Dbfetch

LOCUS       NM_001259642           10136 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster spinophilin, transcript variant C (Spn),
            mRNA.
ACCESSION   NM_001259642
VERSION     NM_001259642.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 10136)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10136)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10136)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 10136)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 10136)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 10136)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 10136)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 10136)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 10136)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 10136)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 10136)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 10136)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 10136)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 10136)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   22 (bases 1 to 10136)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 10136)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   24 (bases 1 to 10136)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   25 (bases 1 to 10136)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_037436).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10136
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="3L"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..10136
                     /gene="Spn"
                     /locus_tag="Dmel_CG16757"
                     /gene_synonym="BcDNA:GM16129; c62E-5; CG16757;
                     Dmel\CG16757; E62; EL62; l(3)06911; spn"
                     /note="Spinophilin"
                     /map="62E4-62E5"
                     /db_xref="FLYBASE:FBgn0010905"
                     /db_xref="GeneID:46194"
     CDS             670..7074
                     /gene="Spn"
                     /locus_tag="Dmel_CG16757"
                     /gene_synonym="BcDNA:GM16129; c62E-5; CG16757;
                     Dmel\CG16757; E62; EL62; l(3)06911; spn"
                     /note="CG16757 gene product from transcript CG16757-RC;
                     CG16757-PC; Spn-PC; SPINOPHILIN; d-spinophilin"
                     /codon_start=1
                     /product="spinophilin, isoform C"
                     /protein_id="NP_001246571.1"
                     /db_xref="FLYBASE:FBpp0293156"
                     /db_xref="GeneID:46194"
                     /db_xref="FLYBASE:FBgn0010905"
                     /translation="MEKPMHHAPAPVGKVSQIANIFQRKPIEIQPVEQLSAVAAAHAA
                     AAAAAAAAHHAHVQGAPAVRTESHSARFNNARALFEKLGVESNSNVSSRLLRSGSRED
                     NLCDGSDRSSSRSSDRSQSPPKRRTPFPSGVSLVHNNNNAAIVAQNGVPPEQRLSNSK
                     FIVEPAAQVVPTSVVKYPQHNISRLKSEEPSPVPPPASGSVSALFASSGGDKPEKPER
                     KFNSRELIEKQKKWTSHFTKTKTTRTHSDLNRCDIIRTVPGTGLIMDSEKVAKPAMEP
                     PQPPPNASPNPPMRAQAPPEIKPRSGKIGSPVKSPPLPPIPAVKPKNVSPVKFNPDRL
                     RQSPTKTADNSPPPPPAKSAAVLQRSLMQEQQELLRNSCDQGVAPIPPEKPRKKSVDL
                     IEDTLPLTNCSTPSSCASPTSSYLMQPAKRGSLDGGSGNGQYPGNGLSGSTNSATSGS
                     PVASASSGPSSPVHTEDEKQENESTEKSEMEYYHGGNYNSVPRRRRSENEGRKSVDES
                     SPSANNSQQQQQHSIPGSAAGSPQRVANKRSSITVNMPAAGLGQRPPSIISTTSQDEG
                     GFNESAPELKAKLQPAYDQTEEQPHSLNYVDVGYRLNPDGSESREVYGSEAELYDTAK
                     VTDMQRKFHGANGFGQESSTVYAIIKPDVQESQPVAPSRSVLIQSPNSSSVEGSPLHR
                     GSYSSPPVGVVSPIRRRNSSNQDQSVGGGGSAKTTPQCSPARSALVKGIAPIASIDAH
                     EEEELDLVEEDEHLAVEYVEVLELQQDEEEEEAPVLPERRAPAQGSLELQDLEYADTS
                     AGEDEEDIINHLKDGDVLDVELIDDVVDEVIKVHVNHSVATAPSIQAATPAAAIPRED
                     SLPDDMTAAEAERLLSSSILENKIRQQSLLSDEQAKEVEQILNAAPSVGVAVATVVAT
                     ATSPTSIKNLIEDLPGQSAVAASAANGEQDIQIAAVPAIVEEDEDEEEDFPEDDEEDH
                     ARADFDANGGDADGDSDDVEAVDIVGYGHASTALNATFVKADSTETETTTTTPSTATT
                     ATTRHDDDEPEWLRDVLEAPKRSLENLLITSATSSRAPGQREELENGYDLHEKHSDLN
                     QTYITGGESLHESIVSVESTQSDATLNQTTTIDDSIISSKHNSTYSLADAEQATSSTV
                     LSTGVTELDDSQYYIPEYPPVRSKEVLVEAGVHYFEDGNFWMEVPGLLDFDDDDCSYP
                     PITVRKNPKVRFSSGPIHVYSTFSVNDYDRRNEDVDPVAASAEYELEKRVEKMHVFPV
                     ELMKGPEGLGLSIIGMGVGADAGLEKLGIFVKTITDNGAAARDGRIQVNDQIIEVDGK
                     SLVGVTQAYAASVLRNTSGLVKFQIGRERDPENSEVAQLIRLSLQADREKEERLKRQQ
                     EEYLRRTLDYSEDSTQPVSANSSVCEGPSSPVQVEHPMEVEATHSQEVESLKRLLQES
                     EMGCLVKEEIIQNLKRKLVKLETTGNENELLSERLRQSERELGNIRKEAANLQNMLQQ
                     SQGQYMALDKKYNKAKRLVREYQQRELDMCHREEFYQQLLQEKDTEYNALVKKLKDRV
                     INLEHELQETQRKAGFPVGLPYDSATLKLTPQMMRKTPPKPLFHKLETELSDTEISDL
                     SPDGDGVKTATVERKVPVKDELDAAVPQHELLDNSINKTKIDLASRGGLANRQLPSAN
                     GNSSTSNGAAVDLGQLSNGNLLKRSRSNSRSSDCTLDDTDEEEEREGSALNLAGAPVA
                     HETISLSNGNSHLLANVNNLLQHHPPAMATVIATPSNGHLGTTTPILLNSTSSASSSS
                     SNQSTAREAQINQLYAQVHKDPSKQQHQQQQQQQQQAQAVTTSIPSIFKNALGSPADN
                     GLNDFHRGSMTTFGTGPATSSNRDLNSSYDSILGSNDKLAENDPAESWMYPSRRRVAP
                     NGSKVPLPGSSFTDQLNQALSDRERRLGDGSSRHSSDDYTEINKSQSAAAINCKTLIN
                     EIRQAVNEAQPKVPWQQQHHQQIQQQPSAHTTGPPSPTSMSSGCSSPGYSPSRTLDLS
                     GSSSSFSDRKAMAAGYTYKGGPVHEWTKDQVGHWLMGIELERYIPVFKENNVEGGALL
                     TLDSKDFKTLGICGDDKHRLKKRLKDLKANIEKERKDMERERREREKAIRKAEKKAAK
                     KK"
ORIGIN      
        1 ggcccgaaat tcaagctaaa cggacgcgtt ttcgtcgcga gtttaaccgc tgcaaaaata
       61 tcaacaataa gtataaattg ccgcgggtac tgagttcata tgatgatcga gtgatttttt
      121 tcatcgtaca attaacgtcc ttcgaaatag gatatattcg agtattccgg gtcgcgagta
      181 tttaaaaaaa aggatttgtg tataccgaaa gggctaaaca aaaagctttt taaagaaatt
      241 tgcattttca tcttgcgcaa aaggcaaacc aaacacacaa aaaatgctga caccgatgag
      301 gccagcggtg ggttgattgg ctgacaacca cgacgacgtc cacggacgag aagaaaaagc
      361 tagacacgct tcagtgcatc gagtgggagg aagtggaagt ggaagcggat ttgcagttga
      421 cagtggggag ccggagcagc atcacctggc tccacttgag tacgaaaaaa agtttgaaaa
      481 aagaaaaaaa aactgcagaa aaagagcact acaaacatcc cgccacaatg acaaatgttt
      541 ggatcggagc caggctttag gtgtagagca ggtttaatca aacaacaaaa agaaaagccg
      601 aggggtccag cgaggagcag gaggaaggac accacatagc acctgaattg accaggagaa
      661 agtttaatca tggagaaacc gatgcatcat gcacccgctc ccgtgggtaa ggtgagccag
      721 atagccaaca tcttccagcg caagcccatc gagatccagc cggtggagca gctaagcgct
      781 gtggctgccg cccacgccgc tgccgccgcc gctgctgctg ctgcccacca cgcccacgtc
      841 caaggagctc cggcagtgcg aacggaatcc cactccgcca ggttcaataa cgcccgggct
      901 ctgttcgaga aattgggcgt tgagtccaac tcgaatgtta gctctcgact gttgagaagt
      961 ggttcgcggg aggacaactt atgtgacggc tcggatcgat cgtcctcacg ctcctcggat
     1021 cgctcacagt cgccgcccaa gcggaggact ccgtttccct ccggggtatc actcgttcac
     1081 aacaacaaca atgccgccat tgtggcccag aatggagtac caccagagca acgcttgagt
     1141 aacagcaaat ttattgtgga accagcggcg caagtggtcc ccacctcggt ggtcaagtac
     1201 ccgcagcaca atatatcccg attgaagtcg gaggagccat cgcctgttcc accaccggcc
     1261 agcgggtcag tgagtgctct gttcgccagt tcaggcggtg acaagccgga gaaaccggag
     1321 cgaaagttca attcacgcga gctgatcgag aagcaaaaga agtggacctc ccattttacc
     1381 aagaccaaaa caactcggac gcacagcgat ctaaaccgct gcgatataat acgtacagtg
     1441 cccggaaccg ggctgatcat ggatagcgaa aaggtggcca aaccggcaat ggaaccgcca
     1501 caacctccac caaatgccag tcccaatccg ccaatgcgag cacaggctcc gccagaaatc
     1561 aagccaagga gcgggaagat tggcagtccg gtcaagtcgc cgccattgcc gcccattccg
     1621 gcggtcaagc caaagaacgt gagcccggtg aagttcaatc cggacaggtt gcgtcagtcg
     1681 ccgactaaaa ctgcggataa ttctccgcca ccacctccgg ccaaatcggc agctgtgctt
     1741 cagagatccc tgatgcagga gcagcaggag ctgttgagga actcctgcga tcagggcgta
     1801 gcccccattc cgccggagaa gccgcgcaaa aagtccgtag atctcatcga ggacactctg
     1861 cccttgacca attgctccac gccctcatcc tgcgcctcgc ccaccagctc atacttaatg
     1921 cagccggcca agaggggatc gctggacggc ggatccggaa acggacagta tcccggcaat
     1981 ggactcagtg gcagcaccaa ttcggccaca tctggctcac cggtggccag tgcctcctcg
     2041 ggaccttcgt cgccagttca cactgaagat gaaaagcagg agaacgagtc cacggagaag
     2101 tcggagatgg agtactacca cggaggcaac tacaacagtg ttcccaggcg acgacgcagc
     2161 gaaaatgaag gtcgcaaatc tgtggacgaa tcttcgccat cggccaacaa ctcccagcaa
     2221 cagcagcaac attccattcc gggctccgcc gccggatctc cacagcgagt ggccaacaag
     2281 cgtagcagca tcacggtgaa catgccggcc gccggtcttg gccagcgtcc cccgagcatt
     2341 atatcgacca ccagccagga cgagggtggt ttcaatgagt ccgcgcccga gctgaaggcc
     2401 aagctgcagc ccgcctacga ccagacggag gagcagccgc atagcctgaa ttacgtggac
     2461 gtcggctatc gcctgaatcc cgatggcagc gaaagtcgcg aggtttacgg atcggaagct
     2521 gaactctacg acacggccaa ggtgaccgat atgcagcgca agttccacgg agccaatggt
     2581 tttggtcagg aatcgagcac ggtttacgcc attatcaagc ctgatgtgca ggagtcccaa
     2641 ccagtggctc cctcaagaag cgttctcatc cagtctccaa attcctccag cgtggaggga
     2701 tctccactgc atcgcgggtc gtatagttcc ccacccgtgg gtgtggtttc acctataagg
     2761 cggcgcaata gcagcaatca ggatcagagt gttggtggtg gaggcagtgc caaaaccacg
     2821 ccccaatgct ctcccgcccg ttcggcctta gtaaagggca ttgcccccat tgcttcgatc
     2881 gatgcgcacg aagaggagga actagatctc gtagaggagg acgagcacct ggccgtggag
     2941 tatgtggagg tgctggaact ccagcaggac gaagaggagg aagaggctcc ggtccttccc
     3001 gagcgacgag ctccggctca aggctccctt gagcttcagg acttggagta tgccgatacc
     3061 agcgctggcg aggatgagga ggacatcata aaccatctaa aggacggcga tgtattggat
     3121 gtggaactaa tcgacgatgt cgtggatgag gtgatcaagg ttcatgtgaa tcacagtgtg
     3181 gccactgccc cttcgattca agctgctaca ccagctgcag cgattccacg ggaggatagc
     3241 ctgccggatg acatgaccgc cgccgaggcc gaaagattgt tgagctctag cattttggaa
     3301 aacaaaatca gacaacagtc gctgctgtcg gacgaacagg ccaaggaagt cgagcaaata
     3361 ctcaacgccg cccccagcgt gggcgtggca gttgctaccg ttgttgccac agcaacatcg
     3421 ccgaccagca tcaagaatct cattgaggat ttgcccgggc aatcggcagt cgccgccagc
     3481 gctgccaacg gggagcagga cattcaaatc gcagctgtcc cagcaattgt cgaggaggac
     3541 gaggacgaag aggaggactt cccggaggac gacgaggagg accacgccag ggccgatttt
     3601 gatgccaacg gcggtgacgc tgacggcgat tccgatgacg ttgaagccgt ggacattgtg
     3661 ggctatggcc atgcatccac agctctgaat gccaccttcg tcaaggccga cagcacagag
     3721 acagagacaa ccaccactac accttcgaca gcaaccacag ccaccactcg ccacgacgac
     3781 gacgagcccg agtggctaag ggatgtccta gaggcaccca agcgcagcct agagaacttg
     3841 cttatcacat ccgccacttc gtccagagca cctggtcagc gtgaagagct ggaaaacggc
     3901 tacgatctac atgagaaaca ttccgatctc aatcaaacgt atattactgg tggggaatca
     3961 ctgcacgagt cgatagtttc cgtggagtcc acgcaatcgg atgccacact caatcagacc
     4021 acgaccatcg acgacagtat catctccagc aagcacaatt ccacctactc cctggcagat
     4081 gccgaacagg ccaccagctc tacggttttg agcactggcg ttaccgaact cgacgacagt
     4141 cagtactaca taccagaata tccgccagtt agaagcaagg aggttctcgt agaggccgga
     4201 gtccattact tcgaagatgg caacttttgg atggaagtgc ctggtctctt agactttgac
     4261 gacgacgact gctcttatcc gcccatcact gtacgcaaga atcccaaggt tcgctttagt
     4321 tccggaccca tccacgtgta ctcgactttt tccgtaaacg actacgatcg ccggaatgaa
     4381 gatgttgatc cggtggccgc ttcggcggaa tacgagctcg aaaagcgcgt ggagaagatg
     4441 catgtcttcc ccgtggaatt gatgaagggt cctgagggtc tgggtctcag tataattggt
     4501 atgggcgttg gcgccgatgc aggcttagag aaactaggaa tctttgtgaa aaccattacc
     4561 gacaacggcg cagcagccag agacggtcgc attcaggtca acgatcagat tatcgaggtg
     4621 gacggcaaga gtctcgtggg cgttacacag gcatatgcag catcagtact gcgcaatact
     4681 tccggtctag tcaaattcca aatcggacgc gagcgcgatc ctgaaaactc tgaggtagcc
     4741 cagctcatac gactgagttt gcaggccgat cgtgaaaaag aggagcgctt gaagcgccaa
     4801 caagaggagt acctgcgccg cactctcgac tattccgagg actccactca gccggtttcg
     4861 gccaactcga gtgtctgcga gggaccctcg agtcccgtcc aagtggaaca tccaatggag
     4921 gtggaggcca cccactcgca ggaggtagag tcgctcaagc ggctgctaca ggagagcgaa
     4981 atgggttgcc tggttaaaga ggagattatt caaaatctta aacgaaagct ggtcaagctc
     5041 gagacgacgg gcaatgagaa cgagctgctt agcgagcgac tgcggcaaag cgagcgggag
     5101 ctgggcaata tccggaagga ggcggccaac ctgcagaaca tgctccagca gtcgcagggt
     5161 cagtatatgg cgctggacaa gaagtacaac aaggccaagc ggctggtcag ggagtaccag
     5221 cagcgagagc tggacatgtg ccatcgcgag gagttctacc agcagctgct ccaggagaag
     5281 gacaccgagt acaatgcgct ggtgaagaag ctgaaggatc gtgtgattaa tctggaacac
     5341 gagctgcagg agacgcagcg caaggccggt tttccagtgg gcctgcccta cgatagtgcc
     5401 actctgaagt tgacgcccca gatgatgcgt aagacgccgc caaagccgct cttccacaag
     5461 ctcgagacgg agctgtcgga tacggagata tcagatctct cacccgacgg cgatggcgtt
     5521 aagacagcca ctgtggagcg taaggttccg gtcaaggacg aactggatgc ggcagtgccg
     5581 cagcacgagc tgctggataa ctcgattaac aaaaccaaaa tcgatctggc ctcccgtggt
     5641 ggtttagcca accgccagtt gccctcagca aatggaaaca gtagcacatc gaatggagcc
     5701 gccgttgatc ttggccagct ttcgaatggg aatctgctca agcgcagccg gagcaacagt
     5761 cgcagctcgg actgcacgct ggatgacacg gatgaggagg aggagcgaga gggctcggca
     5821 ttgaacctag caggcgctcc tgtcgcccat gaaaccatca gtctctccaa tggcaactcg
     5881 catctgctgg ccaacgtgaa taatctgctg cagcaccatc cgccggcaat ggccacagtg
     5941 atcgccacac cttcaaatgg ccacctgggc accaccacgc ccattctgtt gaactccacc
     6001 tcctccgcct cgtccagttc gtccaaccaa tcgacggcac gtgaggcaca gatcaaccag
     6061 ctgtatgccc aggtgcacaa ggatcccagc aagcagcaac atcagcagca gcagcaacaa
     6121 cagcagcagg cccaggccgt gaccaccagt attcctagca ttttcaagaa cgctttgggt
     6181 tctccggcgg acaatggact caacgacttt catcgcggca gcatgaccac ctttggaaca
     6241 ggtccagcca caagcagcaa tcgtgatctc aacagctcgt acgactctat cctgggctcc
     6301 aacgataagc tagcggagaa cgatcccgcc gagagttgga tgtatcccag caggaggcga
     6361 gtggcaccga atggcagcaa agtcccactg ccaggatcca gctttactga tcaactcaac
     6421 caggcgctgt ccgatcgaga gaggcgactc ggcgatggat cctcgcgaca ttctagcgac
     6481 gattacacgg agattaacaa gagccagagc gccgcggcca tcaactgcaa gacgctgatc
     6541 aacgagatcc gccaggcggt gaacgaagca cagcccaaag tgccctggca gcagcagcac
     6601 caccagcaaa tccagcagca gccgtccgcc cacaccaccg gtccgccgtc gcccaccagc
     6661 atgtcctcgg gctgctcctc gcccggatac tcccccagcc gcaccctgga cctgtccggt
     6721 tccagctcta gtttctccga tcgcaaggcg atggcagcgg ggtataccta caagggtggc
     6781 cctgttcatg aatggaccaa ggatcaggtg ggacactggc tgatgggcat cgagctggag
     6841 cgttacatcc ccgtcttcaa ggagaataac gtggagggcg gagctcttct taccctggac
     6901 tcaaaggact tcaaaacctt gggtatctgt ggcgacgaca agcatcgtct gaagaagcgt
     6961 cttaaggacc tgaaggccaa catcgagaag gagcgcaagg atatggagag ggagcgaagg
     7021 gagcgcgaaa aggccatacg caaggccgag aagaaggcgg ccaaaaagaa gtagttgaat
     7081 tctagttgat aagcatcaaa gtagccaaaa accaaaagca tacgcagtat atattgtagt
     7141 ctatatacat acatgcatac acaacacaca caaggaaaac acgcgcgtat atataaacat
     7201 atatctattc ggttatatat ttatatgcat gtaatgataa tataatttat ttgtacaaca
     7261 tacatctatt atacatacgt actacatttt aacctatcga acctaatggc aactagacgt
     7321 aattattcta aaagaaagaa aagcaagaaa agcagcaagt agcagatcag ggtcaggagt
     7381 ggtagtgtag cagtagatct cggttagaaa tgaccccgaa tcccacactc aaaccgggcc
     7441 caatatccaa ccgatggcac tcagactttc ccgactaaaa atcgaactca caaccaaaag
     7501 aagaagctaa gtaactaaca agaaggcgtt ggactgactg attttatgat taatttaaaa
     7561 agaaaaacaa acaaaaggaa ttctttttta agccaaccaa aaccaaaatg aaccatttga
     7621 attggagttg caaacaaaag catatagaac acttaaggaa ttcgctgaac agacttgaac
     7681 ggtgtaagag ctgcttcaaa taaaatacgg aatataaggt taatattgta ataacgttta
     7741 agttaatgca aggcagcacc caagggagtg tctcgttttt ctaattatta atctgtgtaa
     7801 tttaatgact agcgcatatt caataatatt caattctaga tatacatata catatgtgtg
     7861 tgcaacagtt atatgtcaag acatttacgg aacgtactgt actatcccct aaaaattaat
     7921 gctaaagtat tgtactgtat gctatgcctg aaagtcattt aagtacttaa gtgtagagaa
     7981 gctagtggaa gtgtgtgttt tctgttacca accgggctgc caggaaacta actaactaac
     8041 tgaaatgcag tcggttacat ttcgagcagt ttcagcagcc aaatcaatgc aaagtgtcca
     8101 cccaaatttg ttaagcagcc aaaaaagaaa aaggaagcaa gcagcttcaa gagcgatttc
     8161 tattcgttag caagtatgtc tgtgtgaatg ggcgtgattg tagctttaat ttcaatttac
     8221 tttttgtata aatatttatg gaacctttag tattcgtatt tcatattctt agttgtttgt
     8281 atttacttcg tgtgtacttg tgttgtgtac gtagttttat ttaccttata atttcgaaat
     8341 gttgcaataa aaccgcatac atatgccggt gtatgtataa caaatcaagg ctcattctac
     8401 ttatcagata gcatctggtt gaataattcg actccctgtg aatgcaacac cacctaatcg
     8461 agggccacaa caatccaacc gactttgatt tatcgaggaa aaaccaaatt tagcaactag
     8521 tccttggttg attaccaatt agcatataat acttatcaac atacgtatat acgaatactc
     8581 tcttctctct atcactctgt ctctatttga ctttaagacc ccggccgcgg ccagaaggag
     8641 actccatccc accggaatgg aggatcctgt ggacctgacg gccggcagcg cataatcacc
     8701 gcatgtgtct cactcgtctc gtcgcaagtc cttaatatag cttttgaaaa gctcgcctct
     8761 aaacagtgcc accaacgaaa acaaaagaaa atcaaccgtt attacttacg aaaaaacgat
     8821 aaaaaaaaca cctttaaaaa cgaataacta aatcagtaaa ttcagaggcg gctcgcctgc
     8881 gattttgaac gcaaacttcc ggtttttctg ggcatccggc ctttcgaaaa accggtttca
     8941 gatcgcaagc gtgccgtatt ccaagataat tgttattttt ttgaatatgt acctcggtta
     9001 aagtttattt ttgggtaatt gtttgtaagc gttttttaca ccatcaaaaa agaaaagaaa
     9061 aaaatgcaaa aaaaaaaact aacaatcaaa aaccagtttg aaattcgtaa aattaatgat
     9121 acaagtaatt tagctgttgc cccgaaattc ttaaagagta ggggccagtc gcataacata
     9181 aaaaaaaacg aaatgtttga gcctacggaa cacattcgtg cctttttcat tgcgaaaaac
     9241 cgtcccagaa ccagaataac cgatcagagg atgcgaatgc catctattcg ggtctccagt
     9301 ggataccgtc agcatccgaa atcgtagagc ccgagattct ctgtcacgaa tacgttgaaa
     9361 cacctaaatc ccgcaaatgc cttaaatcaa gaaaattata ttacccatta gatatccaac
     9421 attactcagt tcgcttgtag gttttgaagc attttcgaaa tacatatttt agttctccgt
     9481 ttgcaaacaa agttgactgg attttgtgtc cccgacacgt agaggtgtga atttatctgg
     9541 agtttccaca aaccatttct ctcttttgaa atattccgaa aacgttcttc atttctttat
     9601 gttttcccaa cattcgcttc gtatttgagt tggtcctttt tttgtttcgt cctatcagtt
     9661 cggtttctat attggtttgt tcaaatctat tgcagtttgt gtattttttg agtgtactgt
     9721 ttatatttgc aataaaatta aggcggtccc aggagataat taatacttgg gccaatcccc
     9781 aatgaggtgg aattaaaaag atatttatac aactatacaa aataatctat tcgtcgattg
     9841 gtcagcttgc ttcaatctct gttgccattt tattgatact ttcacgcata taaattggaa
     9901 attagattac ccttccctca aattataaaa acggaattgg tcagcgcaaa aagtattgtg
     9961 aaggtttata aaagaaacac tacacttagc aattaatgcg actagccaat tattattgat
    10021 gacagcactg caattagcta aacaagtaaa ttgaaaagta aaaatcgcaa ccaaatcttt
    10081 caaatcatgg aaaataataa atctcaaaat cagtgctaat aaatatactc tgaaat
//