Dbfetch

LOCUS       NM_001038818            4590 bp    mRNA    linear   INV 26-DEC-2023
DEFINITION  Drosophila melanogaster Dual-specificity tyrosine
            phosphorylation-regulated kinase 2 (Dyrk2), transcript variant E,
            mRNA.
ACCESSION   NM_001038818
VERSION     NM_001038818.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4590)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4590)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4590)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4590)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4590)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4590)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4590)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4590)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4590)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4590)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4590)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4590)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4590)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (10-NOV-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   21 (bases 1 to 4590)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-2015) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   22 (bases 1 to 4590)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   23 (bases 1 to 4590)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   24 (bases 1 to 4590)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   25 (bases 1 to 4590)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NT_033779).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4590
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="2L"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4590
                     /gene="Dyrk2"
                     /locus_tag="Dmel_CG4551"
                     /gene_synonym="BG:DS01523.3; CG4551; dDYRK2; Dm2; DmDyrk2;
                     Dmel\CG4551; DYRK; DYRK2; smi35A"
                     /note="Dual-specificity tyrosine phosphorylation-regulated
                     kinase 2"
                     /map="35A1-35A2"
                     /db_xref="FLYBASE:FBgn0016930"
                     /db_xref="GeneID:34831"
     CDS             762..2930
                     /gene="Dyrk2"
                     /locus_tag="Dmel_CG4551"
                     /gene_synonym="BG:DS01523.3; CG4551; dDYRK2; Dm2; DmDyrk2;
                     Dmel\CG4551; DYRK; DYRK2; smi35A"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.12.1"
                     /note="CG4551 gene product from transcript CG4551-RE;
                     CG4551-PE; Dyrk2-PE; dual specificity tyrosine
                     phosphorylation-regulated kinase; smell impaired 35A"
                     /codon_start=1
                     /product="Dual-specificity tyrosine
                     phosphorylation-regulated kinase 2, isoform E"
                     /protein_id="NP_001033907.1"
                     /db_xref="FLYBASE:FBpp0099870"
                     /db_xref="GeneID:34831"
                     /db_xref="FLYBASE:FBgn0016930"
                     /translation="MLDRCEMPIQLDNEKLRRDVRLSGSRLDLPQLCNGSRRLDGHNN
                     HVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNS
                     SSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQH
                     ASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDH
                     KTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCIT
                     FELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ
                     RGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELY
                     TGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRS
                     PGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMS
                     SSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPS
                     QSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVG
                     SGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTATIATTTH
                     HHHHHGGQQQQQSSSGASTMAMSHSQSTGDVSDRAIFGRA"
ORIGIN      
        1 atcgcgcttg tgcggttgtg cggagcggac gagttggaat aaccagcgag gttcaatatt
       61 ttctgtacgg gcgcattgtt tgaggctcgt ttggagaact gcaggcgttc aaaacacgga
      121 atcgaaatcg aataacatag ccccctccac aaaaccaaat caatccaaat tcaaatcgtt
      181 cgcgagtcga aagtgaaatt cgtcgcagca caacggtaaa tcaaagccag acgcgatttt
      241 tgttcaatga atggaataga gccagctaac acaaatcccg ctaaaataat caaattcaat
      301 tacaatttat tgtaaccgct ttaataatta gcattgcaaa gtgtctatgc taaagtgttt
      361 aacagtttaa caaataacac aaatatcggt gattttggtg tgcaagaaat tgagaaaacc
      421 agaaaccaaa acagagatcc gctgatttaa gacgaaagaa gtttcgaaat ctttatgttt
      481 tgcgtgaaca tatagtgaga aactaatcaa caagaattta agtaatctta gacgtcttga
      541 ttgcgcaaga gtaaaccttt ttgttttgga caagttggca cccaacaagc aaaacaaatg
      601 caaatgtgcg ccccaaagac atattacccc gaaagtgatc aataattgtt tgccggaaga
      661 ggagatacaa ctcaaccagt taagcaccgg actcagggtg actactcttc gtggacacga
      721 ttctcttttg gctaaaacga caactcagcg aagtcgacac aatgttggat cgatgcgaaa
      781 tgccgatcca gctggacaac gagaagttgc ggcgggatgt tcgattgtcg ggctctcgac
      841 ttgatttgcc acaactctgt aatggatccc gtcggttgga tggccacaac aaccatgtgg
      901 ctgccaatga gaacacggtt acaacgacat ccctgaatgg aaatggcaac ggcaatggca
      961 atagcaatag caacaacaac aacaacatcg gatcgcccgt ctcctcatcg acaacaaaca
     1021 gcagtaatgg cggcaacgag cgcggctcct ccacaaagtc caatagcagc agtggaagtg
     1081 gcagctcggg aaactcggcc agcagcacgg gaagtggcga gctcaaatgc aatacgccca
     1141 tgacgccatc tgagctggtg aagaagttcc gcaactacct aaccgatctt gagttcgaag
     1201 agctcaaggt gtacaaggaa gtgtggtatt ttggccagca cgccagcaag aactacaaca
     1261 aacccgcccc cacagccaat accacaaatc tgggctatga cgatgataat ggcaactaca
     1321 agatcatcga acacgatcac atagcttttc gttacgagat tctggaggta attggcaagg
     1381 gcagttttgg ccaggtcatc agggcgctgg atcacaagac caacacacac gtggccatca
     1441 agatcataag gaacaagaag cgcttcctca accaggccgt cgtcgaactg aatatcctcg
     1501 atgagctgcg cgaaaaggac gcggatggat ctcataatgt catacacatg ctcgactata
     1561 catatttccg caagcatttg tgtattactt ttgagctaat gagcttgaac ctgtacgaat
     1621 tgataaagaa gaacaactac aatggattca gcatgagtct catacgacgc ttctgcaact
     1681 cgattgtgaa gtgcctgcgt ttgctctata aggaaaacat tattcactgt gatctcaagc
     1741 cggaaaatat cttgctcaaa cagcgtggta gcagctccat taaagttatc gactttggca
     1801 gctcatgcta cgtggatcgc aaaatctata cgtacatcca atcgaggttc tatcgctccc
     1861 cggaggtgat tctcggcctg caatacggca cagccatcga tatgtggagc ttgggctgca
     1921 ttctggccga gctgtacaca ggattcccgc tcttccctgg cgaaaatgaa gtggagcagt
     1981 tagcctgcat catggaggtg ctcggtttgc cgcctaaggt gctcatatcg gttgccaggc
     2041 gacgtcggct gttctttgat tcccgtgatg ccccgcgctg cataactaac accaagggac
     2101 gcaaacggtc gccaggcagc aagtcgctgg cacatatctt gcactgccag gaccgctatt
     2161 tcatcgactt cctgcagcgt tgcttggagt gggatcctgc ggagcggatg acgccggacg
     2221 aggcggccca ccacgagttt ctgcagccat ctgcctccag tcgccatcgc agctgccgca
     2281 tgtcgagcag ttcgtccagt tccggactca acagtgtttc ccagaagtct tcctgctaca
     2341 gcttttcgga gatctcgccg ggcaccaacg gtcccgtggt ggcctcgatc accagcacca
     2401 cggcggtgca caatgccgcg attgctacca caaccaagtc gagacagcag ccgccatctc
     2461 agagtcacgg ccatgcccaa tcgaatggac acctgcccga catcaagtta agtgccagcg
     2521 ataagtacaa tagcatgcag aaggtggcgg tgcgctcgaa gatcacgtcc agcgtctcgg
     2581 atctggagtc cgtgcagcag tactcactgc accgcatcta cggaggagtg ggtagtggca
     2641 gcacacacca tgtctcgtca gcggccacca ggaaacattt gcccggtaca ggcagtggaa
     2701 ttgtgggtgc catgtcttcc aaatacggca gctcaacgtt ggcgcacaac catcacaatg
     2761 tgacgcacca caatgcatcg actgccacca ttgcaacgac cacgcaccac catcaccacc
     2821 atggtgggca gcagcaacag cagtcgtcgt cgggagcatc caccatggcc atgtcgcact
     2881 cacagtccac tggagatgtt tccgacaggg ccatctttgg gagagcttga cttcgggcaa
     2941 ggcccaccaa gctggagctg aagaagtgca agctggtcaa catgatggac ttctggagct
     3001 agaagtggcg tccacagcac tgcgctgatg ttaaggagcg ggacgaggag tagccgatgg
     3061 aatagggctc ctcgcacgta gatttaggta tattgttgta tgtaagctat ataggaattc
     3121 tagacgtgtg tgaattgtat ttgaatgcga gtgcatgctg ttgtacaacc acttgctcct
     3181 gataatccct tccccactcg aaatagttgc atctagctag aagggagtac ctttttgaag
     3241 cactttgcag tattctcagt tgccctgaac cctattttat ttcgctactg ccatagctaa
     3301 aggtattcaa aatcgtattc acacccacaa acccttcctg aaaagtattc tcttccctcc
     3361 aactccctcc atccttttac actgtattca aaatgaacaa accatcaaag ataaaaacaa
     3421 aagaaacgaa acagaagcca gctcaaagga acaagataac ctagatatag tttattagat
     3481 atggcatata ctaaacatag ttgtagacaa catttgtaac gattcaccca acgcatccaa
     3541 tcacccgaac tcaaagatac atacatattt taggggttac gactcaaatc tgtaacaatt
     3601 tcatacagct tccatgtctt ttgcaacagt atcaaggctg ttattagtta catatgcgaa
     3661 acagaaatgt atctatatct taactgtaat tgtatgcgta gtttaagatc ttggaggttc
     3721 gttggccaat atcatacatc acactacagg aaatcaactc tgtagcctgc caatgcaaga
     3781 taaatttgaa ttccgcttgg atacatatac ttgatcccat taaaccaatc catacggaat
     3841 acatgtcata atttaatgaa aacacatatt taaaaactat aaatctatta aaactagacg
     3901 gattgaaaaa aaaatatggc caatatcaca accgaataat aaacaatcca atatacaata
     3961 attgtagtgc gccacatcta agtaaactgt attagtggcg acaaaagcaa aagaaaacaa
     4021 ataaaaatgt tttatccaaa ttaaagtttg tgtattgaag atgaaacaag acggcagaca
     4081 gtttgatatg aacttgagct gggtaagatt gcttaccaaa tccagactgt aatttgaacg
     4141 aagtttgtaa cctgtaatcc tgtaagttta gataacactg tacacaattg caatttttgc
     4201 tcataacttt tgaatatata tcacatagga ctacaatgcc taagcctata tatacaaagc
     4261 tgcgatcctt tggagcttgt ttcgtattat ttgtaaaagt tttctctgcc acttgtcata
     4321 attatgtctt atactttctt tatgggttta ttataaattt tgacaaaaaa caaaacaaat
     4381 ccaattgcaa aaattgtttt acaaagtgtg ttcgaattta acgtttagta ttaattaaaa
     4441 acaatgataa acctttaatt ataaatatat acgtacggat atatcaattt taaattaatg
     4501 acgcatatta attgtataga tcaagaaaaa caacatgtaa tcaattacaa ttacaagaat
     4561 ttcaaaaaat aaatgaaaaa gtatgtactc
//