Dbfetch
LOCUS NM_001169643 2953 bp mRNA linear INV 26-DEC-2023
DEFINITION Drosophila melanogaster peroxin 6, transcript variant C (Pex6),
mRNA.
ACCESSION NM_001169643
VERSION NM_001169643.2
DBLINK BioProject: PRJNA164
BioSample: SAMN02803731
KEYWORDS RefSeq.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (bases 1 to 2953)
AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
Strelets,V., Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: Impact of
High-Throughput Data
JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015)
PUBMED 26109357
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2953)
AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
Russo,S.M. and Gelbart,W.M.
CONSRTM FlyBase Consortium
TITLE Gene Model Annotations for Drosophila melanogaster: The
Rule-Benders
JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015)
PUBMED 26109356
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2953)
AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
TITLE The Release 6 reference sequence of the Drosophila melanogaster
genome
JOURNAL Genome Res 25 (3), 445-458 (2015)
PUBMED 25589440
REFERENCE 4 (bases 1 to 2953)
AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
TITLE Sequence finishing and mapping of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1625-1628 (2007)
PUBMED 17569867
REFERENCE 5 (bases 1 to 2953)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
TITLE The Release 5.1 annotation of Drosophila melanogaster
heterochromatin
JOURNAL Science 316 (5831), 1586-1591 (2007)
PUBMED 17569856
REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE 6 (bases 1 to 2953)
AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
Ashburner,M. and Anxolabehere,D.
TITLE Combined evidence annotation of transposable elements in genome
sequences
JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005)
PUBMED 16110336
REFERENCE 7 (bases 1 to 2953)
AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
Celniker,S.E., Rubin,G.M. and Karpen,G.H.
TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly
JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002)
PUBMED 12537574
REFERENCE 8 (bases 1 to 2953)
AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
Rubin,G.M., Ashburner,M. and Celniker,S.E.
TITLE The transposable elements of the Drosophila melanogaster
euchromatin: a genomics perspective
JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002)
PUBMED 12537573
REFERENCE 9 (bases 1 to 2953)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REFERENCE 10 (bases 1 to 2953)
AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
Gibbs,R.A. and Rubin,G.M.
TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence
JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002)
PUBMED 12537568
REFERENCE 11 (bases 1 to 2953)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REFERENCE 12 (bases 1 to 2953)
AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
Smith,E., Yu,C. and Rubin,G.
CONSRTM Berkeley Drosophila Genome Project
TITLE Drosophila melanogaster release 4 sequence
JOURNAL Unpublished
REFERENCE 13 (bases 1 to 2953)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 14 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 15 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 16 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 17 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 18 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 19 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 20 (bases 1 to 2953)
CONSRTM FlyBase
TITLE Direct Submission
JOURNAL Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE 21 (bases 1 to 2953)
AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
Park,S., Svirskas,R. and Karpen,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 22 (bases 1 to 2953)
AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
Svirskas,R. and Rubin,G.
TITLE Direct Submission
JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
64-121, Berkeley, CA 94720, USA
REMARK Direct Submission
REFERENCE 23 (bases 1 to 2953)
AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
CONSRTM Drosophila Heterochromatin Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE 24 (bases 1 to 2953)
AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
Rockville, MD 20850, USA
COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This
record is derived from an annotated genomic sequence (NT_033778).
On Jul 15, 2014 this sequence version replaced NM_001169643.1.
##Genome-Annotation-Data-START##
Annotation Provider :: FlyBase
Annotation Status :: Full annotation
Annotation Version :: Release 6.54
URL :: http://flybase.org
##Genome-Annotation-Data-END##
FEATURES Location/Qualifiers
source 1..2953
/organism="Drosophila melanogaster"
/mol_type="mRNA"
/db_xref="taxon:7227"
/chromosome="2R"
/genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
gene 1..2953
/gene="Pex6"
/locus_tag="Dmel_CG11919"
/gene_synonym="CG11919; CG30019; DmCG11919; DmelPex6;
Dmel\CG11919; PEX6"
/note="Peroxin 6"
/map="47C5-47C5"
/db_xref="FLYBASE:FBgn0033564"
/db_xref="GeneID:3772165"
CDS 173..2866
/gene="Pex6"
/locus_tag="Dmel_CG11919"
/gene_synonym="CG11919; CG30019; DmCG11919; DmelPex6;
Dmel\CG11919; PEX6"
/note="CG11919 gene product from transcript CG11919-RC;
CG11919-PC; Pex6-PC"
/codon_start=1
/product="peroxin 6, isoform C"
/protein_id="NP_001163114.1"
/db_xref="FLYBASE:FBpp0308554"
/db_xref="GeneID:3772165"
/db_xref="FLYBASE:FBgn0033564"
/translation="MNENDDAKKVVGKRNSVSFDQQDPGQPRFSFSGRVQELVEGYNS
AIQLLAPKWPWFLYPGYLTYAVYWRYAKYYKGKFLLTPIPNRLYDLLIKNEQIKSEHL
VFASQEVYENYAESPDVNFVNLVIRGRRVRIGKPLASDEGNMTQTVIKQMLQEAPHTI
VAQILPAAQCQPNCLYVQENFYGNILDRFQIRSNCWVQVEHFADEQTIPGIATKAHVY
LVADPHELPAELTEVILSNYFNTPRLMHRGHTYRIEVNAELVGTATYAHYYLIFAHLR
HVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLPRQVLDSMAIVENYPSGLR
KPYKLLRSSVDAFLPKKSACLSSKHIFPVFLLQGERGSGKSKLVSAVAQELGMHIYGA
DCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNFEIFGIDNEGNEDLRLLSAFHV
QVQELFNRDRKHPIVVVALTSDRHLKPMIQGLFLEIINIDMPSKEERFEILRWMHVRE
TFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVAAKSQGFLLGDLQL
LYDNAVRMKIRNRLGRTTLDMSHFAKNLTDMQSSFADSLGAPKVPKVYWSDIGGLAKL
KDEIQSSIGLPLKHVHLMGKNLRRSGILLYGPPGTGKTLVAKAVATECNLSFLSVQGP
ELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGGVMDRVVSQL
LAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAAVLR
AQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKE
LVPENVIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASYSV"
ORIGIN
1 agcaaatatc ttaccagaat caaaacattc gtaatgaaga ggagagtaat tgtgaaaaag
61 tgtatttgtc tggcgcctat cccccaactc cttgaacttt gacaccgcct cctcgaaatt
121 aacccttgta ctcgtgcttt ctgttgtgtt tagtccatat ttattgtaaa aaatgaatga
181 aaatgatgat gcgaaaaaag tcgtcggcaa gcggaattcg gtgtcgttcg atcaacaaga
241 tccaggacag ccgagattta gcttctctgg gagagtacag gagctagtcg agggctacaa
301 ttcggccata cagctgctgg cgcccaagtg gccctggttc ctctaccccg gatatctgac
361 atacgccgta tactggcgtt acgccaaata ttacaagggc aagtttctgc tgacccccat
421 tccgaaccgc ctctacgatc tgctgatcaa gaacgagcag attaagtcgg agcacctggt
481 gttcgccagt caggaggtgt acgaaaacta tgcggaatcg ccggacgtca actttgtcaa
541 cttggttatc cgcggcagga gggtaagaat cggtaagccg ctagcttcag acgaaggaaa
601 tatgacccaa acggttatca agcaaatgct ccaggaggcg ccgcatacga ttgtggccca
661 gatcttgccg gctgcacagt gccaacccaa ttgtctgtac gttcaggaga acttctacgg
721 caacatattg gatcgctttc aaatccgctc caactgctgg gtgcaggtag agcattttgc
781 cgatgagcag acaatacctg gaatagcaac caaagcacat gtgtacttag tcgcagatcc
841 ccatgaactt cccgccgaac tgacagaggt catcctgagc aactatttca atacacctcg
901 actcatgcat cgtggacata cctaccgcat cgaggtgaac gcagagttgg tgggcactgc
961 gacttatgcc cactattacc tgatattcgc tcacctacgc cacgtccacc taaagtgtat
1021 tcacctggag acaaagggca gcgagttcga gctgcaagcg attgttgcca aaaactttag
1081 caaccttgtt caagtgcctg catctcacag tttcctgcct cgtcaagtgc ttgacagcat
1141 ggccatcgtt gagaactatc caagtggact tcgaaagccc tataagctgt tgcgctcctc
1201 agtagatgct ttcctgccaa aaaagtccgc ctgcctgtcg tcaaagcaca tatttcctgt
1261 gttcctcctg caaggcgagc gaggatcggg caaatcaaag cttgtgagcg ccgtagccca
1321 agagttgggg atgcatattt acggagcaga ttgcgcagag atcgtttcgc aagttccctc
1381 ccacacggag atgaagctaa aagccgtatt tgccaagagc caagtttgtg aaccgcttat
1441 gatttgcttc cataacttcg agatttttgg catagacaac gagggtaacg aggatctgcg
1501 tctgctttcc gccttccacg tgcaggtcca ggaactcttc aacagggacc gcaagcatcc
1561 gattgtagtg gtggctttga ccagtgacag acaccttaaa cccatgatcc aaggactttt
1621 cttggagatc ataaacattg acatgcccag caaggaggag cgattcgaga ttcttcgctg
1681 gatgcacgtg cgcgagactt tcaacgatat tatctacaat cagaaggcta ttgagcaatt
1741 acccttgttc tcgcgggaaa atcagtcgca attcatgcca cgcatttctc ccagctggag
1801 ggaaaccctc aatgtccttc aggatgtggc tgcaaagtca cagggctttc tgctcggcga
1861 ccttcagttg ctgtacgaca acgcggttcg catgaagatt cgcaataggt tgggtaggac
1921 caccctggat atgtctcact tcgccaagaa cctcactgac atgcagagct ctttcgcgga
1981 cagtttgggt gcgcccaagg tgccgaaggt ttattggtcg gacattggtg gtctagccaa
2041 gctaaaagat gagatccaga gcagcattgg tctgccgctt aagcatgttc acctcatggg
2101 caagaatcta agaagatcgg gaatcctgct ctacggtccc ccaggaacag gcaaaaccct
2161 ggtggccaag gctgtcgcca ctgagtgcaa cctgagtttt ctttccgttc aaggtccaga
2221 gctactaaac atgtatgtcg gccagagcga gcagaatgtt cgcgaggtct tctccagggc
2281 tcgttctgcg gctccttgtg tactcttctt ggacgaactg gattccctgg ctcccaatcg
2341 aggtgtggct ggggactctg gcggtgtaat ggatagggtg gtgtcgcagc tattggcaga
2401 aatggatgga atgagcgatg gcgacactag caagcccata ttcattctgg ccgccaccaa
2461 tcgcccggat cttattgacc ccgctctttt gcgtcctggt cgctttgaca agcttttcta
2521 cgtgggacct tgttcaactg ccgaagacaa ggcagccgtt ttgcgtgccc aaacccagcg
2581 attcgctttg gacgccggtg tggacatgga acagattgcc gagcgtttga agagcgaaat
2641 gagcggcgca gatctgtact ccatctgctc gaatgcatgg ctctccgctg tgaggcgcac
2701 catagacgga cacttgagtg gaacaatatc agagaaggaa ctggtgccgg agaacgtaat
2761 tgtgcaggag gaagatttca cgaagtcttt caacaagttt gtgccctcga tcagcgccaa
2821 ggatctggag tatttcaaca acctaaaggc ttcatatagt gtctagagta tgcgcagatg
2881 gttaactagt tctaagagtt agttttttac agacattttt cgttgttttt caataaaccc
2941 gttgatagtt cac
//