Dbfetch
ID HLA00001; SV 1; standard; DNA; HUM; 3503 BP. XX AC HLA00001; XX SV HLA00001.1 XX DT 01-AUG-1989 (Rel. 1.0.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 1) XX DE HLA-A*01:01:01:01, Human MHC Class I sequence XX KW Human MHC; HLA; Class I; HLA-A; Allele; HLA-A*01:01:01:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-3503 RX PUBMED; 3375250. RA Parham P, Lomen CE, Lawlor DA, Ways JP, Holmes N, Coppin HL, Salter RD, Wan RA AM, Ennis PD; RT "Nature of polymorphism in HLA-A, -B, and -C molecules."; RL Proceedings of the National Academy of Sciences USA 85:4005-4009(1988). XX RN [2] RP 1-3503 RX PUBMED; 2251137. RA Girdlestone J; RT "Nucleotide sequence of an HLA-A1 gene."; RL Nucleic Acids Research 18:6701(1990). XX RN [3] RP 1-3503 RX PUBMED; 9349617. RA Laforet M, Froelich N, Parissiadis A, Pfeiffer B, Schell A, Faller B, RA Woehl-Jaegle ML, Cazenave JP, Tongio MM; RT "A nucleotide insertion in exon 4 is responsible for the absence of RT expression of an HLA-A*01 allele."; RL Tissue Antigens 50:347-350(1997). XX RN [4] RP 1-3503 RX PUBMED; 15140828. RA Stewart CA, Horton R, Allcock RJ, Ashurst JL, Atrazhev AM, Coggill P, RA Dunham I, Forbes S, Halls K, Howson JM, Humphray SJ, Hunt S, Mungall AJ, RA Osoegawa K, Palmer S, Roberts AN, Rogers J, Sims S, Wang Y, Wilming LG, RA Elliott JF, de Jong PJ, Sawcer S, Todd JA, Trowsdale J, Beck S; RT "Complete MHC haplotype sequencing for common disease gene mapping."; RL Genome Research 14:1176-1187(2004). XX RN [5] RP 1-3503 RX PUBMED; 18193213. RA Horton R, Gibson R, Coggill P, Miretti M, Allcok RJ, Almeida J, Forbes S, RA Gilbert JGR, Halls K, Harrow JL, Hart E, Howe K, Jackson DK, Palmer S, RA Roberts AN, Sims S, Stewart CA, Traherne JA, Trevanion S, Wilming L, Rogers RA J, de Jong PJ, Elliott JF, Sawcer S, Todd JA, Trowsdale J, Beck S; RT "Variation analysis and gene annotation of eight MHC haplotypes: The MHC RT Haplotype Project."; RL Immunogenetics 60:1-18(2008). XX RN [6] RP 1-3503 RX PUBMED; 19735485. RA Zhu F, He Y, Zhang W, He J, He J, Xu X, Yan L; RT "Analysis of the complete genomic sequence of HLA-A alleles in the Chinese RT Han population."; RL International Journal of Immunogenetics 36:351-360(2009). XX RN [7] RP 1-3503 RX PUBMED; 24673518. RA Lu L, Xu YP; RT "Genomic full-length sequence of two HLA-A alleles, A*01:01:01:01 and RT A*01:03, identified by cloning and sequencing."; RL Tissue Antigens 83:423-424(2014). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; AJ278305; AJ278305.2. DR EMBL; AL645935; AL645935.7. DR EMBL; CR759913; CR759913.4. DR EMBL; EU445470; EU445470.1. DR EMBL; GU812295; GU812295.1. DR EMBL; HG794373; HG794373.1. DR EMBL; M24043; M24043.1. DR EMBL; OR126295; OR126295.1. DR EMBL; X55710; X55710.1. DR EMBL; Z93949; Z93949.1. XX FH Key Location/Qualifiers FH FT source 1..3503 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, European, Undefined" FT /cell_line="7550800303" FT /cell_line="APD" FT /cell_line="B4702" FT /cell_line="COX" FT /cell_line="DE-SMS_A-575369" FT /cell_line="LCL721" FT /cell_line="MOLT-4" FT /cell_line="PP" FT CDS join(301..373,504..773,1015..1290,1870..2145,2248..2364, FT 2807..2839,2982..3029,3199..3203) FT /codon_start=1 FT /gene="HLA-A" FT /allele="HLA-A*01:01:01:01" FT /product="MHC Class I HLA-A*01:01:01:01 sequence" FT /translation="MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPR FT FIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGT FT LRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMA FT AQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHE FT ATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRY FT TCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRK FT GGSYTQAASSDSAQGSDVSLTACKV" FT UTR 1..300 FT exon 301..373 FT /number="1" FT intron 374..503 FT /number="1" FT exon 504..773 FT /number="2" FT intron 774..1014 FT /number="2" FT exon 1015..1290 FT /number="3" FT intron 1291..1869 FT /number="3" FT exon 1870..2145 FT /number="4" FT intron 2146..2247 FT /number="4" FT exon 2248..2364 FT /number="5" FT intron 2365..2806 FT /number="5" FT exon 2807..2839 FT /number="6" FT intron 2840..2981 FT /number="6" FT exon 2982..3029 FT /number="7" FT intron 3030..3198 FT /number="7" FT exon 3199..3203 FT /number="8" FT UTR 3204..3503 SQ Sequence 3503 BP; 666 A; 1012 C; 1070 G; 755 T; 0 other; caggagcaga ggggtcaggg cgaagtccca gggccccagg cgtggctctc agggtctcag 60 gccccgaagg cggtgtatgg attggggagt cccagccttg gggattcccc aactccgcag 120 tttcttttct ccctctccca acctacgtag ggtccttcat cctggatact cacgacgcgg 180 acccagttct cactcccatt gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg 240 gtcgctgttc taaagtccgc acgcacccac cgggactcag attctcccca gacgccgagg 300 atggccgtca tggcgccccg aaccctcctc ctgctactct cgggggccct ggccctgacc 360 cagacctggg cgggtgagtg cggggtcggg agggaaaccg cctctgcggg gagaagcaag 420 gggccctcct ggcgggggcg caggaccggg ggagccgcgc cgggaggagg gtcgggcagg 480 tctcagccac tgctcgcccc caggctccca ctccatgagg tatttcttca catccgtgtc 540 ccggcccggc cgcggggagc cccgcttcat cgccgtgggc tacgtggacg acacgcagtt 600 cgtgcggttc gacagcgacg ccgcgagcca gaagatggag ccgcgggcgc cgtggataga 660 gcaggagggg ccggagtatt gggaccagga gacacggaat atgaaggccc actcacagac 720 tgaccgagcg aacctgggga ccctgcgcgg ctactacaac cagagcgagg acggtgagtg 780 accccggccc ggggcgcagg tcacgacccc tcatccccca cggacgggcc aggtcgccca 840 cagtctccgg gtccgagatc caccccgaag ccgcgggact ccgagaccct tgtcccggga 900 gaggcccagg cgcctttacc cggtttcatt ttcagtttag gccaaaaatc cccccgggtt 960 ggtcggggcg gggcggggct cgggggactg ggctgaccgc ggggtcgggg ccaggttctc 1020 acaccatcca gataatgtat ggctgcgacg tggggccgga cgggcgcttc ctccgcgggt 1080 accggcagga cgcctacgac ggcaaggatt acatcgccct gaacgaggac ctgcgctctt 1140 ggaccgcggc ggacatggca gctcagatca ccaagcgcaa gtgggaggcg gtccatgcgg 1200 cggagcagcg gagagtctac ctggagggcc ggtgcgtgga cgggctccgc agatacctgg 1260 agaacgggaa ggagacgctg cagcgcacgg gtaccagggg ccacggggcg cctccctgat 1320 cgcctataga tctcccgggc tggcctccca caaggagggg agacaattgg gaccaacact 1380 agaatatcac cctccctctg gtcctgaggg agaggaatcc tcctgggttt ccagatcctg 1440 taccagagag tgactctgag gttccgccct gctctctgac acaattaagg gataaaatct 1500 ctgaaggagt gacgggaaga cgatccctcg aatactgatg agtggttccc tttgacaccg 1560 gcagcagcct tgggcccgtg acttttcctc tcaggccttg ttctctgctt cacactcaat 1620 gtgtgtgggg gtctgagtcc agcacttctg agtctctcag cctccactca ggtcaggacc 1680 agaagtcgct gttcccttct cagggaatag aagattatcc caggtgcctg tgtccaggct 1740 ggtgtctggg ttctgtgctc tcttccccat cccgggtgtc ctgtccattc tcaagatggc 1800 cacatgcgtg ctggtggagt gtcccatgac agatgcaaaa tgcctgaatt ttctgactct 1860 tcccgtcaga cccccccaag acacatatga cccaccaccc catctctgac catgaggcca 1920 ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc tggcagcggg 1980 atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca ggggatggaa 2040 ccttccagaa gtgggcggct gtggtggtgc cttctggaga ggagcagaga tacacctgcc 2100 atgtgcagca tgagggtctg cccaagcccc tcaccctgag atggggtaag gagggagatg 2160 ggggtgtcat gtctcttagg gaaagcagga gcctctctgg agacctttag cagggtcagg 2220 gcccctcacc ttcccctctt ttcccagagc tgtcttccca gcccaccatc cccatcgtgg 2280 gcatcattgc tggcctggtt ctccttggag ctgtgatcac tggagctgtg gtcgctgccg 2340 tgatgtggag gaggaagagc tcaggtggag aaggggtgaa gggtggggtc tgagatttct 2400 tgtctcactg agggttccaa gccccagcta gaaatgtgcc ctgtctcatt actgggaagc 2460 accttccaca atcatgggcc gacccagcct gggccctgtg tgccagcact tactcttttg 2520 taaagcacct gttaaaatga aggacagatt tatcaccttg attacggcgg tgatgggacc 2580 tgatcccagc agtcacaagt cacaggggaa ggtccctgag gacagacctc aggagggcta 2640 ttggtccagg acccacacct gctttcttca tgtttcctga tcccgccctg ggtctgcagt 2700 cacacatttc tggaaacttc tctggggtcc aagactagga ggttcctcta ggaccttaag 2760 gccctggctc ctttctggta tctcacagga cattttcttc ccacagatag aaaaggaggg 2820 agttacactc aggctgcaag taagtatgaa ggaggctgat gcctgaggtc cttgggatat 2880 tgtgtttggg agcccatggg ggagctcacc caccccacaa ttcctcctct agccacatct 2940 tctgtgggat ctgaccaggt tctgtttttg ttctacccca ggcagtgaca gtgcccaggg 3000 ctctgatgtg tctctcacag cttgtaaagg tgagagcttg gagggcctga tgtgtgttgg 3060 gtgttgggtg gaacagtgga cacagctgtg ctatggggtt tctttgcgtt ggatgtattg 3120 agcatgcgat gggctgttta aggtgtgacc cctcactgtg atggatatga atttgttcat 3180 gaatattttt ttctatagtg tgagacagct gccttgtgtg ggactgagag gcaagagttg 3240 ttcctgccct tccctttgtg acttgaagaa ccctgacttt gtttctgcaa aggcacctgc 3300 atgtgtctgt gttcgtgtag gcataatgtg aggaggtggg gagagcaccc cacccccatg 3360 tccaccatga ccctcttccc acgctgacct gtgctccctc tccaatcatc tttcctgttc 3420 cagagaggtg gggctgaggt gtctccatct ctgtctcaac ttcatggtgc actgagctgt 3480 aacttcttcc ttccctatta aaa 3503 //