Dbfetch

LOCUS       NM_133003               5872 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster Rho GTPase activating protein p190
            (RhoGAPp190), transcript variant B, mRNA.
ACCESSION   NM_133003
VERSION     NM_133003.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5872)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5872)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5872)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5872)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5872)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5872)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5872)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5872)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5872)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5872)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5872)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5872)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5872)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5872)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5872)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5872)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_133003.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5872
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5872
                     /gene="RhoGAPp190"
                     /locus_tag="Dmel_CG32555"
                     /gene_synonym="8267; BcDNA:GH17919; BcDNA:GM05133;
                     CG32555; CG8240; CG8267; D-p190; Dmel\CG32555; DRhoGAP;
                     mdcds_56566; p190; p190 RhoGAP; p190-RhoGAP; p190RhoGAP;
                     RhoGAP; RhoGAP P190; RhoGAP-16B12; RhoGap190"
                     /note="Rho GTPase activating protein p190"
                     /map="16B10-16B10"
                     /db_xref="FLYBASE:FBgn0026375"
                     /db_xref="GeneID:32743"
     CDS             75..4760
                     /gene="RhoGAPp190"
                     /locus_tag="Dmel_CG32555"
                     /gene_synonym="8267; BcDNA:GH17919; BcDNA:GM05133;
                     CG32555; CG8240; CG8267; D-p190; Dmel\CG32555; DRhoGAP;
                     mdcds_56566; p190; p190 RhoGAP; p190-RhoGAP; p190RhoGAP;
                     RhoGAP; RhoGAP P190; RhoGAP-16B12; RhoGap190"
                     /note="CG32555 gene product from transcript CG32555-RB;
                     CG32555-PB; RhoGAPp190-PB; Rp190RhoGAP"
                     /codon_start=1
                     /product="Rho GTPase activating protein p190, isoform B"
                     /protein_id="NP_573231.2"
                     /db_xref="FLYBASE:FBpp0074255"
                     /db_xref="GeneID:32743"
                     /db_xref="FLYBASE:FBgn0026375"
                     /translation="MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDH
                     ISVLSQSDFSGRIVNNDHFLYWGDVRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGK
                     MDPYSKRCTATKVFSAEKLMYICKNQLGIEKEYEQKVMPDGRLSIDGFVVVFDVSPVP
                     NRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYELYVREAEKISQRKDYKSTVQL
                     IETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELLDTRSEAVTRLIRN
                     QITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNKKLHQYL
                     DKFALALEYLLPDIGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDMDE
                     AEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLS
                     EVRVLFMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDN
                     ITQEDVRQITDVIQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSL
                     IEEVLSDKSASNHKTPSGGGWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKG
                     EYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICVYSNQQSFETLKDNLERTLLCNL
                     ELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDFIDHTQNHQKYVYDIL
                     NIVILSLKLTEMKSYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKANEH
                     SIIVDVFIGDAKRRVEFILSSYHGTSQYRDELIHGYIYFYSTKRRSSLANLSILAAQN
                     ANIPLQIIAVTESGGVNAFFNSDICQFLITEGNAVADRFKGSFMTFSADQYVKFAFYN
                     PFLKTAWDNKYEVENLHVEESITLDSGEGTLENSVNQMPRPPPRHESYMLSNTLGTDG
                     SGSENYEMAPTRSLNSLNEERDISLDEIYDDNEKPKHLHQKWLEDKSDGRRNMNKNLI
                     WNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQ
                     PGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLGLGLGSGSGCMGDSFLEPV
                     DKDGKRYDHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASSTERRVRQQNAYYKAS
                     KKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGGSGPEKPEPCVPE
                     FMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEKRRIKEETARQRK
                     LQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCVEFIEKEG
                     LDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFS
                     KDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHF
                     VHVSDNSKLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYLEDIVQTMIDQFPYLF
                     CGKDAFVMV"
ORIGIN      
        1 cattagttcc agctctagtt tttgttgttg ttaaattaaa gctcggatgt gaattacaat
       61 aattgaacgt caagatgcgt cagtttaaca tctcggtcat tggactatcc gggaccgaaa
      121 aggaccgcgg gcaggtggga gtgggcaagt catgcctgtg caacagattc atgcgcccga
      181 tggccgacga ctacttcatc gatcacatat cagtgcttag ccaaagcgac tttagtggcc
      241 ggatcgtgaa caacgaccac ttcctttact ggggcgatgt gcgcaagacg acggaggagg
      301 gcgtcgagta ccagtttaat atcatcgagc agacggagtt catggacgac tccacgttcc
      361 aagcctttaa ggtgggaaag atggatccat actcaaagcg gtgcacggcc accaaggtct
      421 tctccgcgga gaagctaatg tacatatgca agaatcagtt gggcatcgag aaggagtacg
      481 aacagaaagt catgcccgat ggccggctca gtatcgatgg ctttgttgtc gtcttcgacg
      541 ttagtccagt gcccaatcgc agtgtggaga agcaggtgga gttcgtgcag aatgtcatcg
      601 caaccatact aaagaacaag aagccactgg tgctggtgac cacaaagaac gacgacgctt
      661 atgagttgta tgttcgagag gcggagaaaa ttagccagcg aaaggactac aagagcactg
      721 tgcagctaat cgagacgtcg gcccacgaga gcatcaacat cgatttggca ttcctcctgc
      781 tcgcccagat gatcgacaag gttaagaacc gtgtcaagat catctcctac caggagtcgg
      841 ccaagtcacg caaagaactg ctggacacac gatccgaggc ggtgacgcga ctaatacgca
      901 accagatcac cgactatcac gtcctgtggt cgcagggctc caagatgctg tcacagtatc
      961 gcgagtggaa cgagttcctc aacatattcg gccacgaggc cggccaaaag ctattccggc
     1021 ggcacatgaa gaagctgcgc gacgatcatc tgaacaaaaa actgcatcag tacttggata
     1081 agtttgccct ggccctggag tacctgctgc cggacatcgg ggctttgaat atcagcgatg
     1141 acgatgcttg ggagtgcgcc aggaactatc tgcagaatca catcgagttc gagcagtact
     1201 tcttcgagtg cccgcaggcc tcgtggacgg agctggtgga catggacgag gcggaggatg
     1261 aggcccgcat tccctttgat gtgctagaga cttccgaggc agagactgtc ttccgtaact
     1321 acttgaactc ggtgcagcag gacaagaaaa aaattggatg gaagcagcaa ttcaaaatgc
     1381 tacttgagga gtcgggcttt gtgacgcccg gcaagcagct gtcggaggtg cgcgtcctct
     1441 tcatgggacg cgaatgcttt gaggcgcttt cggagcacga ctgccagcag atctacgaca
     1501 ttcaccagga cgacatcatt gaaaagagca aacagaattt tgtggagctg ctgctggaac
     1561 atgctcaata ttttctacag ttcaagaacg ttgacaacat cactcaggaa gatgtgcgcc
     1621 agataaccga tgtcatacag gaggattcac gctacaagat gctcgatcgc ttggaccagg
     1681 agcggcggtt gatgcttgtc cagcacctgc gcttcatcca ctgccccatc cgcgatcact
     1741 gcccattctt ttacaactgt gtggatagcc tgattgagga ggtgttgtcc gacaagtcgg
     1801 ccagcaacca caagacgccc agcggcggtg gctggaagag ttccggcagc ggcagtgacc
     1861 gcacgctcaa tcttctgatc gtgggctccg agcacctggc cagcgatctg ctcaacgaca
     1921 tccgcatatg taccggtagc aagggcgagt acatctacga gaaccagacg tattatctca
     1981 attaccgaat cgccaacggc gacatggagg ccttcaaggc catagatgtc tactcgagtg
     2041 gtcttatttg cgtgtactcc aatcagcaat cttttgagac gctcaaggat aacttggagc
     2101 gcacgttgct ctgcaacctg gagctggagg acaagttcga gaatctgccg atcgtgctgg
     2161 tttaccagcc acaggatctc aaggagaacg aggtggaata cttgcgcaac gagggcatgc
     2221 gcctgtcgga gatgctgcac tgcgacttca tcgatcatac gcaaaatcat cagaagtatg
     2281 tctatgatat acttaacata gtcatcctgt cgctaaagct gactgagatg aagagctacg
     2341 agccgtatcc ctccaatcac accgacctgc gcatcctgtg ctgcatcttt tgtggcgatc
     2401 agtatgacat cgagaacatt gtccagccgc tggtggagga atcgacgctg gtcaaggcca
     2461 acgagcactc catcattgtc gacgtcttta ttggcgatgc caagcgacgg gtcgagttta
     2521 tactttcctc atatcatggc actagccagt accgcgatga actaatccat ggctatattt
     2581 acttttactc gaccaagcgt cgatcttcgt tggcaaatct aagcatcctg gcagcccaga
     2641 atgccaatat tccattgcag attatcgcgg tgaccgagag cgggggcgtt aatgcgttct
     2701 tcaacagcga tatttgccag tttctgatca ccgagggcaa tgcggtggcc gatcgcttca
     2761 agggcagctt tatgaccttc tcggcggatc aatatgtcaa gtttgcgttc tataatccat
     2821 tcctgaagac agcctgggac aacaagtacg aggtggagaa cctgcatgtg gaggagtcaa
     2881 ttactttgga ttcgggcgag ggcacgctgg agaactcggt taatcagatg ccacgcccgc
     2941 cgccgcgcca cgagagctac atgctgtcca atacgctggg aaccgacggt tccggcagtg
     3001 agaattacga aatggctcca acccgatctc tcaactcatt aaatgaagaa agagatatat
     3061 cattagatga aatctacgat gacaacgaaa agccgaagca cctgcatcaa aagtggctgg
     3121 aggacaagag cgatgggcga cgcaacatga acaagaattt gatttggaac aacttcagcg
     3181 gatccacaca tgcctacacc accggtcgcc gtcacatcga ctccaatttg aacaaaatcc
     3241 gcccgaaggg acccagtcaa acgctcaaag tgggcgaggc gcccagtcgc aattgcccgg
     3301 ccatgagctc ctccaccttc accctgccca cgcagcagcc gggcaagctg aacatgaaga
     3361 acttccagct ggtcagcgat gcggtggcca agatgaattt caccggctcc ggttcgggtt
     3421 cgggttccgg ctcgggatcg ggcagcactg gactgggcct gggtctgggc tccggcagtg
     3481 gctgcatggg tgattcgttt ttggagccgg tcgacaagga cggcaagcgc tacgatcatg
     3541 cccaattgga tggcgaggat gaggattccg aggagctcgc cgagtacgag cagatctacg
     3601 aaaatgaaga ctgcaccgaa tcggacagct gtgccagttc cacggagcga cgggtgcgcc
     3661 agcagaatgc ctactataag gccagcaaga agccggtggc cgccaagaag cagaaaaaga
     3721 agaaggtggc aattccggtg cagacaccgc gtgttcctcc gttcggctcg tatgtgagtc
     3781 cgccggagat tccgctgcac taccagcgca tggccgttgg cggcagcggg ccagagaaac
     3841 cagagccatg tgttcccgag ttcatgaaga gtgacaagtc gccagagtat tccatggtgc
     3901 cagaactggc gggtgccggc atcttcggtg cagagaatct gcccgagtac aacatgaacc
     3961 aggccaaatg cttgaaggac tttgagaagc tggagaagcg gcgcatcaaa gaggaaacgg
     4021 ccaggcagcg caaactacag gagaaggaga aggagcaaga gaagaagctc aagcgcaaac
     4081 taaagcagaa tgccaagggc ctggttgaat ccgcggaggc gcaattcggc aagctgatga
     4141 ttacctccga gcaaggcgag atccccatct tcctcaacaa gtgcgtcgag tttatcgaga
     4201 aggagggcct cgactccgag ggcatttata gggtgcccgg aagtagggcg catgtcgaca
     4261 tgttgttcca acgcttcgaa gaggatacca atactgagat tgatgcgctc gacattcccg
     4321 tcaatgccgt ggccacggca ctgaaggact tcttctccaa gcgcctgcct ccgctgttca
     4381 gcaaggacat catcaaggag ctggaggaga ttgccggctc gcgaggcgtc ggcaattcca
     4441 aactgaatgt ggaggtcaaa acggaccgaa gttgccgctt gatagcttta aaatcgctgc
     4501 tccagaagct gccgcccatc aactttgcca tactcaaata catattccaa cactttgtgc
     4561 acgtatcaga caattcgaag ctgaatagca tggacagcaa gaacttggcc atttgctggt
     4621 ggccgacact catacccatc gacttcaccg acatgggcca cttcgagcag ctgcgtccgt
     4681 atctggagga cattgtccag acaatgattg accagttccc gtatctgttc tgcggcaagg
     4741 atgcttttgt catggtctag gcctagatcc ccgccaggcc atggcacact tggacttcta
     4801 cttgaccgcc ggacgcgaag ccaaaacgag atagttagat tcaatgtgcg tttgtgtatg
     4861 aatgtgggcc atgtgccagt gccatgtgtg ccatgtgtgc tttgtgtttt ttgggtgaac
     4921 taaggagcat attagtaata gccatagaga gaagatagca ggaggaagct ggaggaggca
     4981 ggaggcgtta gcaggaggca gcccatcgat cgatcgattc attcaaatga ggatcagcag
     5041 ccaggcatat acatatttat aatagtatat aatatacttg ggtctattgt gtgcagtgtg
     5101 tgattagtga ttcctgattg tgtgtgcgag cgagacaaca gaacttggct aagtagggta
     5161 tatttatttt ttatatatac aatatatatt ttgtatcgat ggctttgttg tgtttccgtg
     5221 atatatgtaa acgcgtcaag tattttctct gtgtggtggt gcgtccccct tgtcgttgaa
     5281 tccattgagt gagacctccc ctcgccgccc cccactcccc gcccctcggc caccgccagt
     5341 ctactcctcc tcctcctcct cctcccctgc catccgccac ccacaaacgc tccacccatc
     5401 tcgaggggcg gggcgggggc gccaacgaca aacgcacaac agcaagaaca agaaaatgac
     5461 taaaaactaa aacaaaacaa aaaaagaaaa ataagagaaa aagaaaacca agcgatatat
     5521 atgtgaaagc atggggagat atctagtagg atgtcagcag gaagatggtt aaataaaatt
     5581 tactgtgtat ctgtgtatgt tataaatgta attgtaattg tgtgtttaaa ataatgcgcg
     5641 atcagccaac aaattttcac atatgtaaac acaatagcga taatgctaga tatatgatat
     5701 atatatatat atttaaatac cactaaatgt ctgtgtgtct agtataggag aaagtaggag
     5761 aggtggagcc gtaggagcag ggggaggggg agagaaagga tgagcgaagc gaagtaagga
     5821 atacactata aacaaaatgc aaaaaaaaag caaccaataa gaacaacaga gc
//