Dbfetch
ID HLA06451; SV 2; standard; DNA; HUM; 11542 BP. XX AC HLA06451; XX SV HLA06451.2 XX DT 31-JAN-2011 (Rel. 3.4.0, Created, Version 1) DT 16-JAN-2024 (Rel. 3.55.0, Last Updated, Version 2) XX DE MICA*010:02:01, Human MHC Class I chain-related gene XX KW Human MHC; Class I chain-related gene; MICA; Allele; MICA*010:02:01; XX OS Homo Sapiens (human) OC Eukaryota; Metazoa; Chordata; Vertebrata; Mammalia; Eutheria; Primates; OC Catarrhini; Hominidae; Homo. XX CC -------------------------------------------------------------------------- CC IPD-IMGT/HLA Release Version 3.55.0 CC -------------------------------------------------------------------------- CC Copyrighted by the IPD-IMGT/HLA Database, Distributed under the Creative CC Commons Attribution-NoDerivs License, see; CC http://www.ebi.ac.uk/ipd/imgt/hla/licence/ for further details. CC -------------------------------------------------------------------------- XX RN [1] RP 1-11542 RX PUBMED; 22111573. RA Zhang S, Wang J, Luo M, Li X, Chen Q; RT "Identification of a novel allele MICA*010:02."; RL Tissue Antigens 79:216-217(2012). XX CC -------------------------------------------------------------------------- CC The sequence below is the official allele sequence as approved by the CC WHO Nomenclature Committee for Factors of the HLA System. CC Any cross references may differ from the sequence shown below. CC -------------------------------------------------------------------------- XX DR EMBL; FR751004; FR751004.1. DR EMBL; LR597610; LR597610.1. DR EMBL; LR597611; LR597611.1. XX FH Key Location/Qualifiers FH FT source 1..11542 FT /organism="Homo sapiens" FT /mol_type="genomic DNA" FT /db_xref="taxon:9606" FT /ethnic="Asian, Undefined" FT /cell_line="43279" FT /cell_line="43762" FT /cell_line="DKMS-LSL_ID17163475" FT /cell_line="DKMS-LSL_ID17184301" FT CDS join(20..89,6927..7181,7456..7743,8331..8609,8709..8843, FT 11395..11522) FT /codon_start=1 FT /gene="MICA" FT /allele="MICA*010:02:01" FT /product="MHC Class I chain-related MICA*010:02:01 sequence" FT /translation="MGLGPVFLLLAGIFPFAPPGAAAEPHSLPYNLTVLSWDGSVQSGF FT LAEVHLDGQPFLRYDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK FT DQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETEEWTVPQSSRAQTLAM FT NVRNFLKEDAMKTKTHYHAMHADCLQELRRYLESSVVLRRTVPPMVNVTRSEASEGNIT FT VTCRASSFYPRNIILTWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICRGEEQRFT FT CYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAAIFVIIIFYVRCCKKKTSAAE FT GPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSALGSTGSTEGA" FT UTR 1..19 FT exon 20..89 FT /number="1" FT intron 90..6926 FT /number="1" FT exon 6927..7181 FT /number="2" FT intron 7182..7455 FT /number="2" FT exon 7456..7743 FT /number="3" FT intron 7744..8330 FT /number="3" FT exon 8331..8609 FT /number="4" FT intron 8610..8708 FT /number="4" FT exon 8709..8843 FT /number="5" FT intron 8844..11394 FT /number="5" FT exon 11395..11522 FT /number="6" FT UTR 11523..11542 SQ Sequence 11542 BP; 2367 A; 2968 C; 2782 G; 3425 T; 0 other; gggtggcgac gtcggggcca tggggctggg cccggtcttc ctgcttctgg ctggcatctt 60 cccttttgca cctccgggag ctgctgctgg tgagtggcgt tcctggcggt cctcggcgga 120 gcgggagcag tgggacgttt ccgggggtcg ggtgggtagc ggcgagcgct gtgcggtcag 180 ggcggggctc ctgtgccctg tcggtggcgc agggagctgg acgcggcccg ttaccgccac 240 acttcagccc tgcttccccg tcacttttca gtcctcctcg ggatcgcgca tcacctgcac 300 tttctggtct cctcctgctc tttctctcct cgcgtctcct ccgcttcctc tcacttttcg 360 gacaaaccag tccttctgag gcccatgggt tcccgggctg cctccggggc tgctcctgtg 420 aatggcattc gagtgccctt ccagcgcggc cactgaagca gccacaaccc ccggtgctcg 480 gggcggctct caggtccctg aagtcctgtc ctctcccgga gccgacgtgt tctcagctcc 540 tgggccgcag ctcctggagt aggggccctc ctttctcggg acccggagct ggtgcttcct 600 gctgctgtgg ggactgtggg gggtcctgac tctcaagctg aggggttgga gtctgcaggc 660 tccgggcaga ggattcttcc tgcgacttct ctcatcccca gctcattctc ccctcgcctc 720 tggctccgag ggtcctctcc tctctctcat cccaccccta ctaatgacca gtgatctaag 780 gacaccagat tccctctcac ctcctccctg cccatctcag ggcccgctga gtccttttgc 840 cctcccagct ccctgctacc ccttcctgtg tgctgttctc tgatccattt ctagggtgtc 900 ctctgccctc atcccctgtc cccgccaccg aaggtccctc ctgcacccct tatgggcctt 960 tcctacaagc agccttcacc cagtgctgcc cctatgcctc cccgttccca aatgtccctg 1020 actctaactt tctggtgctg ccttttatcc gggggggtct tccctccatc ccactcccct 1080 ccagaccccc aaggggaacc ctgatgctaa tggcagttgg gccttaggca gggcgcaggg 1140 cagcgcagat gccccctccc ctccagtgca gatgcctgtt ctggaccctg cctcattgtg 1200 gccccttccc cactccttca tcctcagcct caccctcttg aggaccccac cctccagccc 1260 acaggtgctg gaccatccct ccctggtccc tccgcccctc tccaccttgg gaccttgtgc 1320 tgctcctatc tcttgcccag ctgccttggg ccctcagcac gttctcatct ttcagtggga 1380 aagtgggagt gctggagcat atgacagtgc tgagcatctt tcccaagccc caccctcccc 1440 cagagcaccc tcccctcctg tcctcaccct accccaagtt ctcccacagt cactcctgcc 1500 ccatgctcat gccgccctcc agttcttgct ctgcccatct cccctcccca acccagacct 1560 aaaacaggct gttgggccaa ctgttccttg accttccttc ttttcttttg gttccttgac 1620 cccagtgggc tctcactccc cacaccgcat atctaaaatc tgttttgcct gctcttgggg 1680 tgccactgct ccccctccag cattactcct tttggcaggt ccttcctcag gctgagaatc 1740 tccccctcta ccttggtttt ctctctctgg ccagcacccc cactccttgc tttgttttta 1800 atttttaact tttgtttggg tacgtagtag atatatatgt atatatttat ggggtacatg 1860 ggatattttg acacaggcct acaatatgta ataatcacat cagggtaaat gggttatatc 1920 acaacaagca tttatccttt ctttgtgcta caaacaatcc cattatgctc tttcagttat 1980 ttttaaatgt acaataaatt attgttgact gtactcaccc tgctgtgcta tctactagat 2040 cttattcatt ctaattatat ttttgtaccc attattaacc atccctgctc ccccactccc 2100 cactaccctt ctcagcctct ggtaatcatc attctattgt ctctccccat gaggtccatt 2160 gttttaaatt ttggctgcca caaataagtg agaacatgca aagtttgtct gtctgggcct 2220 ggggcttatt tcacttcaca ggatgacctc cagttctttg caaatgacac gatggctgaa 2280 tagttctcca catacacatg tacaccacat tttctttatc catgcgtctg ttgatggaca 2340 cttagattgc ttgcagatct tggctacttt gaatagtgct gcaataaaca tggaaaagta 2400 gatagctctt taatataccg atttcctttc tttggagtat atgcctaaca gtgggagtgc 2460 tggagcatat gacagctcta ttgtattttt agtttttgga agaacctcca cattgtttcc 2520 catagtggtt gtactagttt acgttcccac caacagtgta catcctcacc agcattcctt 2580 atttctacat cctcgccagc attccttatt gcctgtcttc tggataaaag ccagtttatc 2640 tggggtggga tgttatctcg taggagtttt gatttgcctt catctgttga cgaatgatgt 2700 tgagcacctt ttcatatacc tgtttgccat ttatatgtct tcttttgaga aatgactatt 2760 cagatctttt ctcattttta aattggatta ttatattttt tttcctatag ttgttcgagc 2820 tccttatatg tttcagttac tgatcctttg tcagatgaat agtttgaaaa tattttctcc 2880 cattcttgga tggtctcttc attttgttta ttgtttcctt tgctgtgcag aagccttttt 2940 acttgatatg atcccattta tgcaatttta ctttggttac ctgtgcttgt ggggtattac 3000 tttaaaaatc tttgcccagt ccaatatcct agagagtttc cccaatgttt tcttgtatag 3060 tttcatagtt tgaggtcata gatttacatc tttaatccac tttgatttga tttttgtata 3120 tggtgaaaga cagggtctag tttcattctt ctgcataagg atatctagtt tccccagcac 3180 catttttgga gagactctcc tttgccaatg tgtgttcttg gtacctttgt tggaaatgag 3240 tttactgtag atgtatggaa ttgtttctgg gttctctatt ctgtttcatt ggtctgtgtg 3300 tctgttttta tgccagtatc atgctgtttt ggttactgta gctctgtagt ataatttgaa 3360 gtcagataat gtgattcctc tagttttgtt cattttgctc aggatagctt tatctattct 3420 ggtttttttg tggttccata tgcattttag gattattttt attatttctg tgaagaatgt 3480 cattagtgtt ttgataggga ttgcattgaa tctgtagatt actttgggta gtatggatat 3540 ttcaacaaaa ctgattcttc caatccatga acgtggacta tcttttccat tttttgtgtc 3600 cttcaatttt ttgcatcagt gttttttgtt tttggttttt gagatggagt ttcactcttg 3660 ttgcccaggc tagaatgcaa gggtgtgatc ttggctcacc gcaacctccg cctcccaggt 3720 tcaagctatt cttctgcctc agcctcccaa gtagctggga ttacaggcat gtgccactgt 3780 gcctggctaa ttttctattt ttattagaga tggggtttct ctatgttggc caggctagtc 3840 ttgaactcct gacctcaggt gatccacctg cctcggcctc ccaaagtgct gggattacag 3900 gcatgagcca ccacgcccag ccacatcact gttttatagt ttttattgga gaggtctttc 3960 acttcttcag ttaggtttat tcctcagtat tttattttat ttgtagctat tgtaaatggg 4020 attcgtttct tgatttcttt ttcagattat ttgctgttag cactgatttt tgcatgttga 4080 ttttgtatcc tgcaacttta ctcaatttgt tcttcagttc taatggtttt ttggtggagt 4140 ctttaggttt ttccaaatat cagaccacat gatctgcaaa caaggataat ttgacttctt 4200 cttttccagt tttaatgccc tttctttctt tctcctgtct gattgctcta gttaggatct 4260 gcagtactgt gttgcataac tgtggtaaaa ttagtcatcc ttgtcttatt ccagatctta 4320 gagaaaaggc tttcagtttt cccccattca gtatgttact agctgtgagt ttgtcatata 4380 tggcttttat tatattgagg tctgttcctt gtatacttag ttttttgaga gtttttatca 4440 tgaagggatg ttgaatttat caaatgcttt ttcagtatca attgaatgat actggctttt 4500 gtcctttatt ctgttgatat gacgtactac attgattgat ttgtgtatgt taaatcatcc 4560 ttgcatacct ggaatacatt ccacttgctc ataaagaatg atctttttta atgtattgtt 4620 gaatgtggtt tgctagtatt tccttgacga tttttgcatc ggtgttcatc agggatatag 4680 gcctgtagtt ttctttttta tgatgtgtct ttgcctggtt tttgtatcag gatattcctg 4740 gctttgtaaa atgagtttgg aagtattccc tcctcctcta tttttcagaa cagtttgaat 4800 aggactgaca tatgttgttc tttaaaagtt taattgtggt aaattataca ttacataaat 4860 tttactgttt taaccacttt taagtgtata ctcggtggca ttagatacat tcacattttt 4920 gtgcaaccca aaactctgtg cccattaatc ggtaactccc cattcctccc tacctctggc 4980 ccctggtaac caccattcta ctttttgttt ctatgaattt gaccactcta ggtacctcat 5040 ttaagcagaa tcatgtaatg tttgtctttt tgtttctggc ttatttcact tataatattt 5100 ttgaggttcg gtgggcacag tggctcacgc ctggatttcc agcactttgg gaggctgaag 5160 caggtggatc acctgagttt cggagttcga aaccagcctg gccaacatgg tgaaacccca 5220 tctctactaa aaataataaa agttagccgg gcgtgatggc gggtgcctgt aatcccaact 5280 acttgggagg ctgaggcagg agaatcgctt gaatccggga agtggaggtt gcagtgagct 5340 gagatcaggc cactgcactc cagcctgggc aacaagagtg aaattccatc tccaaaaaaa 5400 aaaaataaaa caataataat aataatattt ttgaggttca tccaagttgt agtatgggtc 5460 agaatttcat tccttttaag gatggataat actcattata tgtatgtacc acatcttggt 5520 tatccatccc tcagacaatg gacacttggg ttacttctac cttttggata ttggcaaata 5580 tttcatttcc tttgggtata tatttatttc ctttgggtat ttcttttggg tatatatcca 5640 gaaatagaag cagtacacag gggcttcatt ttctctgtct ctttgccaac cttgctctgt 5700 gtgtgtgtgt atgtgtgtgt gtaggtgtgt gataacagcc atcctgattg gtttcaggtg 5760 gcatctcatt gtggtttgga tttgcatttt cctaatgagt gctgatattg agcatctttt 5820 catgtgtttg ttgatcattt gtaattttct ttgaagaatt ggccatttaa gtcttttgcc 5880 cattttttcc cccacatagc ttctcttatc agatatatga cttgcaatat ttatttcatt 5940 tcggggttga ttgctttttc actctgattg tgccctttga tgcatagatg ttttgaattt 6000 tcatcagtct actttgtcag ttctttctat tctatctgtg ctttggtgtc atatccatga 6060 aagcactgtc aaatcctatg tcatgaacat tatccccaat gtttgcttct aagaaatttt 6120 taggttttag ttcttgagtg tagagtttag gtctttgatt cattttgagt taatttttgt 6180 atatagtgca aattaagagt ccaattttat tttaacaccc cctgccccca gaactatttg 6240 ctgaaaagat caactgactc tttgtcacct gctcacccca gtggacacta gctgttccat 6300 ccaattgctg tcctggggcc ttgtcatgcc actcttccac tttgaaccca agcccacacc 6360 gttgctcccc tctgggatac tgaccccact ataaacttca ctggggctac aaccttccta 6420 ccccttgtgc ctcatgacca ccccctccct tgtccccgcc atgcccatga tgagtctctt 6480 ctcgaggcag ctccccttgc ctccatctca ccctcagcct atgcaccaca gccacactgg 6540 acatgggtcc ctctgagcct gagtcccttc ccattcccac tgtcccctct ggcaagacct 6600 tccttccacc accttcatgc tcctccctcg cccctgcagg gcagcctctc cccttggccc 6660 ctattccctt agggggcttg tggccaccca gtccttgcac ctggcctaca agtttgccat 6720 cttcattccc ccttcttctg ttcatcagcc ccctcctcta tcctcccacc ctcacagttt 6780 tctttgtata tgaaatcctc gttcttgtcc ctttgcccgt gtgcatttcc tgccccagga 6840 aggttgggac agcagacctg tgtgttaaac atcaatgtga agttacttcc aggaagaagt 6900 ttcacctgtg atttcctctt ccccagagcc ccacagtctt ccttataacc tcacggtgct 6960 gtcctgggat ggatctgtgc agtcagggtt tcttgctgag gtacatctgg atggtcagcc 7020 cttcctgcgc tatgacaggc agaaatgcag ggcaaagccc cagggacagt gggcagaaga 7080 tgtcctggga aataagacat gggacagaga gaccagggac ttgacaggga acggaaagga 7140 cctcaggatg accctggctc atatcaagga ccagaaagaa ggtgagagtc ggcaggggca 7200 agagtgactg gagaggcctt ttccagaaaa gttaggggca gagagcaggg acctgtctct 7260 tcccactgga tctggctcag gctgggggtg aggaatgggg gtcagtggaa ctcagcaggg 7320 aggtgagccg gcactcagcc cacacaggga ggcatggagg agggccaggg aggcgtaccc 7380 cctgggctga gttcctcact tgggtggaaa ggtgatgggt tcgggaatgg agaagtcact 7440 gctgggtggg ggcaggcttg cattccctcc aggagattag ggtctgtgag atccatgaag 7500 acaacagcac caggagctcc cagcatttct actacgatgg ggagctcttc ctctcccaaa 7560 acctggagac tgaggaatgg acagtgcccc agtcctccag agctcagacc ttggccatga 7620 acgtcaggaa tttcttgaag gaagatgcca tgaagaccaa gacacactat cacgctatgc 7680 atgcagactg cctgcaggaa ctacggcgat atctagaatc cagcgtagtc ctgaggagaa 7740 caggtaccga cgctggccag gggctctcct ctccctccaa ttctgctaga gttgcctcac 7800 ctcccagatg tgtccaggga aaccctccct gtgctatgga tgaaggcatt tcctgttggc 7860 acatcgtgtc ctgattttcc tctattgtta gagccactgg ataaagacag tgggtcaggg 7920 actggaccat ccagtgttgt aatcagggca agtagaggac cctccgacag aatcctgagc 7980 ctgtggtggg tgtcaggtag gagaggaagc cttcagggcc agggctgccc cctctgcctc 8040 ccagcctgcc catcctggag agttccctcc tggccccaca acccaggagt ccacccctga 8100 catccccctc ctcagcatca atgtggggat cccagagcct gaggccacag tcccaaggcc 8160 catcctcctg ccagcctgga agaactgggc cccagagtga ggacagactt gcaggtcagg 8220 ggtcccggag ggcttcagcc agagtgagaa cagtgaagag aaacagccct gttcctctcc 8280 cctccttaga ggggagcagg gcttcactgg ctctgccctt tcttctccag tgccccccat 8340 ggtgaatgtc acccgcagcg aggcctcaga gggcaacatc accgtgacat gcagggcttc 8400 cagcttctat ccccggaata tcatactgac ctggcgtcag gatggggtat ctttgagcca 8460 cgacacccag cagtgggggg atgtcctgcc tgatgggaat ggaacctacc agacctgggt 8520 ggccaccagg atttgccgag gagaggagca gaggttcacc tgctacatgg aacacagcgg 8580 gaatcacagc actcaccctg tgccctctgg tgagcctagg gtgaccctgg agagggtcag 8640 gccagggtag ggacagcagg gatggctgtg gctctctgcc cagtgtataa caagtccctt 8700 tttttcaggg aaagtgctgg tgcttcagag tcattggcag acattccacg tttctgctgt 8760 tgctgctgct gctgctattt ttgttattat tattttctat gtccgttgtt gtaagaagaa 8820 aacatcagct gcagagggtc caggtgagaa aagcgggcag tttctggaga tggtaaggcc 8880 cctgtctggg cagtagggtc ccctcattgc tcctgcaaag ataggcatgt tggtgacaag 8940 gcttccgtaa caggggatga aagttgggga atttgggaag ggaatggggg cagcatctcc 9000 atctacaccc ataagtgctg cccaagcgag ggtcaaacgc ccagctgtgg catcctcctg 9060 ctgcaggtga ggagtgggca gcagggaggg ctgcggcgcc tgctctgtcc ccatcccggt 9120 ctctgtgtct cttggactca ctagggcgca tccaggtggg gtgagctggg aatcacgtgc 9180 tgaatgctaa gggcctggat gatcacggcc tcagagggag caaatagtaa aggcagctgt 9240 gatctgggga gggccagaaa ctggagagga atctgaggag aggcggtgcc cctattccct 9300 tcctctctgc atccccctcc cctgtttctc cagccatcgg ggcggacacc gagaaaaaga 9360 cctatgaggc ccagcctggg ggccctgcct gtgtagccct ttggagaccc cttgtaacag 9420 ggagggtcct gagcacacat ggccatctct gtccactttg cagctcccca tgcacctcct 9480 ccaggagctt tcttggggtt gttgtgtcct ctgcaccatt cgaggcccta ctctttccag 9540 gttcccacgg cctggcctcc ctgagtttct tgcagatgac atggatgagt agataagcag 9600 atgtccctgg gccatttgag gagtggggcc cagcccctca tcagggcagc tgtggtccct 9660 gttttcatcc tacctccgag tgttttcttc tccagtccct gagggacaca gtcctcaggg 9720 cccatgtttt tggggattta atctgtgctc tgtggcctca ccttgccctc cctgagccaa 9780 tttccctttc taaaggtggt cactgcctgg taagtttgga gtaagggacg gtcagaatca 9840 tttcccctac agtcaggttg tttgatgggg gatgaaaaga gacagcagga agttttgtgt 9900 ttctgcaaag acagaagcag ttcaggcgac agtaagaggc tggggtgtcc aggaggatgt 9960 gtctggcagt agggtcgctg gtttctcatc cttgaaccta attgcactgt caatcggccc 10020 ctcaggcctg agcagatggg aaggtttgtc ccctgccctg cagcaagagg gccctgtcca 10080 ggaggcaccc acaacagggg cagtgcaggt ctgtggtcac tcctgctctc acctgtggcg 10140 tctcccgtag agggattgtc agttctggtt ccctgtgggc aggaatggtt tcctcatagg 10200 tcactggagt tttggctagg aaaagagtat gaagttcatg tgccagtttc tcaaaattcc 10260 tgctttcaat gttgatgtcc agtaaagata ttcgtaattt cagctctata atcttaatag 10320 gatttcctct aatattgtga agcatattat atgaaacagg aacacaaatt tctcaaaatt 10380 cctgcgatgt ccaataaaga ttttcataat ttcagctctg caatcttaat aggatttcct 10440 aatactgtaa agcatattaa atgaaacagg aactcaaatt tggagccccc tctccaggag 10500 gttctgtgtg gagatggtgg ctgtggcagt ggcagttccc aggtgcagag ggtgggcaga 10560 ggcagcctca ggctaagggg tctcccctac tccacatgga gaaaatccct tgtaggttgc 10620 aagggcagtg gccgggtgga atccctgcta gggacagagc aggaaggcct cgcagcctca 10680 ccaagcagca gccctggggt ggagctgcgt ttccagggtt aagcggacca ggcaggagta 10740 gcggttactc aagagcaggt cacaggcttg ggttgtgagg gtcaggagag gccaggcctc 10800 ctcgagcaag gtgggggtcc cagggtcagg tcaggtgcag atcctgtggc agccacgtct 10860 ttccatgctg ggcctgctgg gccccccagg cttcctgatg gggtccccag ttaggagctg 10920 cctgctcagg gctgggaggg gaggagcact gagctgcaga tagagggcag agcccacagt 10980 gggcagggcc tgccctggtg tgtaggtgcc tctgcaggag aggagggcct ggggactgag 11040 agcaagggtc agggcctctc tttggggagg cctctcactg taacaggact ggtcaggcct 11100 gagaggaggg cactgggttc cctcttgggt cttgtccttt agtcttgggg ccctttccct 11160 ccctgcacga tgagtggtgg gcacagggca cgggctgatg ttgatggagt gatgggaggg 11220 aactggcagg ggctgggaaa agcaaggagg gaggaagaaa aaagtggggg cctcatcttc 11280 cctcagagaa agggcaaatc tggttttgga gcaactgaag agagaaaagt ccccagggaa 11340 taaacacaac actgcaccca gtggagcatt tacccatttc cctcttttct ccagagctcg 11400 tgagcctgca ggtcctggat caacacccag ttgggacgag tgaccacagg gatgccacac 11460 agctcggatt tcagcctctg atgtcagctc ttgggtccac tggctccact gagggcgcct 11520 agactctaca gccaggcggc tg 11542 //