Dbfetch
LOCUS NM_079738 6849 bp mRNA linear INV 26-DEC-2023 DEFINITION Drosophila melanogaster DNA polymerase epsilon subunit 1 (PolE1), mRNA. ACCESSION NM_079738 VERSION NM_079738.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6849) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6849) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6849) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6849) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6849) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6849) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6849) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6849) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6849) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6849) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6849) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6849) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6849) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6849) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 21 (bases 1 to 6849) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6849) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 23 (bases 1 to 6849) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 24 (bases 1 to 6849) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_079738.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6849 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="3R" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6849 /gene="PolE1" /locus_tag="Dmel_CG6768" /gene_synonym="6768; BAB17608; CG6768; Dmel\CG6768; DNA pol epsilon; DNApol-epsilon; DNApol-epsilon255; dpolepsilon; dpolepsilon255; dpolepsilonp255; l(3)pl10; l(3)pl10R; pl[10]; pol-epsilon; Polepsilon; Polepsilon255; Polepsilon255KDa" /note="DNA polymerase epsilon subunit 1" /map="94E13-94E13" /db_xref="FLYBASE:FBgn0264326" /db_xref="GeneID:42758" CDS 64..6774 /gene="PolE1" /locus_tag="Dmel_CG6768" /gene_synonym="6768; BAB17608; CG6768; Dmel\CG6768; DNA pol epsilon; DNApol-epsilon; DNApol-epsilon255; dpolepsilon; dpolepsilon255; dpolepsilonp255; l(3)pl10; l(3)pl10R; pl[10]; pol-epsilon; Polepsilon; Polepsilon255; Polepsilon255KDa" /EC_number="2.7.7.7" /EC_number="3.1.11.1" /note="CG6768 gene product from transcript CG6768-RA; CG6768-PA; PolE1-PA; DNApol-epsilon; DNA polymerase epsilon; DNA polymerase epsilon 255kD subunit; DNApolymarase E; pol.epsilon catalytic subunit; lethal (3) pl10" /codon_start=1 /product="DNA polymerase epsilon subunit 1" /protein_id="NP_524462.2" /db_xref="FLYBASE:FBpp0083800" /db_xref="GeneID:42758" /db_xref="FLYBASE:FBgn0264326" /translation="MSDSSKGKVLQNTGKFVSENRTEGDDFFNEAGYRQSRENDKIDS KYGFDRVKDSQERTGYLINMHSNEVLDEDRRLIAALDLFFIQMDGSRFKCTVAYQPYL LIRPEDNMHLEVARFLGRKYSGQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTA MTKVRRELMSAVKRNQERQKSNTYYMQMLATSLAQSSAGSEDATLGKRQQDYMDCIVD IREHDVPYHVRVSIDLRIFCGQWYNIRCRSGVELPTITCRPDILDRPEPVVLAFDIET TKLPLKFPDAQTDQVMMISYMIDGQGYLITNREIISSNVDDFEYTPKPEFEGNFIVFN EENEMQLLQRFFDHIMEVRPHIIVTYNGDFFDWPFVETRAAVYDLDMKQEIGFSKLRD GNYLSRPAIHMDCLCWVKRDSYLPVGSQGLKAVAKAKLRYDPVELDPEDMCRMAVEQP QVLANYSVSDAVATYYLYMKYVHPFIFALNTIIPMEPDEILRKGSGTLCETLLMVEAY HAQIVYPNKHQSELNKLSNEGHVLDSETYVGGHVEALESGVFRADIPCRFRLDPAMVK QLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLD VGAMYPNIILTNRLQPSAMVSDLDCAACDFNKPGVRCKRSMDWLWRGEMLPASRNEFQ RIQQQLETEKFPPLFPGGPQRAFHELSKEDQAAYEKKRLTDYCRKAYKKTKLTKLETR TSTICQKENSFYVDTVRAFRDRRYEYKGLTKVAKASVNAAVASGDAAEIKAAKGREVL YDSLQLAHKCILNSFYGYVMRRGARWHSMPMAGIVCLTGSNIITKAREIIERVGRPLE LDTDGIWCILPGSFPQEFTIHTSHEKKKKINISYPNAVLNTMVKDHFTNDQYHELRKD KENNLPKYDIRDENSIFFEVDGPYLAMVLPAAKEEGKKLKKRYAVFNFDGTLAELKGF EVKRRGELQLIKNFQSSVFEAFLAGSTLEECYASVAKVADYWLDVLYSRGSNLPDSEL FELISENKSMSKKLEEYGAQKSTSISTAKRLAEFLGEQMVKDAGLACKYIISKKPEGA PVTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIRDVLDWNYYIERLGGTIQKII TIPAALQGLANPVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDKL ADMEDLAGKDGGEGAAGCPIVTKRKRIQLEEHDDEEAQPQATTWRQALGAPPPIGETR KTIVEWVRFQKKKWKWQQDQRQRNRQASKRTRGEDPPVVRATGSTATLGGFLRRAQRT LLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQRSAAPPEEGQLWR KVNRVLPRSRPVFNLYRYSVPEQLFRDNSLGMLADLATPDIEGIYETQMTLEFRALMD MGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIYLYQHN TPTAKKEIWSLILMPSKKAFVFALDTVRANQMPNMRQLYTAERLALLKNLTAEEQDKI PVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILL EFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMP PDTVLFGADLFFARLLQRHNFVLWWSASTRPDLGGREADDSRLLAEFEESISVVQNKA GFYPDVCVELALDSLAVSALLQSTRIQEMEGASSAITFDVMPQVSLEEMIGTVPAATL PSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPAL RRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLR NKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDETVSSIVSTTMIRDSERNQ DDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPDENECREKFESLLTLF MQSLAEKKTTEQAIKDISHCAFDFILKLHKNYGKGKPSPGLELIRTLIKALSVDKTLA EQINELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAM KDGVPVWLCAQCYVAYDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSEIKRENLAEFC TCAGNFVPLISGKDIQTLLGTFNKVAANHKMQLLQQTVHQALTTPR" ORIGIN 1 agatttttgg cggcaacaag ttatttacat ttatttattt tatttctgct aaacagcacg 61 gaaatgtccg actccagcaa aggcaaagtg ctgcaaaata cgggtaaatt cgtcagcgag 121 aatcgcacag aaggcgacga cttcttcaat gaggcgggct atcgtcaatc ccgggagaac 181 gataaaatcg actcgaaata tggcttcgat cgggttaagg acagccagga gcggacgggc 241 tacctcatca acatgcattc gaacgaagtt ttggatgagg acagaagatt gattgctgcc 301 ttggacctgt tcttcatcca aatggatggt tcccgcttca aatgcacggt ggcctatcag 361 ccatatttac tcatccgacc agaggataat atgcatctgg aagtggcgcg atttctgggt 421 cgcaagtatt ccggccagat ttctggactg gagcacataa ccaaagaaga tttggatctg 481 cccaatcatc tatccggttt gcagcagcag tacataaaac tttcgtttct caatcagaca 541 gccatgacca aggttagaag ggaactcatg tccgcggtga agagaaatca ggagcgacag 601 aaatccaaca catactacat gcaaatgctg gccacctcgc tggcccaatc ctccgcaggt 661 tccgaggatg ccacattggg taagaggcag caggattaca tggattgtat tgtggacata 721 agggagcatg atgtgcctta ccacgtcaga gtgtccatcg atttgcgcat cttttgtgga 781 cagtggtaca atatcaggtg cagaagtggc gtggaattgc ctacgatcac ctgccgaccg 841 gatattctgg acagacccga gcccgtggtc ctggcctttg atatagaaac cactaagctg 901 ccccttaagt ttcccgatgc ccagacggat caggttatga tgatctcgta catgatcgat 961 ggtcagggtt atctgataac caatcgtgag attatatcat ccaatgtgga cgattttgag 1021 tacactccca agccggaatt cgagggtaac tttatagtat tcaacgaaga gaacgagatg 1081 cagctgctcc agcgcttctt cgatcacatc atggaggtgc gtccccacat cattgttaca 1141 tacaacggcg acttcttcga ttggcccttc gtggagacgc gtgctgcagt gtacgatctg 1201 gacatgaagc aagagattgg cttctccaag ctacgggatg gcaattatct aagtcgccct 1261 gccatacaca tggattgcct atgttgggtg aaacgagatt cttatttacc tgttggatct 1321 caaggcttaa aggcggtggc caaggctaaa ttacgctatg atcctgtgga actcgatccg 1381 gaggatatgt gccgcatggc cgtggaacag ccccaagtgc tggccaatta ctctgtatcc 1441 gatgcggtgg ccacatacta tctgtacatg aagtatgtgc atccatttat cttcgcccta 1501 aatacgatta ttcccatgga acccgatgag atcctaagaa agggttccgg cacactctgt 1561 gaaacgttgc tgatggtgga ggcttaccat gcccagattg tgtatcccaa caagcatcag 1621 agtgagctga ataagctctc caacgaggga cacgtactgg attcggaaac ctatgtgggt 1681 ggtcatgtgg aggctttgga atcgggtgtt ttccgggcgg acataccatg ccgttttcgt 1741 ctagatcctg ctatggtcaa gcaactgcag gagcaggttg atgcagttct gcgccacgct 1801 atcgaagtgg aggaaggcat accgctcgag aaggtcttga atctggatga agtgcggcag 1861 gagattgtgc aggggctaca gggtctgcac gatataccca atcgcttgga gcagccggtc 1921 atctatcact tggatgtggg tgccatgtac cccaacatta ttttgaccaa tcgcctgcag 1981 ccctcggcaa tggttagtga cttagattgt gccgcctgtg acttcaacaa gccaggagtt 2041 cggtgcaaac gttccatgga ctggttgtgg cgcggcgaga tgttgcccgc ctccaggaac 2101 gagtttcagc gcattcagca gcagctggag accgagaagt ttccacccct tttccctggc 2161 ggaccacagc gagcctttca cgagctctcc aaggaggatc aggcggcgta cgagaagaaa 2221 cgtctgacgg attactgccg caaggcttac aagaagacca agctaaccaa attggaaacg 2281 cgcacttcga ccatctgcca gaaggagaac agcttctatg tggacacggt gcgagctttt 2341 cgcgatcgtc gctacgagta caaaggacta accaaagtgg caaaagcatc ggtgaatgct 2401 gcggtggctt cgggagacgc ggcagagatc aaggcagcca agggcaggga ggtgctctac 2461 gattccctgc agttggccca caagtgcatc ctgaactcct tctatggcta cgtgatgagg 2521 agaggagccc gttggcattc catgcctatg gccggcattg tgtgcctcac gggctcgaat 2581 attatcacca aggcgaggga aattatcgag cgagttggtc gaccactcga attggacact 2641 gatggtatat ggtgcatatt gcctggctcc tttccgcagg agtttaccat tcacacgagc 2701 catgagaaga aaaagaagat taacatatca tatccgaatg cagtgctaaa cactatggtt 2761 aaagatcatt ttaccaacga tcagtaccac gagttgagga aggataagga aaacaatcta 2821 cccaaatacg atattcgaga tgagaactct atattcttcg aggtggatgg accctacctt 2881 gccatggtgt tacccgctgc caaagaggag ggcaagaagc tgaagaaaag atatgcggtc 2941 tttaatttcg atggcacact ggctgaactc aagggattcg aggtgaagcg acgcggtgaa 3001 ctgcagctga tcaaaaattt ccagagttcc gtcttcgaag ctttcctcgc tggtagcaca 3061 cttgaggaat gctatgcatc tgtggccaag gtggcggatt actggcttga tgtactctac 3121 agcagaggat caaatctacc cgactcggag ctattcgaac ttatttcgga gaacaagagc 3181 atgtccaaga agcttgagga gtatggcgcc caaaagagta cgtccatctc cacggccaag 3241 cgattggctg agttcctggg cgagcagatg gtaaaggatg cgggtctggc ttgtaagtac 3301 attatttcga agaaacccga aggagcaccc gtcaccgaga gagctattcc cttggccatt 3361 ttccaatccg aaccgagcgt gaggcgacat cacctgcgtc gctggcttaa ggacaacacc 3421 atgggcgatg cggatatacg cgatgtgctc gattggaact actacataga gagattgggt 3481 gggaccattc agaagatcat aaccataccg gcggcactgc agggactggc caatccagtg 3541 cccagagttc agcatccgga ttggttgcac aagaaaatgc tggagaagaa cgatgtgctc 3601 aagcagcgtc gcatcaatga gatgttcacc agcagaccca aaccgaaacc tctagccaca 3661 gaggaggaca agctggccga tatggaagat ttggctggta aagatggcgg tgagggtgct 3721 gcaggctgtc cgatagtcac caagagaaag agaatccagc tggaggagca cgatgacgag 3781 gaggcacagc cgcaggccac cacttggcgt caggccttgg gcgctccacc gcccatcggt 3841 gaaaccagaa agaccatcgt tgagtgggtg agatttcaga agaagaaatg gaaatggcag 3901 caggatcagc gccagcgtaa tcgccaggcg agcaagcgaa ctcgaggcga ggatccgccg 3961 gtggtcagag caacaggatc cacagctaca ctgggcggat tccttagacg tgcacaacgc 4021 accctgttgg accagccgtg gcagatcgta cagttggtgc ccgtcgacga cctgggccac 4081 ttcactgtgt gggccttaat cggcgaagag ttgcacaaga tcaagttgac ggtaccgagg 4141 attttctatg taaatcagcg aagtgcagct cctccagagg agggtcaact ttggcgcaag 4201 gtcaatcgag ttctgccacg atccagacct gttttcaatc tctatcgata tagtgtgccc 4261 gaacagctct tccgggataa ctcgctgggc atgctggcgg atctggcgac gcccgacatt 4321 gagggcatat acgagacgca gatgacgttg gaatttcgcg ccctcatgga catgggctgc 4381 atttgcggtg tccagcgcga ggaggcacgt cgcttggccc aattggccac caaggatctg 4441 gaaacattta gcatcgagca gctggagcag cggccccaga ctcaggtcaa atatttggct 4501 agcgccaaca atcgattgcg caaaatctac ttgtatcagc ataacacacc gacggccaag 4561 aaggagatct ggtcactgat cctaatgccc agcaagaagg catttgtttt tgccttggac 4621 acagtgcgtg ccaatcaaat gccgaacatg aggcaattgt ataccgccga gcgtttggcc 4681 ctgctcaaga atctgacggc agaggagcaa gataaaattc ctgtagagga ttacacattt 4741 gaggttctca ttgaggtgga tgtcaaacaa atttaccggc acatacagcg ggcactgacc 4801 acctacaaac aggagcatca gggacccacc attctgtgcc ttcaaacggc gctgtcggcg 4861 cgtaaactca gcctggccat gccgatcctg ctggagtttc cccaggctga gattcatatc 4921 tccgatgacg ctagtttgct ttctggcctt gattggcagc gacagggctc cagggcagtg 4981 atacgccact ttctgaatct gaacaatgtt cttgatttga tgttggatca gtgtcgctac 5041 ttccatgtgc ccattggcaa tatgccgccg gatactgtgc ttttcggagc ggatcttttc 5101 ttcgctcgct tgctgcagcg gcataacttt gtgctgtggt ggtcggcgag taccagacca 5161 gatttgggtg gccgggaggc ggacgacagc cggctgttgg cggaattcga ggagagcatt 5221 agtgtggtgc aaaacaaggc cggtttctat ccggatgttt gcgtggagct ggctctggat 5281 agcctggcgg tgagtgccct gctccaatcg actaggattc aggaaatgga aggcgcctca 5341 tctgccatta cgttcgatgt gatgccgcag gtctcgctgg aggagatgat tggcactgtt 5401 ccggcggcca ccttgccgag ttatgatgaa acggccctct gttccgccgc cttccgcgtt 5461 atgcgctcca tggtgaatgg ttggttgcga gaggtatcca tcaataggaa catcttctcg 5521 gacttccaga tcgtgcactt ctatcgatgg gtgcgctcca gtaatgcact actctatgat 5581 cctgctttga gaagatctct gaataatctg atgaggaaga tgttcttgcg cattatagcc 5641 gagttcaaga gattgggcgc caccattatc tatgcggact ttaacaggat tatccttagt 5701 tcgggtaaga aaaccgtttc cgatgccctg ggctatgtgg actacattgt gcaaagcttg 5761 aggaacaagg agatgttcca ctccatccaa ctgagcttcg agcaatgctg gaactttatg 5821 ctctggatgg accaggcaaa tttctcggga attaggggaa agctaccaaa gggaatcgat 5881 gagacagtgt cgtcaatagt ttccactacc atgatacggg attctgaacg caatcaagat 5941 gacgacgagg atgaagaaga ggattcggaa aaccgtgatc cagtggagag caacgaggcc 6001 gagcaggatc aagaggatga gctgtccctg gagctcaact ggacaattgg cgaacatctg 6061 cccgatgaaa acgagtgccg cgaaaagttt gaatccctgc tgaccctctt catgcaatct 6121 ttggctgaaa agaagaccac cgagcaggcc atcaaggaca tctcacactg tgcgttcgac 6181 tttatcctga agctgcacaa gaactacggc aagggcaagc cgagcccggg cctagaactt 6241 atccgcactc tgatcaaggc gttgagtgtg gacaaaacgc tggcggagca gatcaacgag 6301 ttgcgccgaa atatgctgcg tctggtgggg attggtgagt tctccgactt ggctgagtgg 6361 gaggatccct gcgacagtca catcatcaac gaggtcatct gcaaagcgtg taatcactgc 6421 agggacctgg atctctgcaa ggacaagcat cgcgccatga aagatggagt acccgtttgg 6481 ctgtgtgccc agtgctatgt ggcctatgat aacgaggaga tcgaaatgag aatgctggat 6541 gcactgcagc gcaagatgat gtcctatgtg ctgcaggatc tgcgctgttc gcgctgcagc 6601 gagatcaagc gcgagaatct ggcagagttc tgcacttgcg ctggcaactt tgtgcccctc 6661 atcagcggga aggacatcca gacactgctg ggcacattca acaaggtggc tgccaaccac 6721 aagatgcagt tgctccagca gactgttcat caggcgctga ccacgccacg ctaggaccta 6781 gtttgttgtt gttttctaga tcgtagggct taaatatatt gtatttataa tggaatttaa 6841 ttcgatttt //