatcgaaac aatatatgtt 9301 ttaatagaga tcggagagag cacttttatg ggatttgctt tttatataca tatgaaatat 9361 acgaaaatat agatgtactt atagcggtgg cagcccgcac tttgggcgat tgcgcgtttc 9421 agattaaaga atttaaatat ttttatatac gaactcgagt agagactcca tatacattta 9481 cgtttagcaa aaatagcgag tagaggccag gctttgcatt cgattacaaa gtgaagagga 9541 agcaaaccaa agacggataa tcaaagtgcg cgcacactcc actcaccaac acacaagaga 9601 ctctgaatca ctcaccacac cacgccacgc cacaccacac caccccccac tagtgtttct 9661 ttctcgtggg caccaagtca tattcatatg tggtacatga ccccttgacc cctagtccta 9721 gtatcaacat tacgaatccc cgacctcaga tttgataaag ggatccctgg gttagacaac 9781 aacgaattgc cgggcaagtg gaaccaggac ctcctgtccc aagaacgcaa cccgcaaaat 9841 gaatgttttc gatcatcaac gaagagattt gaccttgcac cttcatttag tcaaagtcaa 9901 ctcaccaaca cacagacacc tcaaaatgtt tcatcaaaac agcaccttaa tgaatgtttc 9961 accaacatat aacttaaagt tgaatttgaa ctcaacaaca cctcattaca atctcaccat 10021 tacagcatcc aagtattcaa caaaacactc aaccacaaaa actctaatcg tacttaatca 10081 ctctttttgt atcctaatag tatttcaatg aacgtgtact gaatgttttt acttggtgtc 10141 ctctcttatt taggcttaag aaaatcgaaa tcgaaagaaa cggaaatgaa attcaaactt 10201 atatcaaaaa ccaagcacac cgatacattt agcattgtac ttgataagct atcgatacta 10261 gtgttagatg caaatcaaaa tatacacact ccaattaata agtgtatctc tctgtcttat 10321 tctgatatgc gtaccttttt gagggccccc aagatattag gaggccagct aatttatcaa 10381 atacaaataa tcgtagtcat agtgaatgaa ttgaattaaa agtctcgaga ccaaaccaaa 10441 gcatagcaaa gcaaacccaa atccaaaacc aatcaaacta aacgaaacaa tgagccgcga 10501 cgtttgtatt tatgtataga gttccctccc taatcaacag ataataccta taacaatcga 10561 gttccgattt cagaagagtt aggcggcaat taagcaagaa atacaagagg tacagattac 10621 tataatggta ataataagga ttaactcaag ttacgtcaac ttagtggcag tgtaaacgcg 10681 tctagataat taatagatat gaataagaac ttttgacttt tatggctgtt tagagatttt 10741 ataatacgac tatatcgata tagaattata tacatacacg atataaatta agcccaaaaa 10801 tttgcgtaac ttatttacat actcagacac aaacatacgt cacacgacaa attaacttta 10861 gttcccccaa atgattttcg gctagttctg gcttggaata ccgctcccaa tcccatcttc 10921 ggaaattttg gggagtggga gtgtcctctg catcccatgg agggaatgaa atcgaacatt 10981 gtgaaattta gtgtctttac actttaaaga gaatatatac aaaacggatt aattaagaaa 11041 cttgaaaatc acacaaggcg aagtgcagat acagataccg aaacaaatgc agatacacct 11101 acacaaagat gcagatgcat ataaattatg gtaattacat actctcgtac atatgcctaa 11161 aaggatacac gtgtagtaat ctacagccac aaaaaaacaa ttaaaaataa atgtctatat 11221 atgaaacgaa caagatttaa tgtgcgcaat atgcgtgtat c //