Dbfetch
LOCUS NM_001260355 7973 bp mRNA linear INV 26-DEC-2023 DEFINITION Drosophila melanogaster crumbs (crb), transcript variant C, mRNA. ACCESSION NM_001260355 VERSION NM_001260355.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7973) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7973) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7973) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7973) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7973) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7973) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7973) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7973) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7973) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7973) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7973) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7973) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7973) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7973) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 21 (bases 1 to 7973) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7973) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 23 (bases 1 to 7973) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 24 (bases 1 to 7973) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). On Jan 16, 2013 this sequence version replaced NM_001260355.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7973 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="3R" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7973 /gene="crb" /locus_tag="Dmel_CG6383" /gene_synonym="0509/20; 1384/04; CG6383; Crb; CRB; Crbs; crumb; Crumbs; CT19912; DmCrb; Dmel\CG6383; far; l(3)07207; l(3)j1B5; l(3)S050920; l(3)S058104" /note="crumbs" /map="95F10-95F11" /db_xref="FLYBASE:FBgn0259685" /db_xref="GeneID:42896" CDS 550..7311 /gene="crb" /locus_tag="Dmel_CG6383" /gene_synonym="0509/20; 1384/04; CG6383; Crb; CRB; Crbs; crumb; Crumbs; CT19912; DmCrb; Dmel\CG6383; far; l(3)07207; l(3)j1B5; l(3)S050920; l(3)S058104" /note="CG6383 gene product from transcript CG6383-RC; CG6383-PC; crb-PC; lethal (3) 07207; fat rhabdomeres; crumbs" /codon_start=1 /product="crumbs, isoform C" /protein_id="NP_001247284.1" /db_xref="FLYBASE:FBpp0293268" /db_xref="GeneID:42896" /db_xref="FLYBASE:FBgn0259685" /translation="MAKIANASLSQQQKQRQAETATTTTTTVAASVETATTTARSRDR TKSAAQITSHLLKRAISVYSSPQWIPLFILIYLATDVASVAVPTKEAYFNGSTYLRLT TPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPNNRLDV KLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILIL GNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCLNDPCMG HGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPN HSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECAS QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQ CLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCP IDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTT KIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYS CICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSMNGTHCYCAVGYSG DRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECK CTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLS FPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNC IPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSN PCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMS RITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGT YTCECEPGFEGTHCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLLKG CDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTERE EGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGS KLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLK SYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNP CHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAI RSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTP EAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPA PTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLI VEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTC KCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQE QQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLS ALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTDIDQAAFQ SLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSR TNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGT DIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLI ASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGP LCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKD LVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAY CNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDI AIIVIPVVVVLLLIAGALLGTFLVMARNKRATRGTYSPSAQEYCNPRLEMDNVLKPPP EERLI" ORIGIN 1 gctgctcgta cgtacgtttt attggttgct cgcgctcgta acgttttttt cgccccgttt 61 tggccaatgt gtgtgcgcgc gcgtgtgtgt gtgctgcttg cagttcaaaa gggcagcgac 121 aacaacaaga acagcgcacc tctcttttaa gccaagtctt cggcgctcgt atgtgtgtgt 181 gtgtgttggt gtgattcaga atcgtggcct gggaagaaat ggcaaattag ttggctcaaa 241 gtggaatctc tgtgctcaat attcaaattc aggctagaaa gtgtcgcgtg cgaaagtttg 301 caaataatac aactagcaga aaaagaggaa tataacttaa aaaaaataaa aataacctgt 361 tctaagccaa gtgccgattg cgcgcgtgtg tgtgtgtgcg tatgagtgtt tgcgtggagc 421 agagagaagg gagaatgcaa ttaccaacaa caacaagctc aatgagtatc gtttgaatag 481 caataatatc tagccaaaag caaccctttc caatacgaaa actcgacttg agccaacaaa 541 tcagcgatca tggctaaaat cgccaatgcg tcactgtcgc aacaacaaaa acagcggcaa 601 gcagaaacag caacgaccac aacaacaaca gtggcggcat cagtagaaac agcaacaaca 661 acagcaagaa gtcgagaccg cacgaaaagc gcagctcaaa ttacgtcgca tttgctcaag 721 cgcgccattt cagtttattc gtcgcctcaa tggataccgc tcttcatact tatttactta 781 gcaacagatg tcgcctcagt ggcggtgccg acgaaggagg cgtactttaa tggctccact 841 tacctccgcc tcaccacgcc gatgcccatt tgggatcact cggcgattag tttccgctcg 901 tgccgcggcg gcgagatcct cgcccagcag tacaacaaga actccattgt aatctcagtg 961 ctcaatgact ttctgcaaat ctcactggct ggacccgccg tccatgggcc caacaaccgg 1021 ctggatgtca agctgcccta ccaactgctg gacaaccgct ggcatacgct gcagttcaag 1081 tacgagtacg gaaatctcta cctgcatgtg gatcgcgcgg caagcatatt tgccaactcc 1141 acgtacaaca gtcagttcct gactaaccag gacattggct acaaggacgc catcttgata 1201 ctgggaaact ccttctccgg ttgccttctg gatggaccag gtctgcaatt tgtgaacaac 1261 tcgacggtgc agaatgtggt ctttggtcac tgtcccttga ccccgggtcc ctgcagcgat 1321 cacgatcttt tcactcgact gccagacaac ttttgtctga atgatccctg tatgggccat 1381 ggaacctgct cgtccagtcc agagggatac gaatgtcggt gcacggcacg ttactcggga 1441 aaaaattgcc agaaggacaa tggctcgccg tgtgccaaaa atccatgtga gaacggtggt 1501 tcctgcctgg agaattcccg aggggattac cagtgcttct gtgatcccaa ccacagtggt 1561 cagcactgcg agacggaggt gaacatccac ccactctgcc agacgaaccc ctgcctgaac 1621 aatggagcat gtgtggtgat tggcggcagt ggagcactca cctgcgagtg tcccaaagga 1681 tacgctggtg ccaggtgcga ggtggacacg gatgagtgcg cctcacagcc gtgtcagaac 1741 aacggaagct gcatagaccg tatcaatgga ttcagctgcg attgcagcgg caccggttac 1801 acgggtgcgt tctgccagac gaatgtggat gagtgcgaca agaatccgtg cctgaacggc 1861 ggcagatgct tcgataccta cggatggtac acctgccagt gtctggatgg ttggggcggc 1921 gagatttgtg atcgacccat gacatgccag acgcagcagt gtttgaacgg tggcacctgc 1981 ctggacaagc ccatcggctt ccagtgcctc tgtccgccgg agtacactgg tgaactgtgc 2041 caaatcgcac ccagttgcgc acagcagtgc cccatcgatt cggagtgcgt aggcggcaaa 2101 tgcgtttgta agccaggctc atcgggcccc attggtcact gcctgccaac aacaaccaca 2161 ccgacaccag aacaagagcc aacaacaacg ccaagaacca caccaaaccc taacccagct 2221 attcccaaca ccctaacaac aacaaccaag ataccaccaa taacaaccag ccgaacactg 2281 gtgggaacga ccacgggtag caggagacca ccacaacagc cactacaatc tccgacccaa 2341 cgctcggcct ccctgaatgc atgtccccaa gaaaactgct tgaacggtgg cacctgcctg 2401 ggctatagtg gcaattattc ctgtatttgt gctagtggat acacaggtta caactgtcaa 2461 acgagcacgg gcgatggagc ttctgctttg gccctgacac ccatcaactg caatgccacc 2521 aatggaaagt gtctcaatgg aggaacttgc tccatgaacg gaacccactg ctattgcgcc 2581 gtcggctatt cgggagatcg ttgcgagaag gccgagaact gttcgccact gaactgccag 2641 gaaccgatgg tatgtgtcca gaatcagtgc ctctgcccgg agaacaaggt gtgcaaccag 2701 tgcgccacac aaccgtgcca gaatggcggt gaatgtgtgg acctaccgaa tggagactac 2761 gagtgcaagt gcacccgtgg atggactgga cgcacctgtg gcaacgacgt ggacgagtgc 2821 accctgcatc cgaagatctg cggcaatggt atctgcaaga acgagaaggg atcgtacaaa 2881 tgctactgta cgcctggatt taccggagtc cactgcgatt ccgatgtgga cgaatgcctt 2941 agctttccct gcctcaacgg agccacgtgc cacaacaaga taaatgccta cgagtgcgtt 3001 tgccaaccag gatatgaggg agagaactgc gaagtagata tcgatgagtg cggcagtaat 3061 ccctgctcga acggatccac ctgcatcgac aggatcaaca acttcacctg caactgcatt 3121 ccgggaatga cgggccgcat atgtgacatc gacattgacg actgtgtggg agatccctgc 3181 ttgaatggtg gtcagtgcat cgaccaattg ggtggcttcc gttgtgactg cagtggcacc 3241 ggttatgagg gcgagaattg tgagctgaac atagacgaat gcctctcgaa tccgtgcacg 3301 aatggtgcca agtgcctgga cagggttaag gactacttct gcgattgcca caacggctac 3361 aagggaaaga actgtgagca ggacatcaac gagtgcgaga gtaatccctg ccagtacaat 3421 ggcaactgcc tagagcgttc gaacataacg ctttaccaaa tgagtaggat cacggatctg 3481 cccaaggtgt ttagccagcc ctttagcttt gagaatgcca gcggctacga gtgcgtctgt 3541 gtgcccggca tcattggaaa gaactgcgag atcaacatta atgagtgcga cagtaatcca 3601 tgcagcaagc acggaaattg caatgacggg attggaacct atacctgcga atgcgaacct 3661 ggcttcgagg gcacccactg tgagatcaac atagatgaat gtgatcgcta taatccctgc 3721 cagaggggca cttgctatga ccagatagac gactacgact gcgactgcga tgcgaactat 3781 ggaggcaaaa actgttccgt tcttctcaaa ggctgtgacc agaatccttg tttaaatggc 3841 ggtgcctgct tgccgtattt gatcaacgag gtaactcatc tgtacaactg cacctgcgag 3901 aacggcttcc agggcgataa atgcgagaag accaccactc tgtccatggt ggccactagc 3961 ctgatttcgg ttaccacgga acgcgaggaa ggctacgaca ttaatcttca atttaggacc 4021 acactgccca acggagtttt ggctttcgga accaccggcg aaaagaatga accagttagc 4081 tatattttgg agctgattaa tggacgactg aatctacatt cctcgctcct aaataagtgg 4141 gagggcgtgt ttattggatc gaagctgaac gatagcaact ggcacaaggt gtttgtggcc 4201 ataaacactt cgcatctagt cctttcggcc aacgacgagc aggctatttt tccggttggc 4261 tcctatgaaa cggccaataa tagccagcct tcattcccgc gcacatacct cggaggcacc 4321 attcccaatc tgaagtccta tctgcgccac ctcacccacc aaccatcagc ttttgtgggc 4381 tgcatgcaag atataatggt caatggtaaa tggatctttc ccgatgagca ggatgcgaat 4441 atcagttata ccaaactgga aaatgtccag agcggttgtc cgcgcaccga acaatgtaaa 4501 ccgaatcctt gccattcgaa cggtgaatgc acggaccttt ggcacacctt cgcttgtcac 4561 tgtcccagac cattctttgg gcacacatgt cagcacaata tgactgctgc cacttttggc 4621 cacgagaaca caacccattc ggccgtgatt gtggagacca cagatgtggc taggcgagct 4681 attagatcca tcctagacat ttccatgttt attcgtacac gcgagccaac tggtcaagtc 4741 ttttacttgg gcactgatcc acgcaaagcc cccactaaaa atattggcga ctcatatgtg 4801 gccgccaaat tacacggcgg cgagctgctg gtaaagatgc agttcagcgg tactccggag 4861 gcctacaccg ttggtggcca gaaattggac aacggctata accacctgat cgaggtggtg 4921 cgcaatcaaa cgctcgtgca ggtcaagctc aatggcaccg agtacttccg caagacgctg 4981 tccacgacgg gtctgctgga cgcacaggtg ctttacttgg gcggacctgc acccacacgc 5041 gagtcacttc tgggcgcgac cacagaacca ggaataattc cagttccggg agcaggaata 5101 cccattgaag acacaacagt gcccaaggag gcggacgaca gcagggacta ctttaagggc 5161 ataatccagg acgtgaaggt tagcaatggc tcgctcaacc tgattgtgga gatgtattcc 5221 ctaaacgtga cagatgtcca agtgaatgcc aaacctctgg gcgctgtaac catcgatcgt 5281 gcctccgtgt tacctggtga ggtgtccgat gatctgtgcc gaaagaatcc ctgcctccat 5341 aatgccgagt gcaggaacac atggaatgac tacacttgca aatgcccaaa tggttacaag 5401 ggaaagaact gccaggagat cgaattttgc caacacgtta catgtccggg acagagcttg 5461 tgccaaaatc tggacgatgg ctatgagtgt gttacgaaca ccacatttac tgggcaggaa 5521 cgcagtcctc tcgccttctt ctacttccag gagcagcaat ctgacgatat tgtcagtgaa 5581 gcgtctccca agcaaactct taaaccggta attgatattg ccttccgcac tcgtgctgga 5641 ggtactctcc tgtacataga caatgtggac ggattctttg aaattggagt aaacggagga 5701 cgagtgacca tcacctggaa gctaagtgca ctgcattttg gcgagtctgc acgctttgag 5761 aaggagaaca ctgacggaga atggagtcgc atttacctca gggcacacaa cagcaaactg 5821 gagggtggat ggaagggatg ggaatcgatg gtggatccga cgccagcttt ttccacggac 5881 atcgaccaag cggcctttca gtccctgatc gctacaagta cccaggttta cttgggtggc 5941 atgccagagt cgcgacaagc acgaggatcc actttgtctg cccagcaggg ctctcagttc 6001 aagggctgtg tgggagaggc aagggtgggc gatcttttac tgccctactt ctccatggcg 6061 gaactgtatt cgcgcaccaa tgtttcagta cagcaaaagg ctcaattccg tctaaatgcc 6121 acacgacctg aggagggctg catcctgtgc ttccagtcag actgcaaaaa tgacggcttc 6181 tgtcaatctc cttcagatga gtacgcctgc acctgtcagc ctggattcga gggcgatgat 6241 tgcggcacgg acatcgacga gtgtcttaac acggaatgct tgaacaacgg cacctgcatc 6301 aaccaggttg cagctttctt ctgccagtgt cagccaggat tcgagggtca gcactgtgag 6361 caaaacatcg acgagtgtgc ggatcagccg tgccacaacg gtggcaactg cacggatctt 6421 atcgcatcgt acgtgtgcga ctgccctgag gactatatgg gcccgcagtg cgacgtgctg 6481 aagcaaatga cctgcgagaa cgagccatgt cggaatggat caacctgcca gaatggattc 6541 aatgcttcta ctggcaataa ctttacatgt acatgcgtgc ccggcttcga gggtccactg 6601 tgtgacatac ccttctgtga aataacgcct tgcgataacg gtggcctctg cctgaccact 6661 ggagcggtac cgatgtgcaa atgtagtctg ggatacactg gtcgcctgtg cgagcaggac 6721 attaacgagt gcgaatcgaa tccatgccag aacggtggtc agtgtaagga cctcgtcggc 6781 aggtacgagt gcgattgcca gggcaccggg ttcgagggca ttcgctgtga aaatgacatc 6841 gacgagtgca acatggaggg agattactgc ggcggattgg gccggtgttt caacaagccc 6901 ggatccttcc agtgcatctg ccagaaaccc tattgcggag cctactgcaa ctttacggat 6961 ccctgcaacg ctacggacct ctgctcaaac ggcggtcgct gcgtagagtc ctgcggcgcc 7021 aaaccggact actactgcga gtgtccggaa ggtttcgcgg gaaagaattg cacagcaccg 7081 attacggcca aggaggacgg gccttcgacc acagacattg ccatcattgt aatacccgta 7141 gtggtggtgc tgctgctgat cgcgggagcc ctcctgggca ccttcctggt gatggccagg 7201 aacaagcgag caaccagggg cacctatagc ccgagcgcgc aagagtactg caacccacgg 7261 ctggaaatgg acaacgtact gaagccaccg ccggaagagc gactaattta gttttgagtt 7321 ttgagcatga acgacgatta gcaaagcaaa caaaagatat ttttaaatcc gcccatatac 7381 acctagctgt aggagtaact caatgttttg tactaagttg gcccctagtt atggtttaca 7441 tcttaaggtg ctcaaagcaa tagcagcagc agcagcagcc aggcttccac ctcgactcgt 7501 cccttatccc ctgcctacgc tttagttagt taataatgcc gttgtctatt tattctagta 7561 gtttagatga catacgtacc gccctatagt cgttatgtag ttatgttccg atagtttaga 7621 ttcagtattc gatttctcgt atatgtaatc ctaaagctgc gaacaaagtt gagctccgac 7681 gtcgatttcc cctttgcatt ccacaaggaa gcccatcaaa tgtattgtat gagtattttt 7741 gtaaataaga ttgtttgccg actcttaaac taaattagct gagctaaaat cgaaattaaa 7801 aacagaaaat cctatatgcc tatatatacg cgagtatata tatcagtaaa tgtggcctta 7861 taacaaaaaa aaatatagta acgaaaagca atgacaacta gaacagaaaa agtattggtt 7921 aagtaaatca aataaaaaac atattttgct ctagagtatc taagcgtaaa ctt //