Dbfetch

Tyrosine-protein kinase, active site

AccessionIPR008266; (Tyr_kinase_AS) matches 47172 proteins
FullNameTyrosine-protein kinase, active site
TypeActive_site
SignaturesPROSITE: PS00109 PROTEIN_KINASE_TYR
Found inIPR000719; IPR001245; IPR009136; IPR009220; IPR012234; IPR015782; IPR016244; IPR016245; IPR016246; IPR016247; IPR016248; IPR016249; IPR016250; IPR016251; IPR016257; IPR020446; IPR020455; IPR020461; IPR020635; IPR020693; IPR020775; IPR020776; IPR020777; IPR022495;
Abstract

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].

Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:

  • Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction [].

  • Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].

This entry represents the tyrosine protein kinase active site. It also matches a number of proteins belonging to the atypical serine/threonine protein kinase BUD32 family, which lack the conventional structural elements necessary for the substrate recognition and also lack the lysine residue that in all other serine/threonine kinases participates in the catalytic event.

References
  1. Hanks SK, Quinn AM, Hunter T. (1988)
    The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
    Science 241: 42-52
    [PUBMED:3291115] [PUB00005115]
  2. Manning G, Plowman GD, Hunter T, Sudarsanam S. (2002)
    Evolution of protein kinase signaling from yeast to man.
    Trends Biochem. Sci. 27: 514-20
    [PUBMED:12368087] [PUB00015362]
  3. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. (2002)
    The protein kinase complement of the human genome.
    Science 298: 1912-34
    [PUBMED:12471243] [PUB00020114]
  4. Stout TJ, Foster PG, Matthews DJ. (2004)
    High-throughput structural biology in drug discovery: protein kinases.
    Curr. Pharm. Des. 10: 1069-82
    [PUBMED:15078142] [PUB00034898]
  5. Li B, Liu Y, Uno T, Gray N. (2004)
    Creating chemical diversity to target protein kinases.
    Comb. Chem. High Throughput Screen. 7: 453-72
    [PUBMED:15320712] [PUB00034899]
  6. Sharma PS, Sharma R, Tyagi T. (2009)
    Receptor tyrosine kinase inhibitors as potent weapons in war against cancers.
    Curr. Pharm. Des. 15: 758-76
    [PUBMED:19275641] [PUB00052410]
  7. Li E, Hristova K. (2006)
    Role of receptor tyrosine kinase transmembrane domains in cell signaling and human pathologies.
    Biochemistry 45: 6241-51
    [PUBMED:16700535] [PUB00052411]
  8. Roskoski R Jr. (2005)
    Src kinase regulation by phosphorylation and dephosphorylation.
    Biochem. Biophys. Res. Commun. 331: 1-14
    [PUBMED:15845350] [PUB00052412]
Database linksMSDsite: PS00109;
EC: 2.7;
PROSITEDOC: PDOC00100;
PDB: 1ad5; PDB: 1agw; PDB: 1byg; PDB: 1fgi; PDB: 1fgk; PDB: 1fmk; PDB: 1fpu; PDB: 1fvr; PDB: 1gag; PDB: 1gjo; PDB: 1i44; PDB: 1iep; PDB: 1ir3; PDB: 1irk; PDB: 1jpa; PDB: 1jqh; PDB: 1k2p; PDB: 1k3a; PDB: 1k9a; PDB: 1ksw; PDB: 1luf; PDB: 1m14; PDB: 1m17; PDB: 1m52; PDB: 1m7n; PDB: 1mp8; PDB: 1mqb; PDB: 1oec; PDB: 1opj; PDB: 1opk; PDB: 1opl; PDB: 1p14; PDB: 1p4o; PDB: 1pkg; PDB: 1qcf; PDB: 1qpc; PDB: 1qpd; PDB: 1qpe; PDB: 1qpj; PDB: 1r0p; PDB: 1r1w; PDB: 1rjb; PDB: 1rqq; PDB: 1sm2; PDB: 1snu; PDB: 1snx; PDB: 1t45; PDB: 1t46; PDB: 1tki; PDB: 1tqi; PDB: 1tqm; PDB: 1tqp; PDB: 1u46; PDB: 1u4d; PDB: 1u54; PDB: 1u59; PDB: 1vr2; PDB: 1xba; PDB: 1xbb; PDB: 1xbc; PDB: 1xkk; PDB: 1y57; PDB: 1y6a; PDB: 1y6b; PDB: 1yi6; PDB: 1yoj; PDB: 1yol; PDB: 1yom; PDB: 1yvj; PDB: 1ywn; PDB: 1zao; PDB: 1zar; PDB: 2auh; PDB: 2b4s; PDB: 2b7a; PDB: 2bdf; PDB: 2bdj; PDB: 2c0i; PDB: 2c0o; PDB: 2c0t; PDB: 2dq7; PDB: 2e2b; PDB: 2eb2; PDB: 2eb3; PDB: 2etm; PDB: 2f4j; PDB: 2fgi; PDB: 2fo0; PDB: 2g15; PDB: 2g1t; PDB: 2g2f; PDB: 2g2h; PDB: 2g2i; PDB: 2gqg; PDB: 2gs2; PDB: 2gs6; PDB: 2gs7; PDB: 2gsf; PDB: 2h8h; PDB: 2hck; PDB: 2hel; PDB: 2hen; PDB: 2hiw; PDB: 2hk5; PDB: 2hwo; PDB: 2hwp; PDB: 2hyy; PDB: 2hz0; PDB: 2hz4; PDB: 2hzi; PDB: 2hzn; PDB: 2i0v; PDB: 2i0y; PDB: 2i1m; PDB: 2ijm; PDB: 2itn; PDB: 2ito; PDB: 2itp; PDB: 2itq; PDB: 2itt; PDB: 2itu; PDB: 2itv; PDB: 2itw; PDB: 2itx; PDB: 2ity; PDB: 2itz; PDB: 2ivs; PDB: 2ivt; PDB: 2ivu; PDB: 2ivv; PDB: 2j0j; PDB: 2j0k; PDB: 2j0l; PDB: 2j0m; PDB: 2j5e; PDB: 2j5f; PDB: 2j6m; PDB: 2jit; PDB: 2jiu; PDB: 2jiv; PDB: 2jkk; PDB: 2jkm; PDB: 2jko; PDB: 2jkq; PDB: 2of2; PDB: 2of4; PDB: 2ofu; PDB: 2ofv; PDB: 2og8; PDB: 2ogv; PDB: 2oh4; PDB: 2oiq; PDB: 2oj9; PDB: 2oo8; PDB: 2osc; PDB: 2ozo; PDB: 2p0c; PDB: 2p2h; PDB: 2p2i; PDB: 2p4i; PDB: 2pl0; PDB: 2psq; PDB: 2ptk; PDB: 2pvf; PDB: 2pvy; PDB: 2pwl; PDB: 2py3; PDB: 2pz5; PDB: 2pzp; PDB: 2pzr; PDB: 2q0b; PDB: 2qi8; PDB: 2qlq; PDB: 2qo2; PDB: 2qo7; PDB: 2qo9; PDB: 2qob; PDB: 2qoc; PDB: 2qod; PDB: 2qof; PDB: 2qoh; PDB: 2qoi; PDB: 2qok; PDB: 2qol; PDB: 2qon; PDB: 2qoo; PDB: 2qoq; PDB: 2qq7; PDB: 2qu5; PDB: 2qu6; PDB: 2r2p; PDB: 2r4b; PDB: 2rei; PDB: 2rf9; PDB: 2rfd; PDB: 2rfe; PDB: 2rfn; PDB: 2rfs; PDB: 2rgp; PDB: 2rl5; PDB: 2src; PDB: 2v7a; PDB: 2vwb; PDB: 2vwu; PDB: 2vwv; PDB: 2vww; PDB: 2vwx; PDB: 2vwy; PDB: 2vwz; PDB: 2vx0; PDB: 2vx1; PDB: 2w1i; PDB: 2wd1; PDB: 2wgj; PDB: 2wkm; PDB: 2wqb; PDB: 2x2k; PDB: 2x2l; PDB: 2x2m; PDB: 2x9f; PDB: 2xa4; PDB: 2xb7; PDB: 2xba; PDB: 2xir; PDB: 2xp2; PDB: 2xvd; PDB: 2xyn; PDB: 2xyu; PDB: 2y6m; PDB: 2y6o; PDB: 2yfx; PDB: 2yhv; PDB: 2yjr; PDB: 2yjs; PDB: 2yn8; PDB: 2z60; PDB: 2z8c; PDB: 2zm1; PDB: 2zm3; PDB: 2zm4; PDB: 2zv7; PDB: 2zv8; PDB: 2zv9; PDB: 2zva; PDB: 2zyb; PDB: 3a4o; PDB: 3a4p; PDB: 3ac1; PDB: 3ac2; PDB: 3ac3; PDB: 3ac4; PDB: 3ac5; PDB: 3ac8; PDB: 3acj; PDB: 3ack; PDB: 3ad4; PDB: 3ad5; PDB: 3ad6; PDB: 3aox; PDB: 3b2t; PDB: 3b2w; PDB: 3b8q; PDB: 3b8r; PDB: 3bbt; PDB: 3bbw; PDB: 3bce; PDB: 3be2; PDB: 3bea; PDB: 3bel; PDB: 3bkb; PDB: 3bpr; PDB: 3brb; PDB: 3bu3; PDB: 3bu5; PDB: 3bu6; PDB: 3bym; PDB: 3byo; PDB: 3bys; PDB: 3byu; PDB: 3bz3; PDB: 3c1x; PDB: 3c4f; PDB: 3c7q; PDB: 3cbl; PDB: 3cc6; PDB: 3ccn; PDB: 3cd3; PDB: 3cd8; PDB: 3ce3; PDB: 3cjf; PDB: 3cjg; PDB: 3cly; PDB: 3cok; PDB: 3cp9; PDB: 3cpb; PDB: 3cpc; PDB: 3cs9; PDB: 3cth; PDB: 3ctj; PDB: 3d7t; PDB: 3d7u; PDB: 3d94; PDB: 3dk3; PDB: 3dk6; PDB: 3dk7; PDB: 3dkc; PDB: 3dkf; PDB: 3dkg; PDB: 3dko; PDB: 3dpk; PDB: 3dqw; PDB: 3dqx; PDB: 3dtw; PDB: 3dzq; PDB: 3e62; PDB: 3e63; PDB: 3e64; PDB: 3efj; PDB: 3efk; PDB: 3efl; PDB: 3ekk; PDB: 3ekn; PDB: 3el7; PDB: 3el8; PDB: 3emg; PDB: 3en4; PDB: 3en5; PDB: 3en6; PDB: 3en7; PDB: 3en9; PDB: 3enh; PDB: 3eqp; PDB: 3eqr; PDB: 3et7; PDB: 3eta; PDB: 3ewh; PDB: 3eyg; PDB: 3eyh; PDB: 3f3t; PDB: 3f3u; PDB: 3f3v; PDB: 3f3w; PDB: 3f5p; PDB: 3f66; PDB: 3f6x; PDB: 3f82; PDB: 3fqe; PDB: 3fqh; PDB: 3fqs; PDB: 3fup; PDB: 3fxx; PDB: 3fy2; PDB: 3fzo; PDB: 3fzp; PDB: 3fzr; PDB: 3fzs; PDB: 3fzt; PDB: 3g0e; PDB: 3g0f; PDB: 3g5d; PDB: 3g6g; PDB: 3g6h; PDB: 3gen; PDB: 3geq; PDB: 3gop; PDB: 3gqi; PDB: 3gql; PDB: 3gt8; PDB: 3gvu; PDB: 3h3c; PDB: 3hmi; PDB: 3hng; PDB: 3i5n; PDB: 3i81; PDB: 3ik3; PDB: 3ika; PDB: 3io7; PDB: 3iok; PDB: 3js2; PDB: 3jy9; PDB: 3k54; PDB: 3k5v; PDB: 3kck; PDB: 3kf4; PDB: 3kfa; PDB: 3kmm; PDB: 3krj; PDB: 3krl; PDB: 3krr; PDB: 3kul; PDB: 3kxx; PDB: 3kxz; PDB: 3ky2; PDB: 3l8p; PDB: 3l8v; PDB: 3l9p; PDB: 3lcd; PDB: 3lck; PDB: 3lco; PDB: 3lcs; PDB: 3lct; PDB: 3lok; PDB: 3lpb; PDB: 3lq8; PDB: 3lvp; PDB: 3lw0; PDB: 3lxk; PDB: 3lxl; PDB: 3lxn; PDB: 3lxp; PDB: 3lzb; PDB: 3miy; PDB: 3mj1; PDB: 3mj2; PDB: 3mpm; PDB: 3ms9; PDB: 3mss; PDB: 3nw5; PDB: 3nw6; PDB: 3nw7; PDB: 3nyx; PDB: 3nz0; PDB: 3o23; PDB: 3ocs; PDB: 3oct; PDB: 3oez; PDB: 3of0; PDB: 3oxz; PDB: 3oy3; PDB: 3p08; PDB: 3pix; PDB: 3piy; PDB: 3piz; PDB: 3pj1; PDB: 3pj2; PDB: 3pj3; PDB: 3pjc; PDB: 3pls; PDB: 3poz; PDB: 3pp0; PDB: 3pxk; PDB: 3pyy; PDB: 3q32; PDB: 3q6u; PDB: 3q6w; PDB: 3qgw; PDB: 3qgy; PDB: 3qlf; PDB: 3qlg; PDB: 3qqu; PDB: 3qri; PDB: 3qrj; PDB: 3qrk; PDB: 3qti; PDB: 3qup; PDB: 3r7o; PDB: 3rcd; PDB: 3rhk; PDB: 3rhx; PDB: 3ri1; PDB: 3rvg; PDB: 3srv; PDB: 3svv; PDB: 3sxr; PDB: 3sxs; PDB: 3t9t; PDB: 3tcp; PDB: 3tjc; PDB: 3tjd; PDB: 3tt0; PDB: 3tub; PDB: 3tuc; PDB: 3tud; PDB: 3tz7; PDB: 3tz8; PDB: 3tz9; PDB: 3u4w; PDB: 3u51; PDB: 3u6h; PDB: 3u6i; PDB: 3u6j; PDB: 3ue4; PDB: 3ug1; PDB: 3ug2; PDB: 3ugc; PDB: 3uqf; PDB: 3uqg; PDB: 3v5j; PDB: 3v5l; PDB: 3v5q; PDB: 3v8t; PDB: 3v8w; PDB: 3vf8; PDB: 3vf9; PDB: 3vhe; PDB: 3vhk; PDB: 3vid; PDB: 3vjn; PDB: 3vjo; PDB: 3vnt; PDB: 3vo3; PDB: 3vry; PDB: 3vrz; PDB: 3vs0; PDB: 3vs1; PDB: 3vs2; PDB: 3vs3; PDB: 3vs4; PDB: 3vs5; PDB: 3vs6; PDB: 3vs7; PDB: 3vw8; PDB: 3w2o; PDB: 3w2p; PDB: 3w2q; PDB: 3w2r; PDB: 3w2s; PDB: 3w32; PDB: 3w33; PDB: 3zbf; PDB: 3zbx; PDB: 3zc5; PDB: 3zc6; PDB: 3zcl; PDB: 3zep; PDB: 3zew; PDB: 3zfm; PDB: 3zfx; PDB: 3zfy; PDB: 3zmm; PDB: 3zon; PDB: 3zos; PDB: 3zxz; PDB: 3zze; PDB: 3zzw; PDB: 4ag8; PDB: 4agc; PDB: 4agd; PDB: 4agw; PDB: 4anl; PDB: 4anq; PDB: 4ans; PDB: 4aoi; PDB: 4aoj; PDB: 4ap7; PDB: 4aqc; PDB: 4asd; PDB: 4ase; PDB: 4asz; PDB: 4at3; PDB: 4at4; PDB: 4at5; PDB: 4aw5; PDB: 4bb4; PDB: 4bbe; PDB: 4bbf; PDB: 4bkj; PDB: 4brx; PDB: 4c3f; PDB: 4c61; PDB: 4c62; PDB: 4c7t; PDB: 4ccb; PDB: 4ccu; PDB: 4cd0; PDB: 4cki; PDB: 4ckj; PDB: 4ckr; PDB: 4cli; PDB: 4clj; PDB: 4cmo; PDB: 4cmt; PDB: 4cmu; PDB: 4cnh; PDB: 4ctb; PDB: 4ctc; PDB: 4d0w; PDB: 4d0x; PDB: 4d1s; PDB: 4dce; PDB: 4deg; PDB: 4deh; PDB: 4dei; PDB: 4dfl; PDB: 4dfn; PDB: 4dgg; PDB: 4e1z; PDB: 4e20; PDB: 4e4l; PDB: 4e4m; PDB: 4e4n; PDB: 4e5w; PDB: 4e6d; PDB: 4e6q; PDB: 4e93; PDB: 4ebv; PDB: 4ebw; PDB: 4eev; PDB: 4ehz; PDB: 4ei4; PDB: 4ewh; PDB: 4f08; PDB: 4f09; PDB: 4f0i; PDB: 4f4p; PDB: 4f63; PDB: 4f64; PDB: 4f65; PDB: 4feq; PDB: 4ff8; PDB: 4fic; PDB: 4fk6; PDB: 4fl1; PDB: 4fl2; PDB: 4fl3; PDB: 4fnw; PDB: 4fnx; PDB: 4fny; PDB: 4fnz; PDB: 4fob; PDB: 4foc; PDB: 4fod; PDB: 4fvp; PDB: 4fvq; PDB: 4fvr; PDB: 4fyn; PDB: 4fyo; PDB: 4fz6; PDB: 4fz7; PDB: 4g2f; PDB: 4g5j; PDB: 4g5p; PDB: 4gfg; PDB: 4gfm; PDB: 4gfo; PDB: 4gg5; PDB: 4gg7; PDB: 4gih; PDB: 4gii; PDB: 4gj2; PDB: 4gj3; PDB: 4gk2; PDB: 4gk3; PDB: 4gk4; PDB: 4gl9; PDB: 4gmy; PDB: 4gt4; PDB: 4gt5; PDB: 4gu6; PDB: 4gu9; PDB: 4gvj; PDB: 4h1j; PDB: 4h1m; PDB: 4hct; PDB: 4hcu; PDB: 4hcv; PDB: 4hge; PDB: 4hjo; PDB: 4hvd; PDB: 4hvg; PDB: 4hvh; PDB: 4hvi; PDB: 4hvs; PDB: 4hw7; PDB: 4hzr; PDB: 4hzs; PDB: 4i0r; PDB: 4i0s; PDB: 4i0t; PDB: 4i1z; PDB: 4i20; PDB: 4i21; PDB: 4i22; PDB: 4i23; PDB: 4i24; PDB: 4i4e; PDB: 4i4f; PDB: 4i5c; PDB: 4i6q; PDB: 4ibm; PDB: 4id7; PDB: 4iva; PDB: 4ivb; PDB: 4ivc; PDB: 4ivd; PDB: 4iwd; PDB: 4j95; PDB: 4j96; PDB: 4j97; PDB: 4j98; PDB: 4j99; PDB: 4ji9; PDB: 4jia; PDB: 4jnw; PDB: 4joa; PDB: 4jq7; PDB: 4jq8; PDB: 4jr3; PDB: 4jrv; PDB: 4jxf; PDB: 4k11; PDB: 4k2r; PDB: 4k33; PDB: 4k6z; PDB: 4k77; PDB: 4k8a; PDB: 4k9y; PDB: 4kab; PDB: 4kao; PDB: 4kio; PDB: 4knb; PDB: 4l00; PDB: 4l01; PDB: 4l7s; PDB: 4lgg; PDB: 4lgh; PDB: 4li5; PDB: 4ll0; PDB: 4lqm; PDB: 4lrm; PDB: 4lud; PDB: 4lue; PDB: 4m0y; PDB: 4m0z; PDB: 4m12; PDB: 4m13; PDB: 4m14; PDB: 4m15; PDB: 4m3q; PDB: 4mcv; PDB: 4mf0; PDB: 4mf1; PDB: 4mh7; PDB: 4mha; PDB: 4mkc; PDB: 4mxc; PDB: 4mxo; PDB: 4mxx; PDB: 4mxy; PDB: 4mxz; PDB: 4nk9; PDB: 4nka; PDB: 4nks; PDB: 4nwm; PDB: 4ot5; PDB: 4ot6; PDB: 4otq; PDB: 4otr; PDB: 4p2k; PDB: 4p4c; PDB: 4p5q; PDB: 4p5z; PDB: 4p7e; PDB: 4pmm; PDB: 4pmp; PDB: 4pms; PDB: 4pmt; PDB: 4pp9; PDB: 4ppa; PDB: 4ppb; PDB: 4ppc; PDB: 4pqn; PDB: 4puz; PDB: 4pv0; PDB: 4py1; PDB: 4qny; PDB: 4r5s; PDB: 4rfy; PDB: 4rfz; PDB: 4rg0; PDB: 4rio; PDB: 4riw; PDB: 4rj7; PDB: 4tks; PDB: 4v05; PDB: 4wkq; PDB: 4wun; CATH: 1.10.510.10; CATH: 3.30.200.20; SCOP: d.144.1.7; SCOP: d.144.1.9;
Taxonomy DistributionCaenorhabditis elegans: 105
Archaea: 2
Cyanobacteria: 8
Eukaryota: 106
Fungi: 52
OtherEukaryotes: 157
PlastidGroup: 15
Bacteria: 395
Eukaryota: 37
Fungi: 18
OtherEukaryotes: 44
PlastidGroup: 381
Virus: 53
Eukaryota: 3990
PlastidGroup: 3990
Eukaryota: 34625
Bacteria: 1
Eukaryota: 693
Eukaryota: 381
Fungi: 10
Eukaryota: 129
Bacteria: 6
Bacteria: 6
Eukaryota: 44
Eukaryota: 15
Bacteria: 8
Eukaryota: 157
Eukaryota: 46
Bacteria: 76
Eukaryota: 20
Bacteria: 15
Bacteria: 9
Arabidopsis thaliana: 65
Arthropoda: 6860
Bacteria: 5456
Chordata: 16396
Cyanobacteria: 395
Eukaryota: 40342
Fungi: 5437
GreenPlants: 3990
Metazoa: 28819
Nematoda: 3582
OtherEukaryotes: 46
PlastidGroup: 693
Viruses: 497
Archaea: 85
Chordata: 179
Cyanobacteria: 24
Fungi: 2584
GreenPlants: 202
Nematoda: 954
OtherEukaryotes: 20
PlastidGroup: 37
Unclassified: 72
Archaea: 593
Chordata: 15863
Fungi: 2505
Metazoa: 15
PlastidGroup: 129
Unclassified: 2
Arthropoda: 6507
Chordata: 354
Virus: 444
Archaea: 12
Eukaryota: 84
OtherEukaryotes: 84
PlastidGroup: 106
Bacteria: 30
Eukaryota: 15
Fungi: 143
Metazoa: 277
OtherEukaryotes: 15
Virus: 497
Saccharomyces cerevisiae: 14
Bacteria: 37
Fungi: 13
Bacteria: 467
Bacteria: 1
Bacteria: 64
Bacteria: 2998
Bacteria: 4
Archaea: 803
FruitFly: 341
Human: 473
Mouse: 335
Rice: 104
Arthropoda: 353
Bacteria: 1044
Metazoa: 28504
GreenPlants: 3788
Nematoda: 2628
Archaea: 19
Bacteria: 227
Fungi: 37
Metazoa: 117
Cyanobacteria: 248
Metazoa: 23
Cyanobacteria: 63