Dbfetch
Growth factor receptor cysteine-rich domain superfamily
Accession | IPR009030; (Growth_fac_rcpt_cys_sf) matches 47140 proteins |
FullName | Growth factor receptor cysteine-rich domain superfamily |
Type | Homologous_superfamily |
Signatures | SSF:
SSF57184 SSF57184
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Abstract |
This growth factor receptor domain is a cysteine-rich region that is found in a variety of eukaryotic proteins that are involved in the mechanism of signal transduction by receptor tyrosine kinases. Proteins containing the growth factor receptor domain include the insulin-like growth factor-binding proteins (IGFBP) [], the type-1 insulin-like growth-factor receptor (IGF-1R) [], and members of the epidermal growth factor (EGF) receptor family [], such as the receptor protein-tyrosine kinase Erbb-3 (ErbB3) []. The general structure of the growth factor receptor domain is a disulphide-bound fold containing a beta-hairpin with two adjacent disulphides. IGFBPs control the distribution, function and activity of insulin-like growth factors (IGFs) IGF-I and IGF-II, which are key regulators of cell proliferation, differentiation and transformation. All IGFBPs share a common domain organisation, where the highest conservation is found in the N-terminal Cys-rich IGF-binding domain. The N-terminal domain contains 10-12 conserved cysteine residues. IGF-1R is a member of the tyrosine-kinase receptor superfamily that is involved in both normal growth and development and malignant transformation. The Cys-rich domain is flanked by two L-domains, and together they contribute to hormone binding and ligand specificity, even though they do not bind ligand directly. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The extracellular region of ErbB3 is made up of two Cys-rich domains and two L-domains, arranged alternately []. The two L-domains and the first Cys-rich domain are structurally homologous to those found in IGF-1R. The two Cys-rich domains are extended repeats of seven small disulphide-containing modules. A beta-hairpin loop extends from the first Cys-rich domain to contact the C-terminal portion of the second Cys-rich domain, creating a large pore structure. |
References |
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Database links | PDB: 1adx; PDB: 1ajj; PDB: 1boe; PDB: 1d2j; PDB: 1dqb; PDB: 1dx5; PDB: 1emn; PDB: 1emo; PDB: 1f5y; PDB: 1f8z; PDB: 1h30; PDB: 1h59; PDB: 1hj7; PDB: 1hz8; PDB: 1i0u; PDB: 1igr; PDB: 1ijq; PDB: 1ivo; PDB: 1jl9; PDB: 1ldl; PDB: 1ldr; PDB: 1lmj; PDB: 1m6b; PDB: 1mox; PDB: 1n7d; PDB: 1n8y; PDB: 1n8z; PDB: 1nql; PDB: 1p9j; PDB: 1s78; PDB: 1tmr; PDB: 1toz; PDB: 1uzj; PDB: 1uzk; PDB: 1uzp; PDB: 1uzq; PDB: 1wqj; PDB: 1xfe; PDB: 1yy9; PDB: 1z6c; PDB: 1zaq; PDB: 2a91; PDB: 2adx; PDB: 2ahx; PDB: 2bo2; PDB: 2bou; PDB: 2box; PDB: 2c5d; PDB: 2dsp; PDB: 2dsq; PDB: 2dsr; PDB: 2fcw; PDB: 2hr7; PDB: 2jwa; PDB: 2k2s; PDB: 2k2t; PDB: 2ks1; PDB: 2vj3; PDB: 2w2m; PDB: 2w2n; PDB: 2w2o; PDB: 2w2p; PDB: 2w2q; PDB: 2w86; PDB: 2x10; PDB: 3b2u; PDB: 3b2v; PDB: 3be1; PDB: 3bps; PDB: 3c09; PDB: 3fby; PDB: 3fl7; PDB: 3gcw; PDB: 3gcx; PDB: 3gis; PDB: 3h3b; PDB: 3i2t; PDB: 3ltf; PDB: 3ltg; PDB: 3mbw; PDB: 3mx0; PDB: 3mzw; PDB: 3n85; PDB: 3njp; PDB: 3p0y; PDB: 3p11; PDB: 3p5b; PDB: 3qwq; PDB: 3u2p; PDB: 3u7u; PDB: 3u9u; PDB: 3v64; PDB: 3v65; PDB: 3w11; PDB: 4cud; PDB: 4cue; PDB: 4cuf; PDB: 4d0e; PDB: 4d0f; PDB: 4hrl; PDB: 4hrm; PDB: 4hrn; PDB: 4krl; PDB: 4krm; PDB: 4kro; PDB: 4krp; PDB: 4leo; PDB: 4oga; PDB: 4p59; PDB: 4ra0; CATH: 1.20.5.100; CATH: 2.10.220.10; CATH: 2.10.25.10; CATH: 2.10.50.10; CATH: 2.120.10.30; CATH: 2.60.120.200; CATH: 2.60.40.10; CATH: 2.60.40.1770; CATH: 3.80.20.20; CATH: 4.10.40.20; CATH: 4.10.400.10; SCOP: b.29.1.4; SCOP: c.10.2.5; SCOP: g.12.1.1; SCOP: g.3.11.1; SCOP: g.3.9.1; |
Taxonomy Distribution | Caenorhabditis elegans: 65 Bacteria: 1 Eukaryota: 24 Fungi: 3 OtherEukaryotes: 1417 PlastidGroup: 14 Bacteria: 9 Eukaryota: 173 PlastidGroup: 357 Virus: 7 Eukaryota: 1078 PlastidGroup: 1078 Eukaryota: 357 Fungi: 40 Bacteria: 16 Bacteria: 436 Eukaryota: 85 Bacteria: 1 Eukaryota: 1417 Eukaryota: 60 Eukaryota: 29 Bacteria: 3 Bacteria: 3 Bacteria: 1 Archaea: 185 Arthropoda: 7859 Bacteria: 591 Cyanobacteria: 9 Eukaryota: 46310 Fungi: 558 GreenPlants: 1078 Nematoda: 2956 OtherEukaryotes: 60 Viruses: 49 Chordata: 384 Fungi: 150 Metazoa: 35712 Nematoda: 1189 OtherEukaryotes: 29 PlastidGroup: 173 Chordata: 20286 Fungi: 270 Nematoda: 1767 Archaea: 2 Bacteria: 14 Chordata: 743 Fungi: 65 Metazoa: 416 Virus: 32 Cyanobacteria: 1 Eukaryota: 1950 OtherEukaryotes: 1950 PlastidGroup: 24 Bacteria: 5 Eukaryota: 14 Fungi: 32 Metazoa: 179 OtherEukaryotes: 85 Virus: 49 Metazoa: 82 OtherEukaryotes: 27 Eukaryota: 27 Bacteria: 1 Eukaryota: 37178 Eukaryota: 3721 PlastidGroup: 3721 Fungi: 7 Virus: 9 Eukaryota: 197 PlastidGroup: 197 Bacteria: 5 Bacteria: 44 Chordata: 21413 FruitFly: 367 Human: 515 Metazoa: 36022 Mouse: 340 Rice: 84 Arthropoda: 565 Bacteria: 41 GreenPlants: 194 Unclassified: 4 Archaea: 170 GreenPlants: 884 Metazoa: 49 Unclassified: 1 Arthropoda: 7294 |