Dbfetch

LOCUS       NM_001103444            6507 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster topoisomerase related function 4-1,
            transcript variant G (Trf4-1), mRNA.
ACCESSION   NM_001103444
VERSION     NM_001103444.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6507)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6507)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6507)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6507)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6507)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6507)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6507)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6507)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6507)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6507)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6507)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6507)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6507)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6507)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6507)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6507)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6507)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6507)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001103444.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6507
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6507
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /note="Topoisomerase related function 4-1"
                     /map="7F4-7F4"
                     /db_xref="FLYBASE:FBgn0030049"
                     /db_xref="GeneID:31795"
     CDS             878..3286
                     /gene="Trf4-1"
                     /locus_tag="Dmel_CG11265"
                     /gene_synonym="AAF46390; CG11265; Dmel\CG11265; DmTRF4-1;
                     dTrf4-1; Trf4"
                     /EC_number="2.7.7.-"
                     /EC_number="2.7.7.19"
                     /note="CG11265 gene product from transcript CG11265-RG;
                     CG11265-PG; Trf4-1-PG"
                     /codon_start=1
                     /product="topoisomerase related function 4-1, isoform G"
                     /protein_id="NP_001096914.1"
                     /db_xref="FLYBASE:FBpp0111877"
                     /db_xref="GeneID:31795"
                     /db_xref="FLYBASE:FBgn0030049"
                     /translation="MSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAGGAHYYMN
                     NHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVKRIEA
                     VVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACT
                     VRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQ
                     FLLLRDLNEVFTGGISSYSLILMCISFLQMHPRGIYHDTANLGVLLLEFFELYGRRFN
                     YMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQA
                     FKCAYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRI
                     SPLPTAAPTAYATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHP
                     GAHLCQPYVTGTTVSAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQS
                     QSRHRRGSTSSGDDSEDSKDGDVVETTSSAQEVVDIALSTPNGLANMSMPMPVHAVGM
                     PASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIR
                     PGDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQQQLSKSNSSSNYHQ
                     QHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLRVGGGNRYQKSLGGSPIISAGNASNS
                     SSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAISIISISSESSIASSSSSSSRSGQDQQ
                     RDER"
ORIGIN      
        1 gtgcataaaa ggcatagagg cagcaaggag tgaaagagag agctccatcg gcagcgcaac
       61 gaaagtgagc gagaagcaga aattgttagt gcttataagg atatgtgaga agggagagtg
      121 agacagtaag aaagaacgga agaagcagca gcgacgccga ccgacaacaa ctcacttgaa
      181 tgctgacagc attcaaagag gtttagtccc ggcagcgact ttaattaatt tttccctgtg
      241 gagcacaaag atcacatcgg atctatatag agtcacgtct atatattcag accaccagga
      301 cgcagaggat agaggtgaaa ggacgaagcg aaggagagac gcgcgccccc ctcgtttccc
      361 gcccagccaa cagccgtgtg aacccgtctt gaatggatcc atttgttggc tggtttcaga
      421 aggaacagga gggaccatcg ctgtgcacat ggttaaagat ttgggagacg aatgcccaag
      481 agatgggcgc attgcttaat caacagctac agcaggcgac gacgatcaac gggagcacga
      541 gcagcagcag cagcagcagc aatagtgctc gctaaatcgg gtgctcaatt tccgagcgga
      601 ttccctggag atcctgcagc agcaacaaca acagcagcag ctcaacggga ccactcagcg
      661 caacagcacc aacatcaata ccacaagcgg cggcagcact agctcgtcgg cagattccac
      721 cacgaatcgg gacaataact cacccgccaa tagcagttca accaacggac ccggagcagg
      781 aacgggaacg tcaacaggag caggaggtac cggtacaaat agtccggcga cgacagcgtc
      841 aagcacagct gcgaccacga ctggtccagc cactagtatg agcgacacca gcaacaaccc
      901 gccacaatca acgaccacgc ccgccagccg cacgaacagc atctactaca atccatcgcg
      961 gaagaaacga ccggagaaca aggctggcgg agcccactac tatatgaaca accatatgga
     1021 gatgatcgcc aagtacaagg gcgaaccgtg gcgcaagccg gactatccgt atggcgaggg
     1081 cgttatcggg ctgcacgagg agatcgagca tttctatcag tacgtcctgc ccacgccctg
     1141 cgaacacgcc atccgcaacg aggtggtcaa gcgtatcgag gccgttgtcc attccatctg
     1201 gccacaggca gtagtcgaga tctttggctc ctttcgcact ggcctctttt tgcccacctc
     1261 cgacatagat ctcgttgtgt taggtttgtg ggagaagctg ccgctgagaa cgctggagtt
     1321 cgagctagtg agccgtggta tcgccgaggc ttgtacggtg cgtgttctgg acaaggcatc
     1381 agtgcccatc atcaagctga cggaccggga aacgcaagtg aaggtagaca tatcgttcaa
     1441 catgcagagt ggtgttcagt cggcggagct gattaagaag tttaagcgcg actatccagt
     1501 gctggagaag ctagtgcttg tgctgaagca gttcttacta cttcgcgatc tcaacgaggt
     1561 gttcacgggc ggcatctcct cctactcgct gatccttatg tgcatcagct tcctgcagat
     1621 gcatccgcgc ggtatctacc acgatacagc caatctgggg gtgcttctcc tcgagttctt
     1681 cgaactttat ggacgtcgct tcaactacat gaagatcggc atctccataa agaacggtgg
     1741 ccgctacatg cccaaggatg agctgcagcg tgacatggtc gatggccatc gaccctcgct
     1801 cctgtgcatc gaggatccgc tgacgccagg caatgatatc ggtcgaagca gctacggcgt
     1861 cttccaggtg caacaggcat tcaagtgcgc ctaccgcgtg ctcgcccttg ccgtcagtcc
     1921 gctcaacctt ctcggcatcg atccgcgcgt caactcgata ctgggtcgaa tcattcacat
     1981 caccgacgac gtgatcgatt atcgcgaatg gatccgcgag aacttcgaac atctggtggt
     2041 ggtggatcgt atctcgccgc tgcccactgc cgctcccact gcgtacgcca ccgccaatgg
     2101 ggcgccaaaa tatgtgatta tgccctcggg cgccgttgtc cagcagctgt accatcatcc
     2161 ggtgcaggtg cccaccgctc acgggcacag ccatgcgcac agccacagtc acgggcacgc
     2221 gcatcctggc gcccatctgt gccagccgta tgtgaccggg accactgtat ctgctgtaac
     2281 gacgactaca acgatggcgg tggtgaccgt gggcgtgtca gccggcggag tccaacagca
     2341 gcaacagcaa cagaatgcga cggcccatac ccactcgcaa cagcagacac agaaccaatc
     2401 gcagtcgcgc catagacgcg gcagcacctc gtcgggcgat gactccgagg atagcaagga
     2461 cggcgatgtt gtcgagacga cgtcgagtgc tcaggaggtc gttgacatcg cgctatcgac
     2521 gccaaatggc ctggccaaca tgtccatgcc catgccagtg catgctgtcg gaatgcctgc
     2581 gtcgaacagt tggagcggta atggcaatgg aaacggaaac agcagctcat ccacgggctc
     2641 gtcgccggaa atcgcacaca tcgctgccca ggaaatggac cccgagcttg aggatcaaca
     2701 gcaacaacag cagcaccaag agacttctgg aggtaatggc ttcatccgac cgggtgacgt
     2761 cggcaccggt tccaacaggg gaggcggtga cggcagtggc ggccgcaatt acaaccagcg
     2821 gaacaaccac aactccagcg gctactacca ccagcagtac tacgtgccac cgccgatgca
     2881 acagcagctg agcaagtcca actcctcctc caactatcac cagcaacacc atcacagcca
     2941 cagccatggc aatcatagtc accgacaaca gcatcaccac cagcagcagc accaccacca
     3001 gcagcggccg cagcatctgc gtgtgggcgg cggcaatcga taccagaaat cgttgggcgg
     3061 atcgcccatc atcagtgctg gcaatgcgtc gaacagcagc agtaattgca gcaacagcag
     3121 cagcagcagc ggcagcaaca acagccgact gccgccgcta aggggcacgc tggtcaactc
     3181 atcgtcagca atatcaatca tttccatatc ctcagaatca tccattgcta gcagcagctc
     3241 cagttcgtca agatccggtc aggatcagca gcgtgacgag cgataggaat aggatgtagg
     3301 aagatattgt gtatgtctat gacacagaga gaaagagagt gcgacacaga gggacagaga
     3361 atgagagaga aagagatagt tacggtgtta gcaatattta tgggttacat ttctttctca
     3421 ggttaattgt aaactacgct gcatttttct aataaatatc attgaccccc ccgccccccc
     3481 gcctctacct aatccgaaag catctcctca accaatgtaa ctgcgatcag attttctttt
     3541 acactgctgt cttgcttaaa ttgggagagc gacgcagacc tactaagcct agtgttagga
     3601 actttgcctc tgatcgcgct aaatgtattt cagtttgttt ctaaaataaa catgaaagca
     3661 aagaatatat atatatatat atatatatat ttatatatat agatatatat taaattaaat
     3721 taaattgtac cataagcata actgttagct cataagtaga ttgtaagggt ttaaaagatc
     3781 gataaactga agtatgaaat tatgctaatc tcttttccca tacccccccc cccccctttt
     3841 tatccatcat catgcgcatt caagcttcta aagtattttg tagtttctga aatgctctcc
     3901 gtctagtgca atggtaaaca tttttgcaaa cgtaactaat tccctatcca ccccatttcc
     3961 tgccatacaa aaaaaaaaaa aaaattcaaa aaacggaaat cacgcgcgca aaatgttacg
     4021 ctaatattac taagtgaatt tgcgcgcaaa atgtaaaaaa aagcaacata accgctaatg
     4081 caattgaaaa ttaccatttt ccaaagaaat aatagaaatg cgcaatgacc cttgtaactt
     4141 ccaaaaactc gtttaattat attattccga gttagtttta tgcctaaaat gtaaatgttt
     4201 ttatgatacc actattacta ttatgattaa gcctatattt gaagcctata cttagtttta
     4261 attattatta ttataattaa ggtaaaaaaa attgtgagcc tacttaaatt gttcgaacac
     4321 attgtccaac cccaaagcaa ttgtgtttta aagctaaaac aaaaaaaaaa aaacaaaaaa
     4381 acaaaacaaa gaaacaaaac aaaacgacaa aaaaagcaaa aaaaacctac aacgcatctt
     4441 ttgtttaaac ttatttatga ttaattgact attatgatta tgcaatgttg tgcattttgc
     4501 atagattcct gccatttgtt tgtatagttg ttcacaaatc tctgtaaata cttagttacc
     4561 gcccatcccc ctgtgacgca ccgccacgcc tcccgcccca cccaccacgc cccttctaaa
     4621 cgcactgcca ttttgagaaa ggtttttaaa aaacacgtcg aaaaggagct agcagaagag
     4681 tagaaaagaa gatttagact ttgtacatgt ataacatttt aggctgttct tctttttcca
     4741 tttgtaagag acaaagaaac aaagaaagca aaacaaaaaa aaagcccaaa ccagaaacat
     4801 aaacccaact aattgtaaag tcacctaaat agtctacgaa catgtttgtc aatcgagtcg
     4861 cgaacataga gctctgtaat actaggcggc aacatttaaa atttcattct gaaagtgcaa
     4921 catttctgat tcttggagat tgtaaatgac atacacaaaa aaaaaaaaac gcggctttaa
     4981 atgtacatca aaacatgttg caatacttga atatggattt ctctgttgta tggtgtgata
     5041 gcacaatttt tgtttgcatc atttatgtat agttctgtaa tgtctaatgt cttaatattt
     5101 aacttctatt atagtttctc atttggcttt cctttcgatc atatgtatgt atttgtgaac
     5161 tgttgcgaca ttaagcttgt ttgtgaatcg tgagctaaga gttcatagta ttgaatctga
     5221 agtatcgacc ttgagtggtt caaaacctaa agttaatttt ttaattttcg aaatgtgtgt
     5281 gaaagagaaa cgtcatttag gaccctcgat atttcagaaa aatcgagatt aggttcaata
     5341 tctttttttt ttctgttgcc tagtgtgaat taaagcgatg ttcaatgttg acaaaggccg
     5401 aaggtgcgct ctccctttcg cacgacgact cctacaagct ggcagctttg aagcccacct
     5461 tacacataca cactttctca ctcacatcac aaacacacac aagcgcaaag gctcccccca
     5521 cacagatacc cgaacagaga gggacactta acgataaagt tagcatagaa agttggggaa
     5581 gacggggcaa tgagccgtta gtaagaatga gaaagcggtt gcgatagagc gagataaagt
     5641 aataaggaac gaaatagaga gcgagcgaga gtaacatata agaattatta aatttatgca
     5701 ctcgtctgtt gaatatttat atgaattata tgtatgtagt tactaatatt aactaattga
     5761 taaatataca atatttatat gcataacttg tggattaatg tgaacaaaca aatgtttaga
     5821 attagcaatc tagccacgta agactcgtaa atggtaaatc gtaaatcgac aactacttag
     5881 actacataac tgtgtaccag agcatatgta agcacataag cactcccaca cacacacaca
     5941 cgaatacacc actacatgca tactcgctat gaatgttgag attatgtcgt agattttttc
     6001 aatatcgatc acgttttcgc ctagcctagc aagtaagccg cagatctaac tgtaaaacta
     6061 acccatttcc ccactggatt ccatgcattc gaaatcgttt catccttcgt ccatcattgc
     6121 ccattcagtc cttcgttttc gtttcagttt gcgctccgtt cgcagttccc aactttcata
     6181 ttacgtgtgc cgttattgtt atataacaca catgcatata ctcgaaacat acacagtttt
     6241 ttgtcgtcgc gatattagtg ggtattaata aattaaatta aatttaatta actacattta
     6301 acgcaactaa attcaattca agtgaatcaa atgaatcgat cgataataca tgtatgtata
     6361 tgatagagtt caatagctgt gtaagaatcg gaatcgtaac aatttagtat gcaaaaatcg
     6421 taaatctaac tgattgtata attagcgaaa agagaataac ggatgcgata agcaaaacga
     6481 tgcgacaaat aaaagccggc aaaaact
//