Dbfetch
LOCUS NM_001297893 12294 bp mRNA linear INV 26-DEC-2023 DEFINITION Drosophila melanogaster terribly reduced optic lobes (trol), transcript variant AS, mRNA. ACCESSION NM_001297893 VERSION NM_001297893.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 12294) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 12294) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 12294) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 12294) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 12294) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 12294) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 12294) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 12294) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 12294) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 12294) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 12294) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 12294) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 12294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 12294) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 12294) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 12294) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 12294) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 12294) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Apr 22, 2020 this sequence version replaced NM_001297893.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..12294 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..12294 /gene="trol" /locus_tag="Dmel_CG33950" /gene_synonym="anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1" /note="terribly reduced optic lobes" /map="3A3-3A4" /db_xref="FLYBASE:FBgn0284408" /db_xref="GeneID:45320" CDS 185..11602 /gene="trol" /locus_tag="Dmel_CG33950" /gene_synonym="anon-WO0153538.72; BcDNA:GM02481; CG12497; CG33675; CG33950; CG7981; CT23996; Dmel\CG33950; EG:BACR25B3.1; EG:BACR25B3.10; EG:BACR25B3.11; EG:BACR25B3.2; GC7891; l(1)3Ac; l(1)9-96; l(1)G0019; l(1)G0021; l(1)G0023; l(1)G0181; l(1)G0211; l(1)G0271; l(1)G0374; l(1)G0412; l(1)trol; l(1)VA51; l(1)zw1; l(1)zwl; MRE7; pcan; Pcan; Pcn; Perl; Perlecan; Trol; TROL; Trol-A; Trol-B; troll; Troll; zw-1; ZW-1; zw1" /note="CG33950 gene product from transcript CG33950-RAS; CG33950-PAS; trol-PAS; lethal (1) G0271; Trol/perlecan; mRNA-like ncRNA in embryogenesis 7; lethal (1) G0211; lethal (1) G0181; lethal (1) G0412; terribly reduced optic lobes; dPerlecan; lethal (1) G0023; lethal (1) G0374; lethal (1) G0019; lethal (1) G0021" /codon_start=1 /product="terribly reduced optic lobes, isoform AS" /protein_id="NP_001284822.1" /db_xref="FLYBASE:FBpp0309654" /db_xref="GeneID:45320" /db_xref="FLYBASE:FBgn0284408" /translation="MMGSPGSQASAIATSVGIRSGRRGQAGGSLLLRLLAVTFVLAAC HAPLLTNAKQISNLGDDQDFMLADDESLQGINDSEWQLMGDDIDDGLLDDVDETLKPM ETKSEEEDLPTGNWFSQSVHRVRRSINRLFGSDDNQERGRRQQRERSQRNRDAINRQK ELRRRQKEDHNRWKQMRMERQLEKQRLVKRTNHVVFNRATDPRKRASDLYDENEASGY HEEDTTLYRTYFVVNEPYDNEYRDRESVQFQNLQKLLDDDLRNFFHSNYEGNDDEEQE IRSTLERVEPTNDNFKIRVQLRIELPTSVNDFGSKLQQQLNVYNRIENLSAATDGVFS FTESSDIEEEAIDVTLPQEEVEGSGSDDSSCRGDATFTCPRSGKTICDEMRCDREIQC PDGEDEEYCNYPNVCTEDQFKCDDKCLELKKRCDGSIDCLDQTDEAGCINAPEPEPEP EPEPEPEPESEPEAEPEPEPEPEPESEPEQEPEPQVPEANECQANEFRCNNGDCIDAR KRCNNVSDCSEGEDENEECRCYANQFRCNNGDCVSGSAPCNGYSECSDHSDELNCGGT QECLPNQFRCNSGQCVSSSVRCNGRTDCQDSSDEQNCGHRHTEVSQGLETTGVFTTST TSTTAMTPLRIICPPTSFKCENGPCISLGLKCNGRVDCPYDGSDEADCGQISNDIDPA DSNDRRPNQLNLKTYPDSQIIKESREVIFRCRDEGPARAKVKWSRPGGRPLPPGFTDR NGRLEIPNIRVEDAGTYVCEAVGYASYIPGQQVTVNLNVERYNDVGSRPESACTEYQA TCMNGECIDKSSICDGNPDCSDASDEQSCSLGLKCQPNQFMCSNSKCVDRTWRCDGEN DCGDNSDETSCDPEPSGAPCRYNEFQCRSGHCIPKSFQCDNVPDCTDGTDEVGCMAPL PIRPPPQSVSLLEYEVLELTCVATGTPTPTIVWRLNWGHVPDKCESKSYGGTGTLRCP DMRPQDSGAYSCEIINTRGTHFVNPDTIVTVRPVRTDVCEAGFFNMLARKAEECVQCF CFGVAKACDSANLFTYAIHPPILSHRVVSVELSPLRQIVINEAAPGQDLLTLLHGVQF RATNVHFSGRETPYLALPADYMGNQLKSYGGNLRYEVNYRGSGRPVNGPDVIITGNRF TLTYRVRTQPGQNNRVSIPFVPGGWQKPDGRKASREEIMMILANVDNILIRLGYLDST AREVDLINIALDSAGTADKGLGSASLVEKCQCPPGYVGDSCESCASGYVRQPGGPWLG HCVPFIPDSCPSGTYGDPRRGVPCKECPCPLTGSNNFASGCQQSPDGDVVCRCNEGYT GRRCEQCAAGYQGNPLAAGGICRRIPDTSCNVDGTYSVHSNGTCQCKDSVIGEQCDTC KSKSFHLNSFTYTGCIECFCSGVGLDCDSSTWYRDQVTSTFGRSRVDHGFVLVTNYMQ PTPDTVPVSMAAEPNALSFIGSADQSGNTLYWSLPAAFLGNKLSSYGGKLTYTLSYSP LPNGIMSRNSAPDVVIKSGEDLRLIHYRKSQVVPSVANTYSVEIKESAWQRGDEVVAN REHVLMALSDITAIYIKATYTTSTKEASLRQVTLDVATPTNLGTPRAVEVEQCRCPEG YLGLSCEQCAPGYARDPEGGIYLGLCRPCECNGHSKYCNSDTGDCEECSDNTEGPSCE RCAAGYVGDATRGTIYDCQPDEGYPIPSPPAPGNQTLECTAYCQIEGIYDCRGNECLC KRNVIGDQCDQCRPGTYGLSAQNQDGCKECYCSGLASQCRSAALYRQLIPVDFILNAP LITDESGAVQDTENLIPDISRNMYTYTHTSYLPKYWSLRGSVLGNQLFSYGGRLSYSL IVESYGNYERGHDIVLIGNGLKLIWSRPDGNENQEEYNVRLHEDEQWTRQDRESARPA SRSDFMTVLSDLQHILIRATPRVPTQSTSIGNVILESAVTTRTPGATHASDIELCQCP SGYVGTSCESCAPLHYRDASGSCSLCPCDVSNTESCDLVSGGYVECRCKARWKGDRCR EIDTNDPTDIGTEDPVLTQIIVSIQKPEITIVPVGGSMTLSCSGRMRWSNSPVIVNWY KENSRLPENVEVQGGNLYLYDLQVSDSGVYICQAVNNETASVFKDTVSITITKKDQLS PAEIVNLPSHVTFEEYVNNEIICEVLGNPAPRVTWARVDGHADAQSTRTYDNRLIFDS PRKSDEGRYRCQAENDQNRDEKYVIVYVQSNPPQPPPQQDRLYITPEEINGLAGESFQ LNCQFTSVASLRYDWSHNGRSLSSSPARNVEIRGNTLEVRDASESDSGVYTCVAYDVR TRRNFTESARVNIDRREEQPFGNKPIIESLEQNILIIQGEDYSITCEASGSPYPSIKW AKVHDFMPENVHISGNVLTIYGARFENRGVYSCVAENDHGSDLSSTSIDIEPRERPSV KIVSAPLQTFSVGAPASLYCTVEGIPDPTVEWVRVDGQPLSPRHKIQSPGYMVIDDIQ LEDSGDYECRAKNIVGEATGVATITVQEPTLVQIIPDNRDLRLTEGDELSLTCVGSGV PNPEVEWVNEMALKRDLYSPPSNTAILKIYRVTKADAGIYTCHGKNEAGSDEAHVRVE VQERRGDIGGVDDDSDRDPINYNPPQQQNPGIHQPGSNQLLATDIGDNVTLTCDMFQP LNTRWERVDGAPLPRNAYTIKNRLEIVRVEQQNLGQYRCNGIGRDGNVKTYFVKELVL MPLPRIRFYPNIPLTVEAGQNLDVHCQVENVRPEDVHWSTDNNRPLPSSVRIVGSVLR FVSITQAAAGEYRCSAFNQYGNRSQIARVAVKKPADFHQVPQSQLQRHREGENIQLQC TVTDQYGVRAQDNVEFNWFRDDRRPLPNNARTDSQILVLTNLRPEDAGRYICNSYDVD RGQQLPEVSIDLQVLTATPPPNSPIYLPPQLPAKSRDYSLKLDDQSSNLRAGESTDVE CYSSDDTYTDVVWERSDGAPLSNNVRQVGNRLVISNVSPSDAGNYVCKCKTDEGDLYT TSYKLEVEDQPHELKSSKIVYAKVGANADLQCGADESRQPTYRWSRQYGQLQAGRSLM NEKLSLDSVQANDAGTYICTAQYADGETADFPNILVVTGAIPQFRQEPRSYMSFPTLP NSSFKFNFELTFRPENGDGLLLFNGQTRGSGDYIALSLKDRYAEFRFDFGGKPMLVRA EEPLALNEWHTVRVSRFKRDGYIQVDEQHPVAFPTLQQIPQLDLIEDLYIGGVPNWEL LPADAVSQQVGFVGCISRLTLQGRTVELIREAKYKEGITDCRPCAQGPCQNKGVCLES QTEQAYTCICQPGWTGRDCAIEGTQCTPGVCGAGRCENTENDMECLCPLNRSGDRCQY NEILNEHSLNFKGNSFAAYGTPKVTKVNITLSVRPASLEDSVILYTAESTLPSGDYLA LVLRGGHAELLINTAARLDPVVVRSAEPLPLNRWTRIEIRRRLGEGILRVGDGPERKA KAPGSDRILSLKTHLYVGGYDRSTVKVNRDVNITKGFDGCISRLYNFQKPVNLLADIK DAANIQSCGETNMIGGDEDSDNEPPVPPPTPDVHENELQPYAMAPCASDPCENGGSCS EQEDVAVCSCPFGFSGKHCQEHLQLGFNASFRGDGYVELNRSHFQPALEQSYTSMGIV FTTNKPNGLLFWWGQEAGEEYTGQDFIAAAVVDGYVEYSMRLDGEEAVIRNSDIRVDN GERHIVIAKRDENTAILEVDRMLHSGETRPTSKKSMKLPGNVFVGGAPDLEVFTGFRY KHNLNGCIVVVEGETVGQINLSSAAVNGVNANVCPANDDPLGGTEPPVV" ORIGIN 1 acattaggtt gcgcgccatc gttccaggcg gtcgcacatt ccacgtgcca tagccgtaac 61 cacaacctgc cagccgttta aagccaaact aaacaaaacg aaccgaaact gccttcacaa 121 agtacctaag ccaaacctaa atagctgcca aaagaaacca aaaccgccgt tacccggaaa 181 agagatgatg ggatcgccgg gatcccaagc gtccgcgatc gcgacctcgg tcggaatcag 241 aagcgggcgg agaggtcaag cgggaggatc gttgctcctg cgcctccttg ccgtgacctt 301 cgtcctcgcc gcctgccacg caccgctgct gaccaatgcc aagcaaatct caaatcttgg 361 cgatgaccaa gattttatgc tggcagatga tgagtcgctg cagggcatca acgattccga 421 gtggcagctc atgggtgatg acattgacga cggcctactg gacgatgtcg atgagacact 481 gaagcccatg gagaccaagt ccgaggagga agacttgccc actggcaact ggttcagcca 541 gagtgtccat cgcgttcgcc gttccataaa ccgtttattt ggttccgacg acaatcagga 601 acggggacga cgacaacagc gtgagcggtc gcaaaggaat cgcgatgcga ttaatcggca 661 aaaagaactg cgccgcagac aaaaggagga ccacaaccgc tggaagcaaa tgcgaatgga 721 gcgacaactg gagaaacagc gcttggtcaa acggaccaat catgttgtct tcaaccgcgc 781 caccgatcct cgcaagcggg catcggacct ttacgacgag aacgaggcat ccggctatca 841 cgaggaggat acaactctct atcgtaccta cttcgtcgtt aacgaacctt atgacaacga 901 atacagagat cgagaaagcg tacagttcca gaacctgcaa aaacttctgg acgatgatct 961 gcgcaacttc ttccacagca actacgaagg taacgatgac gaggagcagg aaattcgcag 1021 cacactggag cgcgttgaac ccactaatga taacttcaaa attcgcgtgc aactcagaat 1081 agagctgccc acttcggtca acgactttgg aagtaagttg cagcagcaac tgaatgtcta 1141 taatcgtatc gaaaacttga gcgccgctac cgatggcgta ttttccttca ctgaatctag 1201 tgatatcgag gaagaggcaa tcgatgttac attgccccag gaagaggttg agggctctgg 1261 tagcgatgac tccagctgtc gtggagacgc caccttcacc tgtccccgga gcggaaaaac 1321 catttgcgat gaaatgcgct gcgatagaga gatccaatgt cccgatggcg aggacgaaga 1381 gtactgcaac tatccaaatg tttgcactga agatcagttc aagtgcgacg ataagtgtct 1441 ggagctcaaa aaacgctgcg atggaagtat cgattgtctg gatcagaccg acgaggctgg 1501 ctgcattaat gcgccagaac cagaaccaga gcctgaacca gagccagagc ctgaaccgga 1561 atctgaacca gaggccgaac ccgaacccga acctgagcct gagcctgagt ctgaaccaga 1621 acaagaacct gaaccccaag tcccggaagc caatgagtgc caggccaacg agtttagatg 1681 caataatggc gattgtatcg atgccagaaa gcgttgcaac aacgtttcgg attgtagcga 1741 aggcgaggac gagaacgagg agtgccgctg ttacgcaaac caattccgtt gcaacaatgg 1801 tgactgcgtt tccggatcgg ctccctgcaa cggatattcc gagtgcagtg atcactccga 1861 tgagctcaac tgtggtggaa cccaggagtg tctgcccaat caattccgct gcaatagtgg 1921 ccagtgtgtg agctcctcag tgcgatgcaa cggacgaacc gattgccagg atagctccga 1981 tgagcaaaat tgcggtcatc gtcatacaga ggtcagtcaa ggcctggaaa ccactggagt 2041 ttttaccacc tccacgacca gcaccactgc catgacgcca ttgagaatca tctgcccgcc 2101 aacctcattt aaatgcgaaa atggtccctg catttcgctg ggtctcaaat gcaatggacg 2161 agttgattgt ccctatgatg gtagcgatga ggcggattgt ggtcaaatta gcaacgatat 2221 cgatcccgcc gatagtaatg atcgcagacc gaaccaactg aatctcaaga cctatcccga 2281 cagccagatc atcaaggaga gtcgcgaggt catcttccgt tgccgagatg aaggacccgc 2341 acgcgccaag gtcaagtggt cccgcccagg cggacgacca ctgccacctg gtttcaccga 2401 tcggaacggc cgcctggaga ttcccaacat tagggtcgag gatgccggca catatgtttg 2461 cgaggctgtg ggctatgcca gctatattcc cggccagcag gtcaccgtga acctcaacgt 2521 cgagcgctat aacgacgttg gatcccgtcc ggaatcagcc tgcacggaat atcaggccac 2581 ctgcatgaac ggcgaatgta ttgacaagtc gtccatctgt gacggaaatc cggactgttc 2641 ggacgcctcc gatgagcaaa gctgcagttt gggtctcaag tgccagccca accagttcat 2701 gtgctcgaac tcgaagtgcg tggaccgcac ctggcgatgc gatggcgaga atgactgcgg 2761 agataattcc gatgagacct cctgcgatcc ggagccaagt ggcgctccct gccgctataa 2821 tgaattccag tgccgcagtg gtcattgtat acccaagagc ttccagtgcg acaatgttcc 2881 tgattgcacg gacggtaccg atgaagttgg atgcatggca cccttgccaa tccgccctcc 2941 accccaatct gtttcccttt tggagtatga ggtgctcgag cttacgtgcg tggccaccgg 3001 aaccccaact cccacaattg tatggcgtct gaactggggt catgtgcccg ataagtgcga 3061 gtcaaagagc tacggtggaa cgggaacact tcgttgtccg gacatgaggc cgcaggacag 3121 tggagcctac tcgtgcgaaa ttattaacac acgcggcacc cactttgtga acccggacac 3181 cattgttacc gttagaccag tgcgtacaga tgtgtgcgag gccggattct tcaatatgtt 3241 agcccgcaaa gcggaggagt gcgtccagtg cttctgtttc ggagtagcta aagcctgcga 3301 cagtgccaac ttatttacat atgccatcca cccgccgatc ctttcacacc gcgttgtcag 3361 cgttgagctg agtccacttc gacagattgt gatcaatgag gcagcgccag gacaggatct 3421 gctcacactg ctacatggcg ttcagttcag ggccaccaat gttcacttca gcggccggga 3481 gacgccttat ttggccttgc ccgcggatta catgggcaac cagctaaagt cttatggcgg 3541 aaatctacga tacgaggtta actaccgcgg cagcggaaga cccgtcaacg gtccagatgt 3601 aataatcact ggcaatcgtt ttacactaac ttatcgagtt cgcactcagc cgggtcaaaa 3661 caacagggtg agcattccat tcgtgccagg tggatggcaa aagcccgatg gtcgcaaggc 3721 gtcgcgtgag gagatcatga tgattctggc caatgtggac aatatcctga tccgactcgg 3781 atatctggat agcaccgctc gcgaagtgga tcttataaat attgccttgg attcggcagg 3841 cactgccgat aagggactgg gtagtgcgtc tcttgtggag aagtgccagt gcccacctgg 3901 ttatgttggt gattcgtgtg agtcctgtgc ctccggctat gtgcgacagc ccggtggacc 3961 atggttgggt cactgtgtgc cgttcatccc tgattcttgt ccatccggaa cttatggaga 4021 tccccgtcgt ggtgtgccct gcaaggagtg cccatgtcca ctaaccggca gcaataactt 4081 tgccagcggc tgtcaacaaa gtcctgatgg cgacgtggtt tgccgatgta atgagggcta 4141 cacaggcagg cggtgcgaac agtgcgccgc cggataccag ggcaatcctt tggctgcggg 4201 aggaatttgc cgcagaatac ccgatacttc ctgcaacgtg gatggcacct actccgttca 4261 tagcaatgga acctgccaat gcaaggatag cgtaattggc gaacagtgcg acacatgcaa 4321 atcaaagagt ttccacctca attcgtttac atataccggt tgcatcgagt gcttctgcag 4381 cggagtgggc ttggactgtg atagtagcac gtggtatcgc gatcaagtaa cgagcacgtt 4441 tggaagatct cgtgtcgatc acggatttgt tttggttact aactacatgc aacccacgcc 4501 agacaccgta cctgtctcaa tggccgcaga acccaatgcg ttaagcttta taggatcggc 4561 tgatcaatct ggaaatacgc tctactggag tctgccagcc gcctttttgg gaaacaaact 4621 ttcttcatat ggaggcaagc tgacttacac cttaagctac agtcccctgc ccaacggcat 4681 tatgtctcgg aacagtgccc cagatgtggt gatcaagagt ggcgaggatc taaggctcat 4741 ccattatagg aaatcccagg ttgtgcccag tgtggccaac acctattccg tggaaatcaa 4801 ggaaagtgct tggcagcgcg gcgacgaagt tgtggccaac cgtgagcacg ttctgatggc 4861 acttagcgat attacggcca tctacataaa ggccacatac accactagca ccaaggaggc 4921 ctcgttgcga caggtgactt tggacgttgc cactccaacg aaccttggca ctccacgtgc 4981 cgtcgaagtt gaacagtgcc gctgtcccga gggctatttg ggtctttctt gtgagcagtg 5041 cgctcctggc tatgcccgcg atccggaggg cggaatctat ctgggactct gcaggccttg 5101 tgagtgcaat ggacattcca aatattgcaa cagcgatacc ggtgactgcg aagaatgttc 5161 tgacaatacc gaaggtccta gctgtgaacg atgcgctgct ggctatgtgg gtgatgccac 5221 ccgtggaaca atttacgact gccaacccga tgaaggctac ccgatcccga gtcctccggc 5281 acccggcaac caaactttgg aatgcacggc ctattgccaa atagagggca tctatgattg 5341 ccgcggcaac gaatgcctgt gcaagagaaa cgtgattggt gatcaatgcg accaatgccg 5401 ccctggaacc tatggactgt ctgctcaaaa tcaggatggc tgcaaagagt gctactgctc 5461 tggattggcc agccagtgtc gttcggcagc tctgtaccgc cagctaatac cggtggactt 5521 tattcttaac gcaccattaa ttacagacga aagcggagct gtccaggaca ccgagaactt 5581 aattcccgac atatctagga atatgtatac ctacacgcac acctcctatc tgcccaagta 5641 ctggagtctt aggggaagtg tgctgggcaa ccagctattc tcgtacggtg gccgcctgtc 5701 gtacagtcta atagtggagt catatggcaa ctatgagcgt ggccacgata ttgtgcttat 5761 tggcaatgga ttgaagctca tctggtcgcg acccgatgga aatgagaatc aggaggaata 5821 caatgtccga ttgcacgagg acgagcaatg gacccgccag gatcgcgaat cggcacgacc 5881 ggcttctcgg tctgatttca tgactgtgct gtcggatcta cagcacatcc taatccgagc 5941 cacacccaga gtgcccacac aaagcacttc gatcggcaat gtcattctgg agagtgcggt 6001 gaccacaagg acgccaggag ctacgcatgc ttccgacatc gagttgtgcc agtgcccatc 6061 cggatacgtg ggcacctcct gtgaatcatg cgcacctctt cactaccgcg atgctagcgg 6121 atcgtgcagc ctgtgtcctt gcgatgtttc caacacggag tcgtgtgact tggtcagtgg 6181 cggatacgtt gaatgtcgtt gcaaggcacg ttggaagggc gatcggtgtc gcgagatcga 6241 caccaacgat ccaacggata tcggtacaga agatcccgtg ctcacccaga ttatcgtatc 6301 gattcaaaag cctgagatca ccattgtgcc cgtaggcggt tccatgaccc tcagctgtag 6361 cggtcgaatg cgttggagca atagtccagt cattgtgaac tggtacaagg agaacagccg 6421 cctgccagag aatgttgaag tccaaggcgg aaatctgtac ctgtacgatc tacaggtcag 6481 cgattctgga gtctacatct gccaggccgt caacaatgaa accgccagcg tgtttaagga 6541 cactgtatcc attaccataa ccaagaaaga ccagctctca ccggctgaga ttgtgaattt 6601 gccgagccac gttacatttg aggagtacgt gaacaatgag attatctgcg aagtacttgg 6661 caacccagca cccagagtca cctgggcgcg agtggatggc catgcggatg cccaaagtac 6721 ccggacatac gacaaccgct tgatctttga ttcgccaagg aaatcggacg aaggccgcta 6781 tcgctgccag gcggaaaatg accagaaccg agatgagaag tacgtgatcg tctatgttca 6841 gagcaatccg ccccagccgc cgccgcaaca ggatcgattg tacatcacac cggaggagat 6901 taatggcctg gccggcgagt ccttccagtt gaattgccaa tttacaagtg ttgcctctct 6961 gcgctacgat tggtcgcaca atggtcgctc cttatcctct tcgcccgcgc gaaatgttga 7021 gatccgtggc aacaccctgg aagttcgcga tgccagcgaa agcgactccg gcgtctacac 7081 ctgtgtggcg tatgacgtac gcacccgccg caactttacc gagagcgccc gtgttaacat 7141 cgaccgacgc gaagaacaac catttggcaa caaaccgatc atcgagagct tggagcagaa 7201 tatcctgatc atccagggcg aggactatag catcacctgc gaggcgagtg gatcgccata 7261 tccatcgatc aagtgggcca aggtgcacga cttcatgccc gaaaatgtgc acattagtgg 7321 caacgtgctg accatctatg gagcacgatt cgagaatcgc ggtgtctact cctgcgttgc 7381 cgaaaatgac cacggatcag atttgtccag cacaagtatc gacattgaac cccgggagcg 7441 gccgagtgta aagattgtat cggcgcccct gcaaacattt tcggttggcg ctccggcatc 7501 cctctactgc acggtagagg gaattcccga tccgaccgtc gaatgggttc gtgtggacgg 7561 ccaaccgttg tcgccgcgtc acaagatcca gtcacccggc tacatggtaa tcgacgatat 7621 tcagctcgag gatagcggag actatgagtg tcgcgcaaag aacatagtcg gcgaggcgac 7681 cggcgtggcc accattaccg tccaggagcc aactctcgtc cagataattc ccgacaacag 7741 ggatcttagg ctgacggagg gcgatgaact ctcactgacc tgcgttggca gcggcgtccc 7801 aaacccggaa gtcgaatggg ttaatgaaat ggccttgaaa cgggatctct acagcccacc 7861 gagcaataca gcgatcctta agatctaccg agtgaccaag gcggatgcag gcatatacac 7921 ctgccatggc aaaaatgagg cgggtagcga tgaagctcac gttcgcgttg aggtccagga 7981 acggcgagga gatatcggag gagttgatga tgattccgac cgggatccca taaactacaa 8041 tccgccacaa caacaaaacc ctggcatcca ccagccgggc agcaaccaac tcctggccac 8101 cgacattggc gacaatgtga ccctgacctg cgacatgttc caacccctga acacgcgctg 8161 ggaacgcgtc gacggggcac cactgccccg caatgcctac acgattaaaa acaggctgga 8221 gattgtgcgc gtggaacagc aaaatctggg ccagtaccgc tgcaatggaa tcggtcgcga 8281 tggcaacgtt aagacctatt tcgttaaaga gctggtcctt atgcccctgc cccgaatcag 8341 gttctacccg aatattccgc tgaccgtgga ggcgggtcag aatttggatg tgcactgtca 8401 ggtggaaaac gtgcgtccgg aggacgttca ttggagtacc gacaacaatc gaccactgcc 8461 cagttcggtt cgcattgtgg gcagcgtcct gcgcttcgtg tccatcacac aggcagctgc 8521 cggtgaatat cgctgctctg ccttcaacca atatggaaac cgatcgcaga tcgcaagagt 8581 ggcagtaaag aagcccgccg acttccatca ggttccgcag tcccagttgc aacggcaccg 8641 cgagggcgag aacattcaac tgcaatgcac ggtgaccgat caatatggcg taagggctca 8701 agacaatgtt gagttcaact ggttccgcga cgacagaaga cccctgccga acaacgcccg 8761 tacggatagc cagatcctgg tgctgaccaa tttgcgaccc gaggatgcgg gtcgctacat 8821 ctgcaactca tacgacgtgg accgtgggca gcaactgccc gaagtgtcca tcgacttgca 8881 agtactaacg gctaccccgc cacccaacag ccccatctac ctgccaccgc aattgccagc 8941 aaagagccgc gactatagcc tcaaactgga cgatcagtcc tcgaacctgc gagcgggtga 9001 atccaccgat gtcgagtgct actcctccga tgacacctac acagacgtgg tgtgggaacg 9061 ctctgacggg gctccactca gcaataatgt caggcaagtg ggaaatcgtc tggtgatcag 9121 taatgtgtcg ccaagcgatg ccggtaacta cgtgtgcaag tgcaagacgg acgaagggga 9181 tctgtacacc accagctaca aactggaggt cgaggatcag cctcatgaac tcaaaagctc 9241 caagatagtt tacgccaagg ttggcgccaa tgccgatttg cagtgcgggg ccgatgaaag 9301 tcgacagccc acctatcgct ggtctcgcca atacggccaa cttcaagcgg gacgcagtct 9361 aatgaacgag aaactgtccc tggacagtgt gcaggcaaat gatgccggta cgtatatttg 9421 caccgctcaa tacgccgatg gtgagactgc agacttcccc aatatcctgg ttgtgactgg 9481 ggcgattccc cagttccggc aggaacctcg cagctacatg agcttcccca cgctgccaaa 9541 ctcttcgttt aagttcaact tcgagctgac cttccgaccg gaaaacggtg acggtctcct 9601 actgttcaac ggacaaaccc gcggaagtgg cgactacatc gcactttcgc tcaaggatcg 9661 ctatgcggag ttccgttttg attttggtgg taagccaatg ctggtgcgag ctgaggaacc 9721 actggcgctg aatgagtggc acacggttcg tgtgagtcgc ttcaagaggg atggttacat 9781 ccaggtggac gaacaacatc cggtggcctt ccccaccctg cagcaaatac cccaactgga 9841 tctgatcgaa gatttgtata ttggcggagt gcccaactgg gagctcctgc ccgccgatgc 9901 tgttagccag caagttggct tcgtgggctg catcagtcgc ttaactctgc aaggacgcac 9961 cgtggaactg atccgtgagg cgaagtacaa agagggcatc acggactgcc ggccatgtgc 10021 gcaaggacct tgtcaaaaca agggagtctg cttggagagc caaaccgagc aggcctacac 10081 ctgcatttgc cagccgggtt ggactggaag ggattgtgcc attgagggca cccagtgtac 10141 gcccggagtc tgtggcgccg gacgctgcga gaatacggag aacgacatgg agtgcctgtg 10201 cccactgaac cgatccggag atcgatgcca atataatgag attttaaatg agcacagtct 10261 caactttaag ggcaacagct ttgcggccta tggaactcct aaagtcacca aggtcaacat 10321 aacgctctcc gtacgtccgg caagtttgga ggactccgtg attttgtata ctgcagaatc 10381 gactctgccc agcggcgatt acctggcact ggtactgcgt ggtggtcacg cggagctctt 10441 aataaatacg gcagctcgat tggatcccgt ggtagtgcga tctgctgagc cactgcccct 10501 gaaccgctgg acaagaattg agatcagacg tcgcctgggc gaaggaattc tacgggtggg 10561 cgacggacca gagcgaaagg ccaaggcccc aggctcggat cgaattttgt cccttaaaac 10621 gcacctctat gtgggcggct acgatcgctc cacggtcaag gtcaatcggg acgtgaacat 10681 cactaagggc ttcgatggct gcatctccag gctatacaac ttccaaaaac ctgtcaatct 10741 cctagcggac attaaggatg cggcaaatat acagagttgt ggggagacta atatgatcgg 10801 aggtgacgag gatagcgaca atgagccacc agttccgcct ccaactccag atgttcacga 10861 gaacgaactt caaccatatg cgatggcgcc gtgcgccagc gatccatgtg aaaacggagg 10921 aagctgcagt gaacaggagg acgtggccgt atgctcctgt cctttcggat tcagtggcaa 10981 gcactgtcag gagcacctcc aactgggctt caatgcctcg ttccgaggcg atgggtacgt 11041 tgagctgaat cgaagtcact tccaaccagc tttggagcaa tcctacactt ctatgggcat 11101 cgtcttcacc accaacaagc cgaacggtct gctgttctgg tggggccaag aggccggaga 11161 ggagtacacc ggacaggact ttatagctgc cgcagtggtg gatggctatg tggagtactc 11221 aatgaggctc gatggcgagg aggcggtaat ccggaacagc gatatccgcg tagacaatgg 11281 ggagcgacac attgtgatcg ctaagcggga cgaaaacacc gccattctag aggttgatcg 11341 catgctgcat tcgggtgaaa cccgacccac cagcaaaaag tcgatgaagc tgccgggcaa 11401 tgtttttgtc ggtggcgctc ctgacctcga ggtgtttacg ggtttccgat acaagcacaa 11461 tttgaacggc tgcattgtgg tcgtcgaggg cgaaactgtg ggccaaatta atcttagttc 11521 tgctgccgtt aacggagtga atgccaacgt ctgtcccgct aacgacgatc cactgggagg 11581 aaccgaaccg ccagtcgtct gaggacacaa ccaacagccg aaactagctt tttaattaaa 11641 cattaacaaa tgaaacaaaa cgaacaacaa tttttatata tacaacatat gcataagccc 11701 aagaaaatcc acaaaaattg aatattatat cacttacaca taatataaaa aaaacaaaaa 11761 caaaagagaa acgatcactt caactacaat tgcttcttcg atccttaagt ctaagttaaa 11821 gattgtagca aggaaaaatg cgaaaatatc acaaacattt atttaacaaa aacgccatgc 11881 aagaagtgaa acgaaacaga tacaataatg caactaatgc aaaataatac agaaaataca 11941 gttaaagcct agaaccctaa gaacttacta actaactcga gcaacaacaa cgcatactag 12001 ccaactgcaa ccacaaaatc cacaatagtg aaggcatttt aatcataatt ttagtctcta 12061 gcttatacct atgactacga ctcttttttt gccagcccag tgtaaaaagt tggagatcga 12121 aaattggccc tacacacata caagaccacg ttattgatta aaaaccaatt gataatacac 12181 ctacatacat ataatgataa atgaattact aagaatgcaa ctattgtgaa cgagcgaaaa 12241 ccgttgagtg gataaaagcg aatgcagaag atatattaaa atgaaatcaa caac //