Dbfetch

LOCUS       NM_001104049           10046 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster still life (sif), transcript variant I,
            mRNA.
ACCESSION   NM_001104049
VERSION     NM_001104049.4
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 10046)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10046)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10046)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 10046)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 10046)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 10046)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 10046)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 10046)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 10046)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 10046)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 10046)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 10046)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 10046)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 10046)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   22 (bases 1 to 10046)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 10046)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   24 (bases 1 to 10046)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   25 (bases 1 to 10046)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_037436).
            
            On Jul 15, 2014 this sequence version replaced NM_001104049.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10046
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="3L"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..10046
                     /gene="sif"
                     /locus_tag="Dmel_CG34418"
                     /old_locus_tag="CG32414"
                     /old_locus_tag="CG5406"
                     /old_locus_tag="Dmel_CG32414"
                     /old_locus_tag="Dmel_CG5406"
                     /gene_synonym="CG32414; CG34418; CG5256; CG5406;
                     Dmel\CG34418; Dm_3L:26493; lincRNA.447; RhoGEF; Sif; SIF;
                     slf; Stilllife"
                     /exception="dicistronic gene"
                     /note="still life"
                     /map="64E1-64E5"
                     /db_xref="FLYBASE:FBgn0085447"
                     /db_xref="GeneID:43892"
     CDS             782..7000
                     /gene="sif"
                     /locus_tag="Dmel_CG34418"
                     /old_locus_tag="CG32414"
                     /old_locus_tag="CG5406"
                     /old_locus_tag="Dmel_CG32414"
                     /old_locus_tag="Dmel_CG5406"
                     /gene_synonym="CG32414; CG34418; CG5256; CG5406;
                     Dmel\CG34418; Dm_3L:26493; lincRNA.447; RhoGEF; Sif; SIF;
                     slf; Stilllife"
                     /note="CG34418 gene product from transcript CG34418-RI;
                     CG34418-PI; sif-PI; still life; still life type 1; still
                     life type 2; still-life"
                     /codon_start=1
                     /product="still life, isoform I"
                     /protein_id="NP_001097519.2"
                     /db_xref="FLYBASE:FBpp0303155"
                     /db_xref="GeneID:43892"
                     /db_xref="FLYBASE:FBgn0085447"
                     /translation="MGNKLSCSCAPLMRKAYRYEDSPWQSSRRRDGHLLSSFRLWAEV
                     FHVSASGAGTVKWQQVSEDLVPVNITCIQDSPECIFHITAYNSQVDKILDVRLVQPGT
                     RIGQASECFVYWKDPMTNDTWGLNFTSPIDAKQFRECCSPSFKFSRKASSSYSLKLDP
                     PGKGKVKAKRKPLSTPASPSRVRQEPQCTCMSAEQYARLRTDPRVRGSSTLPRNVGSH
                     RITDVDGQQQVGSGKVVSAVSSTSLYDNVASGGPGTNQGADTLPRQMKGGQQDRQDVA
                     NSGVNTNTPGVIVTGVGNVGSDMCGQNHVGSQVGNDDPAACQMDMDLSKSEGTQAGGG
                     LHQSVGTCTSSSKGTGTRNKDFGDDMTRDAHSHDMHQHNVINNNTRRKTKSTEDMNVD
                     TSTLKRMLKPMPSTESPVTSPEMGRRRYNYYNANAAQTLGHPPHMHQHGMAMGMGGGG
                     GGGHHIMNNNTMGRASSQSSRFSGSRSSHEIGRGYPPRNLYLELERERSCIEGSPPSD
                     NVMFDNQCYATTPSSSNGNSDQDQSYGQQQSSGQHPQQQQGPPQRSSRHQHHHQQAPN
                     VTPTPGSPTSRLLLEYEMHLRNTLAKGMDAESYSLHTFEALLSQSMENLANAKSSTLP
                     LPPHRPLSTIRDKERDRDRDGYYSDRNELIRERERERDRGYLSDHNSSFSNSRCASCI
                     GESARAQWFRHSDGWRSGSSTIGSGSGHGMMTQQIPGSGHKRSPWDSLPSLRQDSSLN
                     DSGYKSARADSLEQRAEFIRQDSLRSEYLSDRESRYGIVQQASIESTDSRMCYLTSSE
                     ISDDDRMSLTTAVSDEDDGESVMASPYKAKATGTAASSFNCTGAVRKAGFLSVKKWLL
                     RKKHQIELARKRGWKGYWVCLKGTTLLFYPCDSREGRSVEAAPKHLIIVDGAIMQPIP
                     EHPKRDYIFCLSTAFGDAYLFQAPCQVELENWVNSIHSACAAAFARHRGKTGTLHLLQ
                     EEIFRLEKAIESDHKLKHMAELQQSVVTDQETRHQIQTQILQWEENLERLHCEQFRLR
                     CYMASLQSGELPNPKSLLTHVSRPTKNTLNKLGVFTVSSFHAFICARSPSLLNNLLAG
                     RGATKRRPPMLSRSNSGSSRRSMQMNSRDEPEKTFKVAMPDNAYSTVYLRDAMSVEEF
                     LASACARRNLNPMEHFVRVKKRRDMEDHNYFVPHRNDLIENYLHNHEFVEVCMKILYQ
                     VELQRTTLEQMWGFSVEAELIENAERQDELCCYVSRVEDKSVAMHNGIIKGDEIMVIN
                     GAIVSDLDMMYLESVLQEEQSLSMMMRSSRTEPPDLVGIMRVTDDMIDSLVCPPPPTD
                     PPVMSEEMITGLIVPAPGWNGTSKDLYSPEAESSPATSFVDPAAMAAQLAVGGVGGVV
                     VGGLGVAKPTSRTSSFEIENLLKTAEQETRKSSPTGSVTSSVSTTALTPSRQLTDAEK
                     LRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALFGNIHEIVTFQRQF
                     LQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSFCASHSKAQKVL
                     HPNEGNHALQEFLAARNPKQQHSSTLESYLIKPIQRILKYPLLLQQMRNLTDTRADEH
                     VHLCEALKGMEKVAEHINEMQRIHEEYGAIFDHLFRQHQKSCKQPIDLSPGDLLYYGG
                     VEWLNISDFLGKIKKGLELHAMCFVFKSAVVFLCKERLRQKKKLMGVSSKNATNEVEI
                     IRYQVLIPVTEVQVRASSAKDMDSHFLWELIHLRSQLQRRSEKVYVLSNSTADFRNAF
                     LKTIRQIIRESVRNMSIPMKNFGGSSGSVSGHSSQGMGSMGYPGNSQTLERPKQQITI
                     VHGSHTLGKPKKKSGSQRHSAGNIDYDNLSGSQEADDLPPSVGVVHYASGHTHGQQMQ
                     PAGFRGRSKTVGDVTEITCSSPEPHQQQQQQQQQQQQLMQQGHAHAHPHPHPHPREPP
                     PPPIRQPHLHHHSSDIERIDPGTKSEGEEDSQQGTIRPKATLGRTPNHLTLSTTSTLS
                     VGSTGSQARLIQSSHPPASYQPVLMKDLGSPVWKPRDMINLGTDPQSTTRKDDVKN"
ORIGIN      
        1 agtctcagtt gatctctgcc agagaattgt tgtgtgcaac gcggcggaat ttacatttac
       61 accatattaa cacagaaaaa tatgaagacc caaaaataaa ggaccctcaa gtccaattat
      121 caaacttaac caaaaacaat aacttagaca actaaaagaa tttcaacaaa gttaacaaag
      181 cgtttcagca acaaattttc aaaaacccac aaaccccaaa accaaaaaaa aaaccattaa
      241 aaaaattaaa attacacaaa gtaaacggaa aaagtttgta caattttttt tttttggcat
      301 aaaatgaaaa cagtttttca acgcataagt tatacaaata tggaaaggaa aaatgctggc
      361 gaaaactaag agttcaaggc aaatgtaaga atgaatctgt actctgtatc tggcatgatt
      421 ccaactaagg aaaacgaaaa ctctaaccta aatcaattaa tctaaatagt tctcaaacgg
      481 tttaaagttc caacaacaca atgtacaaag tctaaacatg tttaaaactt ctacttaaaa
      541 ctaaaaactt aaccgaaatc aaggacactt cagttaaagt gctaaatcca taaggaaaca
      601 tcactcaatc ttccaaataa actaagaaaa gcgatcgagt cgctaccaca accatcggca
      661 caaccagcgg tcacagtcgc tgaatcgcgg acaggcgctc tcgcaggcgg acgtgagcgg
      721 catgtggtga catcggggtg cctctggtaa aggatctgcg gcaagctgcg ccaactgcgc
      781 catgggtaac aaactgagct gctcctgtgc cccgctgatg cgcaaggcct atcgctatga
      841 ggattcgccc tggcaaagtt cccgtcgtcg cgatggccat ctattgagtt cgttcaggtt
      901 gtgggcagag gtcttccatg tatcagcgag cggagccggc accgtcaaat ggcaacaagt
      961 gtccgaggat ttggttcctg ttaacatcac ctgcattcag gactcgcccg agtgcatctt
     1021 tcacatcacc gcgtacaaca gtcaggtgga caagatactc gacgtgagac ttgtgcagcc
     1081 aggcacacgc attggccagg catcggagtg tttcgtttac tggaaggatc ccatgaccaa
     1141 cgacacctgg ggcctcaact tcacctcgcc catcgatgcc aagcaattcc gcgagtgctg
     1201 ttcgccttct ttcaaatttt cacgaaaggc ctcgtcgtcg tactcgctga aattggatcc
     1261 ccccggcaag ggcaaggtga aggccaagcg aaagccgctc agcactccgg cgtcgccgtc
     1321 gcgcgtccgc caggagcccc agtgcacctg catgtccgcc gagcagtatg cgcgcctgcg
     1381 aaccgatccc cgtgttagag gttcatccac tttgccgcgt aacgttggtt cgcaccgaat
     1441 caccgacgtc gacggccagc agcaggttgg ctccggaaaa gtggtcagtg cggtgagcag
     1501 cacctcgctg tacgacaacg tggccagcgg tggtcccggt accaaccagg gagcagatac
     1561 cctgccgcgt cagatgaagg gcggtcagca ggatagacag gatgtggcca atagtggagt
     1621 caataccaac actcctggcg taattgtcac cggcgttggc aacgtcggct ccgatatgtg
     1681 cggccaaaat cacgtgggct cacaggtggg caacgatgac ccggccgcgt gccaaatgga
     1741 catggatctc tcgaagagcg agggcacaca ggccggcggc ggactgcatc agagcgtggg
     1801 cacatgcacc tcctcctcca agggcaccgg cacccgcaac aaggactttg gcgatgatat
     1861 gacacgcgac gcgcactcgc acgacatgca ccagcataat gtaatcaaca acaacacccg
     1921 gcggaagacc aagagcaccg aggacatgaa cgtggacacc agcacgctga agcgcatgct
     1981 gaaaccgatg cccagcaccg agtcgccggt gacctcgccg gagatggggc gtcgtcgcta
     2041 taactactac aacgcgaatg cggcccagac attgggccac ccgccgcaca tgcaccagca
     2101 tggaatggcg atgggaatgg gcggtggcgg aggcggcggc caccacatca tgaacaacaa
     2161 cacgatgggc cgtgccagca gtcagtcgtc gcgattctcc ggctcgagat cctcgcatga
     2221 aatcggacgc ggctatccgc cacgtaatct gtacttggaa ctggagcggg aacgtagctg
     2281 catcgagggt tcgccgccct cggacaatgt tatgttcgac aaccagtgct atgcgaccac
     2341 gccgagctcc agcaatggca actcggatca ggatcaatcc tacggacagc agcaatcatc
     2401 gggtcagcat ccccagcagc agcagggacc gccgcagcga tcctcgcgac atcagcacca
     2461 tcatcagcag gctcccaatg tgacacccac tccgggctca cccacttcgc ggctgctact
     2521 cgagtacgag atgcatctga ggaacactct ggccaagggc atggatgccg aatcctacag
     2581 tctgcacact ttcgaagccc tgctctcgca gagcatggag aatttggcca atgcgaaatc
     2641 ttccacgctg ccattgccgc cacatcgacc attgtctacc attcgcgata aggagaggga
     2701 tcgcgatcgt gatggttact acagtgatcg caatgagttg atcagggagc gggaacgcga
     2761 acgcgatcgt ggctatctat cggatcacaa ttccagtttc tccaactcgc gatgcgcctc
     2821 ttgcattggc gaatcggctc gtgcccagtg gttccgtcac tcggatggct ggcgttccgg
     2881 aagttccact attggatccg gatcgggtca tggcatgatg acccagcaga ttcctggctc
     2941 cggtcacaaa cgttcgccct gggattcgct gccttcattg cgacaggata gcagtctcaa
     3001 cgattcgggt tacaagagtg ctcgtgccga ttccctagaa caacgtgccg agtttatacg
     3061 tcaggatagt ttgcgatcag agtatttgag cgatcgcgag tcacgctacg gaattgttca
     3121 acaggcttcc attgagagca ccgattcaag gatgtgctat ctaacatcat cagagatttc
     3181 ggacgatgat cgaatgagcc taactaccgc cgtttcggat gaagatgatg gggaaagtgt
     3241 catggcgtca ccatataaag caaaggcaac tggcaccgct gcatcctcct tcaattgcac
     3301 gggagctgtt cgcaaagccg gcttcctatc ggtaaagaaa tggttactac gcaagaagca
     3361 ccagatcgag ctggcaagaa agcggggctg gaagggctac tgggtgtgcc tgaagggcac
     3421 cacgctgctc ttctatccgt gcgattcccg ggagggccgg agtgtggagg cggcgcccaa
     3481 gcacttgatt atcgtggatg gtgcaattat gcaaccgata ccggagcatc ccaagcgcga
     3541 ctacatcttc tgtctgagta cggcgttcgg cgatgcctat ctcttccagg cgccctgtca
     3601 ggttgagctg gagaactggg tgaatagcat acacagcgcc tgtgccgccg cctttgccag
     3661 gcatcgcgga aaaactggaa cgctacacct gctccaggag gagatcttcc ggctggagaa
     3721 ggccattgag tcggatcaca agctgaagca catggccgaa ctgcagcaat cagttgtcac
     3781 cgatcaggag acgcgtcatc agatccagac gcagatactg cagtgggagg agaatctgga
     3841 gcggctccac tgcgagcagt tccggctgcg ctgctacatg gcctcgctgc aaagtggcga
     3901 gctgcccaat ccgaagtcgc tgctgacaca cgtttcgcgg cccacgaaga acacgctgaa
     3961 caagctgggc gtgttcacgg tctcctcctt ccacgccttc atctgcgccc gctcgccctc
     4021 gctgctcaac aacctgctcg ccggacgcgg ggccaccaag cggcgaccgc cgatgctgtc
     4081 gcggtccaac agcggttcca gccgtcgctc catgcagatg aattcacgtg acgaaccgga
     4141 aaaaactttc aaagttgcaa tgcccgacaa tgcttactcg acagtttatc tacgtgatgc
     4201 catgtctgtg gaggaattcc tcgccagcgc ctgcgcccgt cgcaacctca atcccatgga
     4261 gcactttgtg cgcgtcaaga agcgacgtga catggaggat cacaattact ttgtgccgca
     4321 tcgcaacgat ctgattgaaa attatctaca taatcacgag ttcgtggagg tctgcatgaa
     4381 gatcctgtac caggtggagc tgcagcgcac gactctggag cagatgtggg gcttctccgt
     4441 ggaggctgag ctgatcgaga atgcggaacg gcaggacgaa ctgtgctgct acgtgagtcg
     4501 cgtggaggac aagagtgtgg ccatgcacaa tggcattatc aaaggagacg aaataatggt
     4561 catcaatggc gcaattgtgt ccgatctaga tatgatgtac ttggagagcg tcctgcagga
     4621 ggaacaatcg ctcagcatga tgatgcggtc ctcgcgcacg gagccaccag atctagtggg
     4681 gatcatgagg gttacggacg atatgattga ctcgctggtt tgtccgccgc cgcccacaga
     4741 tccgccggtg atgagcgagg agatgataac tggactgatt gttccggccc ccggttggaa
     4801 tggcactagc aaggatttgt actcgccgga ggctgaaagc tcgccggcca cctcctttgt
     4861 ggatcctgcc gcaatggccg cccagctggc ggtgggcggc gtgggaggcg tggtcgtggg
     4921 cggactgggc gtggccaagc caacgtcgcg tacgagcagc tttgagattg agaatctgct
     4981 aaagaccgcg gagcaagaaa cgcggaaatc gagcccaacc ggctcggtca cctcatcggt
     5041 gtcgaccacg gcattaacac catcacggca gctgaccgat gcggagaagc tgcgcaaagt
     5101 cgtcatggag ctggtggaca cggaacgcac ctatgtgaag cacctaaaca acctgctgga
     5161 gcactatctg gagccaatga aacgcgagac attcctgtcc aatgccgaga tcaacgctct
     5221 gttcggcaac atacacgaga tcgtcacatt ccagcgccaa ttcctgcaga atctggagga
     5281 gtccttggac ctggagccgg atttcaacaa gttcgagcac tgcggccagt tcagaaatgt
     5341 gctctttgcg attggctcgg ccttcctgta ctacgtcaat cacttcaagc tctactcctc
     5401 gttctgtgcc agtcacagca aggcgcagaa agtcctgcat ccgaacgagg gcaatcacgc
     5461 cctgcaggag ttcctcgcag ccaggaatcc caagcagcag catagcagca ccctggaatc
     5521 gtatctgatc aagcccattc agcgcatcct caagtatcca ctgctcctgc agcagatgcg
     5581 caacctcaca gacacccggg ccgatgagca tgtgcatctt tgtgaggcac tcaagggcat
     5641 ggaaaaggtc gccgagcaca tcaacgagat gcaacgcatc cacgaggagt acggtgccat
     5701 attcgatcac ctgttccggc agcaccagaa gtcttgcaaa caacccattg atctaagtcc
     5761 aggggatctg ctctactatg gcggagtgga atggctcaac atctcggact ttctgggcaa
     5821 gatcaagaag ggactggaac tgcatgccat gtgctttgtg tttaagtcgg cagtggtgtt
     5881 cctgtgcaag gagcgactgc gtcaaaagaa gaagttgatg ggcgtttcca gcaagaatgc
     5941 caccaatgag gtcgagatca ttcgctacca ggtgctcata cccgtgaccg aggtgcaagt
     6001 ccgcgccagt tcggccaagg acatggactc ccacttcctg tgggagctca tccatctgcg
     6061 ttcccaattg caacgccgct ccgagaaggt ctatgtgctg tccaacagca ctgccgactt
     6121 ccgcaacgcc ttcctgaaga ccattcgcca gattatccgc gaaagcgtcc ggaacatgtc
     6181 aattccgatg aagaactttg gcggcagctc cggctccgtc tccggccatt cctcgcaggg
     6241 catgggcagc atgggctatc cgggcaactc tcagacgctt gaacgtccca agcagcagat
     6301 caccatcgtt catggctcgc acactctggg caaaccgaag aagaagtccg gctcgcagcg
     6361 ccactcggct ggcaacattg actacgacaa tttgtcgggc agccaggagg cggacgacct
     6421 gccacccagt gtgggcgtgg tccactacgc ctccggccac acccacggcc agcagatgca
     6481 gccagctgga ttccgcggtc gcagcaagac ggtgggcgat gttacagaaa tcacctgctc
     6541 ttccccagaa cctcatcagc agcagcagca gcagcaacag caacagcaac agctgatgca
     6601 gcagggacac gcccatgccc acccacatcc ccatccgcat ccaagggagc caccgccgcc
     6661 tccgatcagg cagccacatc tgcaccatca cagctcggac atcgaaagga tcgatcctgg
     6721 aacgaaatcg gagggcgagg aggactcgca gcagggcaca atcaggccca aggccacact
     6781 gggtcgaacg cccaatcacc tgacgttgag caccacatcg acgctctcgg tgggcagcac
     6841 cggcagccag gcgcgcctca ttcaatcgtc gcatccaccg gccagttacc agccggtgct
     6901 gatgaaggac ctagggtccc cggtgtggaa accacgagac atgataaatt taggcacaga
     6961 tccacagtca acaacccgca aagacgatgt gaaaaattaa atcagaaaaa gcaaagcaaa
     7021 acgtttagta tcaagctaag caagcataag aactcttaat ccacaacttc aaatcctctg
     7081 ttcgatttct caattttacc taatcaagtg taaggcaacg gcaacagaaa cagctaaaag
     7141 caaagcaaag caaaagcaga aagcagaaag caaaagcaga atgcaaacag cagaagcaag
     7201 cagttcaaag ttcaaagcag gcgaacccaa aagcattttt caagctcaat tctgcgatat
     7261 gaagatgcat tgaatcaccg gccatcatcg gtgtttggtg aatggatgtg gttgtttttt
     7321 gaagaatgct tggcttcggt ttgctttcgc tcttttttaa tggataaaac atcgaagagt
     7381 ttttgtcatt ttttacgttt gcgtttttaa acgggagaag caccacgaaa gggatgtcac
     7441 agatcctttt tagaaagaga gaacaaacaa aaaaaaaacg gaacaaaacc taaagcataa
     7501 atgaaaacca aaagagaaga ctttcattta tattgattgt atttaaagtg caaaacatat
     7561 aataaaagca taattaaagc gaaggatttt gagcaaattt aatatgaact aagtgaacag
     7621 atttaacaaa attaagaaat acgagaacaa attcaaatgc atttgtcgct gaaaagactt
     7681 gaaagtaaat ttcgatttaa atacatacat ttattgagga caagacgaag aagcagctgt
     7741 caaagcgacg aggagggaaa cccgtaaaca aattgcaacc atagtattta ggcttagaga
     7801 atttaaatta taaaaaagaa aacaaacgaa gaccccagag atttgcaaaa aaaaatataa
     7861 gaaaaaagaa tgaaacaaaa gtcaaatgca aagtaagcaa aaccaaaggg ttgaatgaaa
     7921 aacattttag ccaattaagc cacacacaca cacacacaaa ctgaagcaaa tcaacacact
     7981 cataagcgta atgagaaaat ttaaatgaaa acagcaatga aaatgtttag ttcgtaggaa
     8041 gtacactgaa aaaatacata aagataccat acaaaatcca cacatacaca taaacgaaaa
     8101 atagcaaaaa tttagtcaaa atgttaaatg gtaaactaaa tgaaaccgaa ataataataa
     8161 cgaagcaaat gattccatgc aattaaattg ggctaacagc ctccacaaag aatccaatca
     8221 gcaaatacaa gcaaacaaaa attaactcaa agcaaactca acacgttaaa gcgggcgaac
     8281 attaaattaa actataaaac tatgcaaaga aaaccaaata aatgaaagta cataagcata
     8341 aaaaagcaaa agaaacccaa ataaaaaaaa agacaacacc ttctagcaga attacaataa
     8401 taattaagaa cttcactttg aacactttga aacaaacaca cgcgaatcga tatagttaaa
     8461 caaaggaagc ctattcccag cccaacaaaa aaaaaaaaat cccatagaca aaggcacagt
     8521 tttcgagaac tcgattaaag gatacttttg attttcctac gtctcaatac cctatggttt
     8581 tcaatttttg taggacgaat ttttagccag acgatgcaaa tatataatcg aatacaatga
     8641 aaaaattcta ccagatgaga aataataatt aattggttgt gaatgcagct tggatgttaa
     8701 ttcgattcag gaacaatgaa atccccaatt gctgaacgtt tgtttatttt actggccgca
     8761 cacacagcag tgtgcgtgtg agtggcaatt gtcttttttt tttcagtgta cttgcagttg
     8821 cattgctcac actcattcat tttgtacgcc accccccccc ctccacccac tctcagaaaa
     8881 acgtcataaa ctcattgaac catatagcaa caaatcgaaa cataatcaaa acatttttta
     8941 ggtttccaat caaattgaat taaatataca aaaaataaac tcgaattaaa caatgagaaa
     9001 aactaagaaa aacgtaataa ttgaaactac agaccataga cagctatatg atgtggagag
     9061 taaatagaaa ttctaaatgt atacaacagt ctaatgatag atcttcatca tcgcatcaac
     9121 gatgaggatg attatgaaga tgaaagctaa tcaaacacgg gacaaaacaa ggagaaattt
     9181 accaaatacc aaatcacaac attttaacat aatttttaca gtttgtataa gttcgacaga
     9241 ggcaacgtac ataaataata attataatga ttaacaataa aaaccaacag tcagttggaa
     9301 gactttagcg aaatgaaata gttaaattat gaaactcatt tgatggcgaa tgaacgtggc
     9361 gtgaaacttt ttgtacgcat ttgactattt ttaaagcatt tttattaaat atatatacat
     9421 acatagtcac tattatacga atgtttgaga accaaacgaa tgtactcatt taattaagtt
     9481 cacgtgcaca caatgcactg gaatctcttt taacaaattg ttatcggata tttgatttgt
     9541 ttaagcgtat tgttagttat atgtacatgt atctcttatc acactttcct ttcgacaagc
     9601 gaacgaggca gcaggaaaaa cgagggtaac aattgcatat taaatacaat ttataagtca
     9661 gccacacaac acacacacac acacacacac acacacacga aaaccaaatt cgaaacagaa
     9721 atcaatagca aaatgcagca ggattggaaa caaatgttgc cattttcgaa tggacaacag
     9781 cagacagcaa cattgaaatt caatttttat tgtaaaccta attagcagct gcaaacaaga
     9841 agaacaaaaa tatattacaa caaaaacgaa catgaaatgg atgttaatac tttttgaaaa
     9901 agagaataaa aaaaaaaaac aaatatgcaa cagtaaagaa agtaaaaaga aatacacaat
     9961 gattatacaa ttgcaaatgc aacttaacac tcaacataag gatagtgaaa atgtgtgaca
    10021 aatgattaaa ttacgaaatc cttttg
//